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51. 发明授权

US5801280A Processes for preparing optically active alcohols and optically active amines 失效
公开(公告)号：US5801280A
公开(公告)日：1998-09-01
申请号：US628154
申请日：1996-04-05
申请人： Yukio Yoneyoshi , Naoto Konya , Gohfu Suzukamo , Masashi Kamitamari , Takashi Miyawaki
发明人： Yukio Yoneyoshi , Naoto Konya , Gohfu Suzukamo , Masashi Kamitamari , Takashi Miyawaki
IPC分类号： C07B53/00 , C07B57/00 , C07C29/143 , C07C33/34 , C07C209/40 , C07C213/02
CPC分类号： C07B53/00 , C07B57/00 , C07C209/40 , C07C213/02 , C07C29/143 , C07B2200/07
摘要： A process for preparing an optically active alcohol by reacting a prochiral ketone corresponding to the optically active alcohol and an acid with a mixture of (1) a boron-containing compound selected from the group consisting of i) a borane compound which is obtained from an optically active .beta.-aminoalcohol and a boron hydride; or obtained from the optically active .beta.-aminoalcohol, a metal borohydride and an acid and ii) an optically active oxazaborolidine and (2) a metal borohydride; and a process for preparing an optically active amine by reacting an oxime derivative and an acid with a mixture of (1) a boron-containing compound selected from the group consisting of i) a borane compound which is obtained from an optically active .beta.-aminoalcohol and a boron hydride, or obtained from said optically active .beta.-aminoalcohol, a metal borohydride and an acid and ii) an optically active oxazaborolidine, and (2) a metal borohydride.

52. 发明授权

US5717116A Process for producing (R)-styrene oxides 失效
标题翻译：制备（R） - 苯乙烯氧化物的方法
公开(公告)号：US5717116A
公开(公告)日：1998-02-10
申请号：US624084
申请日：1996-03-29
申请人： Kenji Saito , Norio Kometani , Azusa Fujiwara , Yukio Yoneyoshi , Gohfu Suzukamo
发明人： Kenji Saito , Norio Kometani , Azusa Fujiwara , Yukio Yoneyoshi , Gohfu Suzukamo
IPC分类号： C07D301/26 , C07D303/02 , C12P7/62 , C12P41/00 , C07D301/24
CPC分类号： C07D303/02 , C07D301/26 , C12P41/004 , C12P7/62
摘要： The present invention provides a process for producing (R)-styrene oxides represented by the formula (1): ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and X are as defined in the specification, which comprises treating a mixture of (R)- and (S)-phenylhalogenomethylcarbinols with a lipase in the presence of a carboxylate to preferentially convert the (S)-phenylhalogenomethylcarbinols, and treating a mixture of the formed carbinol alkylates (3) and (R)-phenylhalogenomethylcarbinols with a base to cyclize the (R)-phenylhalogenomethylcarbinols, and also provides an industrially excellent process for producing (R)-styrene oxides (1) which comprises using a mixture enriched with (R)-phenylhalogenomethylcarbinols as the mixture of (R)- and (S)-phenylhalogenomethylcarbinols (2).
摘要翻译：本发明提供一种由式（1）表示的（R） - 苯乙烯氧化物的制备方法：其中R 1，R 2，R 3和X如说明书中所定义，其包括将 R） - 和（S） - 苯基卤代甲基甲醇与羧酸酯存在下的脂肪酶以优先转化（S） - 苯基卤代甲基甲醇，并将形成的烷基醇烷基化物（3）和（R） - 苯基卤代甲基甲醇的混合物与碱反应（R） - 苯基卤代甲基甲醇环化，并且还提供了工业上优异的（R） - 苯乙烯氧化物（1）的制备方法，其包括使用（R） - 苯基卤代甲基甲醇作为（R） - 和（S） - 苯基卤甲基甲醇（2）。

