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51. 发明申请

US20070002342A1 Systems and methods for evaluating named colors against specified print engines 审中-公开
标题翻译：用于根据指定的打印引擎评估命名颜色的系统和方法
公开(公告)号：US20070002342A1
公开(公告)日：2007-01-04
申请号：US11168918
申请日：2005-06-29
申请人： Javier Morales , Michael Farrell
发明人： Javier Morales , Michael Farrell
IPC分类号： G03F3/08
CPC分类号： H04N1/6055 , H04N1/54
摘要： Systems and methods of evaluating colors may include a print job source that includes at least one print job, the print job including information of at least one named color. The systems and methods may also include a specified desired state determining device configured to determine a desired state in which the named color in the print job may be reproduced. The systems and methods may also include a desired named color appearance determining device configured to determine a desired named color appearance of the named color in the print job that may be reproduced in the desired state. The systems and methods may also include a specified output device to output the print job. The systems and methods may also include an actual named color appearance determining device configured to determine an actual named color appearance of the named color in the print job that may be reproduced by the output device. Further, the systems and methods may include a difference value determining device configured to determine a difference value between the desired named color appearance and the actual named color appearance of the named color in the print job.
摘要翻译：评估颜色的系统和方法可以包括包括至少一个打印作业的打印作业源，所述打印作业包括至少一个命名颜色的信息。系统和方法还可以包括被配置为确定可以再现打印作业中的命名颜色的期望状态的指定的期望状态确定装置。系统和方法还可以包括所需的命名颜色外观确定装置，其被配置为确定可以在期望状态下再现的打印作业中的命名颜色的期望的命名颜色外观。系统和方法还可以包括用于输出打印作业的指定输出设备。系统和方法还可以包括实际命名的颜色外观确定装置，其被配置为确定可由输出装置再现的打印作业中的命名颜色的实际命名颜色外观。此外，系统和方法可以包括差值确定装置，其被配置为确定期望的命名颜色外观与打印作业中命名颜色的实际命名颜色外观之间的差值。

52. 发明申请

US20060274354A1 Automated proofing for digital presses 有权
公开(公告)号：US20060274354A1
公开(公告)日：2006-12-07
申请号：US11142099
申请日：2005-06-01
申请人： Michael Farrell
发明人： Michael Farrell
IPC分类号： G06F3/12 , G06K15/00
CPC分类号： G06F3/1288 , G06F3/1208 , G06F3/1244 , G06F3/1256 , G06Q10/107
摘要： A method of automatic proofing a document submitted for printing on a press having a digital front end includes inputting the document into a raster image processor to produce a post-RIP file. A copy of the post-RIP file is saved as a proofing file in a proofing file storage location and notification is transmitted electronically to each approver that the proofing file is available for review. The computer system monitors the proof decision status of the proofing file. If the proof decision status indicates that the proofing file is approved, the computer system automatically releases the post-RIP file to print.

53. 发明申请

US20050173597A1 Pipe and cable support apparatus and method 审中-公开
标题翻译：管道和电缆支持设备和方法
公开(公告)号：US20050173597A1
公开(公告)日：2005-08-11
申请号：US10775119
申请日：2004-02-11
申请人： Michael Farrell , Mark Moore , Vance Patterson , Donald Thomas , Henry Yonce
发明人： Michael Farrell , Mark Moore , Vance Patterson , Donald Thomas , Henry Yonce
IPC分类号： F16L3/22 , F16L3/223
CPC分类号： F16L3/223 , F16L3/22 , F16L3/222
摘要： The present invention relates to a support block and a system for roof cooling. The support block supports a pipe above a structure, wherein the pipe has a cross sectional area and a diameter of predetermined dimensions, and the support block includes a number of outer surfaces each having an opening and a cavity. Each cavity has a cross sectional area larger than the cross sectional area of a pipe and the opening can be less than the diameter of the cavity cross sectional area or slightly less than the diameter of a pipe. Dovetail notches on the surfaces of the support block are present to attach the support block onto the roof. Adhesives can be used in the dovetail notches or an adaptor plate attached to the roof can be used to attach the support block to the adaptor plate. Alternatively, the support block can be used to assist in supporting and routing any type of conduit or cabling.
摘要翻译：本发明涉及一种用于屋顶冷却的支撑块和系统。支撑块支撑结构上方的管道，其中管道具有预定尺寸的横截面积和直径，并且支撑块包括多个外表面，每个外表面均具有开口和空腔。每个空腔的横截面面积大于管道的横截面面积，并且开口可以小于空腔横截面积的直径或略小于管道的直径。在支撑块的表面上存在燕尾切口以将支撑块附接到屋顶上。粘合剂可用于燕尾槽或连接到屋顶的适配板可用于将支撑块连接到适配器板上。或者，支撑块可用于辅助支撑和布置任何类型的导管或布线。

