专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

51. 发明授权

US4572193A DDI Programmable cardiac tissue stimulator 失效
标题翻译： DDI可编程心脏组织刺激器
公开(公告)号：US4572193A
公开(公告)日：1986-02-25
申请号：US574715
申请日：1984-01-27
申请人： Brian M. Mann , Jason A. Sholder
发明人： Brian M. Mann , Jason A. Sholder
IPC分类号： A61N1/368 , A61N1/36
CPC分类号： A61N1/368
摘要： A cardiac stimulation apparatus capable of stimulation in the DDI modality having a first sensing system (46) for sensing electrical activity in the atrium, a second sensing system (48) for sensing electrical activity in the ventricle, a pulse generator logic (24) connected to the first (46) and second (48) sensing systems responsive to electrical activity sensed by the first (46) and second (48) sensing systems for determining the timing for supplying electrical pulses to the atrium and ventricle for their depolarization, a first circuit within the pulse generator logic (24) for preventing synchronization of timing within the pulse generator (24) for producing apparatus generated pulses to the ventricle when electrical activity is sensed in the atrium, a second circuit within the pulse generator logic (24) for inhibiting an apparatus generated pulse to the atrium when electrical activity is sensed resulting from natural depolarization of the atrium, and pulse generator logic timing means (32, 34, 44) for interacting with the pulse generator logic (24) for carrying out timing functions for pulse generation.
摘要翻译：能够在DDI模式中刺激的心脏刺激装置，其具有用于感测心房中的电活动的第一感测系统（46），用于感测心室中的电活动的第二感测系统（48），连接的脉冲发生器逻辑涉及响应于由第一（46）和第二（48）感测系统感测的电活动的第一（46）和第二（48）感测系统，用于确定为其去极化向心房和心室提供电脉冲的定时，第一脉冲发生器逻辑（24）内的电路，用于防止脉冲发生器（24）内的定时的同步，用于当在心房中检测到电活动时，产生设备产生的脉冲到脉管;脉冲发生器逻辑（24）内的第二电路，用于当由于心房的自然去极化而感测到电活动时，抑制装置产生的心脏脉搏，脉冲发生器逻辑使我（32,34,44），用于与脉冲发生器逻辑（24）相互作用，以执行用于脉冲产生的定时功能。

52. 发明授权

US4324251A Battery monitoring means and method for an implantable tissue stimulator 失效
标题翻译：用于植入式组织刺激器的电池监视装置和方法
公开(公告)号：US4324251A
公开(公告)日：1982-04-13
申请号：US158122
申请日：1980-06-10
申请人： Brian M. Mann
发明人： Brian M. Mann
IPC分类号： A61N1/37 , A61N1/372 , G01R31/36 , A61N1/36
CPC分类号： G01R31/3662 , A61N1/3708 , A61N1/37252
摘要： A battery monitoring means for an implantable tissue stimulator in which a signal related to the internal impedance of an implanted battery is telemetered to an external receiving means. More specifically, the implanted battery is loaded by a varible load until current flowing through the battery lowers its output voltage until it has a predetermined relationship with respect to a reference voltage. The current flowing through the battery to achieve the predetermined relationship is directly related to the internal impedance of the battery. A voltage related to the value of this current is then telemetered to the external receiving means. In a specific embodiment, the variable load is a field effect transistor (FET) connected as a source follower. The impedance of the FET is controlled by the output of an operational amplifier having as inputs the reference voltage and a voltage related to the output voltage of the battery. The monitoring means operates in a closed-loop servo system manner until the two input voltages to the operational amplifier are equal. The other terminal of the battery is connected to a shunting resistor. Thus the voltage drop across the shunting resistor is related to the current drawn from, and the internal impedance of, the battery. This voltage is telemetered to the external receiving means.
摘要翻译：一种用于可植入组织刺激器的电池监视装置，其中与植入电池的内部阻抗相关的信号被遥测到外部接收装置。更具体地，植入的电池通过可变负载加载，直到流过电池的电流降低其输出电压，直到其相对于参考电压具有预定的关系。流过电池以达到预定关系的电流与电池的内部阻抗直接相关。然后将与该电流的值相关的电压遥测到外部接收装置。在具体实施例中，可变负载是作为源极跟随器连接的场效应晶体管（FET）。 FET的阻抗由具有作为输入的运算放大器的输出控制，该运算放大器具有参考电压和与电池的输出电压相关的电压。监控装置以闭环伺服系统方式操作，直到运算放大器的两个输入电压相等。电池的另一端连接到分流电阻。因此，分流电阻上的电压降与电池的电流和内部阻抗有关。该电压被遥测到外部接收装置。

