专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

51. 发明授权

US07550591B2 Imatinib production process 失效
标题翻译：伊马替尼生产过程
公开(公告)号：US07550591B2
公开(公告)日：2009-06-23
申请号：US11743520
申请日：2007-05-02
申请人： Liu Xing , He Xungui , Yuan Wang , Michel Bekhazi , Sonia Krivonos , Edna Danon
发明人： Liu Xing , He Xungui , Yuan Wang , Michel Bekhazi , Sonia Krivonos , Edna Danon
IPC分类号： C07D401/14
CPC分类号： C07D401/04 , C07D295/155
摘要： Provided is a process for producing imatinib and salts thereof, e.g., imatinib mesylate. The process includes reacting 4-(4-methyl-piperazin-1-ylmethyl)-benzoic acid with N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidine-amine in the presence of a carboxylic acid coupling reagent, to produce imatinib, and optionally converting the imatinib into a salt.
摘要翻译：提供生产伊马替尼及其盐的方法，例如甲磺酸伊马替尼。该方法包括使4-（4-甲基 - 哌嗪-1-基甲基） - 苯甲酸与N-（5-氨基-2-甲基苯基）-4-（3-吡啶基）-2-嘧啶胺在羧酸偶联试剂，以产生伊马替尼，以及任选地将伊马替尼转化成盐。

52. 发明申请

US20090012240A1 Process for the preparation of amphiphilic poly(N-vinyl-2-pyrrolidone) block copolymers 有权
标题翻译：制备两亲聚（N-乙烯基-2-吡咯烷酮）嵌段共聚物的方法
公开(公告)号：US20090012240A1
公开(公告)日：2009-01-08
申请号：US12211551
申请日：2008-09-16
申请人： Laibin Luo , David Lessard , Sandra Gori , Maxime Ranger , Yuan Wang , Julie Lafreniere , Jean-Francois Meunier , Genevieve Bibeau , Frederic Lebrun , Lu Wei Liu
发明人： Laibin Luo , David Lessard , Sandra Gori , Maxime Ranger , Yuan Wang , Julie Lafreniere , Jean-Francois Meunier , Genevieve Bibeau , Frederic Lebrun , Lu Wei Liu
IPC分类号： C08F271/02 , C08F269/00
CPC分类号： C08G63/00 , C08F293/005 , C08F297/00 , C08F297/02 , C08L53/00 , C08L2666/02
摘要： The instant invention provides a two-step polymerization process for preparing amphiphilic poly(N-vinyl-2-pyrrolidone), (PVP)-block-polyester copolymers and other diblock and triblock copolymers consisting of PVP as one block. The block copolymers of the invention can be used as vehicles for drug delivery.
摘要翻译：本发明提供了制备两亲聚（N-乙烯基-2-吡咯烷酮），（PVP） - 嵌段 - 聚酯共聚物和由PVP作为一个单元组成的其它二嵌段和三嵌段共聚物的两步聚合方法。本发明的嵌段共聚物可用作药物递送的载体。

53. 发明申请

US20060078266A1 Optical engine and an image projector having the optical engine 审中-公开
标题翻译：光学引擎和具有光学引擎的图像投影仪
公开(公告)号：US20060078266A1
公开(公告)日：2006-04-13
申请号：US11188183
申请日：2005-07-22
申请人： Chao Wu , Yuan Wang , Jui Pan
发明人： Chao Wu , Yuan Wang , Jui Pan
IPC分类号： G02B6/10
CPC分类号： G02B27/0927 , G02B27/0994 , H04N9/315
摘要： An optical engine for an image projector comprises a light source, a taper rod, at least one light condenser, a prism module, a Digital Micromirror Device (DMD) and a projection lens set. One end of the taper rod is adjacent to the light source. Light generated by the light source is guided by the taper rod following a light path. The taper rod has increasing sizes of cross-sections along the light path, so as to decrease the dispersion angle of light, make the light more uniform, and increase the brightness of light. The prism module includes a first prism having a right triangle cross-section and a second prism having a wedge cross-section. The prism module receives the light from the condenser, passes the light toward the DMD, receives the light reflected by the DMD, and then passes the reflected light toward the projection lens set. The projection lens set projects the light on an external projection plane.
摘要翻译：用于图像投影仪的光学引擎包括光源，锥形杆，至少一个光聚光器，棱镜模块，数字微镜器件（DMD）和投影透镜组。锥形杆的一端与光源相邻。由光源产生的光由沿着光路的锥形杆引导。锥形杆具有沿着光路的横截面增大的尺寸，以减小光的色散角，使光线更均匀，并增加光的亮度。棱镜模块包括具有直角三角形横截面的第一棱镜和具有楔形横截面的第二棱镜。棱镜模块接收来自聚光器的光，将光朝向DMD传递，接收由DMD反射的光，然后使反射光朝向投影透镜组。投影透镜组将光投射到外部投影平面上。