53. 发明授权

US5349115A Dimerization of low .alpha.-olefins 失效
标题翻译：低α-烯烃的二聚
公开(公告)号：US5349115A
公开(公告)日：1994-09-20
申请号：US57843
申请日：1993-05-07
申请人： Kotohiro Nomura , Masaru Ishino , Michio Yamamoto , Gohfu Suzukamo , Makoto Itagaki
发明人： Kotohiro Nomura , Masaru Ishino , Michio Yamamoto , Gohfu Suzukamo , Makoto Itagaki
IPC分类号： C07C2/36 , C07C2/24
CPC分类号： C07C2/36 , C07C2531/02 , C07C2531/025 , C07C2531/04 , C07C2531/14 , C07C2531/24
摘要： A process for preparing a dimer of a lower .alpha.-olefin in the presence of Catalyst (A) containing a nickel compound, a trialkylaluminum, a halogenated phenol, a phosphorus compound and a sulfur compound, Catalyst (B) containing a nickel compound, a trialkylaluminum, a fluorinated isopropyl alcohol, a phosphorus compound, a sulfonic acid and water, or Catalyst (C) containing a nickel compound, a trialkylaluminum, a halogenated phenol, a phosphorus compound, a sulfonic acid and water, by which method, the dimer of the lower .alpha.-olefin is prepared in a high yield and high selectivity.
摘要翻译：在含有镍化合物，三烷基铝，卤代酚，磷化合物和硫化合物的催化剂（A）存在下制备低级α-烯烃的二聚体的方法，含有镍化合物的催化剂（B），三烷基铝，氟化异丙醇，磷化合物，磺酸和水，或含有镍化合物，三烷基铝，卤化苯酚，磷化合物，磺酸和水的催化剂（C），通过该方法，二聚体的低级α-烯烃以高产率和高选择性制备。

54. 发明授权

US4542235A Method for producing an optically active 2,2-dimethylcyclopropanecarboxylic acid 失效
标题翻译：光学活性2,2-二甲基环丙烷羧酸的制造方法
公开(公告)号：US4542235A
公开(公告)日：1985-09-17
申请号：US482259
申请日：1983-04-05
申请人： Masayoshi Minai , Tadashi Katsura , Kazuhiko Hamada , Gohfu Suzukamo
发明人： Masayoshi Minai , Tadashi Katsura , Kazuhiko Hamada , Gohfu Suzukamo
IPC分类号： C07C51/487 , C07C61/04
CPC分类号： C07C51/487
摘要： A method for producing an optically active 2,2-dimethylcyclopropanecarboxylic acid useful as an intermediate for dehydropeptidase I inhibitors, medicines and agricultural chemicals, which comprises reacting an optically active diphenylethylamine represented by the formula, ##STR1## wherein R.sub.1 and R.sub.2 are each a hydrogen atom or a lower alkyl group, with 2,2-dimethylcyclopropanecarboxylic acid in a solvent to achieve the optical purification of said acid.
摘要翻译：一种用作脱水肽酶I抑制剂，药物和农药的中间体的光学活性2,2-二甲基环丙烷羧酸的制备方法，其包括使下式表示的光学活性二苯乙胺，其中R1和R2各自为氢原子或低级烷基，与2,2-二甲基环丙烷羧酸在溶剂中实现所述酸的光学纯化。

55. 发明授权

US06388160B1 Method for producing of 2,3-dimethylbutene-1 and 2,3-dimethylbutene-2 失效
标题翻译： 2,3-二甲基丁烯-1和2,3-二甲基丁烯-2的制备方法
公开(公告)号：US06388160B1
公开(公告)日：2002-05-14
申请号：US09577840
申请日：2000-05-25
申请人： Makoto Itagaki , Gohfu Suzukamo , Michio Yamamoto
发明人： Makoto Itagaki , Gohfu Suzukamo , Michio Yamamoto
IPC分类号： C07C200
CPC分类号： C07C11/107 , B01J31/0202 , B01J31/0232 , B01J31/143 , B01J31/2404 , B01J2231/52 , B01J2531/847 , C07C2/36 , C07C2527/128 , C07C2531/02 , C07C2531/025 , C07C2531/04 , C07C2531/10 , C07C2531/14 , C07C2531/22 , C07C2531/24
摘要： There is disclosed a method for producing 2,3-dimethylbutene-1 and 2,3-dimethylbutene-2, which is characterized by the steps of (a) dimerizing propylene in a propylene-dimerization step using a nickel complex catalyst as described below as a propylene-dimerization catalyst having propylene-dimerization activity and DMB-1 selectivity, (b) rectifying the resulting reaction solution to obtain 2,3-dimethylbutene-1 as a distillate and a distillation residue containing 2,3-dimethylbutene-1 in a 2,3-dimethylbutene-1 distillation step, (c) allowing the distillation residue to contact with sulfuric acid, sulfonic acid or hetetopolyacid to isomerize 2,3-dimethylbutene-1 in said distillation residue into 2,3-dimethylbutene-2 in an isomerization step, and (d) rectifying the resulting isomerization reaction solution to obtain 2,3-dimethylbutene-2 in a 2,3-dimethylbutene-2 distillation step, wherein said nickel complex catalyst containing (A) at least one nickel compound and the like, (B) a trialkylaluminum, (C) a trivalent phosphorus compound, (D) a fluorinated isopropanol or a halogenated phenol (E) at least one sulfur compound selected from a sulfonic acid and a dialkylsulfuric acid.
摘要翻译：公开了2,3-二甲基丁烯-1和2,3-二甲基丁烯-2的制备方法，其特征在于以下步骤：（a）使用如下所述的镍络合物催化剂在丙烯二聚步骤中使丙烯二聚具有丙烯二聚活性和DMB-1选择性的丙烯 - 二聚催化剂，（b）将所得反应溶液精馏，得到作为馏出物的2,3-二甲基丁烯-1和含有2,3-二甲基丁烯-1的蒸馏残余物 2,3-二甲基丁烯-1蒸馏步骤，（c）使蒸馏残余物与硫酸，磺酸或氢过氧酸接触，将所述蒸馏残余物中的2,3-二甲基丁烯-1异构化为2,3-二甲基丁烯-2 异构化步骤，和（d）在2,3-二甲基丁烯-2蒸馏步骤中精制所得异构化反应溶液得到2,3-二甲基丁烯-2，其中所述镍络合物催化剂含有（A）至少一种镍化合物和（B）三烷基铝 m，（C）三价磷化合物，（D）氟化异丙醇或卤代苯酚（E）至少一种选自磺酸和二烷基硫酸的硫化合物。

