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51. 发明申请

US20110085165A1 System and Method for Combined Raman and LIBS Detection 有权
标题翻译：用于组合拉曼和LIBS检测的系统和方法
公开(公告)号：US20110085165A1
公开(公告)日：2011-04-14
申请号：US12899055
申请日：2010-10-06
申请人： Jeff Beckstead , Matthew Nelson , Patrick Treado
发明人： Jeff Beckstead , Matthew Nelson , Patrick Treado
IPC分类号： G01J3/44
CPC分类号： G01J3/02 , G01J3/0218 , G01J3/0272 , G01J3/10 , G01J3/28 , G01J3/36 , G01J3/44 , G01J3/443 , G01N21/65 , G01N21/718 , G01N2201/0221 , G01N2201/06113 , G01N2201/0833 , G01N2201/0846
摘要： A system and method for detection and identification of unknown samples using a combination of Raman and LIBS detection techniques. A first region of a sample and a second region of a sample are illuminated using structured illumination to thereby generate a first plurality of interacted photons and a second plurality of interacted photons. This first plurality and second plurality of interacted photons may be passed through a fiber array spectral translator device. Said first plurality of interacted photons are assessed using Raman spectroscopy to thereby generate a Raman data set. Said second plurality of interacted photons are assessed using LIBS spectroscopy to thereby generate LIBS data set. These data sets may be analyzed to identify the sample. These data sets may also be fused for further analysis.
摘要翻译：一种使用拉曼和LIBS检测技术的组合检测和识别未知样品的系统和方法。使用结构照明来照射样品的第一区域和样品的第二区域，从而产生第一多个相互作用的光子和第二多个相互作用的光子。该第一多个和第二多个相互作用的光子可以通过光纤阵列光谱转换器装置。使用拉曼光谱来评估所述第一多个相互作用的光子，从而产生拉曼数据集。使用LIBS光谱来评估所述第二多个相互作用的光子，从而生成LIBS数据集。可以分析这些数据集以识别样品。这些数据集也可以融合进一步分析。

52. 发明申请

US20110085164A1 METHOD AND APPARATUS FOR AUTOMATED SPECTRAL CALIBRATION 有权
标题翻译：自动光谱校准的方法和装置
公开(公告)号：US20110085164A1
公开(公告)日：2011-04-14
申请号：US12897376
申请日：2010-10-04
申请人： Matthew Nelson , Patrick Treado
发明人： Matthew Nelson , Patrick Treado
IPC分类号： G01J3/00 , G01J3/44 , G01J3/42 , G01J3/40
CPC分类号： A61B5/0059 , A61B2560/0223 , G01J3/28 , G01J3/42
摘要： A method and apparatus for automated spectral calibration of a spectroscopy device. A method for simultaneous calibration and spectral imaging of a sample by: simultaneously illuminating the sample and a calibrant with a plurality of illuminating photons; receiving, at the spectrometer, a first plurality of photons collected from the sample and a second plurality of photons collected from the calibrant; forming a calibrant spectrum from the first plurality of collected photons and a sample spectrum from the second plurality of collected photons; comparing the calibrant spectrum with a reference spectrum of the calibrant to determine a wavelength-shift in the calibrant spectrum; applying the wavelength-shift to the sample spectrum to obtain a calibrated sample spectrum.
摘要翻译：一种用于光谱装置的自动光谱校准的方法和装置。一种通过以下步骤同时校准和光谱成像的方法：同时用多个照明光子照射样品和校准物; 在光谱仪处接收从样品收集的第一组多个光子和从校准物收集的第二组多个光子; 从所述第一多个收集的光子形成校准谱，以及来自所述第二多个收集的光子的样品光谱; 将校准谱与校准物的参考光谱进行比较，以确定校准谱中的波长漂移; 将波长偏移应用于样本光谱以获得校准的样本光谱。