54. 发明授权

US06512140B1 Process for the preparation of 1-(mercaptomethyl)-cyclopropaneacetic acid 有权
标题翻译： 1-（巯基甲基） - 环丙烷乙酸的制备方法
公开(公告)号：US06512140B1
公开(公告)日：2003-01-28
申请号：US10122541
申请日：2002-04-15
申请人： Lu Wei Liu , Yuan Wang , Hérika Marrugo , Sylvain Harper , David D. C. Quan , Zhihong (Nancy) Zhou , Gregory Bydlinski
发明人： Lu Wei Liu , Yuan Wang , Hérika Marrugo , Sylvain Harper , David D. C. Quan , Zhihong (Nancy) Zhou , Gregory Bydlinski
IPC分类号： C07L6104
CPC分类号： C07C319/06 , C07C233/08 , C07C319/24 , C07C335/32 , C07C2602/02 , C07D307/94 , C07C323/53
摘要： A process for the preparation of highly pure 1-(mercaptomethyl)-cyclopropaneacetic acid is described. Treatment of 1-(hydroxymethyl)-cyclopropaneacetonitrile with an acid provides the corresponding imino ester and/or halo-amide, which when reacted with thiourea provide the corresponding amide-isothiuronium salt. Hydrolysis of the amide-isothiuronium salt followed by an in situ oxidation allows the facile isolation and purification of 1-[1 -(carboxymethyl)-cyclopropanemethyldisulfanylmethyl]-cyclopropaneacetic acid (also known as 1-(mercaptomethyl)-cyclopropaneacetic acid disulfide). Reduction of the 1-(mercaptomethyl)-cyclopropaneacetic acid disulfide under mild conditions provides the 1-(mercaptomethyl)-cyclopropaneacetic acid with high purity.
摘要翻译：描述了制备高纯度1-（巯基甲基） - 环丙烷乙酸的方法。用酸处理1-（羟基甲基） - 环丙烷乙腈提供相应的亚氨基酯和/或卤代酰胺，当与硫脲反应时，可提供相应的酰胺 - 异硫脲鎓盐。酰胺 - 异硫脲盐的水解随后进行原位氧化，可以轻易分离和纯化1- [1-（羧甲基） - 环丙烷甲基二硫烷基甲基] - 环丙烷乙酸（也称为1-（巯基甲基） - 环丙烷乙酸二硫化物）。在温和条件下还原1-（巯基甲基） - 环丙烷乙酸二硫化物提供了高纯度的1-（巯基甲基） - 环丙烷乙酸。

