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51. 发明授权

US07276064B2 Side-port sheath for catheter placement and translation 失效
标题翻译：用于导管放置和翻译的侧端口护套
公开(公告)号：US07276064B2
公开(公告)日：2007-10-02
申请号：US10856145
申请日：2004-05-27
申请人： Saurav Paul , Kedar Ravindra Belhe , Hong Cao , John Avi Roop , Chou Thao
发明人： Saurav Paul , Kedar Ravindra Belhe , Hong Cao , John Avi Roop , Chou Thao
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B5/042 , A61B2018/143 , A61B2018/1475 , A61B2018/1497
摘要： Side-port sheaths for catheter placement and translation are disclosed. The sheaths include a side-port opening through which a gliding catheter may be deployed during diagnosis or treatment of tissue. The side-port sheath may include a suspension ribbon used to deploy, or that aids in the deployment of, the embedded gliding catheter. The suspension ribbon may be slideably or fixably engaged with an outer surface of the sheath of the gliding catheter.
摘要翻译：公开了用于导管放置和平移的侧端口护套。护套包括侧口开口，在组织的诊断或处理期间可以通过滑动导管展开滑动导管。侧端口护套可以包括用于部署或有助于部署嵌入式滑翔导管的悬挂带。悬挂带可以与滑动导管的护套的外表面可滑动地或可固定地接合。

52. 发明申请

US20070088349A1 Curved ablation catheter 有权
标题翻译：弯曲消融导管
公开(公告)号：US20070088349A1
公开(公告)日：2007-04-19
申请号：US11550302
申请日：2006-10-17
申请人： Kedar Belhe , Saurav Paul , Hong Cao , John Roop
发明人： Kedar Belhe , Saurav Paul , Hong Cao , John Roop
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/00351 , A61B2018/143 , A61B2018/1475 , A61B2018/1497
摘要： A curved ablation catheter imparts ablative energy to target tissue, for example, along a trabecular slope, e.g., in the right atrium along the isthmus between the ostium of the inferior vena cava and the tricuspid valve. The catheter is formed with a preset curvature that, when deployed, both translates linearly and increases in radius to aid in the formation of spot or continuous linear lesions. A method of treating atrial flutter employs the curved ablation catheter.
摘要翻译：弯曲的消融导管向靶组织提供消融能量，例如沿着小梁斜面，例如沿着下腔静脉的口和三尖瓣之间的峡谷的右心房。导管形成有预设曲率，当展开时，两者均线性地平移并且半径增加以帮助形成斑点或连续的线性损伤。治疗心房扑动的方法采用弯曲消融导管。

53. 发明申请

US20050267332A1 Spring-tip, flexible electrode catheter for tissue ablation 有权
标题翻译：弹簧尖端，柔性电极导管用于组织消融
公开(公告)号：US20050267332A1
公开(公告)日：2005-12-01
申请号：US10856904
申请日：2004-05-27
申请人： Saurav Paul , Kedar Belhe , Hong Cao , John Roop , Chou Thao
发明人： Saurav Paul , Kedar Belhe , Hong Cao , John Roop , Chou Thao
IPC分类号： A61B18/14 , A61N1/05
CPC分类号： A61B18/1492 , A61B2018/143 , A61B2018/1435
摘要： A spring-tip, flexible electrode, and a method for using that electrode for tissue ablation, are disclosed. The spring-tip, flexible electrode comprises an enshrouded flexible electrode (e.g., an enshrouded plurality of flexible brush filaments or bristles) for applying ablative energy (e.g., RF energy) to target tissue during the formation of spot or continuous linear lesions. The spring of the spring tip may comprise compressible coils, compressible mesh, or compressible bellows, among other things. The spring provides axial suspension and is capable of axial compression and extension, and is flexible enough for deflection and bending. The axial suspension of the spring tip facilitates the desired contact between the electrode and the tissue surface. A shielded, spring-tip, flexible electrode is also disclosed, and includes a flexible nipple or shield. The spring-tip, flexible electrode facilitates enhanced tissue contact in difficult environments (e.g., during ablation of a contoured or trabeculated surface inside a beating heart) since the flexible electrode readily conforms to surface contours while the bending stress of the spring enhances the contract pressure on the tissue.
摘要翻译：公开了一种弹簧尖端，柔性电极和用于组织消融使用该电极的方法。弹簧尖端的柔性电极包括用于在形成斑点或连续的线性损伤期间向目标组织施加消融能量（例如，RF能量）的带有屏蔽的柔性电极（例如，被包围的多个柔性刷丝或刷毛）。弹簧尖端的弹簧可以包括可压缩线圈，可压缩网或可压缩波纹管等等。弹簧提供轴向悬挂并且能够轴向压缩和伸展，并且具有足够的挠性和弯曲性。弹簧顶端的轴向悬挂有助于电极和组织表面之间的所需接触。还公开了屏蔽的弹簧尖端柔性电极，并且包括柔性接头或屏蔽。弹簧尖端的柔性电极有助于在困难的环境中（例如在跳动心脏内的轮廓或小梁表面的消融期间）增强组织接触，因为柔性电极容易符合表面轮廓，同时弹簧的弯曲应力增加了收缩压力在纸巾上。

