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51. 发明申请

US20050031694A1 Methods for promoting growth of bone, ligament, and cartilage using zvegf4 有权
公开(公告)号：US20050031694A1
公开(公告)日：2005-02-10
申请号：US10910938
申请日：2004-08-03
申请人： Debra Gilbertson , Charles Hart
发明人： Debra Gilbertson , Charles Hart
IPC分类号： A61K38/00 , A61K38/18 , A61K38/19 , C07K14/52 , A61K9/14
CPC分类号： C04B38/06 , A61K38/177 , A61K38/18 , A61K38/1866 , A61K38/22 , C04B2111/00224 , C04B2111/00612 , C07K14/52 , C07K2319/00 , C12N2799/022 , C04B20/008 , C04B35/2641 , C04B35/50 , C04B35/64 , C04B38/0054 , C04B38/007 , C04B41/4578 , A61K2300/00
摘要： Methods for promoting growth of bone, ligament, or cartilage in a mammal are disclosed. The methods comprise administering to said mammal a composition comprising a pharmacologically effective amount of zvegf4 in combination with a pharmaceutically acceptable delivery vehicle. Also disclosed are methods for promoting proliferation or differentiation of osteoblasts, osteoclasts, chondrocytes, or bone marrow stem cells comprising culturing the cells in an effective amount of zvegf4.

52. 发明申请

US20050020884A1 Surgical access system 审中-公开
标题翻译：手术进入系统
公开(公告)号：US20050020884A1
公开(公告)日：2005-01-27
申请号：US10927551
申请日：2004-08-25
申请人： Charles Hart , Edward Pingleton
发明人： Charles Hart , Edward Pingleton
IPC分类号： A61B1/32 , A61B17/00 , A61B17/34
CPC分类号： A61B17/0293 , A61B17/3423 , A61B17/3498 , A61B2017/00265
摘要： The invention is directed to a hand access system that provides hand access to a surgical area while maintaining pneumoperitoneum during laparoscopic surgery. The hand access system comprises a sheath retractor adapted to dilate a wound stretchable to a desired diameter, the sheath retractor includes a first ring being adapted for disposition interiorly of the wound, a second ring being adapted for disposition exteriorly of the wound, and a sheath being disposed in a generally cylindrical form between the first ring and the second ring and operable to exert a radial retraction force on the wound. The hand access system further comprises a detachable hand seal adapted to be removable from the second ring of the sheath retractor. The sheath retractor may be formed of an elastomeric material, and the hand seal may be formed of a gel material and includes a slit providing an instrument seal in the presence of an instrument or hand and a zero seal in the absence of the instrument or hand. In another aspect, there is disclosed a surgical access device adapted for disposition relative to an incision in a patient comprising a valve including a plurality of overlapping sheets defining an access channel, and a ring having an inner diameter for holding the valve by fixing each of the overlapping sheets along a portion of the perimeter, the access channel extends into communication with the incision in the patient. Each of the overlapping sheets includes a portion of the perimeter that is not fixed to the inner diameter of the ring, which provide open edges defining the access channel. The open edges slightly overlap at the center of the ring. The open edges may have different shapes including at least one of a straight edge, concave, convex and a cross-configuration. The hand access device may further comprise a septum seal formed at the proximal and distal ends of the ring.
摘要翻译：本发明涉及一种手动进入系统，其在腹腔镜手术期间提供手术进入手术区域同时保持气腹。手动进入系统包括一个适合于将可拉伸到所需直径的伤口扩张的护套牵开器，所述护套牵开器包括适于在伤口内部配置的第一环，适于在伤口外部配置的第二环，在第一环和第二环之间以大致圆柱形的形式设置并可操作以在伤口上施加径向缩回力。手动进入系统还包括适于从皮带牵开器的第二环移除的可拆卸手动密封件。护套牵开器可以由弹性体材料形成，并且手动密封件可以由凝胶材料形成，并且包括在没有仪器或手的情况下在仪器或手的存在下提供仪器密封的狭缝和零密封。另一方面，公开了一种外科进入装置，其适于相对于患者的切口进行配置，该装置包括阀，所述阀包括限定出入通道的多个重叠片，以及具有用于通过固定每个沿着周边的一部分重叠的片材，进入通道延伸成与患者的切口连通。每个重叠片材包括未固定到环的内径的周边的一部分，其提供限定接入通道的开口边缘。开口边缘在环的中心稍微重叠。开口边缘可以具有不同的形状，包括直边，凹形，凸形和交叉构型中的至少一个。手动进入装置还可以包括形成在环的近端和远端的隔膜密封件。

