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    • 53. 发明授权
    • Quinazoline-3-alkanoic acid derivatives, their salts and their
preparation processes
    • 喹诺酮-3-碱性酸衍生物及其制备方法
    • US5234928A
    • 1993-08-10
    • US721610
    • 1991-07-17
    • Shizuyoshi FujimoriMichiro OhnotaYoshihiro HirataKoji Murakami
    • Shizuyoshi FujimoriMichiro OhnotaYoshihiro HirataKoji Murakami
    • A61K31/505A61K31/517A61P3/08A61P3/10A61P7/02A61P43/00C07D239/80C07D239/95C07D239/96C07D401/06C07D403/04C07D403/06C07D405/06C07D409/06C07D413/06C07D417/04C07D417/06C07D491/056C07D521/00C12N9/99
    • C07D231/12C07D233/56C07D239/80C07D239/95C07D239/96C07D249/08C07D401/06C07D403/04C07D405/06C07D409/06C07D413/06Y02P20/55
    • The present invention relates to quinazoline-3-alkanoic acid derivatives having both an inhibitory effect on platelet aggregation and a hindering effect on aldose reductase together, represented by a general formula [I] ##STR1## [wherein R is hydrogen or a protecting group for carboxyl group, R.sup.1 is a lower alkyl group, alkenyl group, alkinyl group, lower alkoxy group, lower alkylthio group, halogen, phenyl group (this phenyl group may be substituted by one to three of lower alkyls, lower alkoxys, halogens, trifluoromethyls, carboxyethylenes or ethoxycarbonylethylenes, naphthyl group, heterocycle (this heterocycle may be substituted by one to three of lower alkyls), cycloalkyl group or benzoyl group (this benzoyl group may be substituted by lower alkyl or halogen), R.sup.2 and R.sup.3 are identically or differently hydrogens, halogens, lower alkyl groups, lower alkoxy groups, aralkyl groups which may be substituted, nitro groups, imidazolyl groups, imidazolylmethyl groups or ##STR2## (R.sup.4 and R.sup.5 indicate identically or differently hydrogens or lower alkyl groups, or connected with each other to make five- or six-membered heterocycles which may contain other hetero atom, X is carbonyl, thiocarbonyl or methylene group (this methylene group may be substituted by lower alkyl group), A is lower alkylene or lower alkenylene, and n indicates an integer of 1 to 3],their salts, their preparation processes and medicinal drugs containing them.
    • PCT No.PCT / JP90 / 01600 Sec。 371日期:1991年7月17日 102(e)日期1991年7月17日PCT 1990年12月10日PCT PCT。 出版物WO91 / 0902400 日本1991年6月27日。本发明涉及具有对血小板聚集的抑制作用和对醛糖还原酶的阻碍作用的喹唑啉-3-链烷酸衍生物,其通式[I]表示[其中R 是氢或羧基的保护基,R1是低级烷基,烯基,炔基,低级烷氧基,低级烷硫基,卤素,苯基(该苯基可被一至三个低级烷基取代, 低级烷氧基,卤素,三氟甲基,羧乙烯或乙氧基羰基乙烯,萘基,杂环(该杂环可被一至三个低级烷基取代),环烷基或苯甲酰基(该苯甲酰基可被低级烷基或卤素取代),R2 和R 3是相同或不同的氢,卤素,低级烷基,低级烷氧基,可被取代的芳烷基,硝基,咪唑基,咪唑基甲基或IM (R 4和R 5表示相同或不同的氢或低级烷基,或彼此连接以形成可含有其它杂原子的五或六元杂环,X为羰基,硫代羰基或亚甲基(该亚甲基可以 被低级烷基取代),A是低级亚烷基或低级亚烯基,n表示1〜3的整数],它们的盐,它们的制备方法和含有它们的药用药物。
    • 54. 发明授权
    • Electrical connector for flexible plane-type conductor cable
    • 用于柔性平面导线电缆的电气连接器
    • US5137468A
    • 1992-08-11
    • US693199
    • 1991-04-30
    • Koji Murakami
    • Koji Murakami
    • H01R4/24
    • H01R4/2495
    • An electrical connector comprises crimping pieces of tongue-like sheet integrally provided on the side edges of a web in such a manner as to erect therefrom and arc contact portions each comprising an arc substantially normal to the sheet body of the crimping piece, and the crimping piece is formed as a curled portion so as to be superimposed over the contact portion, whereby a flexible plane-type conductor cable is securely held between the superimposed portions for establishing electrical connection therebetween. The arc contact portion is formed as a recessed arc contact portion, and the external arc of the curled portion and this recessed arc are brought into concentric arc relationship.
