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51. 发明申请

US20100239564A1 NOVEL HUMAN GROWTH FACTORS 审中-公开
标题翻译：新的人类成长因素
公开(公告)号：US20100239564A1
公开(公告)日：2010-09-23
申请号：US12567317
申请日：2009-09-25
申请人： Guo-Liang Yu , Patrick J. Dillon , Reinhard Ebner , Gregory A. Endress
发明人： Guo-Liang Yu , Patrick J. Dillon , Reinhard Ebner , Gregory A. Endress
IPC分类号： A61K39/395 , C07H21/00 , C12N15/74 , C07K14/00 , C07K7/06 , C07K7/08 , C12N1/21 , C07K16/18 , A61K38/18 , C12Q1/68 , G01N33/53 , G01N33/567 , A61P35/00
CPC分类号： C07K14/475 , A61K38/00 , C07K2317/92
摘要： The present invention relates to huXAG-1, huXAG-2 and huXAG-3 proteins which are novel human growth factors. In particular, isolated nucleic acid molecules are provided encoding the huXAG-1, huXAG-2 and huXAG-3 proteins. huXAG-1, huXAG-2 and huXAG-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of huXAG-1, huXAG-2 or huXAG-3 activity. Also provided are diagnostic and therapeutic uses of huXAG-1. huXAG-2 and huXAG-3.
摘要翻译：本发明涉及作为新型人生长因子的huXAG-1，huXAG-2和huXAG-3蛋白。特别地，提供编码huXAG-1，huXAG-2和huXAG-3蛋白的分离的核酸分子。还提供huXAG-1，huXAG-2和huXAG-3多肽，载体，宿主细胞和用于制备它们的重组方法。本发明还涉及用于鉴定huXAG-1，huXAG-2或huXAG-3活性的激动剂和拮抗剂的筛选方法。还提供了huXAG-1的诊断和治疗用途。 huXAG-2和huXAG-3。

52. 发明授权

US07611846B2 Diagnostic methods involving human growth factor huXAG-1 有权
标题翻译：涉及人类生长因子huXAG-1的诊断方法
公开(公告)号：US07611846B2
公开(公告)日：2009-11-03
申请号：US11368664
申请日：2006-03-07
申请人： Guo-Liang Yu , Patrick J. Dillon , Reinhard Ebner , Gregory A. Endress
发明人： Guo-Liang Yu , Patrick J. Dillon , Reinhard Ebner , Gregory A. Endress
IPC分类号： G01N33/53 , C07K16/00 , A61K38/27
CPC分类号： C07K14/475 , A61K38/00 , C07K2317/92
摘要： The present invention relates to huXAG-1, huXAG-2 and huXAG-3 proteins which are novel human growth factors. In particular, isolated nucleic acid molecules are provided encoding the huXAG-1, huXAG-2 and huXAG-3 proteins. huXAG-1, huXAG-2 and huXAG-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of huXAG-1, huXAG-2 or huXAG-3 activity. Also provided are diagnostic and therapeutic uses of huXAG-1, huXAG-2 and huXAG-3.
摘要翻译：本发明涉及作为新型人生长因子的huXAG-1，huXAG-2和huXAG-3蛋白。特别地，提供编码huXAG-1，huXAG-2和huXAG-3蛋白的分离的核酸分子。还提供huXAG-1，huXAG-2和huXAG-3多肽，载体，宿主细胞和用于制备它们的重组方法。本发明还涉及用于鉴定huXAG-1，huXAG-2或huXAG-3活性的激动剂和拮抗剂的筛选方法。还提供了huXAG-1，huXAG-2和huXAG-3的诊断和治疗用途。

