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51. 发明授权

US06620179B2 Clot disrupting wire/catheter assembly 失效
公开(公告)号：US06620179B2
公开(公告)日：2003-09-16
申请号：US09867270
申请日：2001-05-29
申请人： Robert Boock , Jeffrey A. Lee
发明人： Robert Boock , Jeffrey A. Lee
IPC分类号： A61B1722
CPC分类号： A61B17/320758 , A61M25/0041 , A61M25/09
摘要： The present invention includes a clot disrupting wire/catheter assembly. The clot disrupting wire/catheter assembly comprises an annular sleeve and a core wire that is positioned within the annular sleeve. The assembly also includes a distal end wire that is attached to the annular sleeve and the core wire.

52. 发明授权

US06309367B1 Aneurysm shield 有权
标题翻译：动脉瘤盾
公开(公告)号：US06309367B1
公开(公告)日：2001-10-30
申请号：US09360026
申请日：1999-07-23
申请人： Robert Boock
发明人： Robert Boock
IPC分类号： A61F500
CPC分类号： A61F2/82 , A61B17/12022 , A61B17/12118 , A61B17/1219 , A61F2002/823
摘要： The present invention includes a device for covering an aneurysm. The device includes an elastic main body that has a symmetry effective for covering an aneurysm and one or more anchor rings for anchoring the main body about the aneurysm.
摘要翻译：本发明包括用于覆盖动脉瘤的装置。该装置包括弹性主体，该弹性主体具有有效覆盖动脉瘤的对称性和一个或多个锚固环，用于将主体锚定在动脉瘤周围。

53. 发明授权

US08034003B2 Tissue extraction and collection device 有权
标题翻译：组织提取和收集装置
公开(公告)号：US08034003B2
公开(公告)日：2011-10-11
申请号：US12056637
申请日：2008-03-27
申请人： Robert S. Pesce , Shelby Cook , Kristian DiMatteo , Kevin Ranucci , Robert Boock
发明人： Robert S. Pesce , Shelby Cook , Kristian DiMatteo , Kevin Ranucci , Robert Boock
IPC分类号： A61B10/00
CPC分类号： A61B10/025 , A61B10/0096 , A61B10/0266 , A61B10/0283 , A61B17/1635 , A61B17/32002 , A61B2017/320064 , A61B2090/0807
摘要： Methods and device for extracting and collecting tissue, which can be used for example in tissue engineering and grafting applications, are disclosed. In one embodiment, a device can include an outer tube. A rotatable shaft can be disposed within the outer tube can have a tissue harvesting tip formed on its distal end, the tissue harvesting tip being effective to excise tissue upon rotation thereof. A tissue collection device can be included to receive and collected excised tissue, and the tissue collection device can indicate the amount of tissue collected therein. For example, the tissue collection device can include a straining element which collects excised tissue and an indicator by which to assess the amount of collected tissue. In some embodiments, the tissue collection device can translate to indicate the amount of collected tissue. In many cases, devices disclosed herein can include driving mechanisms that are adapted to drive a tissue harvesting tip such that the tip excises soft tissue, but stops when contacting bone (or soon after contacting bone). In some embodiments, the tissue harvesting tip can be effective to excise viable tissue samples, such that the samples can exhibit desirable proportions of viable cells. Further, in some embodiments, the tissue harvesting tips can excise a tissue sample with tissue particles falling in certain size ranges.
摘要翻译：公开了用于提取和收集组织的方法和装置，其可以用于组织工程和移植应用中。在一个实施例中，装置可以包括外管。旋转轴可以设置在外管内，可以具有形成在其远端上的组织收集尖端，组织收集尖端有效地在旋转时切除组织。可以包括组织收集装置以接收和收集切除的组织，并且组织收集装置可以指示其中收集的组织的量。例如，组织收集装置可以包括收集切除的组织的应变元件和用于评估收集的组织的量的指示器。在一些实施例中，组织收集装置可以平移以指示收集的组织的量。在许多情况下，本文公开的装置可以包括适于驱动组织收集尖端的驱动机构，使得尖端切除软组织，但是当接触骨骼时（或者在接触骨骼之后不久）停止。在一些实施方案中，组织采集尖端可有效地切除活组织样品，使得样品可以显示出所需比例的活细胞。此外，在一些实施例中，组织采集尖端可以用落在一定尺寸范围内的组织颗粒来切除组织样本。

