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51. 发明授权

US07166304B2 Degradable heterobifunctional poly(ethylene glycol) acrylates 失效
标题翻译：可降解异双功能聚（乙二醇）丙烯酸酯
公开(公告)号：US07166304B2
公开(公告)日：2007-01-23
申请号：US10684946
申请日：2003-10-14
申请人： J. Milton Harris , Xuan Zhao
发明人： J. Milton Harris , Xuan Zhao
IPC分类号： A61K9/00 , A61K47/48 , C12N11/00 , G01N33/543 , C07K17/00
CPC分类号： C08L71/02 , A61K47/60 , C08G65/329 , C08G65/3322 , C08L2203/02 , Y10S530/81 , Y10S530/816 , C08L2666/04
摘要： A heterobifunctional poly(ethylene glycol) is provided having a hydrolytically degradable linkage, a first terminus comprising an acrylate group, and a second terminus comprising a target such as a protein or pharmaceutical agent or a reactive moiety capable of coupling to a target. Hydrogels can be prepared. The hydrogels can be used as a carrier for a protein or a pharmaceutical agent that can be readily released in a controlled fashion.
摘要翻译：提供具有水解可降解键的异双功能聚（乙二醇），包含丙烯酸酯基的第一末端，和包含诸如蛋白质或药物的靶的第二末端或能够与靶偶合的反应性部分。水凝胶可以制备。水凝胶可用作可以以受控方式容易地释放的蛋白质或药剂的载体。

52. 发明授权

US07018624B2 Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels 有权
公开(公告)号：US07018624B2
公开(公告)日：2006-03-28
申请号：US10389560
申请日：2003-03-14
申请人： J. Milton Harris
发明人： J. Milton Harris
IPC分类号： A61K31/77 , C08G65/48 , C08G81/00
CPC分类号： G01N33/528 , A61K47/56 , A61K47/60 , A61K47/6903 , B01L3/508 , B01L99/00 , Y10S424/13 , Y10S530/816
摘要： A degradable PEG hydrogel is described that, upon hydrolysis, releases conjugates of substantially non-peptidic polymers and biologically active molecules. For example, PEG and protein conjugates can be released in vivo from the hydrogels for therapeutic application.

53. 发明授权

US06558658B2 Delivery of poly (ethylene glycol)-modified molecules from degradable hydrogels 失效
公开(公告)号：US06558658B2
公开(公告)日：2003-05-06
申请号：US09824265
申请日：2001-04-02
申请人： J. Milton Harris
发明人： J. Milton Harris
IPC分类号： A61K3127
CPC分类号： G01N33/528 , A61K47/56 , A61K47/60 , A61K47/6903 , B01L3/508 , B01L99/00 , Y10S424/13 , Y10S530/816
摘要： A degradable PEG hydrogel is described that, upon hydrolysis, releases conjugates of substantially non-peptidic polymers and biologically active molecules. For example, PEG and protein conjugates can be released in vivo from the hydrogels for therapeutic application.

54. 发明授权

US06432397B1 Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels 失效
标题翻译：从可降解的水凝胶中递送聚（乙二醇）修饰的分子
公开(公告)号：US06432397B1
公开(公告)日：2002-08-13
申请号：US09426289
申请日：1999-10-25
申请人： J. Milton Harris
发明人： J. Milton Harris
IPC分类号： A61K3177
CPC分类号： G01N33/528 , A61K47/56 , A61K47/60 , A61K47/6903 , B01L3/508 , B01L99/00 , Y10S424/13 , Y10S530/816
摘要： A degradable PEG hydrogel is described that, upon hydrolysis, releases conjugates of substantially non-peptidic polymers and biologically active molecules. For example, PEG and protein conjugates can be released in vivo from the hydrogels for therapeutic application.
摘要翻译：描述了可降解的PEG水凝胶，其在水解时释放基本上非肽聚合物和生物活性分子的共轭物。例如，PEG和蛋白质缀合物可以在体内从水凝胶中释放出来用于治疗应用。