54. 发明授权

US08618265B2 Haptens, hapten conjugates, compositions thereof and method for their preparation and use 有权
标题翻译：半抗原，半抗原共轭物，其组合物及其制备和使用方法
公开(公告)号：US08618265B2
公开(公告)日：2013-12-31
申请号：US12660744
申请日：2010-03-02
申请人： Jerome W. Kosmeder , Mark Lefever , Donald Johnson , Michael Farrell , Zhanna Zhilina , Christopher Bieniarz
发明人： Jerome W. Kosmeder , Mark Lefever , Donald Johnson , Michael Farrell , Zhanna Zhilina , Christopher Bieniarz
IPC分类号： C07K16/00 , C07K1/13 , C07K1/04
CPC分类号： G01N33/5308 , C07D495/04 , C12Q1/6804 , C12Q1/6841 , C12Q1/6886 , G01N33/532 , G01N33/533 , G01N33/58 , G01N33/582 , G01N33/583 , Y10S435/961 , Y10S530/807
摘要： A method for performing a multiplexed diagnostic assay, such as for two or more different targets in a sample, is described. One embodiment comprised contacting the sample with two or more specific binding moieties that bind specifically to two or more different targets. The two or more specific binding moieties are conjugated to different haptens, and at least one of the haptens is an oxazole, a pyrazole, a thiazole, a nitroaryl compound other than dinitrophenyl, a benzofurazan, a triterpene, a urea, a thiourea, a rotenoid, a coumarin, a cyclolignan, a heterobiaryl, an azo aryl, or a benzodiazepine. The sample is contacted with two or more different anti-hapten antibodies that can be detected separately. The two or more different anti-hapten antibodies may be conjugated to different detectable labels.
摘要翻译：描述了用于执行多路诊断测定的方法，例如样品中两种或更多种不同靶标。一个实施方案包括使样品与特异性结合两个或更多个不同靶标的两个或多个特异性结合部分接触。两个或更多个特异性结合部分与不同的半抗原结合，并且至少一个半抗原是恶唑，吡唑，噻唑，除二硝基苯基以外的硝基芳基化合物，苯并呋咱，三萜，脲，硫脲，旋叶，香豆素，环链烷醇，杂二芳基，偶氮芳基或苯并二氮杂。将样品与两种或更多种可分别检测的不同的抗半抗原抗体接触。两种或更多种不同的抗半抗原抗体可以缀合到不同的可检测标记上。

55. 发明授权

US08329401B2 Enzyme-catalyzed metal deposition for the enhanced detection of analytes of interest 有权
标题翻译：酶催化的金属沉积用于增强感兴趣的分析物的检测
公开(公告)号：US08329401B2
公开(公告)日：2012-12-11
申请号：US12608261
申请日：2009-10-29
申请人： Christopher Bieniarz , Michael Farrell
发明人： Christopher Bieniarz , Michael Farrell
IPC分类号： C12Q1/68 , C12M1/00 , C12M1/34 , C12M3/00
CPC分类号： C07F9/093 , C07F9/65517 , C07F9/65522 , C07H15/20 , C07H15/24 , C07H15/26 , G01N33/581
摘要： The invention is directed to enhanced methods for detecting an analyte of interest in situ, by immunoassay, or by hybridization comprising binding an enzyme-labeled conjugate molecule to an analyte of interest in the presence of a redox-inactive reductive species and a soluble metal ion. The enzyme catalyzes the conversion of the inactive reductive species to an active reducing agent, which in turn reduces the metal ion to a metal atom thereby providing an enhanced means of detecting the analyte via metal deposition.
摘要翻译：本发明涉及通过免疫测定或通过杂交来检测目的分析物的增强方法，包括在氧化还原惰性还原物质和可溶性金属离子存在下将酶标记的缀合物分子与目的分析物结合。酶催化无活性还原物质转化为活性还原剂，其又将金属离子还原成金属原子，从而提供通过金属沉积检测分析物的增强方法。