54. 发明授权

US09271782B2 Assessment of electrode coupling of tissue ablation 有权
标题翻译：评估组织消融的电极耦合
公开(公告)号：US09271782B2
公开(公告)日：2016-03-01
申请号：US12095688
申请日：2006-12-06
申请人： Saurav Paul , Kedar Ravindra Belhe , Hong Cao , Chou Thao
发明人： Saurav Paul , Kedar Ravindra Belhe , Hong Cao , Chou Thao
IPC分类号： A61B18/12 , A61B18/14 , A61B19/00 , A61B18/00
CPC分类号： A61B18/1206 , A61B18/1492 , A61B34/20 , A61B2018/00303 , A61B2018/00357 , A61B2018/00577 , A61B2018/00642 , A61B2018/00666 , A61B2018/00702 , A61B2018/0075 , A61B2018/00755 , A61B2018/00869 , A61B2018/00875 , A61B2090/064 , A61B2090/065
摘要： An electrode catheter and a method for assessing electrode-tissue contact and coupling are disclosed. An exemplary electrode catheter comprises an electrode adapted to apply electrical energy. A measurement circuit is adapted to measure impedance between the electrode and ground as the electrode approaches a target tissue. A processor determines a contact and coupling condition for the target tissue based at least in part on reactance of the impedance measured by the measurement circuit. In another exemplary embodiment, the electrode catheter determines the contact and coupling condition based at least in part on a phase angle of the impedance.
摘要翻译：公开了电极导管和用于评估电极组织接触和耦合的方法。示例性电极导管包括适于施加电能的电极。测量电路适于在电极接近目标组织时测量电极和地面之间的阻抗。处理器至少部分地基于由测量电路测量的阻抗的电抗来确定目标组织的接触和耦合条件。在另一示例性实施例中，电极导管至少部分地基于阻抗的相位角确定接触和耦合条件。

55. 发明授权

US08702690B2 Device and method for real-time lesion estimation during ablation 有权
标题翻译：消融期间实时病变评估的装置和方法
公开(公告)号：US08702690B2
公开(公告)日：2014-04-22
申请号：US12742485
申请日：2008-11-17
申请人： Saurav Paul , Hong Cao
发明人： Saurav Paul , Hong Cao
IPC分类号： A61B18/14
CPC分类号： A61B18/1233 , A61B18/1206 , A61B18/1492 , A61B2018/00678 , A61B2018/00702 , A61B2018/00779 , A61B2018/00791 , A61B2018/00827 , A61B2018/00869 , A61B2018/00892 , A61B2090/065
摘要： Disclosed herein are ablation systems and methods for providing feedback on lesion formation in real-time. The methods and systems assess absorptivity of tissue based on a degree of electric coupling or contact between an ablation electrode and the tissue. The absorptivity can then be used, along with other information, including, power levels and activation times, to provide real-time feedback on the lesions being created. Feedback may be provided, for example, in the form of estimated lesion volumes and other lesion characteristics. The methods and systems can provide estimated treatment times to achieve a desired lesion characteristic for a given degree of contact, as well as depth of a lesion being created. The degree of contact may be measured using different techniques, including the phase angle techniques and a coupling index.
摘要翻译：本文公开了用于实时提供病变形成反馈的消融系统和方法。方法和系统基于消融电极和组织之间的电偶联或接触程度来评估组织的吸收性。然后可以使用吸收率以及其他信息，包括功率水平和激活时间，为正在创建的病变提供实时反馈。可以例如以估计的病变体积和其他病变特征的形式提供反馈。方法和系统可以提供估计的治疗时间以达到给定程度的接触所需的病变特征，以及所产生的病变的深度。可以使用不同的技术来测量接触程度，包括相位角技术和耦合指数。

