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51. 发明申请

US20100198283A1 Automatic Orientation Determination for ECG Measurements Using Multiple Electrodes 有权
标题翻译：使用多个电极进行心电图测量的自动测向
公开(公告)号：US20100198283A1
公开(公告)日：2010-08-05
申请号：US12694833
申请日：2010-01-27
申请人： Yi Zhang , Marina Brockway , Carlos Alberto Ricci , Ron Heil , Douglas R. Daum , Robert J. Sweeney , Aaron McCabe
发明人： Yi Zhang , Marina Brockway , Carlos Alberto Ricci , Ron Heil , Douglas R. Daum , Robert J. Sweeney , Aaron McCabe
IPC分类号： A61N1/362 , A61N1/39 , A61B5/04
CPC分类号： A61B5/0006 , A61B5/0031 , A61B5/04011 , A61B5/0422 , A61B5/7207 , A61B5/7217 , A61N1/3756 , G06K9/624
摘要： Cardiac monitoring and/or stimulation methods and systems provide monitoring, defibrillation and/or pacing therapies. A signal processor receives a plurality of composite signals associated with a plurality of sources, separates a signal using a source separation algorithm, and identifies a cardiac signal using a selected vector. The signal processor may iteratively separate signals from the plurality of composite signals until the cardiac signal is identified. The selected vector may be updated if desired or necessary. A method of signal separation involves detecting a plurality of composite signals at a plurality of locations, separating a signal using source separation, and selecting a vector that provides a cardiac signal. The separation may include a principal component analysis and/or an independent component analysis. Vectors may be selected and updated based on changes of position and/or orientation of implanted components and changes in patient parameters such as patient condition, cardiac signal-to-noise ratio, and disease progression.
摘要翻译：心脏监测和/或刺激方法和系统提供监测，除颤和/或起搏治疗。信号处理器接收与多个源相关联的多个复合信号，使用源分离算法分离信号，并使用所选择的向量来识别心脏信号。信号处理器可以迭代地分离来自多个复合信号的信号，直到识别出心脏信号。如果需要或必要，可以更新所选择的向量。信号分离的方法包括在多个位置检测多个复合信号，使用源分离分离信号，以及选择提供心脏信号的向量。分离可以包括主成分分析和/或独立成分分析。可以基于植入组件的位置和/或取向的改变以及患者参数（例如患者状况，心脏信噪比和疾病进展）的变化来选择和更新载体。

52. 发明授权

US07555340B2 Electrogram morphology-based CRT optimization 有权
标题翻译：基于电图形态的CRT优化
公开(公告)号：US07555340B2
公开(公告)日：2009-06-30
申请号：US11097460
申请日：2005-04-01
申请人： Yanting Dong , Jiang Ding , Douglas R. Daum , Scott A. Meyer , Yinghong Yu
发明人： Yanting Dong , Jiang Ding , Douglas R. Daum , Scott A. Meyer , Yinghong Yu
IPC分类号： A61N1/365
CPC分类号： A61N1/368 , A61N1/3682 , A61N1/371
摘要： A method and system for determining an optimum atrioventricular delay (AVD) interval and/or ventriculo-ventricular delay (VVD) intervals for delivering ventricular resynchronization pacing in an atrial tracking or atrial sequential pacing mode. Evoked response electrograms recorded at different AVD and VVD intervals are used to determine the extent of paced and intrinsic activation.
摘要翻译：一种用于确定用于在心房跟踪或心房顺序起搏模式中递送心室再同步起搏的最佳房室延迟（AVD）间隔和/或心室 - 心室延迟（VVD）间隔的方法和系统。以不同的AVD和VVD间隔记录的诱发反应电图用于确定起搏和内在激活的程度。

