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51. 发明专利

FR2558465A1 未知
公开(公告)号：FR2558465A1
公开(公告)日：1985-07-26
申请号：FR8500702
申请日：1985-01-18
申请人： EGYT GYOGYSZERVEGYESZETI GYAR
发明人： VAGO PAL , REITER JOZSEF , GORGENYI FRIGYES , FODOR TAMAS
IPC分类号： C07B61/00 , B01J23/00 , C07C67/00 , C07C231/00 , C07C231/12 , C07C233/00 , C07C237/30 , C07C237/32 , C07C103/29

52. 发明专利

IT1277348B1 未知
公开(公告)号：IT1277348B1
公开(公告)日：1997-11-10
申请号：ITMI951621
申请日：1995-07-26
申请人： EGYT GYOGYSZERVEGYESZETI GYAR
发明人： NAGY MARGIT NATA KRICSFALUSSY , FARSANG CSABA , FEDINA LIDIA , SZEMEREDI KATALIN , SZENASI GABOR , EGRI JANOS , MOSONYI ANTAL , BARTA BORBALA , TOTH GIZELLA NATA GYARMATI , NYARADI IBOLYA , GORGENYI FRIGYES , ORR ZSUZSA , FLORIS GEZA
IPC分类号： A61K9/08 , A61K9/00 , A61K9/12 , A61K31/045 , A61K31/047 , A61K31/23 , A61K31/231 , A61K31/44 , A61K31/4422 , A61K31/455 , A61K47/10 , A61K47/14 , A61P9/08 , A61P9/10 , A61P9/12 , A61P43/00
摘要： In the present invention there is disclosed a pharmaceutical preparation for reducing blood pressure. Being in the form of a spraying solution of nifedipine it contains 1 to 5 percent by weight nifedipine, 5 to 24 percent by weight Poly(ethylene glycol), 50 to 70 percent by weight ethanol, 10 to 30 percent by weight propylene glycol and 0.1 to O.5 percent by weight admixtures. In addition to usual nifedipine solutions it contains 2 to 4 percent by weight ethyl oleate based on the preparation total weight.

53. 发明专利

IT1251427B 未知
公开(公告)号：IT1251427B
公开(公告)日：1995-05-09
申请号：ITMI912837
申请日：1991-10-25
申请人： EGYT GYOGYSZERVEGYESZETI GYAR
发明人： HAJOS GYONGYI , HALASZ ANNA , PALLOS LASZLO , GORGENYI FRIGYES , SZARVAS TIBOR , GELENCSER EVA
IPC分类号： A23J3/04 , A23J3/10 , A23J3/34 , A23L1/305 , A61K38/00 , A61P3/00 , C07K1/107 , C12P21/02 , C12P21/06 , C12D

54. 发明专利

IT1240605B 未知
公开(公告)号：IT1240605B
公开(公告)日：1993-12-17
申请号：IT1967790
申请日：1990-03-14
申请人： EGYT GYOGYSZERVEGYESZETI GYAR
发明人： ERDOS SANDOR , KENDERFI JOZSEF , BARCZAY ERZESEBET , HEGEDUS ARANCA NATA SZIMA , KRISZTIAN MARIA , MANDI ATTILIA , TAJTHI EVA , TOME PETER , CSORGO MARGIT , FEKETE MARTON , GORGENYI FRIGYES , TORMA ZOLTAN
IPC分类号： A61K9/14 , A61K9/16 , A61K9/20 , A61K9/22 , A61K9/28 , A61K9/48 , A61K9/52 , A61K31/44 , A61K31/4422 , A61K31/455 , A61K47/10 , A61K47/32 , A61K47/38 , A61P9/08 , A61P9/10 , A61P9/12 , A61K
摘要： The present invention relates to a process for the preparation of regulated release solid pharmaceutical compositions comprising 4-(2'-nitro-phenyl)-2,6-dimethyl-3,5-dimethoxycarbonyl-1,4-dihydro-pyr idine (referred to further on as "nifedipine") as active ingredient which comprises admixing a solution or solutions of 1 part by weight of nifedipine, 0.1-1.5 parts by weight of one or more hydrophilizing agent(s) and 0.05-1.5 parts by weight of one or more retarding agent(s) formed with one or more identical or different solvent(s) completely or partly and applying the solution(s) thus obtained simultaneously or in succession onto an inert carrier, drying and sieving the product thus obtained and subsequently admixing the same with suitable conventional auxiliary agents and compressing the mixture thus obtained to tablets in a known manner and coating the tablets or filling the mixture into capsules.