53. 发明授权

US07402899B1 Hermetically sealable silicon system and method of making same 有权
标题翻译：密封硅系统及其制作方法
公开(公告)号：US07402899B1
公开(公告)日：2008-07-22
申请号：US11622647
申请日：2007-01-12
申请人： James S. Whiting , Neal L. Eigler , Brian M. Mann , Werner Hafelfinger
发明人： James S. Whiting , Neal L. Eigler , Brian M. Mann , Werner Hafelfinger
IPC分类号： H01L21/30
CPC分类号： H01L23/10 , B81B7/0077 , H01L2924/0002 , H01L2924/01079 , H01L2924/09701 , H01L2924/00
摘要： A device and method for hermetically sealing a medical device is provided. In one aspect, a silicon device is coupled to a sensor, such as a pressure transducer, which benefits from having direct contact with its environment, which in many cases, is the human body. Thus, a method to hermetically seal the non-sensing portion of a silicon device while allowing the sensing portion (e.g. the pressure transducer) to have direct contact with the body is provided. In one aspect, a silicon chip, a gold preform and a metallic housing are each primed for sealing and are assembled. The assembly is then heated to react the gold preform to the silicon chip and to form a molten gold-silicon alloy in-situ to bind the metallic housing to the non-sensing portion of the silicon chip. In this way, the non-sensing portion of the silicon chip is hermetically sealed and protected from exposure, while still permitting exposure of the sensing portion to the environment.
摘要翻译：提供一种用于密封医疗装置的装置和方法。在一个方面，硅器件耦合到诸如压力传感器的传感器，其受益于与其环境的直接接触，其在许多情况下是人体。因此，提供了一种使允许感测部分（例如压力传感器）与身体直接接触的硅器件的非感测部分密封的方法。在一个方面，硅芯片，金预成型件和金属外壳各自用于密封并组装。然后将组件加热以使金预成型件与硅芯片反应，并原位形成熔融的金 - 硅合金，以将金属外壳固定到硅芯片的非感测部分。以这种方式，硅芯片的非感测部分被气密地密封并防止暴露，同时仍然允许感测部分暴露于环境中。

54. 发明授权

US06842643B1 Method and apparatus for resetting programming parameters within an implantable medical device 有权
标题翻译：用于在可植入医疗装置内复位编程参数的方法和装置
公开(公告)号：US06842643B1
公开(公告)日：2005-01-11
申请号：US10051889
申请日：2002-01-16
申请人： Allan R. Schwartz , David W. Adinolfi , Hakan Hornell , Kelly H. McClure , Brian M. Mann
发明人： Allan R. Schwartz , David W. Adinolfi , Hakan Hornell , Kelly H. McClure , Brian M. Mann
IPC分类号： A61N1/08 , A61N1/372
CPC分类号： A61N1/37264 , A61N1/37211
摘要： An external programmer is provided with the capability of automatically resetting the programming state of an implantable medical device to a previous programming state. To this end, the pacemaker maintains parameters representative of current and past programming states. In response to a physician-initiated reset function using an external programmer, the pacemaker transfers information pertaining to the programming states to the external programmer along with a pointer identifying the current state. The physician selects one of the previous programming states and the external programmer then updates the pointer to identify the selected state and transmits the pointer back to the pacemaker. The pacemaker accesses the programming parameters stored therein corresponding to the programming state identified by the new pointer and is reprogrammed. Accordingly, the programming state of the pacemaker is reset to the previous programming state without requiring manual reentry of the parameters. The external programmer may also be configured to enable the physician to modify parameters or to display differences between two or more programming states of the medical device. Also, the external programmer may be configured to enable the physician to merge parameters from two or more programming states to create a new programming state.
摘要翻译：外部编程器具有将可植入医疗装置的编程状态自动复位到先前编程状态的能力。为此，起搏器保持代表当前和过去编程状态的参数。响应于使用外部编程器的医师启动的复位功能，起搏器与标识当前状态的指针一起将关于编程状态的信息传送到外部编程器。医生选择之前的编程状态之一，然后外部编程器更新指针以识别所选择的状态，并将指针发送回起搏器。起搏器根据由新指针识别的编程状态访问存储在其中的编程参数，并重新编程。因此，起搏器的编程状态被重置为先前的编程状态，而不需要手动重新进入参数。外部编程器还可以被配置为使医师能够修改参数或显示医疗设备的两个或多个编程状态之间的差异。此外，外部编程器可以被配置为使得医师能够合并来自两个或多个编程状态的参数以创建新的编程状态。