    • 电连接器包括:卷绕片状片状片状片,其一体地设置在幅材的侧边缘上,以便直立,并且每个包括基本上垂直于压接片的片体的弧的电弧接触部分,以及卷曲 片形成为卷曲部分,以便重叠在接触部分上,由此柔性平面型导体电缆被牢固地保持在叠置部分之间,以在它们之间建立电连接。 弧形接触部分形成为凹弧接触部分,并且卷曲部分的外弧和该凹弧同心圆弧。
    • 56. 发明授权
    • Fibrosis inhibitor
    • 纤维化抑制剂
    • US08729086B2
    • 2014-05-20
    • US12919885
    • 2009-02-26
    • Koji MurakamiTakuya Toramoto
    • Koji MurakamiTakuya Toramoto
    • A61K31/4965C07D241/02
    • C07D241/20A61K31/4965
    • [Object] The main object of the present invention is to provide a fibrosis inhibitor.[Solving Means] The present invention relates to a fibrosis inhibitor containing the heterocyclic derivative represented by the following general formula (1) or a pharmaceutically acceptable salt thereof as an active ingredient; In the formula (1), R1 and R2 are the same or different and each represents an optionally substituted aryl; R3 and R4 are the same or different and each represents hydrogen atom or alkyl; R5 represents hydrogen atom, alkyl or halogen atom; Y represents N or N→O; A represents NR6, and R6 represents hydrogen atom, alkyl, etc.; D represents alkylene or alkenylene which is optionally substituted with hydroxy; E represents phenylene or a single bond; G represents O, S, etc.; and Q represents carboxy, alkoxycarbonyl, etc.
    • 本发明的主要目的在于提供纤维化抑制剂。 本发明涉及含有下述通式(1)表示的杂环衍生物或其药学上可接受的盐作为有效成分的纤维化抑制剂。 在式(1)中,R 1和R 2相同或不同,表示任选取代的芳基; R3和R4相同或不同,各自表示氢原子或烷基; R5代表氢原子,烷基或卤素原子; Y表示N或N→O; A表示NR6,R6表示氢原子,烷基等。 D表示任选被羟基取代的亚烷基或亚烯基; E表示亚苯基或单键; G代表O,S等; Q表示羧基,烷氧基羰基等。
    • 57. 发明授权
    • Communication control system, communication control method, call control server device, and call control program
    • 通信控制系统,通信控制方式,呼叫控制服务器设备和呼叫控制程序
    • US08700783B2
    • 2014-04-15
    • US12996807
    • 2009-06-15
    • Yoshiko SuedaMasashi ToyamaKoji Murakami
    • Yoshiko SuedaMasashi ToyamaKoji Murakami
    • G06F15/16
    • H04M7/003G06Q30/02H04L12/14H04L12/1457H04L12/1485H04L65/1036H04L65/105H04L65/1069H04M15/00H04M15/63H04M15/8292
    • Upon receipt of an access request from a Web terminal, a service providing server transmits a shop ID stored in an external information database to the Web terminal. When the shop ID is selected by the Web terminal, the service providing server acquires external connection destination information, and notifies a SIP proxy server of the information via the Web terminal. When notified of the information, the SIP proxy server identifies internal connection destination information in an internal information database, based on an IP address added at the time of the notification of the external connection destination information. After making a call to a telephone device with the use of the identified internal connection destination information, the SIP proxy server makes a call to the shop with the use of the external connection destination information. After that, the SIP proxy server establishes a connection between the telephone device and the shop.
    • 在从Web终端接收到访问请求时,服务提供服务器将存储在外部信息数据库中的商店ID发送到Web终端。 当由Web终端选择商店ID时,服务提供服务器获取外部连接目的地信息,并通过Web终端向SIP代理服务器通知该信息。 SIP代理服务器在通知该信息时,根据在通知外部连接目的地信息时添加的IP地址,在内部信息数据库中识别内部连接目的地信息。 在通过使用所识别的内部连接目的地信息对电话设备进行呼叫之后,SIP代理服务器通过使用外部连接目的地信息来呼叫商店。 之后,SIP代理服务器建立电话设备和商店之间的连接。