55. 发明专利

AU642073B2 1,2,4-triazolo{1,5-a}pyrimidine 未知
公开(公告)号：AU642073B2
公开(公告)日：1993-10-07
申请号：AU1117592
申请日：1992-02-21
申请人： EGYT GYOGYSZERVEGYESZETI GYAR
发明人： REITER JOZSEF , BERECZ GABOR , ZSILA GIELLA , PETOCZ LUJZA , GIGLER GABOR , FEKETE MARTON , SZECSEY MARIA , SZIRT ENIKO , ROHACS LUDMILA , GORGENYI FRIGYES , CSORGO MARGIT
IPC分类号： A61K31/505 , A61K31/519 , A61P1/04 , A61P9/00 , A61P9/04 , A61P29/00 , A61P43/00 , C07D471/04 , C07D471/14 , C07D487/04 , C07D495/14 , A61K31/535
摘要： Compounds of formula wherein Q represents H or a heterocyclic group containing nitrogen and/or oxygen atoms, S(O)p - R3 wherein p is 0, 1 or 2 and R3 is optionally substitutes alkyl, alkenyl or phenylalky, or optionally substitute phenyl, or a group wherein R4 and R5 represent hydrogen, alkyl, alkenyl, phenylalkyl or di-(alkyl)-aminoalkyl, R1 and R2 represent hydrogen or alkyl or R1 and R2 together form a group wherein Y stands for a CH2 group, sulfur or a group of the formula in which R6 denotes hydrogen or phenylalkyl, n and m is 0-5 and Z represents a group in which R7 and R8 represent hydrogen, alkyl, optionally carrying hydroxy, carboxy, amino, morpholinocarbonyl, [4-(2'-{hydroxy}-ethyl)-piperazin-1'-yl]-carbonyl and/or alkoxycarbonyl or optionally carrying a heterocyclic group containing nitrogen and/or oxygen atoms alkenyl, cycloalkyl, adamantyl or phenylalkyl, alkylaminoalkyl and di-(alkyl)-aminoalkyl; or R7 and R8 form a group in which j and k represent 1, 2 or 3 and W stands for oxygen, a a or a group of the formula in which R10 denotes hydrogen, alkoxycarbonyl oroptionally substituted alkyl, or stands for a group of the formula - S - R9 wherein R9 represents alkyl, optionally substituted by an alkoxycarbonyl-group.

56. 发明专利

AU1117592A 5-(SUBSTITUTED AMINO)-1,2,4-TRIAZOLO{1,5-A}PYRIMIDINE DERIVATIVES 未知
公开(公告)号：AU1117592A
公开(公告)日：1992-08-27
申请号：AU1117592
申请日：1992-02-21
申请人： EGYT GYOGYSZERVEGYESZETI GYAR
发明人： REITER JOZSEF , BERECZ GABOR , ZSILA GIELLA , PETOCZ LUJZA , GIGLER GABOR , FEKETE MARTON , SZECSEY MARIA , SZIRT ENIKO , ROHACS LUDMILA , GORGENYI FRIGYES , CSORGO MARGIT
IPC分类号： A61K31/505 , A61K31/519 , A61P1/04 , A61P9/00 , A61P9/04 , A61P29/00 , A61P43/00 , C07D471/04 , C07D471/14 , C07D487/04 , C07D495/14 , A61K31/535
摘要： Compounds of formula wherein Q represents H or a heterocyclic group containing nitrogen and/or oxygen atoms, S(O)p - R3 wherein p is 0, 1 or 2 and R3 is optionally substitutes alkyl, alkenyl or phenylalky, or optionally substitute phenyl, or a group wherein R4 and R5 represent hydrogen, alkyl, alkenyl, phenylalkyl or di-(alkyl)-aminoalkyl, R1 and R2 represent hydrogen or alkyl or R1 and R2 together form a group wherein Y stands for a CH2 group, sulfur or a group of the formula in which R6 denotes hydrogen or phenylalkyl, n and m is 0-5 and Z represents a group in which R7 and R8 represent hydrogen, alkyl, optionally carrying hydroxy, carboxy, amino, morpholinocarbonyl, [4-(2'-{hydroxy}-ethyl)-piperazin-1'-yl]-carbonyl and/or alkoxycarbonyl or optionally carrying a heterocyclic group containing nitrogen and/or oxygen atoms alkenyl, cycloalkyl, adamantyl or phenylalkyl, alkylaminoalkyl and di-(alkyl)-aminoalkyl; or R7 and R8 form a group in which j and k represent 1, 2 or 3 and W stands for oxygen, a a or a group of the formula in which R10 denotes hydrogen, alkoxycarbonyl oroptionally substituted alkyl, or stands for a group of the formula - S - R9 wherein R9 represents alkyl, optionally substituted by an alkoxycarbonyl-group.