54. 发明授权

US07651596B2 Cellulosic-based interference domain for an analyte sensor 有权
标题翻译：用于分析物传感器的基于纤维素的干扰域
公开(公告)号：US07651596B2
公开(公告)日：2010-01-26
申请号：US11335879
申请日：2006-01-18
申请人： James R. Petisce , Kum Ming Woo , Victor Ha , Melissa Nicholas , Robert Boock
发明人： James R. Petisce , Kum Ming Woo , Victor Ha , Melissa Nicholas , Robert Boock
IPC分类号： G01N27/327 , A61B5/05
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/6833 , A61B5/6848 , A61B5/6849 , G06F19/00 , Y02A90/26
摘要： The present invention relates generally to devices for measuring an analyte in a host. More particularly, the present invention relates to devices for measurement of glucose in a host that incorporate a cellulosic-based interference domain.
摘要翻译：本发明一般涉及用于测量宿主中分析物的装置。更具体地，本发明涉及用于测量掺入基于纤维素基的干扰域的宿主中的葡萄糖的装置。

55. 发明申请

US20060085028A1 Vessel occlusion system 审中-公开
标题翻译：血管闭塞系统
公开(公告)号：US20060085028A1
公开(公告)日：2006-04-20
申请号：US10967661
申请日：2004-10-18
申请人： Robert Boock
发明人： Robert Boock
IPC分类号： A61M29/00
CPC分类号： A61M25/10 , A61M25/04 , A61M2025/1052 , A61M2025/1054 , A61M2025/1084
摘要： The present invention relates to a device for occluding vessels or ducts in a living being. The device includes a frame for anchoring the device in a vessel and a expandable core connected to the frame for occluding the vessel.
摘要翻译：本发明涉及一种用于在生活中封闭血管或管道的装置。该装置包括用于将装置固定在容器中的框架和连接到框架以用于封闭容器的可膨胀芯。

56. 发明申请

US20050177249A1 Scaffolds with viable tissue 审中-公开
标题翻译：具有活组织的支架
公开(公告)号：US20050177249A1
公开(公告)日：2005-08-11
申请号：US10775034
申请日：2004-02-09
申请人： Stephanie Kladakis , Sridevi Dhanaraj , Robert Boock
发明人： Stephanie Kladakis , Sridevi Dhanaraj , Robert Boock
IPC分类号： A61L27/00 , A61F2/00 , A61L27/36 , A61L27/48 , A61L27/56 , A61L27/58 , A61F2/02
CPC分类号： A61L27/48 , A61L27/56 , A61L27/58
摘要： A composite implant is provided for repairing a tissue defect in a patient. In one embodiment, the implant is a porous tissue scaffold having at least one pocket formed therein and adapted to contain a viable tissue. The tissue scaffold can have a variety of configurations, and in one embodiment it includes top and bottom portions that can be at least partially mated to one another, and in an exemplary embodiment that are heated sealed to one another around a perimeter thereof to form an enclosed pocket therebetween. The pocket is preferably sealed with a viable tissue disposed therein. In another embodiment, the tissue scaffold is substantially wedge-shaped and the pocket comprises a hollow interior formed in the tissue scaffold, and/or at least one lumen extending into the tissue scaffold. The tissue scaffold can also optionally include at least one surface feature formed thereof to promote blood vessel formation.
摘要翻译：提供复合植入物来修复患者的组织缺损。在一个实施例中，植入物是多孔组织支架，其具有形成在其中的至少一个口袋并且适于容纳活组织。组织支架可以具有各种构造，并且在一个实施例中，其包括可以彼此至少部分地配合的顶部和底部部分，并且在示例性实施例中，围绕其周边彼此加热密封以形成封闭口袋。口袋优选用设置在其中的活组织密封。在另一个实施例中，组织支架基本上是楔形的，并且口袋包括形成在组织支架中的中空内部和/或延伸到组织支架中的至少一个腔。组织支架还可以任选地包括形成于其中的至少一个表面特征以促进血管形成。

