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51. 发明授权

US5282837A Atrial defibrillator and method 失效
标题翻译：心房除颤器及方法
公开(公告)号：US5282837A
公开(公告)日：1994-02-01
申请号：US685130
申请日：1991-04-12
申请人： John M. Adams , Clifton A. Alferness
发明人： John M. Adams , Clifton A. Alferness
IPC分类号： A61N1/05 , A61N1/39
CPC分类号： A61N1/3918 , A61N1/056 , A61N1/0563 , A61N1/3956 , A61N1/3962 , A61N1/395 , A61N1/3987 , A61N2001/0585
摘要： An implantable atrial defibrillator provides a pulse of defibrillating electrical energy to the atria of the heart in synchronism with sensed R waves in response to non-coincident sensing of an R wave at first and second areas of the heart. The defibrillating pulse is provided after a predetermined number of consecutive R waves are non-coincidently sensed to assure reliable synchronization. The atrial defibrillator is also operational in a marker mode wherein a number of synchronization marker pulses are delivered to the heart for detection on an externally generated electrocardiogram. The atrial fibrillation detector of the defibrillator is normally disabled and is activated when the sensed ventricular activity indicates a probability of atrial fibrillation to conserve a depletable power source. An endocardial lead is also described which ensures that the delivered atrial defibrillating electrical energy is substantially confined to the atria of the heart.
摘要翻译：可植入心房除颤器响应于在心脏的第一和第二区域处的R波的不一致的感测，与感测到的R波同步地向心脏的心房提供除颤电脉冲。在不一致地感测到预定数量的连续R波之后提供除颤脉冲，以确保可靠的同步。心房除颤器还可以在标记模式中操作，其中多个同步标记脉冲被传送到心脏以便在外部产生的心电图上进行检测。除颤器的心房颤动检测器通常被禁用，并且当感测到的心室活动指示心房颤动的概率以节省可消耗的电源时被激活。还描述了一种心内膜导联，其确保输送的心房除颤电能基本上限于心脏的心房。

52. 发明授权

US5135004A Implantable myocardial ischemia monitor and related method 失效
标题翻译：植入式心肌缺血监测及相关方法
公开(公告)号：US5135004A
公开(公告)日：1992-08-04
申请号：US667819
申请日：1991-03-12
申请人： John M. Adams , Clifton A. Alferness
发明人： John M. Adams , Clifton A. Alferness
IPC分类号： A61B5/04 , A61B5/00 , A61B5/042 , A61B5/0452
CPC分类号： A61B5/6852 , A61B5/0031 , A61B5/0422
摘要： An implantable device assists in the diagnosis of myocardial ischemia of a human heart and includes a plurality of electrodes and a like plurality of sense amplifiers for generating an electrogram for each of the electrodes. A digital to analog converter reads the voltage magnitudes of the electrogram ST segments which are then stored in a memory. An implantable receiver/transmitter is arranged to transmit the magnitudes of the electrogram ST segments to a nonimplanted external receiver.
摘要翻译：可植入装置有助于人心脏的心肌缺血的诊断，并且包括多个电极和类似的多个读出放大器，用于产生每个电极的电描记图。数模转换器读取电描记图ST段的电压大小，然后存储在存储器中。可植入接收器/发射器被布置成将电描记图ST段的大小传送到非植入式外部接收器。

53. 发明授权

US08277372B2 Cardiac support device with differential compliance 有权
标题翻译：心脏支持装置符合差异
公开(公告)号：US08277372B2
公开(公告)日：2012-10-02
申请号：US12719553
申请日：2010-03-08
申请人： Clifton A. Alferness , Jai Shankar Raman , John Melmouth Power
发明人： Clifton A. Alferness , Jai Shankar Raman , John Melmouth Power
IPC分类号： A61F2/02
CPC分类号： A61F2/2481 , A61F2002/0068
摘要： A cardiac support device comprising a jacket of flexible and biocompatible material having a first axis for alignment generally parallel to a longitudinal axis of a patient's heart and a second axis that is transverse to the first axis. The material exhibits an amount of expansion in response to a force applied to the material along the first axis that is different than an amount of expansion in response to the force applied to the material along the second axis.
摘要翻译：一种心脏支持装置，其包括柔性和生物相容性材料的护套，其具有大致平行于患者心脏的纵向轴线的对准的第一轴线和横向于第一轴线的第二轴线。该材料响应于沿着第一轴施加到材料上的力而响应于沿着沿着第二轴施加到材料的力而产生的膨胀量不同的膨胀量。