53. 发明申请

US20110012916A1 System and method for component discrimination enhancement based on multispectral addition imaging 有权
标题翻译：基于多光谱加法成像的组件鉴别增强的系统和方法
公开(公告)号：US20110012916A1
公开(公告)日：2011-01-20
申请号：US12799779
申请日：2010-04-30
申请人： Matthew Nelson , Patrick Treado , Charles W. Gardner, JR.
发明人： Matthew Nelson , Patrick Treado , Charles W. Gardner, JR.
IPC分类号： G09G5/02
CPC分类号： G01J3/02 , G01J3/0224 , G01J3/32 , G01J3/44 , G01N21/314 , G01N21/33 , G01N21/35 , G01N21/3581 , G01N21/359 , G01N21/65 , G02B21/16 , G02B21/361
摘要： A system and method for performing multispectral color addition imaging. An optical image is obtained for a sample scene comprising one or more target materials. Spectroscopic data is obtained for one or more target materials. A first and second waveband of interest are obtained for one or more target materials. A ratio of the first and second wavebands of interest is obtained and compared to one or more ranges of threshold values. Based on this comparison, a result is displayed wherein this result comprises a pseudo color overlay on said optical image. The pseudo color image may comprise one or more pseudo colors assigned to one or more target materials so as to differentiate and identify the target materials present in the sample scene.
摘要翻译：用于执行多光谱彩色加成成像的系统和方法。获得包含一个或多个目标材料的样本场景的光学图像。获得一种或多种目标材料的光谱数据。获得针对一种或多种目标材料的第一和第二感兴趣波段。获得感兴趣的第一和第二波段的比率并将其与一个或多个阈值范围进行比较。基于该比较，显示结果，其中该结果包括所述光学图像上的伪颜色覆盖。伪彩色图像可以包括分配给一个或多个目标材料的一种或多种伪颜色，以便区分和识别存在于样本场景中的目标材料。

54. 发明申请

US20100225899A1 Chemical Imaging Explosives (CHIMED) Optical Sensor using SWIR 有权
标题翻译：化学成像炸药（CHIMED）使用SWIR的光学传感器
公开(公告)号：US20100225899A1
公开(公告)日：2010-09-09
申请号：US12754229
申请日：2010-04-05
申请人： Patrick Treado , Matthew Nelson , Charles W. Gardner, JR.
发明人： Patrick Treado , Matthew Nelson , Charles W. Gardner, JR.
IPC分类号： G01N21/00
CPC分类号： G01J3/02 , G01J3/0218 , G01J3/44 , G01N21/3563 , G01N21/359 , G01N33/0057
摘要： A sample is illuminated to thereby generate a plurality of first interacted photons selected. The first interacted photons are assessed using a visible imaging device to thereby determine an area of interest in the sample. The area of interest is illuminated to thereby generate a plurality of second interacted photons. The second interacted photons are assessed using a spectroscopic device to thereby generate a SWIR data set representative of said area of interest. A database is searched wherein said database comprises a plurality of known SWIR data sets associated with an explosive material. The data sets comprise at least one of: a plurality of SWIR spectra and a plurality of spatially accurate wavelength resolved SWIR images. An explosive material in the area of interest is thereby identified as a result of the search.
摘要翻译：照射样品从而产生选择的多个第一相互作用的光子。使用可见成像装置评估第一相互作用的光子，从而确定样品中的感兴趣区域。感兴趣的区域被照亮，从而产生多个第二相互作用的光子。使用光谱装置评估第二相互作用的光子，从而产生表示所述感兴趣区域的SWIR数据集。搜索数据库，其中所述数据库包括与爆炸物质相关联的多个已知的已知SWIR数据集。数据组包括多个SWIR光谱和多个空间准确的波长分辨的SWIR图像中的至少一个。因此，在感兴趣区域中的爆炸性材料被确定为搜索的结果。

