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51. 发明授权

US5944996A Cleaning process using carbon dioxide as a solvent and employing molecularly engineered surfactants 失效
标题翻译：使用二氧化碳作为溶剂并使用分子工程表面活性剂的清洁方法
公开(公告)号：US5944996A
公开(公告)日：1999-08-31
申请号：US850371
申请日：1997-05-02
申请人： Joseph M. DeSimone , Timothy Romack , Douglas E. Betts , James B. McClain
发明人： Joseph M. DeSimone , Timothy Romack , Douglas E. Betts , James B. McClain
IPC分类号： B08B5/00 , B08B3/12 , B08B7/00 , C11D3/02 , C11D3/37 , C11D3/43 , C11D7/02 , C11D7/50 , C11D11/00 , D06L1/00 , B01D11/00
CPC分类号： C11D3/3757 , B08B3/12 , B08B7/0021 , B08B7/0092 , C11D11/0023 , C11D11/0041 , C11D3/02 , C11D3/37 , C11D3/43 , C11D7/02 , C11D7/50 , D06L1/00
摘要： The separation of a contaminant from a substrate that carries the contaminant is disclosed. The process comprises contacting the substrate to a carbon dioxide fluid containing an amphiphilic species so that the contaminant associates with the amphiphilic species and becomes entrained in the carbon dioxide fluid. The substrate is then separated from the carbon dioxide fluid, and then the contaminant is separated from the carbon dioxide fluid.
摘要翻译：公开了污染物与携带污染物的基质的分离。该方法包括将底物接触含有两亲物质的二氧化碳流体，使得污染物与两亲物质相关并且夹带在二氧化碳流体中。然后将基底与二氧化碳流体分离，然后将污染物与二氧化碳流体分离。

52. 发明授权

US11369498B2 Stent and stent delivery system with improved deliverability 有权
公开(公告)号：US11369498B2
公开(公告)日：2022-06-28
申请号：US13014632
申请日：2011-01-26
申请人： James B. McClain , Douglas Taylor , David Enscore
发明人： James B. McClain , Douglas Taylor , David Enscore
IPC分类号： A61F2/958 , A61F2/00 , A61F2/82
摘要： Stent delivery systems having improved deliverability comprising an elongate member having an inflation lumen and a guidewire lumen therein; a balloon having an interior that is in fluid communication with the inflation lumen; and a stent comprising a coating mounted on the balloon. Methods for making stent delivery systems having improved deliverability. Methods for delivering two stent delivery systems concurrently through a guiding catheter, each stent delivery system comprising elongate member having an inflation lumen and a guidewire lumen therein, a balloon having an interior that is in fluid communication with the inflation lumen, and a stent comprising a coating mounted on the balloon. Stent coatings may comprise a pharmaceutical agent at least a portion of which is in crystalline form.

53. 发明授权

US09789233B2 Stents having bioabsorbable layers 有权
公开(公告)号：US09789233B2
公开(公告)日：2017-10-17
申请号：US12426198
申请日：2009-04-17
申请人： James B. McClain , Douglas Taylor
发明人： James B. McClain , Douglas Taylor
IPC分类号： A61F2/06 , A61L31/14 , A61L31/16
CPC分类号： A61L31/148 , A61F2/91 , A61F2210/0004 , A61F2250/0035 , A61F2250/0067 , A61L31/16 , A61L2300/216 , A61L2300/604 , A61L2300/606 , A61L2300/608 , A61L2300/63 , A61L2420/08
摘要： Provided herein is a device comprising: a. stent; b. a plurality of layers on said stent framework to form said device; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.

