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51. 发明申请

US20080268486A1 DUAL MEASUREMENT ANALYTE DETECTION SYSTEM 审中-公开
标题翻译：双测量分析仪检测系统
公开(公告)号：US20080268486A1
公开(公告)日：2008-10-30
申请号：US12171205
申请日：2008-07-10
申请人： James R. Braig , Peter Rule , Kenneth G. Witte , Philip C. Hartstein , Bernhard B. Sterling
发明人： James R. Braig , Peter Rule , Kenneth G. Witte , Philip C. Hartstein , Bernhard B. Sterling
IPC分类号： C12Q1/54 , C12M1/00
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546
摘要： An analyte detection system is configured to measure concentrations of at least first and second analytes in a single material sample supported by a sample element. The measurement of a second analyte can be conditioned on a quantitative or qualitative result of the first measurement. In one embodiment, the first analyte is glucose and the second analyte is a ketone. According to such an embodiment the ketone is measured if the result of the glucose measurement exceeds a previously-specified value or falls outside of a previously-specified range.
摘要翻译：分析物检测系统被配置为测量由样品元素支持的单个材料样品中的至少第一和第二分析物的浓度。第二分析物的测量可以对第一次测量的定量或定性结果进行调节。在一个实施方案中，第一分析物是葡萄糖，第二分析物是酮。根据这样的实施方案，如果葡萄糖测量结果超过预先规定的值或者超出预先规定的范围，则测量酮。

52. 发明申请

US20070081626A1 Method and apparatus for enhancing accuracy of an analyte detection system 审中-公开
标题翻译：用于提高分析物检测系统的精度的方法和装置
公开(公告)号：US20070081626A1
公开(公告)日：2007-04-12
申请号：US11314961
申请日：2005-12-21
申请人： Peter Rule , Richard King
发明人： Peter Rule , Richard King
IPC分类号： G01N23/223
CPC分类号： A61B5/14546 , A61B5/145 , A61B5/14532 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150755 , A61B5/150862 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/4839 , A61M5/14212 , A61M2230/20 , G01N35/1095
摘要： A method of determining an analyte concentration in a patient. The method comprises estimating an analyte concentration for display on a point-of-care monitor, where the estimating includes obtaining two or more measurements of the analyte concentration. Also disclosed is a device for determining an analyte concentration. The device comprises a sensor configured to measure a bodily fluid of a patient and provide information for display on a point-of-care monitor. The information relates to a measurement of an analyte in a sample. The device further comprises a processor and stored program instructions executable by the processor such that the system is operable to estimate an analyte concentration using two or more measurements of the analyte concentration.
摘要翻译：确定患者中分析物浓度的方法。该方法包括估计用于在护理点监测器上显示的分析物浓度，其中估计包括获得分析物浓度的两个或多个测量值。还公开了一种用于确定分析物浓度的装置。该装置包括被配置为测量患者的体液并提供用于在护理点监视器上显示的信息的传感器。该信息涉及样品中分析物的测量。该设备还包括处理器和由处理器可执行的存储的程序指令，使得系统可操作以使用分析物浓度的两个或多个测量来估计分析物浓度。

53. 发明授权

US06631282B2 Device for isolating regions of living tissue 失效
标题翻译：用于隔离活组织区域的装置
公开(公告)号：US06631282B2
公开(公告)日：2003-10-07
申请号：US09970021
申请日：2001-10-02
申请人： Peter Rule , James R. Braig , Daniel S. Goldberger , Julian Cortella , Mark D. Agostino
发明人： Peter Rule , James R. Braig , Daniel S. Goldberger , Julian Cortella , Mark D. Agostino
IPC分类号： A61B500
CPC分类号： A61B5/6841 , A61B5/061 , A61B5/14532 , A61B5/1455
摘要： A device and method are provided for use with a non-invasive optical measurement system, such as a thermal gradient spectrometer for improved determination of analyte concentrations within living tissue. In a preferred embodiment, a site selector is secured to a patient's forearm thereby isolating a measurement site on the patient's skin for determination of blood glucose levels. The site selector attaches to a thermal mass window of the spectrometer and thus forms an interface between the patient's skin and the thermal mass window. When the spectrometer must be temporarily removed from the patient's skin, such as to allow the patient mobility, the site selector is left secured to the forearm so as to maintain a consistent measurement site on the skin. When the spectrometer is later reattached to the patient, the site selector will again form an interface between the gradient spectrometer and the same location of skin as before.
摘要翻译：提供了一种用于非侵入式光学测量系统的装置和方法，所述非侵入性光学测量系统例如用于改善生物体内分析物浓度测定的热梯度光谱仪。在优选实施例中，站点选择器被固定到患者的前臂，从而隔离患者皮肤上的测量部位以确定血糖水平。站点选择器连接到光谱仪的热质量窗口，从而形成患者皮肤和热质量窗口之间的界面。当光谱仪必须临时从病人的皮肤上移除时，例如允许患者移动，将场地选择器固定在前臂上，以保持皮肤上一致的测量部位。当光谱仪后来重新连接到患者时，站点选择器将再次形成梯度光谱仪和与之前相同的皮肤位置之间的界面。

