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51. 发明申请

US20090221597A1 HETEROARYL DERIVATIVES AS CFTR MODULATORS 有权
标题翻译：异氟醚衍生物作为CFTR调节剂
公开(公告)号：US20090221597A1
公开(公告)日：2009-09-03
申请号：US12392298
申请日：2009-02-25
申请人： Sara Hadida Ruah , Mark Miller , Jinglan Zhou , Brian Bear
发明人： Sara Hadida Ruah , Mark Miller , Jinglan Zhou , Brian Bear
IPC分类号： A61K31/501 , A61K31/519 , A61K31/506 , C07D405/12 , C07D491/00 , C07D401/04 , C12Q1/00
CPC分类号： C07D491/048 , A61K31/443 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/513 , A61K31/519 , A61K45/06 , C07D213/75 , C07D239/42 , C07D241/20 , C07D405/12 , C07D405/14 , G01N33/5008 , G01N33/6872 , G01N2333/705 , G01N2333/914 , G01N2500/10 , G01N2570/00
摘要： The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
摘要翻译：本发明涉及ATP结合盒（“ABC”）转运体或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTR”），其组合物及其方法。本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。

52. 发明申请

US20090031318A1 APPLICATION COMPATIBILITY IN MULTI-CORE SYSTEMS 有权
标题翻译：多核系统的应用兼容性
公开(公告)号：US20090031318A1
公开(公告)日：2009-01-29
申请号：US11782060
申请日：2007-07-24
申请人： YADHU GOPALAN , Bor-ming Hsieh , Mark Miller
发明人： YADHU GOPALAN , Bor-ming Hsieh , Mark Miller
IPC分类号： G06F9/46
CPC分类号： G06F9/5033 , G06F9/4881 , G06F9/52 , G06F2209/483 , G06F2209/5018
摘要： Scheduling of threads in a multi-core system running various legacy applications along with multi-core compatible applications is configured such that threads from older single thread applications are assigned fixed affinity. Threads from multi-thread/single core applications are scheduled such that one thread at a time is made available to the cores based on the thread priority preventing conflicts and increasing resource efficiency. Threads from multi-core compatible applications are handled regularly.
摘要翻译：配置运行各种遗留应用程序以及多核兼容应用程序的多核系统中的线程的调度，使得来自较旧单线程应用程序的线程被分配固定的亲和度。调度来自多线程/单核心应用程序的线程，使得一个线程一次可用于基于线程优先级的核心，以防止冲突并提高资源效率。定期处理来自多核兼容应用程序的线程。

53. 发明授权

US07472067B2 Application program interfaces and structures in a resource limited operating system 有权
标题翻译：资源有限的操作系统中的应用程序接口和结构
公开(公告)号：US07472067B2
公开(公告)日：2008-12-30
申请号：US10985806
申请日：2004-11-11
申请人： Sharad Mathur , Gregory Hullender , Mark Miller , Bruce Johnson , Michael Ginsberg
发明人： Sharad Mathur , Gregory Hullender , Mark Miller , Bruce Johnson , Michael Ginsberg
IPC分类号： G10L11/00 , G06F3/00
CPC分类号： G06F9/4843 , G06F9/54 , Y10S707/99952
摘要： A set of Application Program Interfaces (APIs) for a resource-limited environment are disclosed. The APIs provide a mechanism for a computer application to interface with various components and modules of an operating system for a resource-limited environment. The APIs further provide a mechanism to interface with input/output devices commonly found in embedded systems running in a resource-limited environment.
摘要翻译：公开了一套用于资源有限环境的应用程序接口（API）。 API为计算机应用程序提供了一种与资源有限环境的操作系统的各种组件和模块进行接口的机制。 API还提供了一种与在资源有限的环境中运行的嵌入式系统中通常发现的输入/输出设备进行接口的机制。

54. 发明申请

US20080286204A1 MODULATORS OF CFTR 有权
标题翻译： CFTR调制器
公开(公告)号：US20080286204A1
公开(公告)日：2008-11-20
申请号：US12117948
申请日：2008-05-09
申请人： Sara S. Hadida-Ruah , Mark Miller , Brian Bear , Jinglan Zhou , Jason McCartney , Peter Grootenhuis
发明人： Sara S. Hadida-Ruah , Mark Miller , Brian Bear , Jinglan Zhou , Jason McCartney , Peter Grootenhuis
IPC分类号： A61K49/00 , C07D405/12 , C07D211/04 , A61K31/443 , A61K31/4418 , C12Q1/02
CPC分类号： C07D213/75 , C07D405/12 , C07D405/14
摘要： Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
摘要翻译：本发明的化合物及其药学上可接受的组合物可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTR”）。本发明还涉及使用本发明化合物治疗ABC转运蛋白介导的疾病的方法。

