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51. 发明授权

US09403882B2 Sulfation of Wnt pathway proteins 有权
公开(公告)号：US09403882B2
公开(公告)日：2016-08-02
申请号：US13170634
申请日：2011-06-28
申请人： Joshua Rabbani , James J. Donegan , Xiaofeng Li
发明人： Joshua Rabbani , James J. Donegan , Xiaofeng Li
IPC分类号： A61K38/10 , C07K14/47 , C07K14/51 , C07K14/705 , C07K14/71
CPC分类号： A61K38/1709 , A61K38/08 , A61K38/10 , C07K14/47 , C07K14/51 , C07K14/705 , C07K14/71
摘要： Provided is a composition comprising a peptide comprising amino acids and/or amino acid analogs comprising a continuous sequence of a sclerostin fragment comprising Tyr43 or Tyr213. Also provided is a composition comprising a peptide comprising less than about 75 amino acids and/or amino acid analogs including an amino acid or amino acid analog capable of being sulfated, where the composition is capable of inhibiting sclerostin binding to an LRP. Further provided is a composition comprising a peptide comprising less than about 75 amino acids and/or amino acid analogs including an amino acid or amino acid analog capable of being post-translationally sulfated, where the composition is capable of inhibiting binding of a protein ligand comprising a sulfation site to its binding partner. Additionally provided is a method of enhancing a Wnt signaling pathway comprising contacting an LRP5/6 receptor in the Wnt signaling pathway with either of the above-described compositions that comprise a sequence of a sclerostin fragment or is capable of inhibiting sclerostin binding to an LRP, where the tyrosine or tyrosine analog is not sulfated, in a manner sufficient to enhance the Wnt signaling pathway. Further provided is a method of treating a subject having a disease exacerbated by inhibition of a Wnt signaling pathway comprising administering either of the above-described compositions that comprise a sequence of a sclerostin fragment or is capable of inhibiting sclerostin binding to an LRP, where the tyrosine or tyrosine analog is not sulfated, to the subject in a manner sufficient to reduce the inhibition of the Wnt signaling pathway. Also, a method of inhibiting binding of a protein ligand comprising a sulfation site to its binding partner is provided. The method comprises adding the above-described composition that is capable of inhibiting binding of a protein ligand to its binding partner to the protein ligand and its binding partner in a manner sufficient to inhibit binding of the protein ligand to its binding partner.

52. 外观设计

USD760423S1 Electronic pillar candle 有权
公开(公告)号：USD760423S1
公开(公告)日：2016-06-28
申请号：US29493982
申请日：2014-06-16
申请人： Xiaofeng Li
设计人： Xiaofeng Li

53. 外观设计

USD760422S1 Electronic pillar candle 有权
标题翻译：电子支柱蜡烛
公开(公告)号：USD760422S1
公开(公告)日：2016-06-28
申请号：US29493977
申请日：2014-06-16
申请人： Xiaofeng Li
设计人： Xiaofeng Li

54. 发明申请

US20150369431A1 ELECTRIC CANDLE WITH ILLUMINATING PANEL 审中-公开
标题翻译：带有照明面板的电动手柄
公开(公告)号：US20150369431A1
公开(公告)日：2015-12-24
申请号：US14449865
申请日：2014-08-01
申请人： Xiaofeng Li
发明人： Xiaofeng Li
IPC分类号： F21S6/00 , F21V23/04 , H05B33/08 , F21S10/04
CPC分类号： F21S6/001 , F21K9/232 , F21S9/02 , F21S10/046 , F21V23/04 , F21W2121/00 , F21Y2101/00 , F21Y2105/16 , F21Y2113/13 , F21Y2115/10 , H05B33/0803 , H05B33/0815 , H05B33/0842 , H05B33/0857
摘要： The present disclosure, in one embodiment, relates to an electric flameless candle, comprising a body configured in shape and size to simulate a true flame candle. The electric flameless candle further comprising a light source operably connected to the body and positioned to be generally protruding from an exterior surface of the body, the light source comprising a plurality of illuminators electrically operated to illuminate in a way that simulates the movement of a real candle's flame.
摘要翻译：在一个实施例中，本公开涉及一种电动无焰蜡烛，其包括被配置成模拟真实火焰蜡烛的形状和尺寸的主体。电动无焰蜡烛还包括光源，其可操作地连接到主体并且定位成大致从主体的外表面突出，光源包括多个照明器，电子操作以照亮模拟真实的移动的方式蜡烛的火焰