54. 发明申请

US20160317744A1 FLUID COMPONENT ANALYSIS SYSTEM AND METHOD FOR GLUCOSE MONITORING AND CONTROL 审中-公开
标题翻译：流体组分分析系统和葡萄糖监测与控制方法
公开(公告)号：US20160317744A1
公开(公告)日：2016-11-03
申请号：US15089059
申请日：2016-04-01
申请人： Peter Rule
发明人： Peter Rule
IPC分类号： A61M5/172 , A61M5/14 , A61M5/142
CPC分类号： A61M5/1723 , A61B5/1427 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/14557 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150305 , A61B5/150389 , A61B5/150503 , A61B5/150755 , A61B5/150786 , A61B5/150862 , A61B5/155 , A61B5/157 , A61B5/412 , A61B5/4839 , A61B5/7475 , A61M5/1415 , A61M5/142 , A61M5/16827 , A61M2005/1404 , A61M2005/14208 , A61M2005/1726 , A61M2205/12 , A61M2205/18 , A61M2205/3313 , A61M2205/3569 , A61M2205/502 , A61M2205/52 , A61M2230/005 , A61M2230/201 , G06F19/3468
摘要： Disclosed are methods and apparatuses for determining analyte concentration in a sample such as bodily fluid. Systems and methods disclosed herein can also include a treatment dosing system to infuse or inject a treatment dose (e.g. insulin, dextrose, etc.) and provide glycemic control. The dose of the treatment drug may be based on the patient's calculated sensitivity to treatment dosing, for example. The dose of the treatment drug may be based on the concentration of the analyte or the average value for the concentration of the analyte and/or the rate of change of the value of the concentration of the analyte. Delivery of the treatment drug can be cut off if the determined analyte concentration indicates that continued delivery would be harmful to the patient.
摘要翻译：公开了用于测定诸如体液的样品中的分析物浓度的方法和装置。本文公开的系统和方法还可以包括注射或注射治疗剂量（例如胰岛素，葡萄糖等）并提供血糖控制的治疗剂量系统。治疗药物的剂量可以基于例如患者对治疗剂量的计算灵敏度。治疗药物的剂量可以基于分析物的浓度或分析物浓度的平均值和/或分析物浓度值的变化率。如果确定的分析物浓度表明持续传递对患者有害，则可以切断治疗药物的递送。

55. 发明申请

US20110111449A1 IN VITRO DETERMINATION OF ANALYTE LEVELS WITHIN BODY FLUIDS 有权
标题翻译：在身体液体中分析水平的体外测定
公开(公告)号：US20110111449A1
公开(公告)日：2011-05-12
申请号：US13007502
申请日：2011-01-14
申请人： James R. Braig , Peter Rule , Philip C. Hartstein , Bernhard B. Sterling , Jennifer H. Gable , Kenneth I. Li
发明人： James R. Braig , Peter Rule , Philip C. Hartstein , Bernhard B. Sterling , Jennifer H. Gable , Kenneth I. Li
IPC分类号： C12Q1/02 , C12M1/34
CPC分类号： A61B5/157 , A61B5/01 , A61B5/1411 , A61B5/14532 , A61B5/1455 , A61B5/150022 , A61B5/150083 , A61B5/150213 , A61B5/150358 , A61B5/150412 , A61B5/150458 , A61B5/150503 , A61B5/150618 , A61B5/150717 , A61B5/15087 , A61B5/151 , A61B5/15107 , A61B5/15136 , A61B5/1514 , A61B5/15194 , A61B5/6826 , A61B5/6838 , A61B10/0045 , A61B2562/0295 , A61B2562/12 , G01N21/03 , G01N21/0332 , G01N21/35 , G01N21/3577 , G01N21/3581 , G01N33/49 , G01N33/66 , G01N2021/0389 , G01N2201/02 , G01N2201/068
摘要： A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.
摘要翻译：能够在患者附近部署的无试剂全血分析物检测系统具有能够发射包括光谱带的辐射束的源。全血系统还具有光束的光路中的检测器。全血系统还具有容纳源和检测器的壳体。全血系统还具有位于束的光路中的样品元件。样品元件具有不消除光谱带中的辐射束的透射率的样品池和样品池壁。