55. 发明申请

US20080161371A1 Modulators of cystic fibrosis transmembrane conductance regulator 有权
标题翻译：囊性纤维化跨膜电导调节剂的调节剂
公开(公告)号：US20080161371A1
公开(公告)日：2008-07-03
申请号：US11503449
申请日：2006-08-11
申请人： Sarah Hadida-Ruah , Frederick Van Goor , Mark Miller , Jason McCartney , Jinglan Zhou , Vijayalaksmi Arumugam
发明人： Sarah Hadida-Ruah , Frederick Van Goor , Mark Miller , Jason McCartney , Jinglan Zhou , Vijayalaksmi Arumugam
IPC分类号： A61K31/427 , C07D277/20 , C12Q1/02 , C12N5/00 , A61P25/00 , A61P43/00
CPC分类号： C07D417/14 , A61K31/427
摘要： The present invention relates to modulators of cystic fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating CFTR mediated diseases using such modulators.
摘要翻译：本发明涉及囊性纤维化跨膜电导调节剂（“CFTR”）的调节剂，其组合物及其方法。本发明还涉及使用这种调节剂治疗CFTR介导的疾病的方法。

56. 发明授权

US07351478B2 Heat-seal films and method of manufacture 有权
标题翻译：热封膜及其制造方法
公开(公告)号：US07351478B2
公开(公告)日：2008-04-01
申请号：US09810956
申请日：2001-03-16
申请人： Aiko Hanyu , Scott D. Cooper , Mark Miller
发明人： Aiko Hanyu , Scott D. Cooper , Mark Miller
IPC分类号： B32B27/08 , B32B7/12 , C08F210/00 , C08F10/00
CPC分类号： B32B27/32 , B32B27/08 , B32B2323/04 , B32B2323/10 , B32B2439/70 , C08J5/18 , C08J2323/14 , Y10S526/942 , Y10T428/2495 , Y10T428/2826 , Y10T428/31913
摘要： A heat-seal polymer film and method of forming such film is provided. The heat-seal film is formed from metallocene-catalyzed isotactic random copolymers of propylene and at least one other C2 to C8 alpha olefin, such as ethylene random. Such films show improved heat-seal characteristics, such as reduced seal initiation temperatures (SIT's) and improved heat-seal strength, as well as other improved properties.
摘要翻译：提供了一种热封聚合物膜及其形成方法。热密封膜由茂金属催化的丙烯与至少一种其它C 2 -C 8亚烷基（如乙烯无规）的全同立构无规共聚物形成。这种膜显示出改善的热封特性，例如降低的密封起始温度（SIT）和改善的热封强度以及其他改进的性能。

57. 发明授权

US07349505B2 Relayed communication with versatile self-interference cancellation 有权
标题翻译：中继通信具有多功能自干扰消除功能
公开(公告)号：US07349505B2
公开(公告)日：2008-03-25
申请号：US11090966
申请日：2005-03-25
申请人： Richard Blount , Mark Miller , James Murphy
发明人： Richard Blount , Mark Miller , James Murphy
IPC分类号： H04B1/10
CPC分类号： H04B7/2606 , H04B1/525 , H04B7/15585
摘要： Methods, apparatuses, and systems are presented for providing self-interference cancellation in two-way relayed electromagnetic communication between a first and a second device through a relay station, involving retrofitting existing equipment comprising a transmitter system and a receiver system at the first device by adding a canceler module, providing a version of a modulated near signal as a first non-baseband interface signal from the transmitter system to the canceler module, providing a version of a composite signal as a second non-baseband interface signal from the receiver system to the canceler module, generating a cancellation signal at the canceler module corresponding to a relayed version of the modulated near signal, using the first and the second non-baseband interface signals, applying the cancellation signal at the canceler module to a version of the second non-baseband interface signal, to produce a cancellation-processed signal as a third non-baseband interface signal provided to the receiver system.
摘要翻译：提出了方法，装置和系统，用于通过中继站在第一和第二设备之间的双向中继电磁通信中提供自干扰消除，其涉及通过在第一设备上的包括发射机系统和接收机系统的现有设备进行改装，提供消除器模块，提供调制近信号的版本作为从发射机系统到消除器模块的第一非基带接口信号，提供复合信号的版本作为第二非基带接口信号，从接收机系统到所述消除器模块使用所述第一和第二非基带接口信号在对应于调制的近信号的中继版本的所述消除器模块处产生消除信号，在所述消除器模块处将所述消除信号应用于所述第二非基带接口信号的版本， - 基带接口信号，以产生作为第三非基带接口符号的消除处理信号提供给接收机系统。