53. 发明申请

US20090208974A1 Human Neuronal Attachment Factor-1 失效
标题翻译：人类神经元附着因子-1
公开(公告)号：US20090208974A1
公开(公告)日：2009-08-20
申请号：US12364360
申请日：2009-02-02
申请人： Gregg Hastings , Patrick J. Dillon
发明人： Gregg Hastings , Patrick J. Dillon
IPC分类号： G01N33/53
CPC分类号： C07K14/47 , A61K38/00 , Y02A50/411
摘要： A human F-spondin-like protein and DNA (RNA) encoding such protein and a procedure for producing such protein by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for treating spinal cord injuries and damage to peripheral nerves by promoting neural-cell adhesion and neurite extension, inhibiting tumor metastases and tumor angiogenesis, and stimulating wound repair. Antagonists are also disclosed which may be utilized to prevent malaria. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.
摘要翻译：公开了一种编码这种蛋白质的人类F-脊椎样蛋白样蛋白和DNA（RNA）以及通过重组技术产生这种蛋白质的方法。还公开了通过促进神经细胞粘附和神经突延伸，抑制肿瘤转移和肿瘤血管发生以及刺激伤口修复来利用这种多肽来治疗脊髓损伤和损伤周围神经的方法。还公开了可用于预防疟疾的拮抗剂。还公开了用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病例如癌症的本发明多肽的改变水平的诊断测定法。

54. 发明申请

US20090029916A1 Fibroblast Growth Factor-14 审中-公开
标题翻译：成纤维细胞生长因子-14
公开(公告)号：US20090029916A1
公开(公告)日：2009-01-29
申请号：US11968702
申请日：2008-01-03
申请人： John M. Greene , Patrick J. Dillon
发明人： John M. Greene , Patrick J. Dillon
IPC分类号： C07K14/475 , C12N15/11 , C12N15/85 , C12P21/02 , C12N5/10 , A61K38/18 , C07K16/00 , A61K31/7088 , C12Q1/02 , C12Q1/68
CPC分类号： C07K14/50 , A61K38/00 , C12N2799/026
摘要： Disclosed is a human Fibroblast growth factor-14 polypeptide and DNA(RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for promoting wound healing for example as a result of burns and ulcers, to prevent neuronal damage due to associated with stroke and promote neuronal growth, and to prevent skin aging and hair loss, to stimulate angiogenesis, mesodermal induction in early embryos and limb regeneration. Antagonists against such polypeptides and their use as a therapeutic to prevent abnormal cellular proliferation, hyper-vascular diseases and epithelial lens cell proliferation are also disclosed. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.
摘要翻译：公开了人成纤维细胞生长因子-14多肽和编码这种多肽的DNA（RNA）。还提供了通过重组技术产生这种多肽的方法。还公开了利用这种多肽促进伤口愈合的方法，例如作为烧伤和溃疡的结果，以防止与中风相关的神经元损伤并促进神经元生长，并防止皮肤老化和脱发，刺激血管发生，中胚层诱导早期胚胎和肢体再生。还公开了抗这些多肽的拮抗剂及其作为预防异常细胞增殖，高血管疾病和上皮细胞增殖的治疗剂的用途。还公开了用于检测编码序列中的突变和衍生自宿主的样品中多肽浓度变化的诊断方法。

55. 发明授权

US06787640B2 Fibroblast growth factor 14 失效
标题翻译：成纤维细胞生长因子14
公开(公告)号：US06787640B2
公开(公告)日：2004-09-07
申请号：US08462159
申请日：1995-06-05
申请人： John M. Greene , Patrick J. Dillon
发明人： John M. Greene , Patrick J. Dillon
IPC分类号： C07H2100
CPC分类号： C07K14/50 , A61K38/00 , C12N2799/026
摘要： Disclosed is a human Fibroblast growth factor-14 polypeptide and DNA(RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for promoting wound healing for example as a result of burns and ulcers, to prevent neuronal damage due to associated with stroke and promote neuronal growth, and to prevent skin aging and hair loss, to stimulate angiogenesis, mesodermal induction in early embryos and limb regeneration. Antagonists against such polypeptides and their use as a therapeutic to prevent abnormal cellular proliferation, hyper-vascular diseases and epithelial lens cell proliferation are also disclosed. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.
摘要翻译：公开了人成纤维细胞生长因子-14多肽和编码这种多肽的DNA（RNA）。还提供了通过重组技术产生这种多肽的方法。还公开了利用这种多肽促进伤口愈合的方法，例如作为烧伤和溃疡的结果，以防止与中风相关的神经元损伤并促进神经元生长，并防止皮肤老化和脱发，刺激血管发生，中胚层诱导早期胚胎和肢体再生。还公开了抗这些多肽的拮抗剂及其作为预防异常细胞增殖，高血管疾病和上皮细胞增殖的治疗剂的用途。还公开了用于检测编码序列中的突变和衍生自宿主的样品中多肽浓度变化的诊断方法。