55. 发明授权

US5900461A Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules 失效
公开(公告)号：US5900461A
公开(公告)日：1999-05-04
申请号：US27679
申请日：1998-02-23
申请人： J. Milton Harris
发明人： J. Milton Harris
IPC分类号： A61K47/48 , C08G59/14 , C08G65/32 , C08G65/326 , C08G65/329 , C08G65/334 , C08H1/00 , C08G63/48 , C08G63/91 , C12N9/96 , G01N33/544
CPC分类号： A61K47/48215 , C08G65/326 , C08G65/329 , C08G65/334 , Y10S530/815 , Y10S530/816
摘要： A poly(ethylene glycol) derivative is disclosed that is activated with a sulfone moiety for selective attachment to thiol moieties on molecules and surfaces. The activated PEG is water soluble, hydrolytically stable for extended periods, and forms hydrolytically stable linkages with thiol moieties. The linkages generally are not reversible in reducing environments. The PEG derivative is useful for modifying the characteristics of substances including modifying biologically active molecules and surfaces for biocompatibility. Methods for synthesizing the active PEG and for preparing conjugates of the active PEG and other substances, including biologically active substances, are also disclosed.

56. 发明授权

US5739208A Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules 失效
公开(公告)号：US5739208A
公开(公告)日：1998-04-14
申请号：US473734
申请日：1995-06-07
申请人： J. Milton Harris
发明人： J. Milton Harris
IPC分类号： A61K47/48 , C08G59/14 , C08G65/32 , C08G65/326 , C08G65/329 , C08G65/334 , C08H1/00 , C07K3/00 , C12N9/96
CPC分类号： A61K47/48215 , C08G65/326 , C08G65/329 , C08G65/334 , Y10S530/815 , Y10S530/816
摘要： A poly(ethylene glycol) derivative is disclosed that is activated with a sulfone moiety for selective attachment to thiol moieties on molecules and surfaces. The activated PEG is water soluble, hydrolytically stable for extended periods, and forms hydrolytically stable linkages with thiol moieties. The linkages generally are not reversible in reducing environments. The PEG derivative is useful for modifying the characteristics of substances including modifying biologically active molecules and surfaces for biocompatibility. Methods for synthesizing the active PEG and for preparing conjugates of the active PEG and other substances, including biologically active substances, are also disclosed.

57. 发明授权

US5252714A Preparation and use of polyethylene glycol propionaldehyde 失效
标题翻译：制备和使用聚乙二醇丙醛
公开(公告)号：US5252714A
公开(公告)日：1993-10-12
申请号：US618882
申请日：1990-11-28
申请人： J. Milton Harris , M. R. Sedaghat-Herati
发明人： J. Milton Harris , M. R. Sedaghat-Herati
IPC分类号： C07C47/198 , C07C323/22 , C07K1/107 , C07K3/08 , C07C43/10 , C07C47/12 , C07C321/14
CPC分类号： C07K1/1077 , C07C323/22 , C07C47/198
摘要： A new polyethylene glycol derivative (PEG) having the property of not being destroyed by water and also being able to retain reactivity in water and selectively react with amine groups. Also provided is a process for modifying organic or polymer surfaces in water by connecting PEG derivatives to exposed amine groups which provides a process whereby there is efficient linking to organic or polymer surfaces in water by use of the PEG derivatives.
摘要翻译：一种新的聚乙二醇衍生物（PEG），其具有不被水破坏的性质，并且能够在水中保持反应性并与胺基选择性反应。还提供了通过将PEG衍生物连接到暴露的胺基团来改性水中的有机或聚合物表面的方法，其提供了通过使用PEG衍生物有效连接到水中的有机或聚合物表面的方法。