55. 发明授权

US07522797B2 Method and apparatus for fiberscope 有权
标题翻译：纤维镜的方法和装置
公开(公告)号：US07522797B2
公开(公告)日：2009-04-21
申请号：US11798483
申请日：2007-05-14
申请人： Patrick Treado , Matthew Nelson , Joseph Demuth
发明人： Patrick Treado , Matthew Nelson , Joseph Demuth
IPC分类号： G02B6/06 , G01J3/44 , A61B1/06
CPC分类号： A61B1/00165 , A61B1/043 , A61B1/07 , A61B5/0075 , A61B5/0084 , G01J3/02 , G01J3/021 , G01J3/0218 , G01J3/0256 , G01J3/0264 , G01J3/0291 , G01J3/32 , G01J3/44 , G01J2003/1213 , G01N21/33 , G01N21/359 , G01N21/474 , G01N21/645 , G01N21/65 , G01N2021/3155 , G01N2021/4742 , G01N2021/6419 , G01N2021/6421 , G01N2021/6484 , G01N2021/656 , G02B6/06 , G02B6/29398 , G02B23/2423 , G02B23/2469
摘要： The disclosure generally relates to a method and apparatus for a fiberscope. In one embodiment, the disclosure relates to a chemical imaging fiberscope for imaging and collecting optical spectra from a sample having at least one illumination fiber for transmitting light from a first an a second light source to a distal end of a fiberscope; a dichroic mirror disposed at said distal end of the fiberscope such that light from said first light source passes substantially straight through said mirror and light of a predetermined wavelength from said second light source is substantially reflected by said mirror toward said sample to thereby illuminate said sample; and at least one collection fiber for receiving light from said illuminated sample and transmitting the received light to an optical device.
摘要翻译：本发明一般涉及一种纤维镜的方法和装置。在一个实施例中，本公开涉及一种用于从具有至少一个照明光纤的样品成像和收集光谱的化学成像光纤镜，用于将光从第一光源传输到第二光源到光纤镜的远端; 分光镜，设置在所述纤维内窥镜的所述远端处，使得来自所述第一光源的光基本上直通所述镜，并且来自所述第二光源的预定波长的光被所述反射镜基本上反射到所述样品，从而照亮所述样品 ; 以及至少一个收集光纤，用于接收来自所述照明样品的光并将接收到的光发射到光学装置。

56. 发明申请

US20060116206A1 Game device and game progressing method using the same 审中-公开
标题翻译：游戏设备和游戏进行方法使用相同
公开(公告)号：US20060116206A1
公开(公告)日：2006-06-01
申请号：US10516709
申请日：2003-12-24
申请人： Matthew Nelson , Patrick Treado , Jason Attanucci
发明人： Matthew Nelson , Patrick Treado , Jason Attanucci
IPC分类号： A63F13/00
CPC分类号： A63F13/35 , A63F13/12 , A63F13/335 , A63F13/798 , A63F2300/572
摘要： A game machine 1 is provided with progress state controlling means 21 for storing and controlling a state of a progress of a story in a game for each player, player identification means 15 for identifying the player on the basis of an origin of a received mail received through a receiving server 12, instruction obtaining means 16 for analyzing contents of a sentence of the received mail so as to obtain as instruction information, story processing means 18 for judging the state of the progress of the story corresponding to the player identified and for processing a development of the story in the game on the basis of the judged state of progress and the instruction information, reply mail preparing means 19 for preparing a reply mail for sending information in response to the instruction information on the basis of the processed development of the story, and reply mail processing means 20 for sending the prepared reply mail to the identified player through the server 13.
摘要翻译：游戏机1设置有用于存储和控制每个玩家的游戏中的故事进展状态的进度状态控制装置21，用于基于收到的接收邮件的来源识别玩家的玩家识别装置15 通过接收服务器12，用于分析接收到的邮件的句子的内容以获得作为指示信息的指令获取装置16，用于判断与所识别的玩家相对应的故事的进度状态的故事处理装置18和用于处理基于判定的进展状态和指示信息，在游戏中发展故事;回复邮件准备装置19，用于根据处理的发展情况，根据指令信息准备用于发送信息的回复邮件故事和回复邮件处理装置20，用于通过服务器13将准备的回复邮件发送到所识别的玩家。