56. 发明授权

US06573082B1 Streptococcus pneumoniae antigens and vaccines 有权
公开(公告)号：US06573082B1
公开(公告)日：2003-06-03
申请号：US09536784
申请日：2000-03-28
申请人： Gil H. Choi , Charles A. Kunsch , Steven C. Barash , Patrick J. Dillon , Brian Dougherty , Michael R. Fannon , Craig A. Rosen
发明人： Gil H. Choi , Charles A. Kunsch , Steven C. Barash , Patrick J. Dillon , Brian Dougherty , Michael R. Fannon , Craig A. Rosen
IPC分类号： C12N120
CPC分类号： C07K14/3156 , A61K38/00 , A61K39/00 , C07K14/315
摘要： The present invention relates to novel vaccines for the prevention or attenuation of infection by Streptococcus pneumoniae. The invention further relates to isolated nucleic acid molecules encoding antigenic polypeptides of Streptococcus pneumoniae. Antigenic polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention additionally relates to diagnostic methods for detecting Streptococcus nucleic acids, polypeptides and antibodies in a biological sample.

57. 发明申请

US20100196410A1 Streptococcus pneumoniae Antigens and Vaccines 审中-公开
标题翻译：肺炎链球菌抗原和疫苗
公开(公告)号：US20100196410A1
公开(公告)日：2010-08-05
申请号：US12758672
申请日：2010-04-12
申请人： Gil H. Choi , Charles A. Kunsch , Steven C. Barash , Patrick J. Dillon , Brian Dougherty , Michael R. Fannon , Craig A. Rosen
发明人： Gil H. Choi , Charles A. Kunsch , Steven C. Barash , Patrick J. Dillon , Brian Dougherty , Michael R. Fannon , Craig A. Rosen
IPC分类号： A61K39/09 , C07H21/04 , C07K14/315 , C07K16/12 , A61P31/04 , C12N15/63 , C12N15/00 , C12N1/00 , C12P21/00 , C12Q1/68
CPC分类号： C07K14/3156 , A61K38/00 , A61K39/00 , C07K14/315
摘要： The present invention relates to novel vaccines for the prevention or attenuation of infection by Streptococcus pneumoniae. The invention further relates to isolated nucleic acid molecules encoding antigenic polypeptides of Streptococcus pneumoniae. Antigenic polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention additionally relates to diagnostic methods for detecting Streptococcus nucleic acids, polypeptides and antibodies in a biological sample.
摘要翻译：本发明涉及用于预防或减轻肺炎链球菌感染的新型疫苗。本发明还涉及编码肺炎链球菌抗原多肽的分离的核酸分子。还提供了抗原多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。本发明还涉及在生物样品中检测链球菌核酸，多肽和抗体的诊断方法。

58. 发明授权

US07338934B2 Fibroblast growth factor-14 失效
标题翻译：成纤维细胞生长因子-14
公开(公告)号：US07338934B2
公开(公告)日：2008-03-04
申请号：US10787879
申请日：2004-02-27
申请人： John M. Greene , Patrick J. Dillon
发明人： John M. Greene , Patrick J. Dillon
IPC分类号： C07H14/475 , A61K38/18 , C07K14/50
CPC分类号： C07K14/50 , A61K38/00 , C12N2799/026
摘要： Disclosed is a human Fibroblast growth factor-14 polypeptide and DNA(RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for promoting wound healing for example as a result of burns and ulcers, to prevent neuronal damage due to associated with stroke and promote neuronal growth, and to prevent skin aging and hair loss, to stimulate angiogenesis, mesodermal induction in early embryos and limb regeneration. Antagonists against such polypeptides and their use as a therapeutic to prevent abnormal cellular proliferation, hyper-vascular diseases and epithelial lens cell proliferation are also disclosed. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.
摘要翻译：公开了人成纤维细胞生长因子-14多肽和编码这种多肽的DNA（RNA）。还提供了通过重组技术产生这种多肽的方法。还公开了利用这种多肽促进伤口愈合的方法，例如作为烧伤和溃疡的结果，以防止与中风相关的神经元损伤并促进神经元生长，并防止皮肤老化和脱发，刺激血管发生，中胚层诱导早期胚胎和肢体再生。还公开了抗这些多肽的拮抗剂及其作为预防异常细胞增殖，高血管疾病和上皮细胞增殖的治疗剂的用途。还公开了用于检测编码序列中的突变和衍生自宿主的样品中多肽浓度变化的诊断方法。

