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51. 发明授权

US07470681B2 Pyrimidine compounds 失效
标题翻译：嘧啶化合物
公开(公告)号：US07470681B2
公开(公告)日：2008-12-30
申请号：US11193002
申请日：2005-07-29
申请人： Lijun Sun , Mitsunori Ono , Teresa Przewloka , Elena Kostik , Yumiko Wada
发明人： Lijun Sun , Mitsunori Ono , Teresa Przewloka , Elena Kostik , Yumiko Wada
IPC分类号： A61K31/506 , A61P17/06 , A61P19/02 , A61P25/28 , C07D401/04 , C07D405/04 , C07D413/04 , C07D417/04 , C07D239/24
CPC分类号： C07D239/48 , A61K31/5377 , A61K31/541 , C07D401/12 , C07D401/14 , C07D403/12
摘要： This invention features pyrimidine compounds of formula (I): R1 is each of R2 and R4 is H; R3 is H, alkyl, aryl, heteroaryl, cyclyl, heterocyclyl, or alkylcarbonyl; R5 is H or alkyl; n is 0, 1, 2, 3, 4, 5, or 6; X is NRc; Y is covalent bond, CH2, C(O), C═N—Rc, C═N—ORc, C═N—SRc, O, S, S(O), S(O2), or NRc; Z is N or CH; one of U and V is N, and the other is CRc; and W is O, S, S(O), S(O2), NRc, or NC(O)Rc; in which each of Ra and Rb, independently, is H, alkyl, aryl, heteroaryl; and Rc is H, alkyl, aryl, heteroaryl, cyclyl, heterocyclyl, or alkylcarbonyl.
摘要翻译：本发明具有式（I）的嘧啶化合物：R1各自为R 2，R 4为H; R3是H，烷基，芳基，杂芳基，环基，杂环基或烷基羰基; R5是H或烷基; n是0，1，2，3，4，5或6; X是NRc; Y是共价键，CH2，C（O），C-N-Rc，C-N-ORc，C-N-SRc，O，S，S（O），S（O 2）或NRc; Z是N或CH; U和V之一是N，另一个是CRc; 并且W是O，S，S（O），S（O 2），NR c或NC（O）R c; 其中R a和R b各自独立地为H，烷基，芳基，杂芳基; Rc是H，烷基，芳基，杂芳基，环基，杂环基或烷基羰基。

52. 发明授权

US07410990B2 Heterocyclic compounds 有权
公开(公告)号：US07410990B2
公开(公告)日：2008-08-12
申请号：US11542963
申请日：2006-10-03
申请人： Lijun Sun , Mitsunori Ono , Yumiko Wada , Weiwen Ying , Teresa Przewloka , Elena Kostik
发明人： Lijun Sun , Mitsunori Ono , Yumiko Wada , Weiwen Ying , Teresa Przewloka , Elena Kostik
IPC分类号： A61K31/4184 , A61K31/5377 , C07D265/30 , C07D235/30
CPC分类号： C07D473/34 , C07D473/16 , C07D473/18
摘要： This invention features a compound of formula (I): R1 is aryl or heteroaryl; each of R2 and R4, independently, is H, halogen, CN, alkyl, ORa, or NRaRb; R3 is H, halogen, CN, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cyclyl, heterocyclyl, ORa, OC(O)Ra, OC(O)NRaRb, NRaRb, NRaC(O)Rb, NRaS(O)RbNRaS(O)2Rb, NRaC(O)NRbRc, NRaC(S)NRbRc, NRaC(NRb)NRcRd, NRaC(O)ORb, S(O)NRaRb, S(O)2NRaRb, S(O)Ra, S(O)2Ra, C(O)Ra, C(O)ORa, or C(O)NRaRb; R5 is H or alkyl; n is 0, 1, 2, 3, 4, 5, or 6; A is O, S, S(O), S(O)2, or NRe; B is N or CRf; X is O, S, S(O), S(O)2, NRe, or C(O); Y is a covalent bond, C(O), C═NRa, O, S, S(O), S(O)2, or NRe; Z is N or CH; each of U and V, independently, is N or CR; and W is O, S, or NRe; in which each of Ra, Rb, Rc, and Rd, independently, is H, alkyl, aryl, heteroaryl, cyclyl, or heterocyclyl; Re is H, alkyl, aryl, acyl, or sufonyl; and Rf is H, alkyl, aryl, acyl, sulfonyl, alkoxyl, amino, ester, amide, CN, or halogen. The compound is useful for treating an interleukin-12 overproduction-related disorder.