55. 发明授权

US06782291B1 Implantable cardiac stimulation device with automatic evoked response sensing electrode configuration selection and method 有权
标题翻译：可植入心脏刺激装置具有自动诱发响应感应电极配置选择和方法
公开(公告)号：US06782291B1
公开(公告)日：2004-08-24
申请号：US09655438
申请日：2000-09-05
申请人： Gene A. Bornzin , Joseph J. Florio , Laurence S. Sloman , Brian M. Mann , Jason A. Sholder
发明人： Gene A. Bornzin , Joseph J. Florio , Laurence S. Sloman , Brian M. Mann , Jason A. Sholder
IPC分类号： A61N1372
CPC分类号： A61N1/3686 , A61N1/36185 , A61N1/371
摘要： An implantable cardiac stimulation device applies pacing stimulation pulses to a heart and senses evoked responses to the pacing stimulation pulses. A pulse generator applies the stimulation pacing pulses to the heart in accordance with a pacing configuration. A sensor control selects an evoked response sensing electrode configuration from among a plurality of evoked response sensing electrode configurations in response to the pacing configuration. A sensor is then programmed to sense the evoked responses with the selected evoked response sensing electrode configuration. In accordance with a preferred embodiment, signal-to-noise ratios obtained with the various electrode configurations are used to select a best electrode configuration for sensing evoked responses.
摘要翻译：可植入心脏刺激装置将起搏刺激脉冲应用于心脏并感测对起搏刺激脉冲的诱发反应。脉冲发生器根据起搏配置将刺激起搏脉冲施加到心脏。传感器控制器响应于起搏配置从多个诱发响应感测电极配置中选择诱发响应感测电极配置。然后将传感器编程为用所选择的诱发响应感测电极配置感测诱发的反应。根据优选实施例，用各种电极配置获得的信噪比用于选择用于感测诱发响应的最佳电极配置。

56. 发明授权

US06584354B1 Implantable stimulation device and method for determining atrial autocapture using PVC response 失效
标题翻译：植入式刺激装置及使用PVC反应确定心房自体收缩的方法
公开(公告)号：US06584354B1
公开(公告)日：2003-06-24
申请号：US09906505
申请日：2001-07-17
申请人： Brian M. Mann , Melinda Endaya , Paul A. Levine
发明人： Brian M. Mann , Melinda Endaya , Paul A. Levine
IPC分类号： A61N137
CPC分类号： A61N1/3712 , A61N1/3714 , A61N1/37247
摘要： A pacemaker programmer and diagnostic system retrieves information stored within a pacemaker and analyzes the retrieved data in real time. The stored information can be retrieved by means of a telemetry communication link. The pacemaker automatically lengthens a post-ventricular atrial refractory period (PVARP). The pacemaker determines atrial capture threshold by generating atrial stimulation pulses while maintaining the ventricular stimulation pulse amplitude at a level known to ensure ventricular capture, and by detecting loss of atrial capture. In response to loss of atrial capture, a processor automatically triggers a premature ventricular contraction (PVC) response to prevent a retrograde P-wave from initiating a pacemaker-mediated tachycardia. Also in response to loss of atrial capture, the processor sets the atrial stimulation pulse amplitude to a value above the atrial capture threshold in a subsequent cardiac cycle, and restores the PVARP to its pre-test value.
摘要翻译：起搏器程序员和诊断系统检索存储在起搏器内的信息，并实时分析检索到的数据。所存储的信息可以通过遥测通信链路来检索。心脏起搏器自动延长心室不应期（PVARP）。起搏器通过产生心房刺激脉冲来确定心房捕获阈值，同时将心室刺激脉冲幅度保持在已知的水平以确保心室捕获，并通过检测心房捕获的损失。为了应对心房捕获的丧失，处理器自动触发早期心室收缩（PVC）反应，以防止逆行P波起始起搏器介导的心动过速。另外为了响应于心房捕获的丢失，处理器将心房刺激脉冲幅度设置为高于心房捕获阈值的值，并将PVARP恢复到其预测值。