53. 发明申请

US20090124916A1 Acoustic physiological sensor 审中-公开
标题翻译：声学生理传感器
公开(公告)号：US20090124916A1
公开(公告)日：2009-05-14
申请号：US12319833
申请日：2009-01-13
申请人： Robert J. Sweeney , Douglas R. Daum
发明人： Robert J. Sweeney , Douglas R. Daum
IPC分类号： A61B5/02
CPC分类号： A61B7/00 , A61N1/3622 , A61N1/36557 , A61N1/3684
摘要： This document describes, among other things, a body having at least one acoustically detectable property that changes in response to a change in a physiological condition, such as ischemia. The body is positioned with respect to a desired tissue region. At least one acoustic transducer is used to acoustically detect a change in physical property. In one example, the body is pH sensitive and/or ion selective. A shape or dimension of the body changes in response to pH and/or ionic concentration changes resulting from a change in an ischemia state. An indication of the physiological condition is provided to a user.
摘要翻译：本文件尤其描述了具有至少一种声学可检测性质的身体，其响应于生理状态（例如缺血）的变化而变化。身体相对于期望的组织区域定位。使用至少一个声换能器来声学地检测物理特性的变化。在一个实例中，身体是pH敏感和/或离子选择性的。身体的形状或尺寸响应于缺血状态改变引起的pH和/或离子浓度变化而变化。向用户提供生理状态的指示。

54. 发明授权

US07479112B2 Acoustic physiological sensor 有权
公开(公告)号：US07479112B2
公开(公告)日：2009-01-20
申请号：US10648837
申请日：2003-08-26
申请人： Robert J. Sweeney , Douglas R. Daum
发明人： Robert J. Sweeney , Douglas R. Daum
IPC分类号： A61B5/02
CPC分类号： A61B7/00 , A61N1/3622 , A61N1/36557 , A61N1/3684
摘要： This document describes, among other things, a body having at least one acoustically detectable property that changes in response to a change in a physiological condition, such as ischemia. The body is positioned with respect to a desired tissue region. At least one acoustic transducer is used to acoustically detect a change in physical property. In one example, the body is pH sensitive and/or ion selective. A shape or dimension of the body changes in response to pH and/or ionic concentration changes resulting from a change in an ischemia state. An indication of the physiological condition is provided to a user.

55. 发明授权

US07101339B2 Respiration signal measurement apparatus, systems, and methods 有权
标题翻译：呼吸信号测量装置，系统和方法
公开(公告)号：US07101339B2
公开(公告)日：2006-09-05
申请号：US10319794
申请日：2002-12-13
申请人： Douglas R. Daum , Qingsheng Zhu , Avram Scheiner
发明人： Douglas R. Daum , Qingsheng Zhu , Avram Scheiner
IPC分类号： A61B5/08
CPC分类号： A61N1/36521
摘要： A cardiac rhythm management apparatus and system may include a first sensor to sense an atrial respiration signal, a second sensor to sense a ventricular respiration signal, and a measurement module capable of being communicatively coupled to the first and second sensors to monitor the atrial and ventricular respiration signals and to select a resulting signal as an indication of respiration. An article may cause a machine to implement a method which includes measuring a second signal responsive to a first signal, measuring a third signal responsive to a first signal, determining a respiration-to-cardiac ratio associated with each one of the second and third signals, and providing a resulting signal including a selected portion of a selected one of the second and third signals as an indication of respiration.
摘要翻译：心律管理装置和系统可以包括用于感测心房呼吸信号的第一传感器，用于感测心室呼吸信号的第二传感器，以及能够通信地耦合到第一和第二传感器以监测心房和心室的测量模块呼吸信号，并选择一个结果信号作为呼吸指示。物品可以使机器实现一种方法，其包括响应于第一信号测量第二信号，响应于第一信号测量第三信号，确定与第二和第三信号中的每一个相关联的呼吸心脏比并且提供包括所选择的第二和第三信号中的一个的选定部分的结果信号作为呼吸的指示。