57. 发明专利

CA2061629A1 5-(SUBSTITUTED AMINO)-1,2,4- TRIAZOLO[1,5-A]PYRIMIDINE DERIVATIVES 未知
公开(公告)号：CA2061629A1
公开(公告)日：1992-08-23
申请号：CA2061629
申请日：1992-02-21
申请人： EGYT GYOGYSZERVEGYESZETI GYAR
发明人： REITER JOZSEF , BERECZ GABOR , ZSILA GIELLA , PETOCZ LUJZA , GIGLER GABOR , FEKETE MARTON , SZECSEY MARIA , SZIRT ENIKO , ROHACS LUDMILA , GORGENYI FRIGYES , CSORGO MARGIT
IPC分类号： A61K31/505 , A61K31/519 , A61P1/04 , A61P9/00 , A61P9/04 , A61P29/00 , A61P43/00 , C07D471/04 , C07D471/14 , C07D487/04 , C07D495/14 , C07D487/14 , A61K31/535
摘要： 5-(SUBSTITUTED AMINO)-1, 2, 4-TRIAZOLO¢1,5-a!PYRIMIDINE DERIVATIVES A b s t r a c t The invention relates to new 5-(substituted amino) -1,2,4-triazolo¢1,5-3!pyrimidine derivatives and a process for the preparation thereof. The invention also relates to pharmaceutical compositions comprising the said compounds and to the use thereof for the treatment of diseases. The 5-(substituted amino)-1,2,4-triazolo¢1,5-a!-pyrimidines according to the invention correspond to the general Formula (I), (I) wherein Q represents hydrogen or a 6-membered heterocyclic group containing one or more nitrogen and/or oxygen atom(s) optionally carrying a C1-4 alkyl substituent, or a group of the Formula S(O)pR3, wherein p stands for 0, 1 or 2, and R3 denotes straight or branched chained C1-8 alkyl, C2-6 alkenyl or phenyl-(C1-4 alkyl), which latter may optionally carry one or more halogen or nitro substituent(s), or phenyl optionally substituted by one or more nitro or trifluoromethyl; or a group of the Formula NR4R5, wherein R4 and R5 each represent hydrogen, straight or branched C1-12 alkyl, C2-6 alkenyl, phenyl-(C1-4 alkyl) or di-(C1-4 alkyl)-amino-(C1-6 alkyl); R1 and R2 each represent hydrogen or straight or branched chained C1-4 alkyl, or R1 and R2 together form a group of the Formula (CH2)n-Y-(CH2)m, wherein Y stands for a CH2 group, a sulfur atom or a group of the Formula NR6, wherein R6 denotes phenyl-(C1-4 alkyl), n and m each represent 0, 1, 2, 3, 4 or 5; Z stands for a group of the Formula NR7R8, wherein R7 and R8 each represent hydrogen, C2-6 alkenyl, C3-8 cycloalkyl, adamantyl or phenyl-(C1-4 alkyl), which latter may optionally carry one or more substituent(s) selected from the group consisting of halogen, hydroxy, C1-4 alkyl, C1-4 alkoxy, amino and nitro; (C1-4 alkyl)-amino-(C1-6 alkyl), di-(C1-4 alkyl)-amino-(C1-6 alkyl) or C1-6 alkyl, which latter may optionally be substituted by a hydroxy, amino, carboxy, morpholinocarbonyl, ¢4-(2-hydroxy-ethyl)-piperazin-1-yl!-carbonyl, (C1-4 alkoxy)-car-bonyl or a 5- or 6-membered saturated or unsaturated heterocyclic group containing one or more nitrogen and/or oxygen atom(s) and being optionally condensed with a benzene ring; or R7 and R8 together form a group of the Formula (CH2)j-W-(CH2)k , wherein j and k each represent 1, 2 or 3, and W stands for oxygen or a CH2 or CHOH group or a group of the Formula NR10, wherein R10 denotes hydrogen, C1-4 alkoxycarbonyl or C1-4 alkyl, which latter may optionally carry a substituent selected from the group consisting of hydroxy or phenyl; or a group of the Formula SR9, wherein R9 stands for C1-4 alkyl substituted by a (C1-4 alkoxy)-carbonyl group, with the proviso that if Q represents hydrogen or a group of the Formula S(O)pR3, R1 and R2 are other than hydrogen or C1-4 alkyl, and possess valuable positive inotropic and antianginal effects which are complemented by acute antiinflammatory, ulcus and gastric acid secretion inhibiting, furthermore by weaker tranquillant, spasmolytic and analgesic properties.