54. 发明授权

US09510856B2 Drug delivery medical device 有权
标题翻译：药物输送医疗器械
公开(公告)号：US09510856B2
公开(公告)日：2016-12-06
申请号：US13384216
申请日：2010-07-16
申请人： James B. McClain , Charles Douglas Taylor , John Neet , Brett G. Zani
发明人： James B. McClain , Charles Douglas Taylor , John Neet , Brett G. Zani
IPC分类号： A61M31/00 , A61M37/00 , A61B17/20 , A61B17/3207 , A61L29/08 , A61L29/16 , A61B17/00 , A61B17/22 , A61M25/10
CPC分类号： A61M25/10 , A61B17/320725 , A61B2017/00893 , A61B2017/22051 , A61B2017/22061 , A61B2017/22065 , A61L29/085 , A61L29/16 , A61L2300/416 , A61L2300/606 , A61M2025/105
摘要： Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on the substrate, wherein the coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within the coating and on the substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of the medical device in the body of the subject a portion of the pharmaceutical agent and/or active biological agent is delivered at the intervention site along with at least a portion of the polymer and/or a at least a portion of the pharmaceutical carrying agents.
摘要翻译：提供一种涂覆的可植入医疗装置，包括：基底; 以及涂层，其设置在所述基底上，其中所述涂层包含至少一种聚合物和至少一种治疗期望形态的药剂和/或至少一种活性生物剂和任选的一种或多种药物载体; 其中基本上所有的药剂和/或活性生物制剂都保留在涂层内和衬底上，直到可植入装置部署在受试者身体内部的介入部位，并且其中在将医疗装置部署在受试者的身体中时一部分药剂和/或活性生物剂在干预部位与至少一部分聚合物和/或药物载体的至少一部分一起递送。

55. 发明授权

US08834913B2 Medical implants and methods of making medical implants 有权
标题翻译：医疗植入物和制造医疗植入物的方法
公开(公告)号：US08834913B2
公开(公告)日：2014-09-16
申请号：US12648106
申请日：2009-12-28
申请人： Wendy J. Shaw , Clement R. Yonker , John L. Fulton , Barbara J. Tarasevich , James B. McClain , Doug Taylor
发明人： Wendy J. Shaw , Clement R. Yonker , John L. Fulton , Barbara J. Tarasevich , James B. McClain , Doug Taylor
IPC分类号： A61F2/00 , A61K31/727
CPC分类号： A61L31/10 , A61K31/727 , A61L31/16 , A61L2300/42 , A61L2400/18
摘要： A medical implant device having a substrate with an oxidized surface and a silane derivative coating covalently bonded to the oxidized surface. A bioactive agent is covalently bonded to the silane derivative coating. An implantable stent device including a stent core having an oxidized surface with a layer of silane derivative covalently bonded thereto. A spacer layer comprising polyethylene glycol (PEG) is covalently bonded to the layer of silane derivative and a protein is covalently bonded to the PEG. A method of making a medical implant device including providing a substrate having a surface, oxidizing the surface and reacting with derivitized silane to form a silane coating covalently bonded to the surface. A bioactive agent is then covalently bonded to the silane coating. In particular instances, an additional coating of bio-absorbable polymer and/or pharmaceutical agent is deposited over the bioactive agent.
摘要翻译：一种具有氧化表面的基底和与氧化表面共价结合的硅烷衍生物涂层的医用植入装置。生物活性剂与硅烷衍生物涂层共价键合。一种可植入支架装置，其包括具有氧化表面的支架芯，其具有与其共价键合的硅烷衍生物层。包含聚乙二醇（PEG）的间隔层与硅烷衍生物层共价键合，蛋白质与PEG共价键合。一种制造医疗植入装置的方法，包括提供具有表面的基底，氧化表面并与衍生的硅烷反应以形成共价键合到该表面的硅烷涂层。然后将生物活性剂共价键合到硅烷涂层。在特定情况下，生物吸收性聚合物和/或药剂的附加涂层沉积在生物活性剂上。

56. 发明授权

US06919167B2 Positive tone lithography in carbon dioxide solvents 失效
标题翻译：二氧化碳溶剂中的正色光刻技术
公开(公告)号：US06919167B2
公开(公告)日：2005-07-19
申请号：US10294222
申请日：2002-11-14
申请人： James DeYoung , James B. McClain
发明人： James DeYoung , James B. McClain
IPC分类号： G03F20060101 , G03F7/00 , G03F7/32 , G03F7/36
CPC分类号： G03F7/36 , G03F7/32 , G03F7/325 , G03F7/327
摘要： A method for carrying out positive tone lithography with a carbon dioxide solvent system is carried out by (a) providing a substrate having a polymer resist layer formed thereon; (b) exposing at least one portion of the polymer resist layer to radiant energy to form at least one light field region in the polymer resist layer; and then (c) contacting the polymer resist layer to a carbon dioxide solvent system, the solvent system preferably comprising a polar group, under conditions in which the at least one light field region is preferentially removed.
摘要翻译：通过（a）提供其上形成有聚合物抗蚀剂层的基材，进行用二氧化碳溶剂系统进行正色调光刻的方法; （b）将聚合物抗蚀剂层的至少一部分暴露于辐射能以在聚合物抗蚀剂层中形成至少一个光场区域; 然后（c）在其中优选除去所述至少一个光场区域的条件下，使所述聚合物抗蚀剂层与二氧化碳溶剂体系接触，所述溶剂体系优选包含极性基团。