53. 发明申请

US20090077584A1 Methods, systems, and products for sharing presence information 审中-公开
标题翻译：用于共享状态信息的方法，系统和产品
公开(公告)号：US20090077584A1
公开(公告)日：2009-03-19
申请号：US11901319
申请日：2007-09-17
申请人： Jay Oliver Glasgow , Brett D. Johnson , Laurence Siegel , Charles Hart
发明人： Jay Oliver Glasgow , Brett D. Johnson , Laurence Siegel , Charles Hart
IPC分类号： H04N5/445
CPC分类号： H04N5/44543 , H04N7/173 , H04N21/252 , H04N21/44222 , H04N21/4532 , H04N21/6582 , H04N21/84
摘要： Methods, systems, and products are disclosed for sharing presence information. Presence notifications are received from users, and the presence notifications describe content items currently being received by the users. A popularity of one or more of the content items being received by the users is determined. An electronic programming guide is provided that includes information regarding the one or more of the content items and the determined popularity associated with the one or more of the content items.
摘要翻译：公开了用于共享存在信息的方法，系统和产品。来自用户的存在通知，存在通知描述用户当前正在接收的内容。确定由用户接收的一个或多个内容项的流行度。提供电子节目指南，其包括关于一个或多个内容项目的信息以及与一个或多个内容项目相关联的所确定的流行度。

54. 发明申请

US20070244497A1 LAPAROSCOPIC SCISSOR BLADES 有权
标题翻译： LAPAROSCOPIC SCISSOR刀片
公开(公告)号：US20070244497A1
公开(公告)日：2007-10-18
申请号：US11735798
申请日：2007-04-16
申请人： Russell Ahlberg , Charles Hart , Steven Kessler
发明人： Russell Ahlberg , Charles Hart , Steven Kessler
IPC分类号： A61B17/3201
CPC分类号： A61B17/3201 , A61B17/320016 , B24B3/52 , B26B13/06 , B26B13/08
摘要： A laparoscopic scissor with a shaft for use through an access port, such as a trocar cannula, with one or more parabolic, cubic, quadratic or higher order cutting blades extending from the shaft is provided.
摘要翻译：提供了一种具有轴的腹腔镜剪刀，其通过诸如套管针套管的进入口使用，具有从轴延伸的一个或多个抛物线，立方，二次或更高次级的切割刀片。

55. 发明申请

US20070135781A1 DEVICE FOR ISOLATING AND REMOVING TISSUE FROM A BODY CAVITY 有权
标题翻译：用于从体腔分离和去除组织的装置
公开(公告)号：US20070135781A1
公开(公告)日：2007-06-14
申请号：US11549701
申请日：2006-10-16
申请人： Charles Hart
发明人： Charles Hart
IPC分类号： A61M1/00
CPC分类号： A61B17/00234 , A61B2017/00287
摘要： A tissue isolation and removal device has a containment pouch that is opened and supported by the device. The pouch has two open/close portions both able to be closed and reopened. One portion positioned away from tissue being inserted in the pouch and covering the other portion to enclose or isolate any tissue captured in the other portion.
摘要翻译：组织隔离和去除装置具有由装置打开和支撑的容纳袋。该袋具有两个打开/关闭部分，能够关闭并重新打开。位于远离组织的一部分被插入袋中并覆盖另一部分以包围或隔离在另一部分中捕获的任何组织。