56. 发明申请

US20120283141A1 ENZYME-CATALYZED METAL DEPOSITION FOR THE ENHANCED DETECTION OF ANALYTES OF INTEREST 有权
标题翻译：用于增强感兴趣分析者的酶催化金属沉积
公开(公告)号：US20120283141A1
公开(公告)日：2012-11-08
申请号：US13530001
申请日：2012-06-21
申请人： Christopher Bieniarz , Michael Farrell
发明人： Christopher Bieniarz , Michael Farrell
IPC分类号： G01N33/53 , C40B40/06
CPC分类号： C07F9/093 , C07F9/65517 , C07F9/65522 , C07H15/20 , C07H15/24 , C07H15/26 , G01N33/581
摘要： The invention is directed to enhanced methods for detecting an analyte of interest in situ, by immunoassay, or by hybridization comprising binding an enzyme-labeled conjugate molecule to an analyte of interest in the presence of a redox-inactive reductive species and a soluble metal ion. The enzyme catalyzes the conversion of the inactive reductive species to an active reducing agent, which in turn reduces the metal ion to a metal atom thereby providing an enhanced means of detecting the analyte via metal deposition.
摘要翻译：本发明涉及通过免疫测定或通过杂交来检测目的分析物的增强方法，包括在氧化还原惰性还原物质和可溶性金属离子存在下将酶标记的缀合物分子与目的分析物结合。酶催化无活性还原物质转化为活性还原剂，其又将金属离子还原成金属原子，从而提供通过金属沉积检测分析物的增强方法。

57. 发明授权

US07695929B2 Haptens, hapten conjugates, compositions thereof and method for their preparation and use 有权
公开(公告)号：US07695929B2
公开(公告)日：2010-04-13
申请号：US11982627
申请日：2007-11-01
申请人： Jerome W. Kosmeder , Mark Lefever , Donald Johnson , Michael Farrell , Zhanna Zhilina , Christopher Bieniarz
发明人： Jerome W. Kosmeder , Mark Lefever , Donald Johnson , Michael Farrell , Zhanna Zhilina , Christopher Bieniarz
IPC分类号： G01N33/53 , C07K16/00
CPC分类号： G01N33/5308 , C07D495/04 , C12Q1/6804 , C12Q1/6841 , C12Q1/6886 , G01N33/532 , G01N33/533 , G01N33/58 , G01N33/582 , G01N33/583 , Y10S435/961 , Y10S530/807
摘要： A method for performing a multiplexed diagnostic assay, such as for two or more different targets in a sample, is described. One embodiment comprised contacting the sample with two or more specific binding moieties that bind specifically to two or more different targets. The two or more specific binding moieties are conjugated to different haptens, and at least one of the haptens is an oxazole, a pyrazole, a thiazole, a nitroaryl compound other than dinitrophenyl, a benzofurazan, a triterpene, a urea, a thiourea, a rotenoid, a coumarin, a cyclolignan, a heterobiaryl, an azo aryl, or a benzodiazepine. The sample is contacted with two or more different anti-hapten antibodies that can be detected separately. The two or more different anti-hapten antibodies may be conjugated to different detectable labels.