56. 发明授权

US07738085B2 Device and method for in vitro determination of analyte concentration within body fluids 有权
标题翻译：用于体外测定体液中分析物浓度的装置和方法
公开(公告)号：US07738085B2
公开(公告)日：2010-06-15
申请号：US12343218
申请日：2008-12-23
申请人： James R. Braig , Peter Rule , Philip C. Hartstein , Bernhard B. Sterling , Jennifer H. Gable , Kenneth I. Li
发明人： James R. Braig , Peter Rule , Philip C. Hartstein , Bernhard B. Sterling , Jennifer H. Gable , Kenneth I. Li
IPC分类号： G01N33/48
CPC分类号： A61B5/157 , A61B5/01 , A61B5/1411 , A61B5/14532 , A61B5/1455 , A61B5/150022 , A61B5/150083 , A61B5/150213 , A61B5/150358 , A61B5/150412 , A61B5/150458 , A61B5/150503 , A61B5/150618 , A61B5/150717 , A61B5/15087 , A61B5/151 , A61B5/15107 , A61B5/15136 , A61B5/1514 , A61B5/15194 , A61B5/6826 , A61B5/6838 , A61B10/0045 , A61B2562/0295 , A61B2562/12 , G01N21/03 , G01N21/0332 , G01N21/35 , G01N21/3577 , G01N21/3581 , G01N33/49 , G01N33/66 , G01N2021/0389 , G01N2201/02 , G01N2201/068
摘要： A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.
摘要翻译：能够在患者附近部署的无试剂全血分析物检测系统具有能够发射包括光谱带的辐射束的源。全血系统还具有光束的光路中的检测器。全血系统还具有容纳源和检测器的壳体。全血系统还具有位于束的光路中的样品元件。样品元件具有不消除光谱带中的辐射束的透射率的样品池和样品池壁。

57. 发明申请

US20100121170A1 FLUID COMPONENT ANALYSIS SYSTEM AND METHOD FOR GLUCOSE MONITORING AND CONTROL 有权
标题翻译：流体组分分析系统和葡萄糖监测与控制方法
公开(公告)号：US20100121170A1
公开(公告)日：2010-05-13
申请号：US12559328
申请日：2009-09-14
申请人： Peter Rule
发明人： Peter Rule
IPC分类号： A61B5/145 , A61M5/14
CPC分类号： A61M5/1723 , A61B5/1427 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/14557 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150305 , A61B5/150389 , A61B5/150503 , A61B5/150755 , A61B5/150786 , A61B5/150862 , A61B5/155 , A61B5/157 , A61B5/412 , A61B5/4839 , A61B5/7475 , A61M5/1415 , A61M5/142 , A61M5/16827 , A61M2005/1404 , A61M2005/14208 , A61M2005/1726 , A61M2205/12 , A61M2205/18 , A61M2205/3313 , A61M2205/3569 , A61M2205/502 , A61M2205/52 , A61M2230/005 , A61M2230/201 , G06F19/00 , G06F19/3468
摘要： Disclosed are methods and apparatuses for determining analyte concentration in a sample such as bodily fluid. Systems and methods disclosed herein can also include a treatment dosing system to infuse or inject a treatment dose (e.g. insulin, dextrose, etc.) and provide glycemic control. The dose of the treatment drug may be based on the patient's calculated sensitivity to treatment dosing, for example. The dose of the treatment drug may be based on the concentration of the analyte or the average value for the concentration of the analyte and/or the rate of change of the value of the concentration of the analyte. Delivery of the treatment drug can be cut off if the determined analyte concentration indicates that continued delivery would be harmful to the patient.
摘要翻译：公开了用于测定诸如体液的样品中的分析物浓度的方法和装置。本文公开的系统和方法还可以包括注射或注射治疗剂量（例如胰岛素，葡萄糖等）并提供血糖控制的治疗剂量系统。治疗药物的剂量可以基于例如患者对治疗剂量的计算灵敏度。治疗药物的剂量可以基于分析物的浓度或分析物浓度的平均值和/或分析物浓度值的变化率。如果确定的分析物浓度表明持续传递对患者有害，则可以切断治疗药物的递送。

