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    • 53. 发明授权
    • Process for preparing pharmacologically acceptable salt of N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl amino acids
    • 制备N-(1(S) - 乙氧基羰基-3-苯基丙基)-L-丙氨酰氨基酸的药理学可接受盐的方法
    • US06335453B1
    • 2002-01-01
    • US09269107
    • 1999-03-19
    • Yasuyoshi UedaKoichi KinoshitaTadashi MoroshimaYoshifumi YanagidaYoshihide Fuse
    • Yasuyoshi UedaKoichi KinoshitaTadashi MoroshimaYoshifumi YanagidaYoshihide Fuse
    • C07K5062
    • C07K5/0222C07K5/06026
    • There is provided a process for preparing a pharmacologically acceptable salt of N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-amino acid which comprises condensing an amino acid and N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanine.N-carboxyanhydride under basic condition, carrying out decarboxylation under between neutral and acidic condition to obtain N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-amino acid, and forming a pharmacologically acceptable salt thereof, wherein the production of a by-product (3): is suppressed by carrying out in an aqueous liquid a series of operations till formation of the pharmacologically acceptable salt or till isolation of the pharmacologically acceptable salt. The present invention enables to prepare the pharmacologically acceptable salt of N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-amino acid having high quality, in a commercial scale with high yield and economical efficiency.
    • 提供了制备N-(1(S) - 乙氧基羰基-3-苯基丙基)-L-丙氨酰 - 氨基酸的药学上可接受的盐的方法,其包括将氨基酸和N-(1(S) - 乙氧基羰基 - 3-苯基丙基)-L-丙氨酸N-羧酸酐,在中性和酸性条件下进行脱羧,得到N-(1(S) - 乙氧基羰基-3-苯基丙基)-L-丙氨酰 - 氨基酸,和 形成其药理学上可接受的盐,其中通过在含水液体中进行一系列操作直到形成药理学上可接受的盐或直到药理学上可接受的盐的分离来抑制副产物(3)的产生。 本发明能够以高产率和经济效益以商业规模制备质量高的N-(1(S) - 乙氧基羰基-3-苯基丙基)-L-丙氨酰 - 氨基酸的药理学上可接受的盐。
    • 60. 发明授权
    • Hair cosmetic
    • 头发化妆品
    • US08293220B2
    • 2012-10-23
    • US13322565
    • 2010-05-27
    • Koichi Kinoshita
    • Koichi Kinoshita
    • A61K8/00A61K8/44A61Q5/02
    • A61Q5/12A61K8/39A61K8/416A61K8/42A61K8/731A61K8/8152
    • The present invention provides a hair cosmetic composition contains (A) a di-long-chain cationic surfactant represented by formula (1); (B) an ethylene oxide adduct of 1,2-alkanediol represented by formula (2) and/or an N-acyl-N-methylmonoethanolamide represented by formula (3); and (C) a hydrophobicized alkyl cellulose represented by formula (4) and/or a cationic polymer represented by formula (5), and (D) water (chemical formulas not shown). The hair cosmetic composition has remarkably high safety and excellent stability. In addition, the composition exhibits excellent spreadability over hair upon application thereof and can finish hair with suppleness and less stickiness. Also, even when the composition has a low base material content, a lamellar liquid crystal structure can be formed. Quite surprisingly, the hair cosmetic composition can provide hair with conditioning effects together with excellent viscoelasticity and shows such excellent performance as to cause no problem even though the rinsing step is omitted.
    • 本发明提供含有(A)由式(1)表示的二长链阳离子表面活性剂的毛发化妆品组合物。 (B)由式(2)表示的1,2-链烷二醇和/或由式(3)表示的N-酰基-N-甲基单乙醇酰胺的环氧乙烷加成物; 和(C)由式(4)表示的疏水化烷基纤维素和/或式(5)表示的阳离子聚合物和(D)水(化学式未示出)。 头发美容组合物具有非常高的安全性和优异的稳定性。 此外,该组合物在使用时在头发上展现出优异的铺展性,并且可以以柔软和较少的粘性完成头发。 此外,即使组合物的基材含量低,也可以形成层状的液晶结构。 令人惊奇的是,毛发化妆品组合物可以赋予头发调理效果优异的粘弹性,并且即使省略了漂洗步骤,也显示出优异的性能即使没有问题。