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51. 发明专利

DK117419B 未知
公开(公告)号：DK117419B
公开(公告)日：1970-04-27
申请号：DK364466
申请日：1966-07-13
申请人： HOECHST AG
发明人： SCHMIDT F
IPC分类号： A61K31/64 , C07C67/00 , C07C301/00 , C07C303/36 , C07C303/40 , C07C311/58 , C07C311/59 , C07D309/14 , C07C143/78 , C07C147/06

52. 发明专利

NO118556B 未知
公开(公告)号：NO118556B
公开(公告)日：1970-01-12
申请号：NO16030765
申请日：1965-11-02
申请人： HOECHST AG
发明人： SCHMIDT F , WEYER R , MUTH K , WEBER H , AUMUELLER W

53. 发明专利

NO117176B 未知
公开(公告)号：NO117176B
公开(公告)日：1969-07-14
申请号：NO15891065
申请日：1965-07-13
申请人： HOECHST AG
发明人： MUTH K , AUMUELLER W , WEYER R , WEBER H , SCHMIDT F
IPC分类号： A61K31/17 , A61K31/64 , A61P3/08 , C07C67/00 , C07C301/00 , C07C303/36 , C07C303/40 , C07C311/54 , C07C311/58 , C07D335/02

54. 发明专利

IN139938B PROCESS FOR THE MANUFACTURE OF BENZENESULFONYL UREAS 未知
公开(公告)号：IN139938B
公开(公告)日：1976-08-21
申请号：IN1194CA1975
申请日：1975-06-17
申请人： HOECHST AG
发明人： WEBER H , MUTH K , SCHMIDT F , AUMULLER W , WEYER R
IPC分类号： C07C127/14

55. 发明专利

IN139503B PROCESS FOR THE MANUFACTURE OF BENZENESULFONYL-UREAS 未知
公开(公告)号：IN139503B
公开(公告)日：1976-06-26
申请号：IN1914CA1974
申请日：1974-08-24
申请人： HOECHST AG
发明人： WEBER H , AUMULLER W , WEYER R , MUTH K , SCHMIDT F
IPC分类号： A61K31/64 , C07C67/00 , C07C301/00 , C07C303/36 , C07C303/40 , C07C311/58 , C07C311/59 , C07D309/14 , C07C127/16 , C07C143/78

56. 发明专利

FI49157B 未知
公开(公告)号：FI49157B
公开(公告)日：1974-12-31
申请号：FI352767
申请日：1967-12-30
申请人： HOECHST AG
发明人： MUTH K , AUMUELLER W , WEBER H , WEYER R , SCHMIDT F
IPC分类号： C07C311/59 , A61K31/64 , C07C311/58 , C07C143/78

57. 发明专利

ZA735332B BENZENESULFONYL-UREAS AND PROCESSES FOR PREPARING THEM 未知
公开(公告)号：ZA735332B
公开(公告)日：1974-07-31
申请号：ZA735332
申请日：1973-08-06
申请人： HOECHST AG
发明人： WEYER R , AUMUELLER W , HITZEL V , SCHMIDT F
IPC分类号： C07D239/26 , C07C311/58 , C07C311/59 , C07C311/60 , C07D213/75 , C07D215/38 , C07D239/42 , C07D263/58 , C07D277/82 , C07D

58. 发明专利

FI45957B 未知
公开(公告)号：FI45957B
公开(公告)日：1972-07-31
申请号：FI75066
申请日：1966-03-23
申请人： HOECHST AG
发明人： AUMUELLER W , WEBER H , SCHMIDT F , MUTH K , WEYER R
IPC分类号： A61K31/64 , C07C67/00 , C07C301/00 , C07C303/36 , C07C303/40 , C07C311/54 , C07C311/58 , C07C143/78
摘要： 1,127,672. Benzene-sulphonyl ureas. FARBWERKE HOECHST A.G. 24 March, 1966 [24 March, 1965], No. 13149/66. Heading C2C. Novel compounds of the formula (wherein R is C 2-8 alkyl, C 2-8 alkenyl, phenyl- C 1-4 alkyl, cyclohexyl-C 1-4 alkyl, endo-(methylene or ethylene) - cyclohexyl, - cyclohexenyl, - cyclohexylmethyl or -cyclohexenylmethyl, C 1-4 alkyl-cyclohexyl, C 1-4 alkoxy-cyclohexyl, C 5-8 cycloalkyl, cyclohexenyl or cyclohexenylmethyl ; Z and Z 1 are hydrogen, halogen, C 1-4 alkyl or C 1-4 alkoxy; X is a 2 carbon saturated or unsaturated hydrocarbon radical; and Y is C 1-3 alkylene) and salts thereof, are prepared by (1) reacting the amine RNH 2 or a salt thereof with the appropriately substituted benzenesulphonyl isocyanate, carbamic acid ester or halide, thiocarbamic acid ester or urea; or (2) reacting an R-substituted isocyanate, carbamic acid ester or halide, thiocarbamic acid ester or urea with the appropriately substituted benzene sulphonamide or salt thereof; or (3) reacting an R-substituted urea, isourea ether, isothiourea ether or parabanic acid with the appropriately substituted benzenesulphonyl chloride and hydrolysing the product; or (4) replacing the sulphur atom in a correspondingly substituted benzenesulphonyl thiourea by an oxygen atom; or (5) oxidizing a correspondingly substituted benzenesulphenyl urea or benzenesulphinyl urea; or (6) acylating the appropriate aminoalkyl-benzenesulphonyl urea. N - [4 - {# - (#,# - - diphenylpropionamido) - ethyl} - benzenesulphonyl] - N 1 - (2,5 - endomethylene - cyclohexylmethyl) - thiourea is prepared from the appropriate sulphonamide and 2,5 - endomethylene - cyclohexyl isothiocyanate, and is converted to the methyl ether of the corresponding iso-urea by warming with methanol, potassium carbonate and mercury oxide. The benzene-sulphonyl ureas of the invention, which are stated to have long-lasting hypoglycemic action, may be made up into pharmaceutical compositions for oral administration with suitable carriers.