58. 发明授权

US07252493B1 Temperature control system to independently maintain separate molten polymer streams at selected temperatures during fiber extrusion 有权
标题翻译：温度控制系统，用于在纤维挤出过程中独立维持分离的熔融聚合物流
公开(公告)号：US07252493B1
公开(公告)日：2007-08-07
申请号：US10676271
申请日：2003-10-02
申请人： Brian Johnston , Jeff Haggard , Arnold Wilkie , Ruey Chern , Mark Miller , Tony Owen , John Quinlivan , Ted Mire , Brent Soucier , Kevin Moschetti
发明人： Brian Johnston , Jeff Haggard , Arnold Wilkie , Ruey Chern , Mark Miller , Tony Owen , John Quinlivan , Ted Mire , Brent Soucier , Kevin Moschetti
IPC分类号： D01D1/06 , D01D4/02
CPC分类号： D01D4/06 , D01D1/09
摘要： A temperature control system for use in a fiber extrusion process includes a number of metering pump assemblies including inlets to receive at least two molten polymer streams from a supply source that is connectable to the system. A pump block disposed proximate the metering pump assemblies includes a plurality of flow paths extending within the pump block, where the flow paths are aligned to receive molten polymer flowing from outlets of the metering pump assemblies and to deliver the molten polymer to a spinneret. The flow paths are arranged in flow path sets within the pump block, and each flow path set includes at least one flow path and is spaced a selected distance from the other flow path sets within the pump block so as to facilitate independent control of the temperature of a molten polymer flowing through each flow path set.
摘要翻译：用于纤维挤出方法的温度控制系统包括多个计量泵组件，其包括从可连接到系统的供应源接收至少两个熔融聚合物流的入口。设置在计量泵组件附近的泵块包括在泵块内延伸的多个流动路径，其中流动路径对准以接收从计量泵组件的出口流动的熔融聚合物并将熔融聚合物输送到喷丝头。流动路径布置在泵块内的流动路径组中，并且每个流动路径组包括至少一个流动路径，并且与泵块内的其它流动路径组间隔开选定的距离，以便于独立控制温度的熔融聚合物流过每个流动路径组。

59. 发明申请

US20060293504A1 Polypropylene having reduced residual metals 失效
标题翻译：聚丙烯具有减少的残余金属
公开(公告)号：US20060293504A1
公开(公告)日：2006-12-28
申请号：US11473358
申请日：2006-06-22
申请人： Kenneth Blackmon , Mark Douglass , Kevin McGovern , Mark Miller , Joseph Thorman
发明人： Kenneth Blackmon , Mark Douglass , Kevin McGovern , Mark Miller , Joseph Thorman
IPC分类号： C08F6/00
CPC分类号： C08F110/06 , C08F6/02 , C08L23/10 , C08F2500/12 , C08L23/14
摘要： Polymerization processes are described herein. The polymerization processes generally include introducing a catalyst system to a reaction zone, introducing an olefin monomer to the reaction zone, contacting the olefin monomer with the catalyst system to form a polyolefin and contacting the polyolefin with a quench agent, wherein the quench agent is at least partially soluble in the olefin monomer.
摘要翻译：本文描述了聚合方法。聚合方法通常包括将催化剂体系引入反应区，将烯烃单体引入反应区，使烯烃单体与催化剂体系接触以形成聚烯烃并使聚烯烃与骤冷剂接触，其中骤冷剂处于最少部分溶于烯烃单体。

60. 发明申请

US20060270442A1 LEADER-FOLLOWER POWER CONTROL 有权
标题翻译：领导力量控制
公开(公告)号：US20060270442A1
公开(公告)日：2006-11-30
申请号：US11462811
申请日：2006-08-07
申请人： Mark Miller , John O'Neill
发明人： Mark Miller , John O'Neill
IPC分类号： H04B7/00
CPC分类号： H04W52/245 , H04B7/18513 , H04W52/146 , H04W52/46
摘要： In a satellite or other relayed communication system having a plurality of subscriber terminals that communicate through an elevated wireless relay (typically a satellite operating in bent pipe mode), a technique for subscriber terminal power control is provided whereby the power level is controlled via leader-follower operation relying on sharing control factors determined at a single calibrated subscriber terminal transmitter (the leader terminal) to create traffic to be compared to the received traffic of the other subscriber terminals. The power level of the subscriber terminals is then adjusted based on the relationship of their received energy to the received energy of the leader terminal.
摘要翻译：在具有多个用户终端的卫星或其他中继通信系统中，通过升高的无线中继（通常是以弯管模式运行的卫星）进行通信，提供了一种用于用户终端功率控制的技术，跟随器操作依赖于在单个校准的用户终端发射机（领导终端）处确定的共享控制因素，以创建要与其他用户终端的接收业务进行比较的业务。然后根据其接收的能量与领先终端的接收能量的关系来调整用户终端的功率电平。

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