57. 发明授权

US06629947B1 Systems and methods for delivering flowable substances for use as implants and surgical sealants 失效
标题翻译：用于输送可用作植入物和手术密封剂的可流动物质的系统和方法
公开(公告)号：US06629947B1
公开(公告)日：2003-10-07
申请号：US09330175
申请日：1999-06-11
申请人： Ronald A. Sahatjian , Robert Boock
发明人： Ronald A. Sahatjian , Robert Boock
IPC分类号： A61F1320
CPC分类号： A61B17/12131 , A61B17/12022 , A61B17/12036 , A61B17/12186 , A61B2017/00495
摘要： A system for delivering a flowable substance capable of changing from liquid to solid for use as implants and surgical sealants includes a first reservoir containing a first flowable substance including a bulking agent, a second reservoir containing a second flowable substance including a reacting agent, and a cannula. A method of delivering flowable substance that changes from liquid to solid for use as implants and surgical sealants includes introducing a cannula having first and second lumens into the body, passing a flowable substance including a bulking agent through the first lumen, passing a second flowable substance including a reacting agent through the second lumen, mixing the first and second flowable substances in the cannula so that the bulking agent reacts with the reacting agent to form a flexible elongated fiber in the cannula, and moving the fiber through the opening in the cannula and into the body to form at least one of an implant and surgical seal.
摘要翻译：用于输送能够从液体变为固体以用作植入物和手术密封剂的可流动物质的系统包括：第一储存器，其包含含有填充剂的第一可流动物质;第二储存器，含有包含反应剂的第二可流动物质;以及套管。一种输送从液体变为固态的可流动物质的方法，用作植入物和手术密封剂包括将具有第一和第二内腔的套管引入体内，使包含填充剂的可流动物质通过第一腔，通过第二可流动物质包括通过所述第二腔的反应剂，将所述第一和第二可流动物质混合在所述套管中，使得所述填充剂与所述反应剂反应以在所述套管中形成柔性细长纤维，并且通过所述插管中的所述开口移动所述纤维，进入体内以形成植入物和手术密封件中的至少一个。

58. 发明授权

US09192370B2 Suture anchor with improved drive head 有权
标题翻译：具有改进的驱动头的缝合锚
公开(公告)号：US09192370B2
公开(公告)日：2015-11-24
申请号：US13589468
申请日：2012-08-20
申请人： Robert Boock , Nathan Cauldwell
发明人： Robert Boock , Nathan Cauldwell
IPC分类号： A61B17/04
CPC分类号： A61B17/0401 , A61B2017/0409 , A61B2017/0414 , A61B2017/044
摘要： A suture anchor is provided including an elongate shank defining a longitudinal axis and having at least one bone-engaging thread formed thereon, and a drive head having a proximal end and a distal end mated to the elongate shank. The drive head has a substantially oval shape and includes at least one suture attachment member formed in a portion of the drive head. The configuration of the drive head is particularly advantages in that it provides a suture anchor having improved physical properties, including a high failure torque and a high stripping strength.
摘要翻译：提供了缝合锚，其包括限定纵向轴线的细长柄，并且具有形成在其上的至少一个骨接合螺纹，以及具有与所述细长柄配合的近端和远端的驱动头。驱动头具有大致椭圆形并且包括形成在驱动头的一部分中的至少一个缝合线附接构件。驱动头的构造是特别的优点，因为它提供了具有改进的物理性能的缝合锚，其包括高故障扭矩和高剥离强度。

59. 发明申请

US20110024043A1 CONTINUOUS ANALYTE SENSORS AND METHODS OF MAKING SAME 审中-公开
公开(公告)号：US20110024043A1
公开(公告)日：2011-02-03
申请号：US12829337
申请日：2010-07-01
申请人： Robert Boock , Jeff Jackson , Huashi Zhang , Jason Mitchell
发明人： Robert Boock , Jeff Jackson , Huashi Zhang , Jason Mitchell
IPC分类号： C23F1/08 , B05C9/00
摘要： Described here are embodiments of processes and systems for the continuous manufacturing of implantable continuous analyte sensors. In some embodiments, a method is provided for sequentially advancing an elongated conductive body through a plurality of stations, each configured to treat the elongated conductive body. In some of these embodiments, one or more of the stations is configured to coat the elongated conductive body using a meniscus coating process, whereby a solution formed of a polymer and a solvent is prepared, the solution is continuously circulated to provide a meniscus on a top portion of a vessel holding the solution, and the elongated conductive body is advanced through the meniscus. The method may also comprise the step of removing excess coating material from the elongated conductive body by advancing the elongated conductive body through a die orifice. For example, a provided elongated conductive body 510 is advanced through a pre-coating treatment station 520, through a coating station 530, through a thickness control station 540, through a drying or curing station 550, through a thickness measurement station 560, and through a post-coating treatment station 570.

60. 发明申请

US20090247856A1 POLYMER MEMBRANES FOR CONTINUOUS ANALYTE SENSORS 审中-公开
公开(公告)号：US20090247856A1
公开(公告)日：2009-10-01
申请号：US12413231
申请日：2009-03-27
申请人： Robert Boock , Monica A. Rixman , Huashi Zhang , Michael J. Estes , Kristina Lawrence
发明人： Robert Boock , Monica A. Rixman , Huashi Zhang , Michael J. Estes , Kristina Lawrence
IPC分类号： A61B5/1468
CPC分类号： C12Q1/002 , A61B5/14532 , A61B5/14546 , A61B5/1486 , A61B5/14865 , C12Q1/006
摘要： Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise-causing species.

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