56. 发明授权

US6156940A Process for producing optically active carbinols 失效
标题翻译：光学活性甲醇的制备方法
公开(公告)号：US6156940A
公开(公告)日：2000-12-05
申请号：US56797
申请日：1998-04-08
申请人： Kenji Saito , Norio Kometani , Azusa Fujiwara , Yukio Yoneyoshi , Gohfu Suzukamo
发明人： Kenji Saito , Norio Kometani , Azusa Fujiwara , Yukio Yoneyoshi , Gohfu Suzukamo
IPC分类号： C07C29/143 , C07D317/54 , C07C27/00
CPC分类号： C07D317/54 , C07C29/143 , C07B2200/07
摘要： The present invention relates to a process for producing optically active halomethyl phenyl carbinols of the formula (1), comprising reducing halomethyl phenyl ketones of the formula (2) using an asymmetric reducing agent obtained from boranes and optically active .alpha.-phenyl-substituted-.beta.-amino alcohols of the formula (3) or optically active .alpha.-non-substituted-.beta.-amino alcohols of the formula (4).The present invention further relates to a process for producing optically active carbinols, comprising reacting a prochiral ketone with, an asymmetric reducing agent obtained from optically active .beta.-amino alcohols of the formula (5), a metal boron hydride and Lewis acid or lower dialkyl sulfuric acid. All of the formulas (1) to (5) are the same as shown in the specification.
摘要翻译：本发明涉及一种制备式（1）的光学活性卤代甲基苯基甲醇的方法，其包括使用由硼烷和光学活性的α-苯基取代的β取代的β-不饱和还原剂还原式（2）的卤代甲基苯基酮（3）的氨基醇或式（4）的光学活性的α-壬基取代的β-氨基醇。本发明还涉及一种光学活性甲醇的制备方法，其包括使前手性酮与由式（5）的光学活性β-氨基醇获得的不对称还原剂，金属硼氢化物和路易斯酸或低级二烷基硫酸。所有式（1）至（5）与说明书中所示的相同。

57. 发明授权

US6025531A Processes for preparing optically active alcohols and optically active amines 失效
标题翻译：制备光学活性醇和光学活性胺的方法
公开(公告)号：US6025531A
公开(公告)日：2000-02-15
申请号：US89349
申请日：1998-06-03
申请人： Yukio Yoneyoshi , Naoto Konya , Gohfu Suzukamo
发明人： Yukio Yoneyoshi , Naoto Konya , Gohfu Suzukamo
IPC分类号： C07B53/00 , C07B57/00 , C07C29/143 , C07C33/34 , C07C209/40 , C07C213/02
CPC分类号： C07B53/00 , C07B57/00 , C07C209/40 , C07C213/02 , C07C29/143 , C07B2200/07
摘要： A process for preparing an optically active alcohol by reacting a prochiral ketone corresponding to the optically active alcohol and an acid with a mixture of (1) a boron-containing compound selected from the group consisting of i) a borane compound which is obtained from an optically active .beta.-aminoalcohol and a boron hydride; or obtained from the optically active .beta.-aminoalcohol, a metal borohydride and an acid and ii) an optically active oxazaborolidine and (2) a metal borohydride; and a process for preparing an optically active amine by reacting an oxime derivative and an acid with a mixture of (1) a boron-containing compound selected from the group consisting of i) a borane compound which is obtained from an optically active .beta.-aminoalcohol and a boron hydride, or obtained from said optically active .beta.-aminoalcohol, a metal borohydride and an acid and ii) an optically active oxazaborolidine, and (2) a metal borohydride.
摘要翻译：通过使对应于光学活性醇的前手性酮与酸与（1）选自以下的混合物的混合物反应制备光学活性醇的方法：i）硼烷化合物，其由光学活性β-氨基醇和硼氢化物; 或由光学活性β-氨基醇，金属硼氢化物和酸获得，和ii）光学活性的恶唑硼烷和（2）金属硼氢化物; 和通过使肟衍生物和酸与（1）选自以下的含硼化合物的混合物制备光学活性胺的方法：i）由光学活性β-氨基醇获得的硼烷化合物和硼氢化物，或从所述光学活性β-氨基醇，金属硼氢化物和酸获得的硼氢化物，和ii）光学活性的恶唑硼烷，和（2）金属硼氢化物。