56. 发明申请

US20070060507A1 GROWTH FACTOR HOMOLOG ZVEGF3 有权
标题翻译：生长因子HOMOLOG ZVEGF3
公开(公告)号：US20070060507A1
公开(公告)日：2007-03-15
申请号：US11552378
申请日：2006-10-24
申请人： Zeren Gao , Charles Hart , Christopher Piddington , Paul Sheppard , Kimberly Shoemaker
发明人： Zeren Gao , Charles Hart , Christopher Piddington , Paul Sheppard , Kimberly Shoemaker
IPC分类号： A61K38/18 , C07K14/475
CPC分类号： C07K14/52 , A01K2217/05 , A61K38/1858 , C07K14/475 , C12N2799/022
摘要： Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO:2 or residues 235-345 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译：公开了多肽生长因子，其制备方法，编码它们的多核苷酸，针对它们的抗体以及使用它们的方法。多肽包含与SEQ ID NO：2的残基46-163或SEQ ID NO：2的残基235-345至少90％相同的氨基酸区段。还公开了多肽的多聚体。多肽，多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节，作为细胞培养基的组分和诊断剂。

57. 发明申请

US20070009863A1 Off-highway vehicle trail map directory 审中-公开
标题翻译：非公路车辆轨迹图目录
公开(公告)号：US20070009863A1
公开(公告)日：2007-01-11
申请号：US10964955
申请日：2004-10-14
申请人： Alan Hart , Charles Hart
发明人： Alan Hart , Charles Hart
IPC分类号： G09B29/00
CPC分类号： G09B29/02 , G09B29/10
摘要： A trail map directory for off-highway vehicles is disclosed. The directory includes a binder having a plurality of individual map pages laminated for dry ease writing and for ease of cleaning. A mechanism is provided for releasably attaching each map page to the binder. A key map is positioned towards the front of the binder, and the key map is subdivided into individual regional map display portions corresponding to the individual map pages. Each map page is preferably a substantially flat, relatively stiff laminated panel. The panel has first and second faces located on opposite surfaces thereof, and first and second side edges which define the width dimension of the panel. Each panel first face includes an enlarged map display portion indexed relative to the key map and is in the form of an enhanced topographical map overlaid with off-road trails present within the map boundary. The trails are color-coded to indicate relative difficulty of use. The first face further includes trail symbols relative to the indicated off-road trails. Each second face includes an index to trail symbols appearing on the first face. The second face may also include GPS coordinates pertinent to the geographical points on the topographical map as well as driving directions to the off-road trails. Finally, an apparatus is disposed along each panel first side edge for releasably attaching the panel to the binder for removal for individual use.
摘要翻译：公开了一种用于非公路车辆的轨迹图目录。该目录包括具有多个单独的地图页面的粘合剂，用于干燥书写和易于清洁。提供了一种用于将每个地图页面可释放地附接到装订器的机构。关键地图朝向装订器的前部定位，并且将关键图细分成与各个地图页对应的各个区域地图显示部分。每个地图页面优选地是基本平坦的，相对较硬的层压板。面板具有位于其相对表面上的第一和第二面，以及限定面板的宽度尺寸的第一和第二侧边缘。每个面板第一面包括相对于键映射索引的放大地图显示部分，并且是以与地图边界内存在的越野轨迹重叠的增强的地形图的形式。路线是颜色编码的，表示使用相对困难。第一面还包括相对于指示的越野路线的轨迹符号。每个第二面包括一个索引，用于跟踪出现在第一面上的符号。第二面还可以包括与地形图上的地理点相关的GPS坐标以及到越野小径的驾驶方向。最后，沿着每个面板第一侧边缘设置一个装置，用于可释放地将面板连接到粘合剂上用于单独使用。

58. 发明申请

US20050159358A1 Growth factor homolog zvegf3 有权
标题翻译：生长因子同源物zvegf3
公开(公告)号：US20050159358A1
公开(公告)日：2005-07-21
申请号：US11021088
申请日：2004-12-22
申请人： Zeren Gao , Charles Hart , Christopher Piddington , Paul Sheppard , Kimberly Shoemaker , Debra Gilbertson , James West
发明人： Zeren Gao , Charles Hart , Christopher Piddington , Paul Sheppard , Kimberly Shoemaker , Debra Gilbertson , James West
IPC分类号： A61K38/00 , A61K38/18 , C07K14/475 , C07K14/52 , C07H21/04
CPC分类号： C07K14/52 , A01K2217/05 , A61K38/1858 , C07K14/475 , C12N2799/022
摘要： Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO:2 or residues 235-345 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译：公开了多肽生长因子，其制备方法，编码它们的多核苷酸，针对它们的抗体以及使用它们的方法。所述多肽包含与SEQ ID NO：2的残基46-163或SEQ ID NO：2的残基235-345至少90％相同的氨基酸区段。还公开了多肽的多聚体。多肽，多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节，作为细胞培养基的组分和诊断剂。