58. 发明授权

US07682789B2 Method for quantifying biomolecules conjugated to a nanoparticle 有权
标题翻译：用于定量与纳米颗粒缀合的生物分子的方法
公开(公告)号：US07682789B2
公开(公告)日：2010-03-23
申请号：US11800360
申请日：2007-05-04
申请人： Xiao-Bo Chen , Christopher Bieniarz , Michael Farrell
发明人： Xiao-Bo Chen , Christopher Bieniarz , Michael Farrell
IPC分类号： C12Q1/68 , G01N33/53 , C07K14/00 , C07H21/00 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/37 , B82Y15/00 , G01N33/54313 , G01N33/582 , Y10T436/143333 , Y10T436/17 , Y10T436/25125
摘要： Disclosed embodiments concern quantifying a biomolecule conjugated to a nanoparticle. Quantifying typically comprises determining the number of biomolecules per nanoparticle. Any suitable biomolecule can be used, including but not limited to, amino acids, peptides, proteins, haptens, nucleic acids, oligonucleotides, DNA, RNA, and combinations thereof. A single type of biomolecule may be conjugated to the nanoparticle, more than one biomolecule of a particular class may be conjugated to the nanoparticle, or two or more classes of biomolecules may be conjugated to the nanoparticle. Certain disclosed embodiments comprise enzymatically or chemically digesting a biomolecule conjugated to the nanoparticle, or displacing a biomolecule using ligand-exchange chemistry. Where biomolecule concentrations are determined, any technique suitable for determining biomolecule concentration can be used, such as spectrophotometric techniques, including measuring tryptophan fluorescence and using a standard fluorescence intensity versus biomolecule concentration curve.
摘要翻译：公开的实施方案涉及量化与纳米颗粒缀合的生物分子。量化通常包括确定每个纳米颗粒的生物分子的数量。可以使用任何合适的生物分子，包括但不限于氨基酸，肽，蛋白质，半抗原，核酸，寡核苷酸，DNA，RNA及其组合。单一类型的生物分子可以与纳米颗粒结合，特定类别的多于一种生物分子可以与纳米颗粒缀合，或者两种或更多类别的生物分子可以与纳米颗粒缀合。某些公开的实施方案包括酶或化学消化与纳米颗粒缀合的生物分子，或使用配体交换化学位移生物分子。在确定生物分子浓度的情况下，可以使用适合于测定生物分子浓度的任何技术，例如分光光度技术，包括测量色氨酸荧光并使用标准荧光强度与生物分子浓度曲线。

59. 发明授权

US07541455B2 Microwave mediated synthesis of nucleic acid probes 有权
标题翻译：微波介导的核酸探针合成
公开(公告)号：US07541455B2
公开(公告)日：2009-06-02
申请号：US11018897
申请日：2004-12-21
申请人： Christopher Bieniarz , Michael Farrell , Jerome W. Kosmeder , Mark Lefever
发明人： Christopher Bieniarz , Michael Farrell , Jerome W. Kosmeder , Mark Lefever
IPC分类号： C07H21/02 , C07H21/04 , C12Q1/68
CPC分类号： C07H21/00 , B01J2219/00452 , B01J2219/00572 , B01J2219/00576 , B01J2219/00722 , C40B40/06
摘要： A method for preparing a nucleic acid probe is provided. The method comprises forming an activated cytosine or cytidine by a bisulfite catalyzed reaction; and covalently linking a reporter molecule to the activated cytosine or cytidine, wherein said activating step, said covalently linking step, or both are conducted in the presence of microwave energy. Also provided by the invention are nucleic acid probes.
摘要翻译：提供了制备核酸探针的方法。该方法包括通过亚硫酸氢盐催化反应形成活化的胞嘧啶或胞苷; 并将报告分子与活化的胞嘧啶或胞苷共价连接，其中所述活化步骤，所述共价连接步骤或两者均在微波能量存在下进行。本发明还提供了核酸探针。

60. 外观设计

USD585079S1 Refrigerator with knife rack 有权
标题翻译：带刀架的冰箱
公开(公告)号：USD585079S1
公开(公告)日：2009-01-20
申请号：US29278196
申请日：2007-03-21
申请人： Michael Farrell
设计人： Michael Farrell

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