55. 外观设计

USD744128S1 Electronic taper candle having a flame-shaped element illuminated on two sides thereof 有权
标题翻译：具有在其两侧照亮的火焰状元件的电子锥形蜡烛
公开(公告)号：USD744128S1
公开(公告)日：2015-11-24
申请号：US29493990
申请日：2014-06-16
申请人： Xiaofeng Li
设计人： Xiaofeng Li

56. 发明授权

US09046537B2 Method for treating inflammation by administering a compound which binds LDL-receptor-related protein (LRP) ligand binding domain 有权
标题翻译：通过施用结合LDL-受体相关蛋白（LRP）配体结合结构域的化合物来治疗炎症的方法
公开(公告)号：US09046537B2
公开(公告)日：2015-06-02
申请号：US12221863
申请日：2008-08-07
申请人： Elazar Rabbani , Xiaofeng Li , Dakai Liu , Yazhou Zhang , Richard Jin , Riddhi Bhattacharyya , Wei Cheng , James J. Donegan
发明人： Elazar Rabbani , Xiaofeng Li , Dakai Liu , Yazhou Zhang , Richard Jin , Riddhi Bhattacharyya , Wei Cheng , James J. Donegan
IPC分类号： A01N43/00 , A61K31/33 , A01N61/00 , A61K31/00 , A61K31/535 , A01N43/02 , A61K31/335 , A01N43/16 , A61K31/35 , G01N33/92 , A61K31/015 , A61K31/395 , G01N33/50 , G01N33/564 , A61K38/00
CPC分类号： A61K31/538 , A61K31/015 , A61K31/185 , A61K31/192 , A61K31/235 , A61K31/395 , A61K31/535 , A61K38/00 , G01N33/5011 , G01N33/5041 , G01N33/564 , G01N33/92 , G01N2333/705 , G01N2800/24
摘要： The present invention relates to the field of therapeutic methods, compositions and uses thereof, that affect, directly or indirectly, the behavior of LRP receptors. These compositions and methods result in the treatment of inflammatory, immunological and metabolic conditions. More particularly, the methods and compositions of the invention are directed to the identification of small molecules, drugs and/or pharmacological agents that affect the Wnt pathway by affecting normal complex formation among various signaling receptors, the LRP5 and LRP6 receptor, and related ligands.
摘要翻译：本发明涉及直接或间接影响LRP受体的行为的治疗方法，组合物和用途领域。这些组合物和方法导致治疗炎症，免疫和代谢疾病。更具体地，本发明的方法和组合物涉及通过影响各种信号传导受体（LRP5和LRP6受体）和相关配体之间的正常复合物形成来鉴定影响Wnt途径的小分子，药物和/或药理学试剂。

57. 发明申请

US20150078007A1 ELECTRONIC FLAMELESS CANDLE 审中-公开
标题翻译：电子无焰蜡烛
公开(公告)号：US20150078007A1
公开(公告)日：2015-03-19
申请号：US14552786
申请日：2014-11-25
申请人： Xiaofeng Li
发明人： Xiaofeng Li
IPC分类号： F21S10/04 , F21V23/04 , F21S6/00
CPC分类号： F21S10/04 , A61L9/03 , A61L9/12 , A61L9/127 , A61L2209/111 , A61L2209/12 , A61L2209/133 , F21S6/001 , F21S9/02 , F21V23/04 , F21V23/0442 , F21V33/004 , F21W2121/00 , F21Y2115/10 , H05B33/0845 , H05B37/0272 , H05B37/0281
摘要： An electronic flameless candle including a body having a top surface, a bottom surface, a sidewall between the top surface and the bottom surface, and a cavity defined by the top surface, the bottom surface and the sidewall, the body configured in shape and size to simulate a true flame candle. The candle may also include a light source operably connected to the body, the light source electrically operated to illuminate in a way that simulates a natural flicker of a real candle flame. The candle may also include a scent component, operably connected to the body, the scent component configured to emit a scent when heated and/or a sensor component, operably connected to the body, the sensor component configured to sense an environmental condition and affect a mode of the light source upon the sensing of the environmental condition.
摘要翻译：一种电子无焰蜡烛，包括具有顶表面，底表面，顶表面和底表面之间的侧壁的本体，以及由顶表面，底表面和侧壁限定的腔体，其形状和尺寸模拟真正的火焰蜡烛。蜡烛还可以包括可操作地连接到身体的光源，光源电动操作以照射模拟真实烛火焰的自然闪烁的方式。蜡烛还可以包括可操作地连接到身体的香味组分，被配置为在加热时发出气味的气味组分和/或可操作地连接到身体的传感器组件，传感器组件被配置成感测环境状况并影响在感测环境条件时光源的模式。