56. 发明申请

US20130190754A1 Pressure-sensitive flexible polymer bipolar electrode 有权
标题翻译：压敏柔性聚合物双极电极
公开(公告)号：US20130190754A1
公开(公告)日：2013-07-25
申请号：US13555929
申请日：2012-07-23
申请人： Saurav Paul , Harry A. Puryear , Riki Thao , Hong Cao
发明人： Saurav Paul , Harry A. Puryear , Riki Thao , Hong Cao
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B18/1206 , A61B2018/00023 , A61B2018/00577 , A61B2018/00875
摘要： The present invention is directed to bipolar ablation systems. A bipolar electrode system for ablation therapy is disclosed, including a pressure-sensitive conducting composite layer and a pair of electrodes in electrical conductive contact or communication with the pressure-sensitive conducting composite layer. Energy (e.g., ablation energy) is delivered via the pressure-sensitive conductive composition when sufficient pressure is applied to transform the pressure-sensitive conductive composite to an electrical conductor. An electrically insulative flexible layer, which may include a passageway for a fill material is also disclosed. In some embodiments, the systems can also be used for targeted delivery of compounds, such as drugs, using a bipolar electrode.
摘要翻译：本发明涉及双相消融系统。公开了一种用于消融治疗的双极电极系统，包括压敏导电复合层和一对导电接触或与压敏导电复合层连通的电极。当施加足够的压力以将压敏导电复合材料转化为电导体时，经由压敏导电组合物递送能量（例如，消融能量）。还公开了可以包括用于填充材料的通道的电绝缘柔性层。在一些实施方案中，所述系统也可用于使用双极电极靶向递送化合物，例如药物。

57. 发明申请

US20130023784A1 METHOD AND APPARATUS FOR COMPLEX IMPEDANCE COMPENSATION AND FOR DETERMINING TISSUE MORPHOLOGY BASED ON PHASE ANGLE 审中-公开
公开(公告)号：US20130023784A1
公开(公告)日：2013-01-24
申请号：US13584368
申请日：2012-08-13
申请人： Clint Schneider , Hong Cao , Saurav Paul
发明人： Clint Schneider , Hong Cao , Saurav Paul
IPC分类号： A61B5/053 , A61B18/14
CPC分类号： A61B5/053
摘要： A compensation circuit has a predetermined, known complex impedance and is located in a handle of a catheter or in a distal end of a cable that connects to the catheter. The compensation circuit is probed with a pilot signal produced by a compensation control that is external to the catheter, by way of an electrical connection through the connecting cable. The compensation control measures the complex impedance, which is the combination of the circuit's known impedance as well as that of the cable. The compensation control then determines the difference between the measured and the known complex impedances. The difference represents that which is attributable to the cable, and is used to compensate or cancel out such cable-related contributions to complex impedance in measurements made over other electrical connections in the same cable. In another aspect, an unknown tissue is identified as one of a plurality of possible tissue types such as regular myocardium, scar and fat based on the measured phase angle of the complex impedance of the unknown tissue.

58. 发明授权

US08267926B2 Assessment of electrode coupling for tissue ablation 有权
标题翻译：组织消融电极耦合评估
公开(公告)号：US08267926B2
公开(公告)日：2012-09-18
申请号：US12096071
申请日：2006-12-06
申请人： Saurav Paul , Hong Cao , Kedar Ravindra Belhe , Chou Thao
发明人： Saurav Paul , Hong Cao , Kedar Ravindra Belhe , Chou Thao
IPC分类号： A61B18/04
CPC分类号： A61B18/1206 , A61B18/1492 , A61B34/20 , A61B2018/00303 , A61B2018/00357 , A61B2018/00577 , A61B2018/00642 , A61B2018/00666 , A61B2018/00702 , A61B2018/0075 , A61B2018/00755 , A61B2018/00869 , A61B2018/00875 , A61B2090/064 , A61B2090/065
摘要： An electrode catheter and a method for assessing electrode-tissue contact and coupling are disclosed. An exemplary electrode catheter comprises an electrode adapted to apply electrical energy. A measurement circuit is adapted to measure impedance between the electrode and ground as the electrode approaches a target tissue. A processor determines a contact and coupling condition for the target tissue based at least in part on reactance of the impedance measured by the measurement circuit. In another exemplary embodiment, the electrode catheter determines the contact and coupling condition based at least in part on a phase angle of the impedance.
摘要翻译：公开了电极导管和用于评估电极组织接触和耦合的方法。示例性电极导管包括适于施加电能的电极。测量电路适于在电极接近目标组织时测量电极和地面之间的阻抗。处理器至少部分地基于由测量电路测量的阻抗的电抗来确定目标组织的接触和耦合条件。在另一示例性实施例中，电极导管至少部分地基于阻抗的相位角确定接触和耦合条件。