59. 发明专利

FR2597343B1 未知
公开(公告)号：FR2597343B1
公开(公告)日：1991-11-29
申请号：FR8705504
申请日：1987-04-17
申请人： EGYT GYOGYSZERVEGYESZETI GYAR
发明人： SEBESTYEN GYULA , SIMONYI ISTVAN , MIHOLICS GIZELLA , KOVACS MARTA , GORGENYI FRIGYES , FEKETE MARTON , VAGO PAL , SERES ISTVAN , EGRI JANOS , SZELI-NEE-SEGER MARIA
IPC分类号： A61K31/555 , A61P31/04 , A61P31/10 , C07D215/30 , A61K33/30 , C07F3/06
摘要： The invention refers to a novel pharmaceutical composition having especially antimycotic activity and comprising the zinc complex of 5-chloro-7-iodo-8-hydroxyquinoline of formula (I) (I) and one or more pharmaceutically acceptable carriers. The pharmaceutical composition of the invention can be used for the effective treatment of mycotic infections on the skin surface, mucous membranes or nails. The complex of formula (I) is prepared by reacting a solution of an alkali metal salt of 5-chloro-7-iodo-8-hydroxyquinoline with a solution containing an excess of an inorganic or organic zinc salt or a zinc complex having a lower stability constant than that of the complex of formula (I) and separating the product precipitated.

60. 发明专利

ES2019826A6 PROCEDIMIENTO DE PREPARACION DE DERIVADOS QUINAZOLINOS. 未知
公开(公告)号：ES2019826A6
公开(公告)日：1991-07-01
申请号：ES9001130
申请日：1990-04-20
申请人： EGYT GYOGYSZERVEGYESZETI GYAR
发明人： REITER JOSEF , PONGO LASZLO , GORGENYI FRIGYES , FEKETE MARTON , CSORGO MARGIT , SZTUHAR ILONA
IPC分类号： A61K31/505 , A61K31/517 , A61P9/12 , B01J27/14 , C07D307/24 , C07D405/06 , C07D405/12
摘要： PROCEDIMIENTO DE PREPARACION DE DERIVADOS QUINAZOLINOS. LA INVENCION SE RELACIONA CON UN PROCEDIMIENTO DE PREPARACION DE DERIVADOS QUINAZOLINOS DE FORMULA GENERAL I, EN LA QUE RBS1 Y RBS2 PUEDEN SER IGUALES O DIFERENTES Y REPRESENTAN HIDROGENO O ALQUILO INFERIOR, O FORMAN CONJUNTAMENTE UN GRUPO ETILENO O TRIMETILENO, Y N ES 2 O 3, CARACTERIZADO POR LA REACCION DE UN DERIVADO 1,2 DIMETOXI FENIL 4 ISOTIOUREA, CON UN DERIVADO DIAMINCARBOXIFURANO, EVENTUALMENTE SUSTITUIDOS, Y POSTERIOR CICLACION, TERMICA O CATALITICA, DEL COMPUESTO ASI OBTENIDO. LA INVENCION SE RELACIONA ASIMISMO, CON LA PREPARACION DE LOS COMPUESTOS INTERMEDIOS DE REACCION. LOS COMPUESTOS OBJETO DE ESTA INVENCION TIENEN INTERESANTES PROPIEDADES FARMACEUTICAS COMO ANTIHIPERTENSIVOS Y BLOQUEADORES DE SI1 RECEPTORES.

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