53. 发明授权

US07345094B2 Paclitaxel enhancer compounds 有权
公开(公告)号：US07345094B2
公开(公告)日：2008-03-18
申请号：US11244324
申请日：2005-10-05
申请人： Keizo Koya , Lijun Sun , Shoujun Chen , Noriaki Tatsuta , Yaming Wu , Mitsunori Ono
发明人： Keizo Koya , Lijun Sun , Shoujun Chen , Noriaki Tatsuta , Yaming Wu , Mitsunori Ono
IPC分类号： A61K31/16 , C07C327/00 , C07C233/00
CPC分类号： A61K47/48176 , A61K31/16 , A61K31/165 , A61K31/277 , A61K31/337 , A61K31/381 , A61K31/44 , A61K31/505 , A61K31/53 , A61K47/58 , C07C327/56 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D209/42 , C07D209/44 , C07D213/83 , C07D261/18 , C07D305/14 , C07D307/68 , C07D333/38 , C07D333/68 , C07D407/12
摘要： Disclosed is a compound represented by the Structural Formula (I): Y is a covalent bond, a phenylene group or a substituted or unsubstituted straight chained hydrocarbyl group. In addition, Y, taken together with both >C=Z groups to which it is bonded, is a substituted or unsubstituted aromatic group. Preferably, Y is a covalent bond or —C(R7R8)—. R1 and R2 are independently an aryl group or a substituted aryl group, R3 and R4 are independently —H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group. R5-R6 are independently —H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group. R7 and R8 are each independently —H, an aliphatic or substituted aliphatic group, or R7 is —H and R8 is a substituted or unsubstituted aryl group, or, R7 and R8, taken together, are a C2-C6 substituted or unsubstituted alkylene group. Z is ═O or ═S. Also disclosed are pharmaceutical compositions comprising the compound of the present invention and a pharmaceutically acceptable carrier or diluent. Also disclosed is a method of treating a subject with cancer by administering to the subject a compound of Structural Formula (I) in combination with Paclitaxel or an analog of Paclitaxel.

54. 发明申请

US20070280982A1 Antimicrobial compositions comprising hop acid alkali salts and uses thereof 审中-公开
标题翻译：包含啤酒花酸碱盐的抗微生物组合物及其用途
公开(公告)号：US20070280982A1
公开(公告)日：2007-12-06
申请号：US11731764
申请日：2007-03-29
申请人： Mitsunori Ono , Keiko Yamaguchi , Naoto Yamaguchi
发明人： Mitsunori Ono , Keiko Yamaguchi , Naoto Yamaguchi
IPC分类号： A23L3/34 , A01N25/08
CPC分类号： A23L3/3472 , A01N61/00 , A01N65/08 , A23L3/3463
摘要： The invention features anti-microbial compositions comprising compositions of hop acid alkali metal salts and alkaline earth metal salts and methods of using them to inhibit microbial growth.
摘要翻译：本发明的特征在于包含Hop酸碱金属盐和碱土金属盐组合物的抗微生物组合物和使用它们抑制微生物生长的方法。