59. 发明授权

US08118809B2 Flexible conductive polymer electrode and method for ablation 有权
标题翻译：柔性导电聚合物电极和消融方法
公开(公告)号：US08118809B2
公开(公告)日：2012-02-21
申请号：US11963430
申请日：2007-12-21
申请人： Saurav Paul , Hong Cao , Chou Thao
发明人： Saurav Paul , Hong Cao , Chou Thao
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/00005 , A61B2018/00023 , A61B2018/00029 , A61B2018/00077 , A61B2018/00136 , A61B2018/00148 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821
摘要： An electrode for ablation therapy includes a flexible conductive element for conducting electrical energy and a flexible conductive polymer member in electrically conductive contact with the conductive element. A catheter shaft may be coupled to the conductive element and/or the flexible conductive polymer member. The flexible conductive element may be formed as a helical coil, a mesh coating or wrap, or any other suitable form, and may surround (wholly or partially) a flexible electrically insulative, and optionally thermally conductive, member. A heat sink may be thermally coupled to at least one of the flexible conductive polymer member and the flexible electrically insulative member. The flexible electrically insulative member may include a passageway for coolant fluid to cool the electrode during ablation. The passageway may include at least one efflux hole to permit coolant fluid to flow from the passageway, or may define a closed loop.
摘要翻译：用于消融治疗的电极包括用于传导电能的柔性导电元件和与导电元件导电接触的柔性导电聚合物构件。导管轴可以联接到导电元件和/或柔性导电聚合物构件。柔性导电元件可以形成为螺旋线圈，网状涂层或包裹物或任何其它合适的形式，并且可以围绕（全部或部分地）柔性电绝缘和任选地导热的构件。散热器可以热耦合到柔性导电聚合物构件和柔性电绝缘构件中的至少一个。柔性电绝缘构件可以包括用于在消融期间冷却电极的冷却剂流体的通道。通道可以包括至少一个排出孔，以允许冷却剂流体从通道流出，或者可以限定闭环。

60. 发明申请

US20110178092A1 HIV-1 Protease Inhibitors 审中-公开
标题翻译： HIV-1蛋白酶抑制剂
公开(公告)号：US20110178092A1
公开(公告)日：2011-07-21
申请号：US11960120
申请日：2007-12-19
申请人： Akbar Ali , Michael D. Altman , Saima G. Anjum , Hong Cao , Sripriya Chellappan , Miguel X. Fernandes , Michael K. Gilson , Visvaldas Kairys , Nancy King , Ellen Nalivaika , Moses Prabu , Tariq M. Rana , Kiran Kumar Sai , Celia A. Schiffer , Bruce Tidor
发明人： Akbar Ali , Michael D. Altman , Saima G. Anjum , Hong Cao , Sripriya Chellappan , Miguel X. Fernandes , Michael K. Gilson , Visvaldas Kairys , Nancy King , Ellen Nalivaika , Moses Prabu , Tariq M. Rana , Kiran Kumar Sai , Celia A. Schiffer , Bruce Tidor
IPC分类号： A61K31/501 , C07D403/12 , A61K31/4178 , C07D401/14 , A61K31/4439 , C07D413/12 , A61K31/422 , C07C311/29 , A61K31/18 , C07D277/36 , A61K31/426 , C07D277/64 , A61K31/428 , C07C233/81 , A61K31/166 , C07D215/48 , A61K31/47 , A61P31/18
CPC分类号： C07C311/05 , C07C233/36 , C07C235/20 , C07C235/50 , C07C235/60 , C07C235/74 , C07C237/22 , C07C311/29 , C07C2601/02 , C07C2601/10 , C07C2601/14 , C07D215/48 , C07D263/24 , C07D277/36 , C07D277/64 , C07D307/20 , C07D307/79 , C07D401/14 , C07D403/12 , C07D413/12 , C07D417/12 , C07D493/04
摘要： Described are novel protease inhibitors and methods for using said protease inhibitors in the treatment of human immunodeficiency virus (HIV) infection.
摘要翻译：描述了新型蛋白酶抑制剂和使用所述蛋白酶抑制剂治疗人类免疫缺陷病毒（HIV）感染的方法。

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