56. 发明授权

US06907288B2 Cardiac rhythm management system adjusting rate response factor for treating hypotension 有权
标题翻译：心律管理系统调整治疗低血压的速率反应因子
公开(公告)号：US06907288B2
公开(公告)日：2005-06-14
申请号：US09879665
申请日：2001-06-12
申请人： Douglas R. Daum
发明人： Douglas R. Daum
IPC分类号： A61N1/36 , A61N1/365 , A61N1/362
CPC分类号： A61N1/36564 , A61N1/36521 , A61N1/36542
摘要： A cardiac rhythm management system detects hypotension, such as by using thoracic impedance to detect a fluid shift away from the thorax. In response to an episode of detected hypotension, it increases a pacing rate response factor mapping a metabolic need to an indicated pacing rate provided by the system. The metabolic need is indicated by an accelerometer, a respiration sensor, or other metabolic need sensor indicating a subject's need for adjusting cardiac output.
摘要翻译：心律管理系统检测低血压，例如通过使用胸部阻抗来检测远离胸部的液体移位。响应于检测到的低血压事件，它增加了一种将代谢需求映射到系统提供的指示起搏速率的起搏速率响应因子。代谢需要由加速度计，呼吸传感器或其他代谢需求传感器指示，指示受试者需要调节心输出量。

57. 发明授权

US06751502B2 Cardiac rhythm management system with defibrillation threshold prediction 有权
公开(公告)号：US06751502B2
公开(公告)日：2004-06-15
申请号：US09808419
申请日：2001-03-14
申请人： Douglas R. Daum , Weimin Sun
发明人： Douglas R. Daum , Weimin Sun
IPC分类号： A61N139
CPC分类号： A61N1/3937 , A61N1/3943
摘要： A cardiac rhythm management device predicts defibrillation thresholds without any need to apply defibrillation shocks or subjecting the patient to fibrillation. Intravascular defibrillation electrodes are implanted in a heart. By applying a small test energy, an electric field near one of the defibrillation electrodes is determined by measuring a voltage at a sensing electrode offset from the defibrillation electrode by a known distance. A desired predetermined minimum value of electric field at the periphery of the heart is established. A distance between one of the defibrillation electrodes and the heart periphery is measured, either fluoroscopically or by measuring a voltage at an electrode located at or near the heart periphery. Using the measured electric field and the measured distance to the periphery of the heart, the defibrillation energy needed to obtain the desired electric field at the heart periphery is estimated. This estimation is based on an elliptical model of the electric field distribution around the dipole foci formed by the defibrillation electrodes, or other suitable electric field model.

58. 发明授权

US06511444B2 Transmyocardial revascularization using ultrasound 有权
标题翻译：超声心肌血运重建
公开(公告)号：US06511444B2
公开(公告)日：2003-01-28
申请号：US09523989
申请日：2000-01-31
申请人： Kullervo Hynynen , Douglas R. Daum , Mark T. Buchanan , Todd Fjield
发明人： Kullervo Hynynen , Douglas R. Daum , Mark T. Buchanan , Todd Fjield
IPC分类号： A61B1722
CPC分类号： A61B17/22004 , A61B2017/00247 , A61B2018/00392 , A61B2018/00642
摘要： A method and apparatus for performing transmyocardial revascularization using ultrasound is disclosed. The apparatus includes a phased array ultrasonic device that includes a plurality of ultrasonic transducer elements which are controlled using a feedback control system so that each ultrasonic transducer element produces an ultrasonic wave of particular power and phase in order to achieve constructive interference at a desired acoustic focus. The constructive interference creates high pressure amplitudes for vaporizing the target tissue at the focus. A method is provided for vaporizing target tissue for which a plurality of ultrasonic transducers are focused so as to provide constructive interference within the target tissue. The ultrasonic beams are launched and produce a rapid rise in tissue temperature that will vaporize the target tissue within the focal zone.
摘要翻译：公开了一种使用超声波进行心肌心肌血运重建的方法和装置。该装置包括相控阵超声波装置，其包括使用反馈控制系统控制的多个超声波换能器元件，使得每个超声波换能器元件产生特定功率和相位的超声波，以便在期望的声学焦点处实现建构性干扰。建构性干扰产生用于在焦点处蒸发靶组织的高压振幅。提供一种用于蒸发多个超声换能器被聚焦的目标组织以便在目标组织内提供建设性干扰的方法。超声波束被发射并且产生组织温度的快速上升，这将使焦点区域内的目标组织蒸发。