58. 发明申请

US20090192367A1 ANALYTE DETECTION SYSTEM WITH PERIODIC SAMPLE DRAW AND BODY FLUID ANALYZER 审中-公开
标题翻译：具有周期性抽样和体液分析仪的分析检测系统
公开(公告)号：US20090192367A1
公开(公告)日：2009-07-30
申请号：US12343421
申请日：2008-12-23
申请人： James R. Braig , Peter Rule
发明人： James R. Braig , Peter Rule
IPC分类号： A61B5/15
CPC分类号： A61B5/1486 , A61B5/145 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/14557 , A61B5/1495 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150358 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/4839 , A61B2562/0295 , A61M5/14232 , A61M2005/1726 , A61M2230/201 , G01N27/3271 , G01N33/49
摘要： An embodiment of a system for analyzing a body fluid of a patient comprises a fluid transport network having a patient end configured to provide fluid communication with the body fluid in the patient and a fluid delivery point spaced from the patient end. A pump system is coupled to the fluid transport network. The pump system has an infusion mode in which the pump system is operable to pump an infusion fluid toward the patient end of the fluid transport network and a draw mode in which the pump system is operable to draw the body fluid from the patient into the fluid transport network through the patient end. At least one electrochemical test element is located near the fluid delivery point of the fluid transport network. The electrochemical test element is positioned to receive a portion of the body fluid delivered to the delivery point by the fluid transport network. An analyte detection system is configured to receive the test element and to measure at least one analyte in the portion of the body fluid.
摘要翻译：用于分析患者体液的系统的实施例包括流体输送网络，其具有构造成提供与患者体液的流体连通的患者端和与患者端间隔开的流体输送点。泵系统耦合到流体输送网络。泵系统具有输液模式，其中泵系统可操作以将输液流体朝向流体输送网络的患者端泵送，并且抽吸模式，其中泵系统可操作以将体液从患者吸入流体运输网络通过病人端。至少一个电化学测试元件位于流体输送网络的流体输送点附近。电化学测试元件被定位成接收由流体输送网络输送到输送点的体液的一部分。分析物检测系统被配置为接收测试元件并测量体液部分中的至少一种分析物。

59. 发明申请

US20090157430A1 SYNCHRONIZATION AND CONFIGURATION OF PATIENT MONITORING DEVICES 审中-公开
标题翻译：患者监测装置的同步和配置
公开(公告)号：US20090157430A1
公开(公告)日：2009-06-18
申请号：US12251339
申请日：2008-10-14
申请人： Peter Rule , Gil Rivas
发明人： Peter Rule , Gil Rivas
IPC分类号： G06Q50/00 , A61B5/00 , G06Q90/00
CPC分类号： A61B5/0002 , A61B5/14532 , A61B5/14546 , A61B5/14557 , A61B5/1459 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150267 , A61B5/150755 , A61B5/150786 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/412 , A61B5/4839 , G06F19/3418 , G06Q50/24 , G16H40/40
摘要： Some embodiments provide a system for synchronizing and configuring monitoring devices. In some embodiments, a patient monitoring device settings module is configured to automatically provide configuration settings to a plurality of patient monitoring devices. A monitoring device data module is configured to receive measurement data from at least one of the patient monitoring devices. An electronic medical records system interface is configured to provide patient data at least partially derived from the received measurement data to an electronic medical records system. A patient records interface is configured to provide patient data to at least one of the patient monitoring devices.
摘要翻译：一些实施例提供用于同步和配置监视设备的系统。在一些实施例中，患者监视设备设置模块被配置为自动地向多个患者监视设备提供配置设置。监视设备数据模块被配置为从至少一个患者监视设备接收测量数据。电子医疗记录系统接口被配置为将至少部分地从接收到的测量数据导出的患者数据提供给电子病历系统。患者记录界面被配置为向至少一个患者监视设备提供患者数据。

60. 发明申请

US20070161951A1 TREATMENT OF VASCULAR OCCLUSIONS USING ELEVATED TEMPERATURES 审中-公开
标题翻译：使用高温治疗血管闭塞症
公开(公告)号：US20070161951A1
公开(公告)日：2007-07-12
申请号：US11685643
申请日：2007-03-13
申请人： Douglas Hansmann , Peter Rule
发明人： Douglas Hansmann , Peter Rule
IPC分类号： A61F7/12
CPC分类号： A61B17/2202 , A61B2018/046
摘要： A method for providing a therapeutic effect to a treatment site within a patient's vasculature comprises positioning a catheter at the treatment site. The catheter includes a heating element and a fluid delivery lumen that is coupled to an exit port within a distal region of the catheter. The method further comprises passing the therapeutic compound through the delivery lumen and the exit port at a flow rate. The heated therapeutic compound is provided to the treatment site. The method further comprises exposing at least a portion of the treatment site and at least a portion of the delivered heated therapeutic compound to ultrasonic energy generated by the ultrasound radiating member.
摘要翻译：用于向患者的脉管系统内的治疗部位提供治疗效果的方法包括将导管定位在治疗部位。导管包括加热元件和流体输送腔，其与导管的远侧区域内的出口连接。该方法还包括以流速使治疗化合物通过输送腔和出口。将加热的治疗化合物提供给治疗部位。所述方法还包括将所述处理部位的至少一部分和所递送的加热治疗化合物的至少一部分暴露于由所述超声波辐射部件产生的超声波能量。

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