55. 发明申请

US20070148210A1 Composition for Enhancing Physical Performance 有权
标题翻译：用于增强身体表现的组合
公开(公告)号：US20070148210A1
公开(公告)日：2007-06-28
申请号：US11675576
申请日：2007-02-15
申请人： Thomas Lines , Mitsunori Ono
发明人： Thomas Lines , Mitsunori Ono
IPC分类号： A61K36/48 , A61K36/16 , A61K31/714 , A61K31/7048 , A61K31/353 , A61K31/525 , A61K31/522 , A61K31/51
CPC分类号： A61K31/352 , A23L2/02 , A23L33/105 , A23L33/15 , A23V2002/00 , A61K31/185 , A61K31/353 , A61K31/355 , A61K31/375 , A61K31/4415 , A61K31/445 , A61K31/455 , A61K31/51 , A61K31/522 , A61K31/525 , A61K31/675 , A61K31/7048 , A61K31/714 , A61K36/16 , A61K36/185 , A61K36/48 , A61K45/06 , A61K2300/00 , A23V2250/214 , A23V2250/2116 , A23V2250/2108 , A23V2250/7042 , A23V2250/7044 , A23V2250/7046 , A23V2250/704 , A23V2250/7052 , A23V2250/706 , A23V2250/712 , A23V2250/70 , A23V2200/322 , A23V2250/21168 , A23V2200/33 , A23V2200/30
摘要： This invention relates to a composition that contains quercetin, vitamin B1, vitamin B2, vitamin B3, vitamin B6, vitamin B12, vitamin C, caffeine, epigallocatechin gallate, epicatechin, epicatechin gallate, and epigallocatechin.
摘要翻译：本发明涉及含有槲皮素，维生素B1，维生素B2，维生素B3，维生素B6，维生素B12，维生素C，咖啡因，表没食子儿茶素没食子酸酯，表儿茶素，表儿茶素没食子酸酯和表没食子儿茶素的组合物。

56. 发明申请

US20070027151A1 Heterocyclic compounds 有权
公开(公告)号：US20070027151A1
公开(公告)日：2007-02-01
申请号：US11542963
申请日：2006-10-03
申请人： Lijun Sun , Mitsunori Ono , Yumiko Wada , Weiwen Ying , Teresa Przewloka , Elena Kostik
发明人： Lijun Sun , Mitsunori Ono , Yumiko Wada , Weiwen Ying , Teresa Przewloka , Elena Kostik
IPC分类号： A61K31/5377 , C07D473/14
CPC分类号： C07D473/34 , C07D473/16 , C07D473/18
摘要： This invention features a compound of formula (I): R1 is aryl or heteroaryl; each of R2 and R4, independently, is H, halogen, CN, alkyl, ORa, or NRaRb; R3 is H, halogen, CN, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cyclyl, heterocyclyl, ORa, OC(O)Ra, OC(O)NRaRb, NRaRb, NRaC(O)Rb, NRaS(O)RbN, RaS(O)2Rb, NRaC(O)NRbRc, NRaC(S)NRbRc, NRaC(NRb)NRcRd, NRaC(O)ORb, S(O)NRaRb, S(O)2NRaRb, S(O)Ra, S(O)2Ra, C(O)Ra, C(O)ORa, or C(O)NRaRb; R5 is H or alkyl; n is 0, 1, 2, 3, 4, 5, or 6; A is O, S, S(O), S(O)2, or NRe; B is N or CRf; X is O, S, S(O), S(O)2, NRe, or C(O); Y is a covalent bond, C(O), C═NRa, O, S, S(O), S(O)2, or NRe; Z is N or CH; each of U and V, independently, is N or CR; and W is O, S, or NRe; in which each of Ra, Rb, Rc, and Rd, independently, is H, alkyl, aryl, heteroaryl, cyclyl, or heterocyclyl; Re is H, alkyl, aryl, acyl, or sufonyl; and Rf is H, alkyl, aryl, acyl, sulfonyl, alkoxyl, amino, ester, amide, CN, or halogen. The compound is useful for treating an interleukin-12 overproduction-related disorder.