59. 发明授权

US08626288B2 Systems, devices and methods for modulating autonomic tone 有权
标题翻译：用于调节自主神经色调的系统，装置和方法
公开(公告)号：US08626288B2
公开(公告)日：2014-01-07
申请号：US12397464
申请日：2009-03-04
申请人： Allan C. Shuros , Shantha Arcot-Krishnamurthy , Bruce H. KenKnight , Douglas R. Daum
发明人： Allan C. Shuros , Shantha Arcot-Krishnamurthy , Bruce H. KenKnight , Douglas R. Daum
IPC分类号： A61N1/368
CPC分类号： A61N1/362 , A61N1/36114 , A61N1/3627
摘要： Various embodiments intermittently deliver a sympathetic stimulus, including deliver a sequence of stress-inducing pacing pulses adapted to increase sympathetic tone during the stress-inducing pacing. The stress-inducing pacing results in a parasympathetic reflex after the sequence of stress-inducing pacing. The embodiment further delivers neural stimulation to elicit a parasympathetic response or a sympathetic response in a coordinated manner with respect to the sequence of stress-inducing pacing pulses. The neural stimulation is timed to elicit the parasympathetic response after the sequence of stress-inducing pacing pulses and concurrent with at least a portion of the parasympathetic reflex to the sequence of stress-inducing pacing to enhance a parasympathetic effect of the parasympathetic reflex, or to elicit the sympathetic response during the sequence of stress-inducing pulses to provide a larger sympathetic stimulus, resulting in an enhanced parasympathetic reflex in response to the large sympathetic stimulus.
摘要翻译：各种实施方案间歇地递送交感刺激，包括递送适于在应力诱导起搏期间增加交感神经张力的应力诱发起搏脉冲序列。应激诱导起搏导致应激诱导起搏顺序后的副交感神经反射。该实施方案进一步递送神经刺激以相对于应力诱导起搏脉冲的序列以协调的方式引发副交感神经反应或交感神经反应。神经刺激被定时以在应力诱发起搏脉冲序列之后引起副交感神经反应，并且与应激诱导起搏序列的至少一部分副交感神经反射并发，以增强副交感神经反射的副交感作用，或在应激诱导脉冲序列期间引起交感神经反应以提供更大的交感神经刺激，导致响应于大的交感神经刺激的增强的副交感神经反射。

60. 发明授权

US07962210B2 Implantable medical device with voice responding and recording capacity 有权
标题翻译：具有语音响应和记录能力的植入式医疗设备
公开(公告)号：US07962210B2
公开(公告)日：2011-06-14
申请号：US12468648
申请日：2009-05-19
申请人： Douglas R. Daum , Qingsheng Zhu , Bruce H. KenKnight
发明人： Douglas R. Daum , Qingsheng Zhu , Bruce H. KenKnight
IPC分类号： A61N1/362
CPC分类号： A61N1/37217 , A61N1/3625 , A61N1/3627 , A61N1/37247
摘要： An implantable medical device such as a cardiac pacemaker or implantable cardioverter/defibrillator with the capability of receiving communications in the form of speech spoken by the patient. An acoustic transducer is incorporated within the device which along with associated filtering circuitry enables the voice communication to be used to affect the operation of the device or recorded for later playback.
摘要翻译：一种可植入医疗装置，例如心脏起搏器或植入式心律转复除颤器，具有以患者所说话语的形式接收通信的能力。声学换能器结合在该装置内，连同相关联的滤波电路使声音通信能够用于影响装置的操作或被记录以供稍后播放。

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