57. 发明授权

US06397421B1 Methods and apparatus for conserving vapor and collecting liquid carbon dioxide for carbon dioxide dry cleaning 失效
标题翻译：用于保存蒸汽和收集液态二氧化碳进行二氧化碳干洗的方法和装置
公开(公告)号：US06397421B1
公开(公告)日：2002-06-04
申请号：US09404957
申请日：1999-09-24
申请人： David E. Brainard , James B. McClain , Michael E. Cole , Steve L. Worm
发明人： David E. Brainard , James B. McClain , Michael E. Cole , Steve L. Worm
IPC分类号： D06B1500
CPC分类号： D06F43/08 , D06F43/007
摘要： A method for conserving carbon dioxide vapor in a carbon dioxide dry cleaning system employing a liquid carbon dioxide cleaning solution to clean articles, where the method includes removing carbon dioxide vapor from a wash tank to a vapor tank, storing the carbon dioxide vapor in the vapor tank; and charging the wash tank with carbon dioxide vapor from the vapor tank. The method may be performed as part of a wash cycle that includes filling the wash tank with cleaning solution, washing articles to be cleaned in the wash tank, and emptying the cleaning solution out of the wash tank. An apparatus may also be employed for conserving carbon dioxide vapor in a carbon dioxide dry cleaning system employing a liquid carbon dioxide cleaning solution to clean articles, where the apparatus includes a wash tank for contacting the articles to be cleaned with the liquid carbon dioxide cleaning solution, a working tank for storing liquid carbon dioxide cleaning solution, a vapor tank for storing carbon dioxide vapor, a first piping system providing fluid communication between the wash tank and the vapor tank, where the first piping system includes a first line and a first valve residing in the first line, and a second piping system providing fluid communication between the working tank and the wash tank. Methods and apparatus for collecting liquid carbon dioxide in a collecting tank are also provided.
摘要翻译：一种在二氧化碳干洗系统中保存二氧化碳蒸汽的方法，该系统采用液态二氧化碳清洗液清洁物品，其中该方法包括将二氧化碳蒸气从洗涤槽中除去至蒸气罐，将二氧化碳蒸气储存在蒸气中坦克; 并将来自蒸气罐的二氧化碳蒸汽向洗涤槽充电。该方法可以作为洗涤循环的一部分进行，其包括用洗涤溶液填充洗涤槽，在洗涤槽中清洗要清洗的物品，并将清洗溶液从清洗槽中排出。还可以使用一种装置来保存二氧化碳干洗系统中的二氧化碳蒸气，二氧化碳干洗系统采用液态二氧化碳清洗液来清洁物品，其中该设备包括用于将待清洗的物品与液体二氧化碳清洗液接触的洗涤槽，用于储存液体二氧化碳清洗溶液的工作罐，用于储存二氧化碳蒸气的蒸气罐，提供洗涤槽和蒸汽箱之间流体连通的第一管道系统，其中第一管道系统包括第一管线和第一阀居住在第一行，以及第二管道系统，其在工作罐和洗涤槽之间提供流体连通。还提供了用于在收集罐中收集液体二氧化碳的方法和装置。

58. 发明授权

US06351973B1 Internal motor drive liquid carbon dioxide agitation system 失效
标题翻译：内部电机驱动液体二氧化碳搅拌系统
公开(公告)号：US06351973B1
公开(公告)日：2002-03-05
申请号：US09497308
申请日：2000-02-03
申请人： James B. McClain , Gary C. Schrebe
发明人： James B. McClain , Gary C. Schrebe
IPC分类号： D06F4302
CPC分类号： D06F43/02
摘要： A cleaning apparatus adapted for use with a carbon dioxide cleaning medium comprises a body member, a door connected to the body member and together with the body member forming a pressure vessel, a basket disposed within the body member, a motor contained within the pressure vessel, and a drive mechanism contained within the pressure vessel for rotating the basket with the motor. Because the motor and drive mechanism are both contained within the pressure vessel, the need for a rotating shaft that penetrates the pressure vessel, and which must be sealed at least in part against the high pressure liquid contained therein, is obviated.
摘要翻译：适用于二氧化碳清洁介质的清洁装置包括主体构件，连接到主体构件的门，以及形成压力容器的主体构件，设置在主体构件内的篮子，容纳在压力容器内的马达以及包含在压力容器内的驱动机构，用于使电动机旋转筐。因为电动机和驱动机构都被包含在压力容器内，所以需要一个贯穿压力容器的旋转轴，并且必须至少部分地与其中包含的高压液体密封。