57. 发明申请

US20060287554A1 Process for producing inorganic salts of hop acids 审中-公开
标题翻译：柠檬酸无机盐的制备方法
公开(公告)号：US20060287554A1
公开(公告)日：2006-12-21
申请号：US11302308
申请日：2006-04-24
申请人： Kevin Madsen , Mark Bossert , Mitsunori Ono
发明人： Kevin Madsen , Mark Bossert , Mitsunori Ono
IPC分类号： C07C61/06 , C07C45/61
CPC分类号： C07F3/003 , C07C49/743
摘要： The invention relates to a novel process for preparing hops compounds and compositions produced by this process.
摘要翻译：本发明涉及一种制备啤酒花化合物和通过该方法制备的组合物的新方法。

58. 发明申请

US20060116374A1 Taxol enhancer compounds 有权
标题翻译：紫杉醇增强剂化合物
公开(公告)号：US20060116374A1
公开(公告)日：2006-06-01
申请号：US11244427
申请日：2005-10-05
申请人： Keizo Koya , Lijun Sun , Shoujun Chen , Noriaki Tatsuta , Yaming Wu , Mitsunori Ono , Zhi-Qiang Xia
发明人： Keizo Koya , Lijun Sun , Shoujun Chen , Noriaki Tatsuta , Yaming Wu , Mitsunori Ono , Zhi-Qiang Xia
IPC分类号： A61K31/5377 , A61K31/53 , A61K31/505 , A61K31/337
CPC分类号： C07D307/68 , A45D2008/006 , A61K31/337 , A61K31/505 , A61K31/53 , A61K31/5377 , A61K47/58 , C07C327/56 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D209/42 , C07D209/44 , C07D213/83 , C07D261/18 , C07D333/38 , C07D333/68
摘要： One embodiment of the present invention is a compound represented by the Structural Formula (I): Y is a covalent bond of a substituted or unsubstituted straight chained hydrocarbyl group. In addition, Y, taken together with both >C=Z groups to which it is bonded, is a substituted or unsubstituted aromatic group. Preferably, Y is a covalent bond or —C(R7R8)—. R1 is an aliphatic group, a substituted aliphatic group, a non-aromatic heterocyclic group, or a substituted non-aromatic heterocyclic group, R2-R4 are independently —H, an aliphatic group, a substituted aliphatic group, a non-aromatic heterocyclic group, a substituted non-aromatic heterocyclic group, an aryl group or a substituted aryl group, or R1 and R3 taken together with the carbon and nitrogen atoms to which they are bonded, and/or R2 and R4 taken together with the carbon and nitrogen atoms to which they are bonded, form a non-aromatic heterocyclic ring optionally fused to an aromatic ring. R5-R6 are independently —H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group. R7 and R8 are each independently —H, an aliphatic or substituted aliphatic group, or R7 is —H and R8 is a substituted or unsubstituted aryl group, or, R7 and R8, taken together, are a C2-C6 substituted or unsubstituted alkylene group. Z is ═O or ═S. Also disclosed are pharmaceutical compositions comprising the compound of the present invention and a pharmaceutically acceptable carrier or diluent.
摘要翻译：本发明的一个实施方案是由结构式（I）表示的化合物：Y是取代或未取代的直链烃基的共价键。此外，Y与它所键合的两个> C = Z基团一起是取代或未取代的芳族基团。优选地，Y是共价键或-C（R 7 R 8） - 。 R 1是脂族基团，取代的脂族基团，非芳族杂环基团或取代的非芳香族杂环基团，R 2 -R 4 独立地，-H，脂族基团，取代的脂族基团，非芳香族杂环基，取代的非芳族杂环基，芳基或取代的芳基，或R 1， SUB和R 3与它们所键合的碳原子和氮原子一起，和/或R 2和R 4结合在一起与其键合的碳原子和氮原子形成任选地稠合到芳香环的非芳族杂环。 R 5 -R 6独立地是-H，脂族基团，取代的脂族基团，芳基或取代的芳基。 R 7和R 8各自独立地为-H，脂族或取代的脂族基团或R 7为-H， 8是取代或未取代的芳基，或者R 7和R 8一起是C2-C6取代或未取代的亚烷基。 Z是-O或-S。还公开了包含本发明化合物和药学上可接受的载体或稀释剂的药物组合物。