54. 发明申请

US20120165856A1 REMOVABLE ANCHORED LUNG VOLUME REDUCTION DEVICES AND METHODS 有权
标题翻译：可拆卸的锚定式减压装置及方法
公开(公告)号：US20120165856A1
公开(公告)日：2012-06-28
申请号：US13415616
申请日：2012-03-08
申请人： Clifton A. Alferness
发明人： Clifton A. Alferness
IPC分类号： A61M29/00
CPC分类号： A61B17/12104 , A61B17/12022 , A61B17/1204 , A61B17/12159 , A61B17/12172 , A61B2017/1205 , A61B2017/22051 , A61B2017/22067 , A61F2002/043
摘要： An intra-bronchial device may be placed and anchored in an air passageway of a patient to collapse a lung portion associated with the air passageway. The device includes an obstructing member that prevents air from being inhaled into the lung portion, and an anchor that anchors the obstruction device within the air passageway. The anchor may piercingly engage the air passageway wall. The anchor may be releasable from the air passageway for removal of the obstructing member. The anchor may be releasable by collapsing a portion of the obstructing member, or by drawing the obstructing member toward the larynx. The obstructing member may be a one-way valve.
摘要翻译：可以将支气管内装置放置并锚定在患者的空气通道中以折叠与空气通道相关联的肺部分。该装置包括防止空气被吸入肺部的阻塞构件，以及将阻塞装置固定在空气通道内的锚固件。锚固件可以穿透空气通道壁。锚固件可以从空气通道释放以去除阻塞构件。锚固件可以通过塌缩阻塞构件的一部分，或者通过将阻塞构件拉向喉部来释放。阻塞构件可以是单向阀。

55. 发明授权

US08177805B2 Removable anchored lung volume reduction devices and methods 有权
标题翻译：可拆卸锚固肺体积减少装置及方法
公开(公告)号：US08177805B2
公开(公告)日：2012-05-15
申请号：US13198546
申请日：2011-08-04
申请人： Clifton A. Alferness
发明人： Clifton A. Alferness
IPC分类号： A61M29/00
CPC分类号： A61B17/12104 , A61B17/12022 , A61B17/1204 , A61B17/12159 , A61B17/12172 , A61B2017/1205 , A61B2017/22051 , A61B2017/22067 , A61F2002/043
摘要： An intra-bronchial device may be placed and anchored in an air passageway of a patient to collapse a lung portion associated with the air passageway. The device includes an obstructing member that prevents air from being inhaled into the lung portion, and an anchor that anchors the obstruction device within the air passageway. The anchor may piercingly engage the air passageway wall. The anchor may be releasable from the air passageway for removal of the obstructing member. The anchor may be releasable by collapsing a portion of the obstructing member, or by drawing the obstructing member toward the larynx. The obstructing member may be a one-way valve.
摘要翻译：可以将支气管内装置放置并锚定在患者的空气通道中以折叠与空气通道相关联的肺部分。该装置包括防止空气被吸入肺部的阻塞构件，以及将阻塞装置固定在空气通道内的锚固件。锚固件可以穿透空气通道壁。锚固件可以从空气通道释放以去除阻塞构件。锚固件可以通过塌缩阻塞构件的一部分，或者通过将阻塞构件拉向喉部来释放。阻塞构件可以是单向阀。