57. 发明授权

US06285908B1 Implantable stimulation device and method for determining atrial autocapture using programmable AV delay 有权
标题翻译：可植入刺激装置及使用可编程AV延迟确定心房自体电位的方法
公开(公告)号：US06285908B1
公开(公告)日：2001-09-04
申请号：US09379043
申请日：1999-08-23
申请人： Brian M. Mann , Melinda Endaya , Paul A. Levine
发明人： Brian M. Mann , Melinda Endaya , Paul A. Levine
IPC分类号： A61N1362
CPC分类号： A61N1/3712 , A61N1/3682 , A61N1/3714
摘要： A pacemaker programmer and diagnostic system retrieves information stored within a pacemaker and analyzes the retrieved data in real time. The stored information can be retrieved by means of a telemetry communication link. The pacemaker automatically lengthens a post-ventricular atrial refractory period (PVARP). The pacemaker determines atrial capture threshold by generating atrial stimulation pulses while maintaining the ventricular stimulation pulse amplitude at a level known to ensure ventricular capture, and by detecting loss of atrial capture. In response to the loss of atrial capture, a processor automatically shortens the AV delay in a subsequent cardiac cycle, to reduce the possibility of a retrograde P-wave initiating a pacemaker-mediated tachycardia (PMT). Also in response to the loss of atrial capture, the pacemaker records the atrial capture threshold, restores the PVARP to its pre-test value, and sets the atrial stimulation pulse amplitude to a value above the atrial capture threshold.
摘要翻译：起搏器程序员和诊断系统检索存储在起搏器内的信息，并实时分析检索到的数据。所存储的信息可以通过遥测通信链路来检索。心脏起搏器自动延长心室不应期（PVARP）。起搏器通过产生心房刺激脉冲来确定心房捕获阈值，同时将心室刺激脉冲幅度保持在已知的水平以确保心室捕获，并通过检测心房捕获的损失。为了响应于心房捕获的丧失，处理器在随后的心动周期中自动缩短AV延迟，以减少逆行P波启动起搏器介导的心动过速（PMT）的可能性。另外为了应对心房捕获的损失，起搏器记录心房捕获阈值，将PVARP恢复到其预测值，并将心房刺激脉冲幅度设置为高于心房捕获阈值的值。

58. 发明授权

US06259950B1 Implantable stimulation device and method for determining a trial autocapture using backup atrial stimulation 有权
标题翻译：植入式刺激装置和使用备用心房刺激确定试验性自体捕获的方法
公开(公告)号：US06259950B1
公开(公告)日：2001-07-10
申请号：US09395640
申请日：1999-09-14
申请人： Brian M. Mann , Melinda Endaya , Paul A. Levine
发明人： Brian M. Mann , Melinda Endaya , Paul A. Levine
IPC分类号： A61N1368
CPC分类号： A61N1/3712 , A61N1/3714 , A61N1/37247
摘要： A pacemaker programmer and diagnostic system retrieves information stored within a pacemaker and analyzes the retrieved data in real time. The stored information can be retrieved by means of a telemetry communication link. The pacemaker automatically lengthens an AV delay. The pacemaker determines atrial capture by generating atrial stimulation pulses while maintaining the ventricular stimulation pulse amplitude at a level known to ensure ventricular capture, and by detecting loss of atrial capture. In response to the loss of atrial capture, a processor automatically records the atrial capture threshold, and restores the AV delay to its pre-test value. The pulse generator also delivers a backup atrial stimulation pulse concurrent with a ventricular stimulation pulse to reduce the possibility of a retrograde P-wave initiating a pacemaker-mediated tachycardia (PMT).
摘要翻译：起搏器程序员和诊断系统检索存储在起搏器内的信息，并实时分析检索到的数据。所存储的信息可以通过遥测通信链路来检索。起搏器自动延长AV延迟。起搏器通过产生心房刺激脉冲来确定心房捕获，同时将心室刺激脉冲幅度保持在已知的水平以确保心室捕获，并通过检测心房捕获的损失。响应于心房捕获的丢失，处理器自动记录心房捕获阈值，并将AV延迟恢复到其测试前值。脉冲发生器还提供与心室刺激脉冲同时的备用心房刺激脉冲，以减少起搏器介导的心动过速（PMT）逆行P波的可能性。