55. 发明授权

US5580867A Myocardial protection during ischemia and reperfusion 失效
标题翻译：缺血和再灌注期间心肌保护
公开(公告)号：US5580867A
公开(公告)日：1996-12-03
申请号：US303826
申请日：1994-09-09
申请人： Jean-Gilles Latour , Denis Gravel , Serge Beno it , Yuan Wang
发明人： Jean-Gilles Latour , Denis Gravel , Serge Beno it , Yuan Wang
IPC分类号： A61K31/55 , A61K31/554 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/14 , C07D281/10
CPC分类号： A61K31/554 , C07D281/10
摘要： Myocardial protection is achieved by administering to a patient an effective amount of a benzothiazepine derivative. The benzothiazepine derivatives have the following general chemical formula: ##STR1## wherein R.sub.1 represents hydrogen or methyl,R.sub.2 represents hydrogen or acetyl,R.sub.3 represents hydrogen or methyl, andR.sub.4 represents hydrogen or a halogen,with the proviso that R.sub.1 cannot be methylwhen R.sub.2 =acetyl, R.sub.3 =methyl and R.sub.4 =hydrogen.The above compounds may also be used in other clinical conditions such as treatment of stable and unstable angina, non-Q-wave myocardial infarction, cerebral trauma ischemia and reperfusion, organ graft preservation, etc.
摘要翻译：通过向患者施用有效量的苯并硫氮杂衍生物来实现心肌保护。苯并硫氮杂衍生物具有以下一般化学式：其中R 1表示氢或甲基，R 2表示氢或乙酰基，R 3表示氢或甲基，R 4表示氢或卤素，条件是R 1在R 2不能为甲基时 =乙酰基，R3 =甲基，R4 =氢。上述化合物也可用于治疗稳定不稳定型心绞痛，非Q波心肌梗死，脑创伤缺血再灌注，器官移植物保存等其他临床病症。

56. 发明授权

US5548197A Method and apparatus for determining motor speed using zero crossing times 失效
标题翻译：使用零交叉时间确定电机速度的方法和装置
公开(公告)号：US5548197A
公开(公告)日：1996-08-20
申请号：US314019
申请日：1994-09-28
申请人： Peter J. Unsworth , Yuan Wang
发明人： Peter J. Unsworth , Yuan Wang
IPC分类号： G01P3/48 , H02P27/02 , H02P3/18
CPC分类号： H02P27/026 , G01P3/48
摘要： A method and apparatus to be used with a motor controller for determining the speed of the motor rotor using current zero crossing times of the stator winding currents. An error signal set, consisting of phase angle errors between consecutive zero crossings over a sampling period, is generated and analyzed in a region of interest in either the time or frequency domain, producing a signal frequency, the signal frequency being the frequency of the motor rotor.
摘要翻译：一种与电动机控制器一起使用的方法和装置，用于使用定子绕组电流的当前零交叉时间来确定电动机转子的速度。在时域或频域中的感兴趣区域中生成并分析由采样周期之间的连续过零点之间的相位角误差组成的误差信号组，产生信号频率，信号频率为电机频率转子。

57. 发明授权

US11673136B2 Nanopore devices for sensing biomolecules 有权
公开(公告)号：US11673136B2
公开(公告)日：2023-06-13
申请号：US15945717
申请日：2018-04-04
申请人： Quan Qing , Yuan Wang , Joshua Sadar
发明人： Quan Qing , Yuan Wang , Joshua Sadar
IPC分类号： B01L3/00 , C12Q1/6869 , G01N27/327 , B82Y15/00 , G01N33/487
CPC分类号： B01L3/5027 , B01L3/502707 , B01L3/502761 , C12Q1/6869 , G01N27/3276 , G01N27/3278 , B01L2300/0645 , B01L2300/0896 , B82Y15/00 , G01N33/48721 , C12Q1/6869 , C12Q2565/607 , C12Q2565/629 , C12Q2565/631
摘要： The present disclosure provides chips, devices and methods for sequencing a biomolecule. The biomolecule may be DNA, RNA. a protein, or a peptide. The chip comprises a substrate; a first and second fluid chamber; fluid channels connecting the first and second fluid chamber; a first and second electrode disposed on opposing sides of the central fluid channel and having a nanogap therebetween, wherein the width of the nanogap is modulated by confined electrochemical deposition; and a passivation layer disposed on top of the first and second electrodes and the fluid channel.

58. 发明授权

US09823457B2 Multiplane optical microscope 有权
公开(公告)号：US09823457B2
公开(公告)日：2017-11-21
申请号：US14591760
申请日：2015-01-07
申请人： Tongcang Li , Sadao Ota , Jeongmin Kim , Yuan Wang , Xiang Zhang
发明人： Tongcang Li , Sadao Ota , Jeongmin Kim , Yuan Wang , Xiang Zhang
IPC分类号： G02B21/18 , G02B21/36 , G02B21/06 , G02B21/16
CPC分类号： G02B21/18 , G02B21/06 , G02B21/16 , G02B21/361 , G02B21/367
摘要： This disclosure provides systems, methods, and apparatus related to optical microscopy. In one aspect, an apparatus includes a sample holder, a first objective lens, a plurality of optical components, a second objective lens, and a mirror. The apparatus may directly image a cross-section of a sample oblique to or parallel to the optical axis of the first objective lens, without scanning.