59. 发明授权

US06233772B1 Carbon dioxide cleaning apparatus with rotating basket and external drive 失效
标题翻译：带旋转篮和外部驱动器的二氧化碳清洗设备
公开(公告)号：US06233772B1
公开(公告)日：2001-05-22
申请号：US09306360
申请日：1999-05-06
申请人： James B. McClain , Gary Schrebe
发明人： James B. McClain , Gary Schrebe
IPC分类号： D06B2318
CPC分类号： D06F43/007 , D06F37/28 , D06F37/308 , D06F43/00 , D06F43/02 , D06F43/08
摘要： A cleaning apparatus adapted for cleaning fabrics, garments and the like with a carbon dioxide cleaning medium comprises a wash vessel having a wall portion; a rotating basket positioned in the wash vessel; a drive shaft penetrating the wash vessel wall portion, the shaft operatively associated with the rotating basket; a double mechanical seal connected to the wall portion with the drive shaft passing therethrough; a seal liquid reservoir; a seal liquid inlet line connected to the seal liquid reservoir and the double mechanical seal and configured to supply seal liquid to the double mechanical seal; and a pump, compressed gas line, or other pressure supply means operatively associated with the seal liquid reservoir for maintaining the pressure of seal liquid in the double mechanical seal sufficient to seal the rotating shaft when the wash vessel contains a liquid carbon dioxide cleaning medium from escape of cleaning medium around the rotating shaft. Means such as a pump operatively associated with inlet and outlet lines are provided for circulating liquid carbon dioxide cleaning medium through the wash vessel during cleaning of articles therein. A motor or other drive means is operatively associated with the drive shaft for rotating the rotating basket during cleaning of articles therein. The seal liquid is preferably selected to be compatible with (e.g., soluble in) the cleaning medium.
摘要翻译：适于用二氧化碳清洁介质清洁织物，衣服等的清洁装置包括具有壁部分的洗涤容器; 位于洗涤容器内的旋转篮子; 穿过洗涤容器壁部分的驱动轴，所述轴与所述旋转篮可操作地相关联; 连接到壁部分的双重机械密封件，其中驱动轴穿过其中; 密封液储存器; 连接到密封液体储存器的密封液体入口管线和双重机械密封件，并且构造成将密封液体供应到双重机械密封件; 以及与密封液体储存器可操作地相关联的泵，压缩气体管线或其他压力供应装置，用于在双重机械密封件中保持密封液体的压力足以在洗涤容器含有液体二氧化碳清洁介质时密封旋转轴，清洁介质绕旋转轴的逸出。提供诸如与入口管线和出口管线可操作地相关联的泵的装置，用于在其中清洁物品期间循环液体二氧化碳清洁介质通过洗涤容器。马达或其他驱动装置与驱动轴可操作地相关联，用于在清洁物品的过程中转动旋转的筐。优选选择密封液体与（例如溶解于）清洁介质相容。

60. 发明授权

US10117972B2 Drug delivery medical device 有权
公开(公告)号：US10117972B2
公开(公告)日：2018-11-06
申请号：US14131878
申请日：2012-07-12
申请人： James B. McClain , Charles Douglas Taylor , Brett G. Zani , John Neet , Timothy Charles Kiorpes
发明人： James B. McClain , Charles Douglas Taylor , Brett G. Zani , John Neet , Timothy Charles Kiorpes
IPC分类号： A61F2/07 , A61L31/08 , A61L29/08 , A61L29/16 , A61B17/12 , A61L31/16 , A61M25/10 , B05D7/24
摘要： Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on the substrate, wherein the coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within the coating and on the substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of the medical device in the body of the subject a portion of the pharmaceutical agent and/or active biological agent is delivered at the intervention site along with at least a portion of the polymer and/or a at least a portion of the pharmaceutical carrying agents.

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