59. 发明授权

US5800472A Recommended replacement time trigger for use within an implantable rate-responsive pacemaker 失效
标题翻译：推荐的更换时间触发器可用于植入式速率响应式起搏器
公开(公告)号：US5800472A
公开(公告)日：1998-09-01
申请号：US802624
申请日：1997-02-19
申请人： Brian M. Mann
发明人： Brian M. Mann
IPC分类号： A61N1/37 , A61N1/378
CPC分类号： A61N1/3708
摘要： A multi-mode rate-responsive pacemaker provides an accurate recommended replacement time (RRT) indicator which provides for full rate response performance until RRT is indicated without any decrease in longevity due to a premature triggering of RRT during rate response. An RRT trigger signal is generated whenever the battery voltage falls below a prescribed RRT threshold voltage. In one embodiment, a sustained battery voltage (determined based, e.g., on a long-term average of the battery voltage) that is less than the RRT threshold voltage must be detected before the RRT trigger signal is generated. In another embodiment, two RRT threshold voltages are used rather than one. A normal RRT threshold voltage is used when the pacer is not operating in a rate-responsive mode, and a lower RRT threshold voltage is used when the pacer is operating in a rate-responsive mode. In yet another embodiment, when the pacemaker is operating in a rate-responsive mode, the RRT trigger signal is not generated until a time delay longer than a typical exercise duration has elapsed during which the battery voltage continuously remains below the RRT threshold.
摘要翻译：多模式速率响应起搏器提供准确的推荐更换时间（RRT）指示器，其提供全速率响应性能，直到RRT被指示，而在速率响应期间由于过早触发RRT而使得寿命没有任何降低。每当电池电压低于规定的RRT阈值电压时，产生RRT触发信号。在一个实施例中，必须在生成RRT触发信号之前检测小于RRT阈值电压的持续电池电压（例如基于电池电压的长期平均值确定）。在另一实施例中，使用两个RRT阈值电压而不是一个。当起搏器不以速率响应模式操作时，使用正常的RRT阈值电压，并且当起搏器以速率响应模式操作时，使用较低的RRT阈值电压。在另一个实施例中，当起搏器以速率响应模式操作时，不会产生RRT触发信号，直到电池电压连续保持低于RRT阈值以下的时间延迟超过典型运动持续时间。

60. 发明授权

US5573003A Low-power delta modulator for intracardial signal monitoring in a cardiac device 失效
标题翻译：用于心脏设备中心内信号监测的低功耗增量调制器
公开(公告)号：US5573003A
公开(公告)日：1996-11-12
申请号：US379067
申请日：1995-01-27
申请人： Brian M. Mann , Min-Yaug Yang
发明人： Brian M. Mann , Min-Yaug Yang
IPC分类号： A61N1/37 , A61B5/0402
CPC分类号： A61N1/3704
摘要： A low-power delta modulator analog-to-digital converter is provided that is suitable for use in a cardiac stimulating device for monitoring intracardial signals. The delta modulator consumes less power than previously available delta modulators because portions of the delta modulator circuitry are shut down when the signal to be digitized is not rapidly varying. The device uses slow clock pulses for sampling the input signal and subsequently digitizes the sampled signal using a faster clock. After a sampled signal has been digitized, the result is held until the next slow clock pulse. Power consumption is reduced since the delta modulator does not draw substantial amounts of power during this holding period. Further, the output of the delta modulator reflects the magnitude of the change in the analog input, with a separate bit for representing direction. Thus, when the input signal remains constant from one slow clock pulse to the next, the delta modulator does not draw significant power even on that next slow clock pulse.
摘要翻译：提供了一种适用于监测心内信号的心脏刺激装置中的低功率增量调制器模拟 - 数字转换器。 Δ调制器消耗的功率比以前可用的delta调制器少，因为当要被数字化的信号不会迅速变化时，Δ调制器电路的部分被关闭。器件使用慢时钟脉冲对输入信号进行采样，然后使用更快的时钟数字化采样信号。在采样信号被数字化之后，结果保持到下一个慢时钟脉冲。功率消耗降低，因为在该保持期间增量调制器不会产生大量的功率。此外，Δ调制器的输出反映了模拟输入的变化的大小，并且具有用于表示方向的单独位。因此，当输入信号从一个慢时钟脉冲保持恒定到下一个时钟脉冲时，增量调制器即使在该下一个慢时钟脉冲上也不会产生显着的功率。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式