59. 发明授权

US06929930B2 Streptococcus pneumoniae SP042 polynucleotides 失效
标题翻译：肺炎链球菌SP042多核苷酸
公开(公告)号：US06929930B2
公开(公告)日：2005-08-16
申请号：US09765272
申请日：2001-01-22
申请人： Gil H. Choi , Charles A. Kunsch , Steven C. Barash , Patrick J. Dillon , Brian Dougherty , Michael R. Fannon , Craig A. Rosen
发明人： Gil H. Choi , Charles A. Kunsch , Steven C. Barash , Patrick J. Dillon , Brian Dougherty , Michael R. Fannon , Craig A. Rosen
IPC分类号： G01N33/53 , A01K67/027 , A61K38/00 , A61K39/00 , A61K39/09 , A61K48/00 , A61P31/04 , C07K14/315 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/00 , C12N5/10 , C12N5/18 , C12N15/09 , C12N15/31 , C12P21/02 , C12Q1/68 , G01N33/50 , G01N33/569 , G06F17/30 , C07H21/04 , C12N15/00 , C12P21/06
CPC分类号： C07K14/3156 , A61K38/00 , A61K39/00 , C07K14/315
摘要： The present invention relates to novel vaccines for the prevention or attenuation of infection by Streptococcus pneumoniae. The invention further relates to isolated nucleic acid molecules encoding antigenic polypeptides of Streptococcus pneumoniae. Antigenic polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention additionally relates to diagnostic methods for detecting Streptococcus nucleic acids, polypeptides and antibodies in a biological sample.
摘要翻译：本发明涉及用于预防或减轻肺炎链球菌感染的新型疫苗。本发明还涉及编码肺炎链球菌抗原多肽的分离的核酸分子。还提供了抗原多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。本发明还涉及在生物样品中检测链球菌核酸，多肽和抗体的诊断方法。

60. 发明授权

US06818412B2 Human growth factors 失效
标题翻译：人类生长因子
公开(公告)号：US06818412B2
公开(公告)日：2004-11-16
申请号：US10078337
申请日：2002-02-21
申请人： Guo-Liang Yu , Patrick J. Dillon , Reinhard Ebner , Gregory A. Endress
发明人： Guo-Liang Yu , Patrick J. Dillon , Reinhard Ebner , Gregory A. Endress
IPC分类号： G01N33567
CPC分类号： C07K14/475 , A61K38/00 , C07K2317/92
摘要： The present invention relates to huXAG-1, huXAG-2 and huXAG-3 proteins which are novel human growth factors. In particular, isolated nucleic acid molecules are provided encoding the huXAG-1, huXAG-2 and huXAG-3 proteins. huXAG-1, huXAG-2 and huXAG-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of huXAG-1, huXAG-2 or huXAG-3 activity. Also provided are diagnostic and therapeutic uses of huXAG-1. huXAG-2 and huXAG-3.
摘要翻译：本发明涉及作为新型人生长因子的huXAG-1，huXAG-2和huXAG-3蛋白。特别地，提供编码huXAG-1，huXAG-2和huXAG-3蛋白的分离的核酸分子。还提供huXAG-1，huXAG-2和huXAG-3多肽，载体，宿主细胞和用于制备它们的重组方法。本发明还涉及用于鉴定huXAG-1，huXAG-2或huXAG-3活性的激动剂和拮抗剂的筛选方法。还提供了huXAG-1的诊断和治疗用途。 huXAG-2和huXAG-3。

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