59. 发明申请

US20050148633A1 Method for modulating calcium ion-release-activated calcium ion channels 审中-公开
标题翻译：钙离子释放活化钙离子通道调节方法
公开(公告)号：US20050148633A1
公开(公告)日：2005-07-07
申请号：US10897682
申请日：2004-07-22
申请人： Yu Xie , Mats Holmqvist , Jerome Mahiou , Mitsunori Ono , Lijun Sun , Shoujun Chen , Shijie Zhang , Jun Jiang , Dinesh Chimmanamada , Andrea Fleig , Chih-Yi Yu
发明人： Yu Xie , Mats Holmqvist , Jerome Mahiou , Mitsunori Ono , Lijun Sun , Shoujun Chen , Shijie Zhang , Jun Jiang , Dinesh Chimmanamada , Andrea Fleig , Chih-Yi Yu
IPC分类号： A61K31/35 , A61K31/381 , A61K31/40 , A61K31/41 , A61K31/415 , A61K31/4196 , A61K31/42 , A61K31/4439 , A61K31/444 , A61K31/535 , A61K31/724 , A61P20060101 , A61P27/00 , C07D20060101
CPC分类号： C07C233/66 , A61K31/40 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/535 , C07C237/42 , C07D213/81 , C07D231/14 , C07D239/28 , C07D263/34 , C07D277/56 , C07D285/06 , C07D333/38 , Y02A50/422
摘要： The invention relates to a method for modulating Ca2+-release-activated Ca2+ channels (CRAC) in a cell by administering to the cell a compound of formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof wherein X, Y, A, Z, L and n are defined herein.
摘要翻译：本发明涉及一种通过向细胞施用式（I（I））化合物来调节细胞中的Ca 2+ - 释放激活的Ca 2+ 2 +通道（CRAC）的方法）或其药学上可接受的盐，溶剂化物，包合物或前药，其中X，Y，A，Z，L和n如本文所定义。

60. 发明申请

US20050031737A1 Antioxidative compositions 有权
标题翻译：抗氧化组合物
公开(公告)号：US20050031737A1
公开(公告)日：2005-02-10
申请号：US10935586
申请日：2004-09-07
申请人： Thomas Lines , Mitsunori Ono
发明人： Thomas Lines , Mitsunori Ono
IPC分类号： A23L1/30 , A23L1/302 , A61K31/355 , A61K31/375 , A61K31/4415 , A61K31/445 , A61K31/51 , A61K31/714
CPC分类号： A61K31/445 , A23L33/105 , A23L33/15 , A23V2002/00 , A61K31/355 , A61K31/375 , A61K31/4415 , A61K31/51 , A61K31/714 , A61K2300/00 , A23V2250/214 , A23V2250/2108 , A23V2250/7042 , A23V2250/7044 , A23V2250/7046 , A23V2250/7052 , A23V2250/704 , A23V2250/2116 , A23V2250/70
摘要： This invention relates to a composition that contains quercetin, vitamin B1, vitamin B2, vitamin B3, vitamin B6, vitamin B12, vitamin C, caffeine, epigallocatechin gallate, epicatechin, epicatechin gallate, epigallocatechin, and polypheron E.
摘要翻译：本发明涉及含有槲皮素，维生素B1，维生素B2，维生素B3，维生素B6，维生素B12，维生素C，咖啡因，表没食子儿茶素没食子酸酯，表儿茶素，表儿茶素没食子酸酯，表没食子儿茶素和多聚乙肝的组合物。

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