59. 发明专利

FI45954B 未知
公开(公告)号：FI45954B
公开(公告)日：1972-07-31
申请号：FI167465
申请日：1965-07-13
申请人： HOECHST AG
发明人： MUTH K , WEBER H , SCHMIDT F , AUMUELLER W , WEYER R
IPC分类号： A61K31/17 , A61K31/64 , A61P3/08 , C07C67/00 , C07C301/00 , C07C303/36 , C07C303/40 , C07C311/54 , C07C311/58 , C07D335/02 , C07C143/78

60. 发明专利

SE345262B 未知
公开(公告)号：SE345262B
公开(公告)日：1972-05-23
申请号：SE381266
申请日：1966-03-23
申请人： HOECHST AG
发明人： AUMUELLER W , WEBER H , MUTH K , WEYER R , SCHMIDT F
IPC分类号： A61K31/64 , C07C67/00 , C07C301/00 , C07C303/36 , C07C303/40 , C07C311/54 , C07C311/58 , C07C143/82 , C07C143/833
摘要： 1,127,672. Benzene-sulphonyl ureas. FARBWERKE HOECHST A.G. 24 March, 1966 [24 March, 1965], No. 13149/66. Heading C2C. Novel compounds of the formula (wherein R is C 2-8 alkyl, C 2-8 alkenyl, phenyl- C 1-4 alkyl, cyclohexyl-C 1-4 alkyl, endo-(methylene or ethylene) - cyclohexyl, - cyclohexenyl, - cyclohexylmethyl or -cyclohexenylmethyl, C 1-4 alkyl-cyclohexyl, C 1-4 alkoxy-cyclohexyl, C 5-8 cycloalkyl, cyclohexenyl or cyclohexenylmethyl ; Z and Z 1 are hydrogen, halogen, C 1-4 alkyl or C 1-4 alkoxy; X is a 2 carbon saturated or unsaturated hydrocarbon radical; and Y is C 1-3 alkylene) and salts thereof, are prepared by (1) reacting the amine RNH 2 or a salt thereof with the appropriately substituted benzenesulphonyl isocyanate, carbamic acid ester or halide, thiocarbamic acid ester or urea; or (2) reacting an R-substituted isocyanate, carbamic acid ester or halide, thiocarbamic acid ester or urea with the appropriately substituted benzene sulphonamide or salt thereof; or (3) reacting an R-substituted urea, isourea ether, isothiourea ether or parabanic acid with the appropriately substituted benzenesulphonyl chloride and hydrolysing the product; or (4) replacing the sulphur atom in a correspondingly substituted benzenesulphonyl thiourea by an oxygen atom; or (5) oxidizing a correspondingly substituted benzenesulphenyl urea or benzenesulphinyl urea; or (6) acylating the appropriate aminoalkyl-benzenesulphonyl urea. N - [4 - {# - (#,# - - diphenylpropionamido) - ethyl} - benzenesulphonyl] - N 1 - (2,5 - endomethylene - cyclohexylmethyl) - thiourea is prepared from the appropriate sulphonamide and 2,5 - endomethylene - cyclohexyl isothiocyanate, and is converted to the methyl ether of the corresponding iso-urea by warming with methanol, potassium carbonate and mercury oxide. The benzene-sulphonyl ureas of the invention, which are stated to have long-lasting hypoglycemic action, may be made up into pharmaceutical compositions for oral administration with suitable carriers.

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