59. 发明申请

US20050149096A1 Catheter with conduit traversing tip 审中-公开
标题翻译：导管穿过导管
公开(公告)号：US20050149096A1
公开(公告)日：2005-07-07
申请号：US10745262
申请日：2003-12-23
申请人： Said Hilal , Matthew Petrime , Charles Hart
发明人： Said Hilal , Matthew Petrime , Charles Hart
IPC分类号： A61B17/00 , A61B17/02 , A61B17/34 , A61M25/00 , A61M25/01 , A61M29/00
CPC分类号： A61M25/0069 , A61B17/0218 , A61B17/3207 , A61B17/3478 , A61B2017/00473 , A61B2017/22094 , A61B2017/3454 , A61B2017/346 , A61M25/0068 , A61M25/01
摘要： A catheter facilitating traversal of restrictions in body conduits includes a shaft having a distal tip with a shape that is non-conical, radially twisted, and rectangular in radial cross section. An outer surface of the tip includes at least one side section extending from a blunt point radially outwardly with progressive positions proximally along an axis of the tip. The side section includes a proximal portion in proximity to the shaft, and a distal portion twisted radially with respect to the proximal portion. The catheter can be adapted for placement over a guidewire and can be made transparent thereby facilitating visualization through an endoscope in the catheter.
摘要翻译：促进身体管道中的限制的穿透的导管包括具有远侧末端的轴，其具有非圆锥形，径向扭曲并且具有径向横截面矩形的形状。尖端的外表面包括至少一个侧面部分，其从钝点径向向外延伸，并且沿着尖端的轴线向近侧延伸。侧部包括靠近轴的近侧部分和相对于近端部分径向扭转的远端部分。导管可以适于放置在导丝上并且可以制成透明的，从而便于通过导管中的内窥镜进行可视化。

60. 发明申请

US20050004543A1 Diaper design having zones of reduced stiffness and continuous breathability 有权
标题翻译：尿布设计具有刚度降低和连续透气性的区域
公开(公告)号：US20050004543A1
公开(公告)日：2005-01-06
申请号：US10612601
申请日：2003-07-01
申请人： Charles Schroer , Glenn Glasscock , Charles Hart , John Moody , Meredith Tharp , Jason Woodard
发明人： Charles Schroer , Glenn Glasscock , Charles Hart , John Moody , Meredith Tharp , Jason Woodard
IPC分类号： A61F13/15 , A61F13/20
CPC分类号： A61F13/514 , A61F13/49017 , A61F13/51474 , A61F13/515
摘要： The present invention relates to an absorbent article, such as a disposable diaper, comprising of a topsheet, barrier cuffs, an optional acquisition layer, an absorbent core, a barrier layer, and a backsheet. The diaper is arranged so as to create breathable zones of reduced stiffness surrounding the wearer's thighs. That is, the layers of material forming the diaper are arranged so the area surrounding the wearer's thighs includes only the backsheet, barrier cuffs and leg elastics. No liquid-impervious material is present within the breathable zones of reduced stiffness. Furthermore, these breathable zones of reduced stiffness preferably are formed so that only hydrophobic material is present. Thus, the present invention provides a better fitting, less irritating absorbent article by reducing the stiffness and increasing the breathability of the diaper in the area surrounding the wearer's thighs, resulting in increase comfort and fit around the wearer's thighs.
摘要翻译：本发明涉及一种吸收性物品，例如一次性尿布，其包括顶片，阻挡袖口，任选的收集层，吸收芯，阻挡层和底片。尿布布置成在穿着者的大腿周围形成具有降低的刚度的透气区域。也就是说，形成尿布的材料层被布置成使得围绕穿戴者大腿的区域仅包括底片，阻挡箍和腿部弹性件。透气性较差的区域内不存在液体不透液性物质。此外，优选地形成具有降低的刚性的这些透气区域，使得仅存在疏水性材料。因此，本发明通过降低尿布在穿着者大腿周围的区域的刚性和增加透气性来提供更好的适合性，较少刺激性的吸收制品，从而增加舒适性并适合佩戴者的大腿周围。

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