58. 发明授权

US6008364A Process for producing alkenyl--substituted pyridine derivative 失效
标题翻译：烯基取代的吡啶衍生物的制备方法
公开(公告)号：US6008364A
公开(公告)日：1999-12-28
申请号：US112981
申请日：1998-07-10
申请人： Michio Yamamoto , Gohfu Suzukamo
发明人： Michio Yamamoto , Gohfu Suzukamo
IPC分类号： C07D213/06 , C07D213/127 , C07D211/70
CPC分类号： C07D213/06
摘要： There is provided a process for producing an alkenyl-substituted pyridine derivative using, a solid base catalyst which is obtained by heating a metal oxide selected from the group consisting of alumina, an alkaline earth metal oxide and a hydrotalcite withan alkali metal,an alkali compound and an alkali metal oran alkali compound and an alkali metal hydride under an inert gas atmosphere at a temperature within the range of 100-700.degree. C.
摘要翻译：提供了一种使用固体碱催化剂制备烯基取代的吡啶衍生物的方法，该固体碱催化剂是通过用碱金属加热从氧化铝，碱土金属氧化物和水滑石中选择的金属氧化物，碱化合物和碱金属或碱性化合物和碱金属氢化物在惰性气体气氛中在100-700℃的温度范围内

59. 发明授权

US5066630A Method for removing nitrogen-containing organic compounds from crystalline metallosilicate 失效
标题翻译：从金属陶瓷中除去含氮有机化合物的方法
公开(公告)号：US5066630A
公开(公告)日：1991-11-19
申请号：US537432
申请日：1990-06-13
申请人： Masaru Kitamura , Hiroshi Ichihashi , Gohfu Suzukamo
发明人： Masaru Kitamura , Hiroshi Ichihashi , Gohfu Suzukamo
IPC分类号： B01J37/08 , C01B37/02 , C01B39/04 , C01B39/06 , C01B39/08 , C01B39/12 , C01B39/36
CPC分类号： C01B39/082 , C01B33/185 , C01B33/2876 , C01P2006/60 , C01P2006/80
摘要： Nitrogen-containing organic compounds are removed from crystalline metallosilicates containing the same by firing the crystalline metallosilicates in the presence of a gas containing molecular oxygen and additionally a lower alcohol represented by the formula (I):R--OH (I)wherein R represents an alkyl group of 1-4 carbon atoms.

60. 发明授权

US4968793A Process for producing .epsilon.-caprolactam 失效
标题翻译：生产ε-己内酰胺的方法
公开(公告)号：US4968793A
公开(公告)日：1990-11-06
申请号：US468935
申请日：1990-01-23
申请人： Masaru Kitamura , Hiroshi Ichihashi , Gohfu Suzukamo , Yasuo Nakamura
发明人： Masaru Kitamura , Hiroshi Ichihashi , Gohfu Suzukamo , Yasuo Nakamura
IPC分类号： C07D201/04
CPC分类号： C07D201/04
摘要： .epsilon.-caprolactam is produced by gas phase reaction of cyclohexanone oxime using a solid acid as a catalyst in the presence of a compound represented by the formula (I): R.sub.1 --O--R.sub.2 (wherein R.sub.1 represents a lower alkyl group which may be substituted with a fluorine atom and R.sub.2 represents a hydrogen atom, a lower alkyl group or a phenyl group) such as a lower alcohol or an ether compound. The solid acid includes a crystalline metallosilicate or a crystalline silicate.

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