58. 发明授权

US08637546B2 Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DDP-IV) 失效
标题翻译：作为二肽基肽酶-IV（DDP-IV）抑制剂的药物组合物
公开(公告)号：US08637546B2
公开(公告)日：2014-01-28
申请号：US13437999
申请日：2012-04-03
申请人： David J. Madar , Stevan W. Djuric , Melissa J. Michmerhuizen , Hana A. Kopecka , Xiaofeng Li , Kenton L. Longenecker , Zhonghua Pei , Daisy Pireh , Hing L. Sham , Kent D. Stewart , Bruce G. Szczepankiewicz , Paul E. Wiedeman , Hong Yong
发明人： David J. Madar , Stevan W. Djuric , Melissa J. Michmerhuizen , Hana A. Kopecka , Xiaofeng Li , Kenton L. Longenecker , Zhonghua Pei , Daisy Pireh , Hing L. Sham , Kent D. Stewart , Bruce G. Szczepankiewicz , Paul E. Wiedeman , Hong Yong
IPC分类号： A61K31/445 , C07D295/00
CPC分类号： C07D207/27 , C07D207/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
摘要： The present invention relates to compounds which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.
摘要翻译：本发明涉及抑制二肽基肽酶IV（DPP-IV）的化合物，其可用于预防或治疗糖尿病，特别是II型糖尿病，以及高血糖症，X综合征，高胰岛素血症，肥胖，动脉粥样硬化和各种免疫调节疾病。

59. 外观设计

USD658655S1 Keyboard 有权
公开(公告)号：USD658655S1
公开(公告)日：2012-05-01
申请号：US29391783
申请日：2011-05-12
申请人： Shannon Tyler Moore , Donald Somerset McKenzie , Kevin Roy Sugden , Chao Chen , Xiaofeng Li
设计人： Shannon Tyler Moore , Donald Somerset McKenzie , Kevin Roy Sugden , Chao Chen , Xiaofeng Li

60. 发明申请

US20100041599A1 Compositions and methods for bone formation, bone remodeling and toxin protection 审中-公开
标题翻译：用于骨形成，骨重建和毒素保护的组合物和方法
公开(公告)号：US20100041599A1
公开(公告)日：2010-02-18
申请号：US12228757
申请日：2008-08-15
申请人： Dakai Liu , Richard Jin , Xiaofeng Li , Yazhou Zhang , Wei Cheng , Riddhi Bhattacharyya
发明人： Dakai Liu , Richard Jin , Xiaofeng Li , Yazhou Zhang , Wei Cheng , Riddhi Bhattacharyya
IPC分类号： A61K38/22 , C12Q1/68 , A61P19/08
CPC分类号： A61K31/538 , G01N33/5041 , G01N33/6803 , G01N2333/51
摘要： The present invention identifies compounds that disrupt the interaction between anthrax proteins and LRP5/6 receptors, resulting in a reduction in anthrax toxicity. The compounds act to disrupt the intracellular transport of toxin complexes into a target cell. The present invention also provides methods for testing the effect of compounds on Wnt activity, through the use of in vitro experiments involving cells that have in at least one gene mutation involved in the Wnt pathway.
摘要翻译：本发明鉴定了破坏炭疽蛋白与LRP5 / 6受体之间相互作用的化合物，导致炭疽毒性降低。这些化合物起着破坏细胞内毒素复合物进入靶细胞的作用。本发明还提供了通过使用涉及在Wnt途径中涉及至少一个基因突变的细胞的体外实验来测试化合物对Wnt活性的影响的方法。

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