59. 发明授权

US09442250B2 Waveguide arrangements based on adiabatic elimination 有权
标题翻译：基于绝热消除的波导安排
公开(公告)号：US09442250B2
公开(公告)日：2016-09-13
申请号：US14813440
申请日：2015-07-30
申请人： Haim Suchowski , Michael Mrejen , Chihhui Wu , Yuan Wang , Xiang Zhang
发明人： Haim Suchowski , Michael Mrejen , Chihhui Wu , Yuan Wang , Xiang Zhang
IPC分类号： G02B6/28 , G02F1/01 , G02B6/293 , G02B6/122 , G02B6/12 , G02F1/00
CPC分类号： G02B6/29331 , B82Y20/00 , G02B6/122 , G02B6/1226 , G02B2006/12097 , G02F1/00 , G02F1/0118 , G02F1/015 , G02F1/3133 , G02F2001/0152
摘要： This disclosure provides systems, methods, and apparatus related to nanophotonics. In one aspect, an arrangement of waveguides includes a substrate and three waveguides. Each of the three waveguides may be a linear waveguide. A second waveguide is positioned between a first waveguide and a third waveguide. The dimensions and positions of the first, the second, and the third waveguides are specified to substantially eliminate coupling between the first waveguide and the third waveguide over a distance of about 1 millimeter to 2 millimeters along lengths of the first waveguide, the second waveguide, and the third waveguide.
摘要翻译：本公开提供了与纳米光子学相关的系统，方法和装置。在一个方面，波导的布置包括基板和三个波导。三个波导中的每一个可以是线性波导。第二波导位于第一波导和第三波导之间。第一波导，第二波导和第三波导的尺寸和位置被规定为基本上消除了第一波导和第三波导沿第一波导，第二波导的长度大约1毫米至2毫米的距离的第一波导和第三波导之间的耦合，和第三波导。

60. 发明授权

US09034172B2 Electrochemical test sensor 有权
标题翻译：电化学测试传感器
公开(公告)号：US09034172B2
公开(公告)日：2015-05-19
申请号：US12877207
申请日：2010-09-08
申请人： Yuan Wang , Raeann Gifford , Hualin Jiang , Jeffery S. Reynolds , Jianfeng Fei
发明人： Yuan Wang , Raeann Gifford , Hualin Jiang , Jeffery S. Reynolds , Jianfeng Fei
IPC分类号： G01N27/30 , G01N33/50 , G01N27/327
CPC分类号： G01N27/3272
摘要： An electrochemical test sensor for detecting the concentration of an analyte in a fluid sample. The electrochemical test sensor includes a housing that has a first end and a second opposing end. The housing includes an opening at the first end to receive a fluid test sample. An electrode assembly includes a substrate, a working electrode, a counter electrode and a reagent. The substrate has a first surface and an opposing second surface. The working electrode is disposed on the first surface of the substrate, and the counter electrode is disposed on the second surface of the substrate. The electrode assembly is positioned within the housing to define a reaction channel. The electrochemical test sensor may be used with a removable lancet mechanism or integrated within a lancet mechanism to form one integral unit.
摘要翻译：一种电化学测试传感器，用于检测流体样品中分析物的浓度。电化学测试传感器包括具有第一端和第二相对端的壳体。壳体包括在第一端处的开口以接收流体测试样品。电极组件包括衬底，工作电极，对电极和试剂。衬底具有第一表面和相对的第二表面。工作电极设置在基板的第一表面上，并且相对电极设置在基板的第二表面上。电极组件定位在壳体内以限定反应通道。电化学测试传感器可与可拆卸的柳叶刀机构一起使用或集成在刺血针机构内以形成一个整体单元。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式