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    • 51. 发明授权
    • Isoxazolines for controlling invertebrate pests
    • 用于控制无脊椎害虫的异恶唑啉
    • US08552218B2
    • 2013-10-08
    • US13561546
    • 2012-07-30
    • George Philip LahmWesley Lawrence ShoopMing Xu
    • George Philip LahmWesley Lawrence ShoopMing Xu
    • C07C259/10
    • A01N43/42A01M1/10A01M1/2005A01N43/80A61K9/1075A61K31/42A61K31/4439A61K31/444A61K31/4709A61K31/4725A61K45/06C07D215/12C07D261/04C07D413/04C07D413/12C07D413/14C07D417/12C07D417/14A61K2300/00
    • Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, wherein A1, A2, A3, A4, A5 and A6 are independently selected from the group consisting of CR3 and N; provided that at most 3 of A1, A2, A3, A4, A5 and A6 is N; B1, B2 and B3 are independently selected from the group consisting of CR2 and N; each R3 is independently H, halogen, C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, C3-C6 halocycloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 alkylthio, C1-C6 haloalkylthio, C1-C6 alkylsulfinyl, C1-C6 haloalkylsulfinyl, C1-C6 alkylsulfonyl, C1-C6 haloalkylsulfonyl, C1-C6 alkylamino, C2-C6 dialkylamino, —CN or —NO2; and R1, R2, R4, R5, W and n are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the invention.
    • 公开了式1的化合物,包括所有几何和立体异构体,N-氧化物及其盐,其中A1,A2,A3,A4,A5和A6独立地选自CR3和N; A1,A2,A3,A4,A5和A6中最多有3个为N; B1,B2和B3独立地选自CR2和N; 每个R 3独立地是H,卤素,C 1 -C 6烷基,C 1 -C 6卤代烷基,C 3 -C 6环烷基,C 3 -C 6卤代环烷基,C 1 -C 6烷氧基,C 1 -C 6卤代烷氧基,C 1 -C 6烷硫基,C 1 -C 6卤代烷硫基, C6烷基亚磺酰基,C1-C6卤代烷基亚磺酰基,C1-C6烷基磺酰基,C1-C6卤代烷基磺酰基,C1-C6烷基氨基,C2-C6二烷基氨基,-CN或-NO2; 并且R1,R2,R4,R5,W和n如本公开所定义。 还公开了含有式1化合物和控制无脊椎动物害虫的方法的组合物,包括使无脊椎害虫或其环境与生物有效量的本发明化合物或组合物接触。
    • 52. 发明授权
    • Naphthalene isoxazoline invertebrate pest control agents
    • 萘异恶唑啉无脊椎动物害虫防治剂
    • US08410153B2
    • 2013-04-02
    • US12663751
    • 2008-06-20
    • George Philip LahmJeffrey Keith LongMing Xu
    • George Philip LahmJeffrey Keith LongMing Xu
    • A61K31/42C07D261/04
    • A01N43/80C07D261/04
    • Disclosed are compounds of Formula 1, wherein R1 is halogen, C1-C2 haloalkyl or C1-C2 haloalkoxy; R2 is H, halogen or cyano; R3 is H, halogen or CF3; R4 is H, C2-C7 alkylcarbonyl or C2-C7 alkoxycarbonyl; and R5 is C1-C6 alkyl or C1-C6 haloalkyl, each substituted with one substituent independently selected from hydroxy, C1-C6 alkoxy, C1-C6 alkylthio, C1-C6 alkylsulfinyl, C1-C6 alkylsulfonyl, C2-C7 alkylaminocarbonyl, C3-C9 dialkylaminocarbonyl, C2-C7 haloalkylaminocarbonyl and C3-C9 halodialkylaminocarbonyl. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the invention.
    • 公开了式1的化合物,其中R 1是卤素,C 1 -C 2卤代烷基或C 1 -C 2卤代烷氧基; R2是H,卤素或氰基; R3是H,卤素或CF3; R4是H,C2-C7烷基羰基或C2-C7烷氧基羰基; 并且R 5是被一个独立地选自羟基,C 1 -C 6烷氧基,C 1 -C 6烷硫基,C 1 -C 6烷基亚磺酰基,C 1 -C 6烷基磺酰基,C 2 -C 7烷基氨基羰基,C 3 -C 6烷基氨基羰基, C 9二烷基氨基羰基,C 2 -C 7卤代烷基氨基羰基和C 3 -C 9卤代二烷基氨基羰基。 还公开了含有式1化合物和控制无脊椎动物害虫的方法的组合物,包括使无脊椎害虫或其环境与生物有效量的本发明化合物或组合物接触。
    • 56. 发明申请
    • ANIMAL PEST CONTROL METHOD
    • 动物虫控制方法
    • US20100173948A1
    • 2010-07-08
    • US12663848
    • 2008-06-26
    • George Philip LahmJeffrey Keith LongMing Xu
    • George Philip LahmJeffrey Keith LongMing Xu
    • A01N43/40A01N43/80A01P7/00A01P17/00
    • A61K31/4439A01N43/80A61K9/0019A61K9/0053A61K31/42
    • Disclosed is a method for protecting an animal from a parasitic invertebrate pest comprising treating an animal orally or by injection with a pesticidally effective amount of a compound of Formula 1, wherein R1 is halogen, C1-C3 haloalkyl or C1-C3 haloalkoxy; R2 is H, halogen, C1-C3 alkyl, C1-C3 haloalkyl or cyano; R3 is H, halogen, C1-C3 haloalkyl or C1-C3 haloalkoxy; R4 is halogen, C1-C3 alkyl, C1-C3 haloalkyl or C1-C3 haloalkoxy; R5 is H, CH3, C2-C4 alkylcarbonyl, C2-C4 haloalkylcarbonyl, C2-C5 alkoxycarbonyl or CH2O(C1-C3 alkyl); R6 is C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl or C3-C6 halocycloalkyl, each group substituted with one R7; or R6 is (CH2)mQ; and Q, R7, R8a and R8b are as defined in the disclosure.
    • 公开了一种保护动物免受寄生无脊椎害虫的方法,包括用杀虫有效量的式1化合物口服或注射处理动物,其中R1是卤素,C1-C3卤代烷基或C1-C3卤代烷氧基; R2是H,卤素,C1-C3烷基,C1-C3卤代烷基或氰基; R3是H,卤素,C1-C3卤代烷基或C1-C3卤代烷氧基; R4是卤素,C1-C3烷基,C1-C3卤代烷基或C1-C3卤代烷氧基; R5是H,CH3,C2-C4烷基羰基,C2-C4卤代烷基羰基,C2-C5烷氧基羰基或CH2O(C1-C3烷基); R6是C1-C6烷基,C1-C6卤代烷基,C3-C6环烷基或C3-C6卤代环烷基,每个基团被一个R7取代; 或R6是(CH2)mQ; 并且Q,R7,R8a和R8b如本公开所定义。