56. 发明申请

US20100198020A1 System And Method For Computer-Implemented Method For Actively Managing Increased Insulin Resistance In Type 2 Diabetes Mellitus 审中-公开
标题翻译：计算机实施方法的系统和方法，用于积极管理2型糖尿病中增加的胰岛素抵抗
公开(公告)号：US20100198020A1
公开(公告)日：2010-08-05
申请号：US12757920
申请日：2010-04-09
申请人： Clifton A. Alferness , Gust H. Bardy
发明人： Clifton A. Alferness , Gust H. Bardy
IPC分类号： A61B5/00
CPC分类号： G06F19/3475 , G06F19/3456 , G06F19/3481 , G16H15/00 , G16H50/50
摘要： A computer-implemented method for actively managing increased insulin resistance in Type 2 diabetes mellitus is provided. A computer-generated model of glycemic effect for a Type 2 diabetic patient for digestive response is established on a computer workstation. A rise in postprandial blood glucose from a meal planned for ingestion by the patients estimated as displayed through the digestive response model. A coefficient applied to the digestive response model for an initial degree of insulin resistance experienced by the patient is adjusted. Following a physiologic increase in insulin resistance, a rise in postprandial blood glucose from a subsequent meal planned for ingestion by the patient is estimated as displayed through the digestive response model. The coefficient applied to the digestive response model for a subsequent degree of insulin resistance experienced by the patient is adjusted.
摘要翻译：提供了一种主动管理2型糖尿病胰岛素抵抗增加的计算机实现方法。在计算机工作站上建立了计算机生成的2型糖尿病患者消化反应的血糖效应模型。膳食中餐后血糖升高，计划由通过消化反应模型显示的患者进行摄入。调整用于患者经历的初始胰岛素抵抗程度的消化反应模型的系数。在胰岛素抵抗的生理上升后，通过消化反应模型估计出计划由患者摄取的随后的膳食中餐后血糖的升高。调整用于患者经历的随后的胰岛素抵抗程度的消化反应模型的系数。

57. 发明申请

US20100145670A1 SYSTEM AND METHOD FOR MANAGING TYPE 2 DIABETES MELLITUS THROUGH A PERSONAL PREDICTIVE MANAGEMENT TOOL 审中-公开
标题翻译：通过个人预测管理工具管理2型糖尿病的系统和方法
公开(公告)号：US20100145670A1
公开(公告)日：2010-06-10
申请号：US12030130
申请日：2008-02-12
申请人： Clifton A. Alferness , Gust H. Hardy
发明人： Clifton A. Alferness , Gust H. Hardy
IPC分类号： G06G7/58
CPC分类号： G06F19/3475 , G06F19/3456 , G06F19/3481 , G16H15/00 , G16H50/50
摘要： A system and method for managing Type 2 diabetes mellitus through a personal predictive management tool is provided. An insulin resistance for a Type 2 diabetes patient is identified. A time course curve is maintained for a patient population including expected blood glucose levels for a type of human-consumable food. The blood glucose levels following consumption of the food is estimated by adjusting the time course curve as a function of the patient-specific insulin resistance that has been manifested.
摘要翻译：提供了一种通过个人预测管理工具管理2型糖尿病的系统和方法。确定2型糖尿病患者的胰岛素抵抗。对于患者群体维持时间过程曲线，包括一种人类可食用食物的预期血糖水平。通过调整作为患者特异性胰岛素抵抗的函数的时程曲线来估计消费食物后的血糖水平。

