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    • 52. 发明授权
    • 3-hydrazino-2,5-dioxopyrrolidine-3-carboxylates, process for production of the same, and use of the same
    • 3-肼基-2,5-二氧代吡咯烷-3-羧酸酯,其制备方法及其用途
    • US08003808B2
    • 2011-08-23
    • US12309101
    • 2007-06-13
    • Daisuke Tanaka
    • Daisuke Tanaka
    • C07D207/30
    • C07D207/416
    • The present invention provides 3-hydrazino-2,5-dioxopyrrolidine-3-carboxylates of the formula (I): wherein R1 is a C1-6 alkyl group, etc., R2 is a hydrogen atom or a COOR3 group, wherein R3 is a tert-C4-6 alkyl group, a 2,2,2-trichloroethyl group or a benzyl group in which the benzene ring moiety may be optionally substituted by one or two atoms or groups independently selected from the group consisting of a halogen atom, a C1-4 alkyl group, a C1-4 alkoxy group, a cyano group and a nitro group, and a salt thereof, which are useful as a novel intermediate for preparing tetrahydropyrrolo[1,2-a]pyrazin-4-spiro-3′-pyrrolidine derivatives such as Ranirestat being promising therapeutic agents for diabetic complications in a short process and in an economically advantageous and safe manner, and the process for preparing the same.
    • 本发明提供式(I)的3-肼基-2,5-二氧代吡咯烷-3-羧酸盐:其中R1是C1-6烷基等,R2是氢原子或COOR3基团,其中R3是 叔-C4-6烷基,2,2,2-三氯乙基或苄基,其中苯环部分可以任选地被一个或两个独立地选自以下的原子或基团取代:卤素原子, C 1-4烷基,C 1-4烷氧基,氰基和硝基及其盐,可用作制备四氢吡咯并[1,2-a]吡嗪-4-螺 - 3'-吡咯烷衍生物如兰尼斯特(Ranirestat)在短时间内以治疗糖尿病并发症为前景的治疗剂以及经济上有利和安全的方法及其制备方法。
    • 56. 发明授权
    • Direct fuel injection internal combustion engine
    • 直燃式内燃机
    • US07086378B2
    • 2006-08-08
    • US10990957
    • 2004-11-18
    • Daisuke TanakaKoji HirayaIsamu HottaHirofumi Tsuchida
    • Daisuke TanakaKoji HirayaIsamu HottaHirofumi Tsuchida
    • F02B3/02
    • F02B23/101Y02T10/125
    • A direct fuel injection internal combustion engine includes a fuel injector arranged above a center portion of the piston and positioned higher than a combustion chamber upper surface of a cylinder head. The cylinder head includes a recess portion in which a tip of the fuel injector is disposed in a cross sectional view of the cylinder head in a plane perpendicular to a fuel injection center axis. The recess portion is provided with a channel extending longitudinally away from the tip of the fuel injector configured and arranged to reduce negative pressure within the recess portion. The channel is oriented in such a direction as to avoid the interference between the channel and other parts of the cylinder head. When the fuel injector is a multi-hole fuel injector, the channel can be oriented toward a direction along a centerline between two adjacent injection vents of the fuel injector.
    • 直接燃料喷射内燃机包括布置在活塞的中心部分上方并位于高于气缸盖的燃烧室上表面的燃料喷射器。 气缸盖包括凹部,燃料喷射器的前端在与燃料喷射中心轴线垂直的平面中在气缸盖的横截面视图中设置。 所述凹部设置有纵向延伸远离所述燃料喷射器的末端的通道,所述末端构造和布置成减小所述凹部内的负压。 通道朝向避免通道与气缸盖的其他部分之间的干涉的方向。 当燃料喷射器是多孔燃料喷射器时,通道可以朝向沿燃料喷射器的两个相邻喷射通气口之间的中心线的方向。
    • 58. 发明申请
    • Direct fuel injection internal combustion engine
    • 直燃式内燃机
    • US20050139191A1
    • 2005-06-30
    • US10990957
    • 2004-11-18
    • Daisuke TanakaKoji HirayaIsamu HottaHirofumi Tsuchida
    • Daisuke TanakaKoji HirayaIsamu HottaHirofumi Tsuchida
    • F02B23/10F02M61/18F02B3/00
    • F02B23/101Y02T10/125
    • A direct fuel injection internal combustion engine includes a fuel injector arranged above a center portion of the piston and positioned higher than a combustion chamber upper surface of a cylinder head. The cylinder head includes a recess portion in which a tip of the fuel injector is disposed in a cross sectional view of the cylinder head in a plane perpendicular to a fuel injection center axis. The recess portion is provided with a channel extending longitudinally away from the tip of the fuel injector configured and arranged to reduce negative pressure within the recess portion. The channel is oriented in such a direction as to avoid the interference between the channel and other parts of the cylinder head. When the fuel injector is a multi-hole fuel injector, the channel can be oriented toward a direction along a centerline between two adjacent injection vents of the fuel injector.
    • 直接燃料喷射内燃机包括布置在活塞的中心部分上方并位于高于气缸盖的燃烧室上表面的燃料喷射器。 气缸盖包括凹部,燃料喷射器的前端在与燃料喷射中心轴线垂直的平面中在气缸盖的横截面视图中设置。 所述凹部设置有纵向延伸远离所述燃料喷射器的末端的通道,所述末端构造和布置成减小所述凹部内的负压。 通道朝向避免通道与气缸盖的其他部分之间的干涉的方向。 当燃料喷射器是多孔燃料喷射器时,通道可以朝向沿燃料喷射器的两个相邻喷射通气口之间的中心线的方向。
    • 59. 发明申请
    • Washer pump and filter used for washer pump
    • 洗衣机泵和过滤器用于洗衣机泵
    • US20050063845A1
    • 2005-03-24
    • US10668341
    • 2003-09-24
    • Shin AkimotoDaisuke Tanaka
    • Shin AkimotoDaisuke Tanaka
    • F04D29/70F04B35/04
    • F04D29/708
    • A washer pump includes a case partitioned into a motor chamber, which accommodates an armature rotated when it is electrically energized, and partitioned into a pump chamber, which accommodates an impeller rotated being coupled to an armature shaft of the armature, wherein washing liquid is sucked into the pump chamber from a liquid suction port, which is communicated with the pump chamber, by the rotation of the impeller, and the washing liquid is discharged from a liquid discharge port which is communicated with the pump chamber, and the washer pump is characterized in that: a ventilation hole is provided on a partition wall to partition the pump chamber and the liquid suction port, a filter for filtering the washing liquid is detachably attached to the liquid suction port, an air passage is provided in the filter, and the air passage is communicated with the ventilation hole.
    • 洗衣机泵包括分隔成电动机室的壳体,其容纳当其被激励时旋转的电枢,并且分隔成泵室,该泵室容纳与电枢的电枢轴相连接的叶轮,其中吸入洗涤液体 通过叶轮的旋转从与泵室连通的液体吸入口进入泵室,并且洗涤液体从与泵室连通的液体排出口排出,并且清洗泵的特征在于 其特征在于,在分隔壁上设置通气孔以分隔泵室和液体吸入口,用于过滤洗涤液的过滤器可拆卸地附接到液体吸入口,在过滤器中设置空气通道, 空气通道与通风孔连通。