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    • 53. 发明授权
    • Preparation of 3-vinyl-substituted 2,2-dimethylcyclopropane-1-carboxylic
acids and esters and intermediates therefor
    • 制备3-乙烯基取代的2,2-二甲基环丙烷-1-羧酸及其酯及其中间体
    • US4992577A
    • 1991-02-12
    • US355578
    • 1989-05-22
    • Reinhard LantzschDieter ArltManfred Jautelat
    • Reinhard LantzschDieter ArltManfred Jautelat
    • C07C45/63C07C45/72C07C49/227C07C49/235C07C51/00
    • C07C45/72C07C45/63C07C49/227C07C49/235C07C51/00
    • A process for preparing a compound of the formula ##STR1## in which Y is halogen, alkyl or cycloalkyl optionally substituted by halogen or C.sub.1-4 -alkoxy, alkenyl optionally substituted by halogen, aryl, heteroaryl or alkoxycarbonyl,X is hydrogen, halogen or optionally halogen-substituted alkyl, orX and Y, together with the adjacent C atom, form a saturated cycloalkphatic ring having up to 6 C atoms, andR is hydrogen or C.sub.1 -C.sub.4 -alkyl, comprising reacting an aldehyde of the formula ##STR2## with 2-methylbutan-3-one of the formula ##STR3## in the presence of a hydrohalic acid thereby to form a 4,4-dimethyl-3-halogeno-1-hexen-5-one of the formula ##STR4## in which Hal is halogen, halogenating said compound to produce a compound of the formula ##STR5## and reacting said compound with a base of the formulaR--OM (VI)in whichM is one equivalent of an alkali or alkaline earth metal ion.Compounds IV and V are new. By suitable conditions the trans isomer is selectively produced.
    • 制备式(I)化合物的方法,其中Y为卤素,任选被卤素或C 1-4 - 烷氧基取代的烷基或环烷基,任选被卤素,芳基,杂芳基或烷氧基羰基取代的链烯基,X为氢 ,卤素或任选的卤素取代的烷基,或X和Y与相邻的C原子一起形成具有至多6个C原子的饱和环烷基环,R是氢或C 1 -C 4烷基,包括使 式(II)化合物与式(III)的2-甲基丁-3-酮在氢卤酸存在下反应,从而形成4,4-二甲基-3-卤代-1-己烯-5 其中Hal是卤素的式(Ⅳ)化合物,卤化所述化合物以制备下式化合物(Ⅴ),并使所述化合物与式R-OM(Ⅵ)的碱反应在 其中M为1当量碱金属或碱土金属离子。 化合物IV和V是新的。 通过合适的条件选择性地制备反式异构体。
    • 57. 发明授权
    • 2-(2,2-Dimethyl-3-buten-1-yl)-2-oxazolines
    • 2-(2,2-二甲基-3-丁烯-1-基)-2-恶唑啉
    • US4358598A
    • 1982-11-09
    • US212051
    • 1980-12-01
    • Manfred JautelatDieter Arlt
    • Manfred JautelatDieter Arlt
    • C07D263/04C07D263/12C07D263/10
    • C07D263/04C07D263/12
    • A process comprising reacting a 2-methyloxazoline of the formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 each independently is hydrogen, alkyl, aralkyl, optionally substituted aryl or two of them together form a ring,with a 3-methyl-2-buten-1-yl derivative of the formula ##STR2## in which X is halide, sulphonate or phosphate, thereby to produce a 2-methyl-3-(3-methyl-2-butenyl)-2-oxazolinium salt of the formula ##STR3## reacting the oxazolinium salt with an alcoholate of the formulaR.sup.5 --O--M (V)in whichM is one equivalent of an alkali metal or alkaline earth metal cation,to produce an oxazolidine of the formula ##STR4## pyrolyzing the oxazolidine to produce a 2-methylene-3-(3-methyl-2-butenyl)-oxazolidine of the formula ##STR5## and heating the 2-methylene-3-(3-methyl-2-butenyl)-oxazolidine to produce a 2-(2,2-dimethyl-3-buten-1-yl)-2-oxazoline of the formula ##STR6## The compounds (II), (III) and (IV) are new.
    • 一种方法包括使式(VI)的2-甲基恶唑啉(其中R 1,R 2,R 3和R 4各自独立地为氢,烷基,芳烷基,任选取代的芳基或其中的两个一起形成环)与3 (VII)的2-甲基-2-丁烯-1-基衍生物,其中X是卤化物,磺酸盐或磷酸盐,从而产生2-甲基-3-(3-甲基-2-丁烯基) - 式(Ⅳ)的2-恶唑啉盐使恶唑啉盐与式为R5-OM(Ⅴ)的醇化物反应,其中M为1当量碱金属或碱土金属阳离子,得到 (III)将式(III)热解得到式(II)的2-亚甲基-3-(3-甲基-2-丁烯基) - 恶唑烷并加热2-亚甲基-3-( 3-甲基-2-丁烯基) - 恶唑烷以制备下式的2-(2,2-二甲基-3-丁烯-1-基)-2-恶唑啉(I)化合物(II),( III)和(IV)是新的。