58. 发明申请

US20100138453A1 SYSTEM AND METHOD FOR GENERATING A PERSONALIZED DIABETES MANAGEMENT TOOL FOR DIABETES MELLITUS 审中-公开
标题翻译：用于产生糖尿病患者的个体化糖尿病管理工具的系统和方法
公开(公告)号：US20100138453A1
公开(公告)日：2010-06-03
申请号：US12030104
申请日：2008-02-12
申请人： Clifton A. Alferness , Gust H. Bardy
发明人： Clifton A. Alferness , Gust H. Bardy
IPC分类号： G06F17/30 , G06Q99/00 , G06F7/00
CPC分类号： G06Q50/22 , G06F19/3456 , G16H50/50
摘要： A system and method for generating a personalized diabetes management tool for diabetes mellitus is provided. An insulin activity curve for a patient population for an insulin preparation for diabetes mellitus treatment is identified. A personal insulin activity model for the patient is generated. An insulin sensitivity is determined by taking a derivative of the rate of change of blood glucose over time for the insulin preparation. An insulin sensitivity coefficient for the insulin preparation for a patient of diabetes mellitus is established. The insulin sensitivity coefficient is applied to the patient population insulin activity curve over a duration of action of the insulin preparation.
摘要翻译：提供了一种用于产生用于糖尿病的个性化糖尿病管理工具的系统和方法。鉴定用于糖尿病治疗的胰岛素制剂的患者群体的胰岛素活性曲线。产生患者的个人胰岛素活性模型。胰岛素敏感性是通过取胰岛素制剂随时间变化的血糖变化率来确定的。建立糖尿病患者胰岛素制剂的胰岛素敏感性系数。在胰岛素制剂的作用持续时间内，将胰岛素敏感性系数应用于患者群体胰岛素活性曲线。

59. 发明申请

US20080288060A1 Treating Valvular Insufficiency 审中-公开
标题翻译：治疗无效率
公开(公告)号：US20080288060A1
公开(公告)日：2008-11-20
申请号：US11631832
申请日：2005-07-06
申请人： David Martin Kaye , John Melmouth Power , Clifton A. Alferness , Adam Lucas Bilney , Mark L. Mathis
发明人： David Martin Kaye , John Melmouth Power , Clifton A. Alferness , Adam Lucas Bilney , Mark L. Mathis
IPC分类号： A61F2/24
CPC分类号： A61B17/0401 , A61B17/0487 , A61B17/064 , A61B17/068 , A61B17/221 , A61B2017/00243 , A61B2017/0409 , A61B2017/0441 , A61B2017/0445 , A61B2017/0448 , A61B2017/0453 , A61B2017/0458 , A61B2017/0464 , A61B2017/0496 , A61B2017/0649 , A61B2017/081 , A61B2017/2215 , A61F2/2445
摘要： In a method of treating valvular insufficiency in a patient, a plurality of filaments (2) are used to engage tissue at spaced apart locations of an annulus (1) of the valve being treated. The engaged filaments (2) are drawn inward so as to draw the engaged tissue around the valve annulus (1) inward. The filaments (2) are then secured with the engaged tissue in the drawn-in configuration. Inward drawing of the engaged tissue improves valve function by reducing the valve annulus (1). Alternatively or additionally, anchor means may be used to secure the filaments to a region of robust tissue, thus drawing the engaged tissue toward the anchor means to further improve valve function.
摘要翻译：在治疗患者瓣膜功能不全的方法中，多个细丝（2）用于在所治疗的瓣膜（1）的间隔开的位置处接合组织。所接合的细丝（2）向内拉，以便将所接合的组织向内抽吸到瓣膜环（1）周围。然后，细丝（2）以接合的组织固定在牵引构造中。通过减小瓣膜环（1）来改变接合组织的内部抽吸来提高瓣膜功能。或者或另外，锚固装置可以用于将细丝固定到坚固的组织的区域，从而将接合的组织拉向锚固装置以进一步改善瓣膜功能。

60. 发明授权

US07166071B2 Cardiac reinforcement device 失效
公开(公告)号：US07166071B2
公开(公告)日：2007-01-23
申请号：US10668918
申请日：2003-09-23
申请人： Clifton A. Alferness
发明人： Clifton A. Alferness
IPC分类号： A61F2/02
CPC分类号： A61F2/2481 , A61F2002/2484 , A61F2250/0003 , A61M1/1008 , A61M1/106 , A61M1/1068 , A61M1/12
摘要： The present disclosure is directed to a cardiac reinforcement device (CRD) and method for the treatment of cardiomyopathy. The CRD provides for reinforcement of the walls of the heart by constraining cardiac expansion, beyond a predetermined limit, during diastolic expansion of the heart. A CRD of the invention can be applied to the epicardium of the heart to locally constrain expansion of the cardiac wall or to circumferentially constrain the cardiac wall during cardiac expansion.

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