58. 发明授权

US4690749A Polymer-coated surfaces to control surface zeta potential 失效
标题翻译：聚合物涂层表面以控制表面ζ电位
公开(公告)号：US4690749A
公开(公告)日：1987-09-01
申请号：US808981
申请日：1985-12-16
申请人： James M. Van Alstine , J. Milton Harris , Steve Shafer , Robert S. Snyder , Blair Herren
发明人： James M. Van Alstine , J. Milton Harris , Steve Shafer , Robert S. Snyder , Blair Herren
IPC分类号： B01D57/02 , C03C17/32 , C08J7/04 , G01N27/447 , B01D13/02 , C25D13/00
CPC分类号： B01D57/02 , C03C17/32 , C08J7/047 , G01N27/44752 , Y10T428/2991 , Y10T428/2995 , Y10T428/2998
摘要： A method for eliminating or controlling electroosmosis and other zeta potential related phenomena in electrophoresis comprising conducting electrophoresis employing electrophoretic surfaces coated with covalently bound hydrophilic, neutral polymers is described. An electrophoretic chamber for eliminating or controlling electroosmosis and other zeta potential related phenomena in electrophoresis comprising electrophoretic surfaces coated with covalently bound hydrophilic, neutral polymers, is also disclosed as well as particles exhibiting controlled electrophoretic mobility. The method and electrophoretic chamber not only eliminate electroosmosis, but allow for specific control of electroosmosis. The coated electrophoretic surface is stable relative to prior art coatings and over a broad range of pH. The point of optical focus for accurate mobility measurements is increased from a narrow stationary level to the entire chamber, facilitating accurate measurements by mechanical means. The method also reduces or eliminates assymetric fluid flows due to electroosmosis in electrophoresis chambers of square or rectangular cross-section.
摘要翻译：描述了消除或控制电泳中的电渗和其他ζ电位相关现象的方法，包括使用涂覆有共价结合的亲水性中性聚合物的电泳表面进行电泳。还公开了一种用于消除或控制电泳中电渗和其它ζ电位相关现象的电泳室，其包括用共价结合的亲水性中性聚合物涂覆的电泳表面，以及显示受控电泳迁移率的颗粒。该方法和电泳室不仅消除了电渗，而且允许特定的电渗控制。涂覆的电泳表面相对于现有技术的涂层和宽泛的pH值是稳定的。精确移动性测量的光学焦点从狭窄的静止水平增加到整个腔室，有助于通过机械手段进行精确的测量。该方法还减少或消除由于正方形或矩形横截面的电泳室中的电渗而导致的不对称流体流动。

59. 发明申请

US20120123055A1 Multifunctional Forms of Polyoxazoline Copolymers and Drug Compositions Comprising the Same 有权
标题翻译：多官能团形式的聚恶唑啉共聚物和药物组合物组成
公开(公告)号：US20120123055A1
公开(公告)日：2012-05-17
申请号：US13356552
申请日：2012-01-23
申请人： Kunsang Yoon , Michael David Bentley , J. Milton Harris , Zhihao Fang , Tacey Viegas
发明人： Kunsang Yoon , Michael David Bentley , J. Milton Harris , Zhihao Fang , Tacey Viegas
IPC分类号： C08G73/02
CPC分类号： A61K47/48207 , A61K38/09 , A61K47/59 , C08G73/0233
摘要： The present disclosure provides copolymers of 2-substituted-2-oxazolines possessing two or three reactive functional groups which are also chemically orthogonal. The copolymers described may be random copolymers, block copolymers or a mixture of random and block copolymer configurations. Furthermore, the present disclosure provides novel methods for synthesizing the above polymers and for conjugating to molecules such as targeting, diagnostic and therapeutic agents.
摘要翻译：本公开提供了具有两个或三个也是化学正交的反应性官能团的2-取代-2-恶唑啉的共聚物。所述共聚物可以是无规共聚物，嵌段共聚物或无规嵌段共聚物构型的混合物。此外，本公开提供了用于合成上述聚合物并用于与靶标，诊断和治疗剂等分子缀合的新方法。

60. 发明授权

US08110651B2 Multifunctional forms of polyoxazoline copolymers and drug compositions comprising the same 有权
标题翻译：多官能形式的聚恶唑啉共聚物和包含它们的药物组合物
公开(公告)号：US08110651B2
公开(公告)日：2012-02-07
申请号：US12744472
申请日：2009-01-12
申请人： Kunsang Yoon , J. Milton Harris , Michael David Bentley
发明人： Kunsang Yoon , J. Milton Harris , Michael David Bentley
IPC分类号： C08G73/06 , C08G75/02 , C08G69/00
CPC分类号： C08G73/0233 , C08G73/028
摘要： The present disclosure provides copolymers of 2-substituted-2-oxazolines possessing two or three reactive functional groups which are also chemically orthogonal. The copolymers described may be random copolymers, block copolymers or a mixture of random and block copolymer configurations. Furthermore, the present disclosure provides novel methods for synthesizing the above polymers and for conjugating to molecules such as targeting, diagnostic and therapeutic agents.
摘要翻译：本公开提供了具有两个或三个也是化学正交的反应性官能团的2-取代-2-恶唑啉的共聚物。所述共聚物可以是无规共聚物，嵌段共聚物或无规嵌段共聚物构型的混合物。此外，本公开提供了用于合成上述聚合物并用于与靶标，诊断和治疗剂等分子缀合的新方法。

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