57. 发明授权

US08269174B2 Method and apparatus for compact spectrometer for multipoint sampling of an object 有权
标题翻译：用于多物体采样的紧凑型光谱仪的方法和装置
公开(公告)号：US08269174B2
公开(公告)日：2012-09-18
申请号：US12719904
申请日：2010-03-09
申请人： Charles W. Gardner , Patrick J. Treado , Matthew Nelson , Robert Schweitzer
发明人： Charles W. Gardner , Patrick J. Treado , Matthew Nelson , Robert Schweitzer
IPC分类号： G01J5/02
CPC分类号： G01J3/02 , G01J3/0205 , G01J3/0218 , G01J3/0224 , G01J3/0256 , G01J3/027 , G01J3/0272 , G01J3/0283 , G01J3/0291 , G01J3/10 , G01J3/44 , G01N21/31 , G01N21/6456 , G01N21/6486 , G01N21/65
摘要： A method and a portable device for assessing the occurrence of an agent in a sample. A sample is illuminated with photons emanating from a portable device to produce photons reflected, emitted, or absorbed from a set of multiple points in the sample having a defined geometric relationship. The portable device is used to simultaneously illuminate the sample and analyze the photons reflected, emitted, or absorbed from the set of multiple points using spectroscopic methods, including infrared, fluorescence, and UV/visible. The agent assessed may include a hazardous agent, a chemical agent, a biological agent, a microorganism, a bacterium, a protozoan, a virus, and combinations thereof.
摘要翻译：一种用于评估样品中的试剂的发生的方法和便携式装置。用便携式设备发出的光子照射样品，以产生从具有确定的几何关系的样品中的一组多个点反射，发射或吸收的光子。便携式设备用于同时照亮样品并使用包括红外，荧光和紫外/可见光在内的光谱方法分析从该组多个点反射，发射或吸收的光子。所评估的试剂可以包括危险剂，化学试剂，生物制剂，微生物，细菌，原生动物，病毒及其组合。

58. 发明申请

US20100309464A1 Raman Chemical Imaging of Threat Agents Using Pulsed Laser Excitation and Time-Gated Detection 审中-公开
标题翻译：使用脉冲激光激发和时间门控检测的威胁剂的拉曼化学成像
公开(公告)号：US20100309464A1
公开(公告)日：2010-12-09
申请号：US12619336
申请日：2009-11-16
申请人： Patrick J. Treado , Matthew Nelson , Jeffrey Cohen , John Maier
发明人： Patrick J. Treado , Matthew Nelson , Jeffrey Cohen , John Maier
IPC分类号： G01J3/44
CPC分类号： G01J3/2803 , G01J3/0218 , G01J3/027 , G01J3/0291 , G01J3/2889 , G01J3/44 , G01N21/274 , G01N21/65 , G01N2201/0216 , G01N2201/0697
摘要： The disclosure provides for a system and method for detecting a threat agent. A sample is illuminated to produce photons Raman scattered and emitted by the sample. The Raman scattered photons are collected using time-gated detection without collecting the emitted photons. A Raman spectroscopic data set is generated from said Raman scattered photons wherein said Raman spectroscopic data comprises at least one of a Raman spectrum and a Raman chemical image. The Raman spectroscopic data is assessed to thereby determine the presence or absence of a threat agent in the sample. The sample may be in a target area. The sample may be illuminated using a pulsed laser or an intensity modulated laser. The illumination source may be synchronized with a gating element that enables time-gated detection.
摘要翻译：本公开提供了用于检测威胁代理的系统和方法。样品被照亮以产生被样品分散和发射的光子拉曼。使用时间门控检测收集拉曼散射的光子，而不收集发射的光子。从所述拉曼散射光子产生拉曼光谱数据集，其中所述拉曼光谱数据包括拉曼光谱和拉曼化学图像中的至少一个。评估拉曼光谱数据，从而确定样品中威胁剂的存在或不存在。样本可能在目标区域。可以使用脉冲激光或强度调制激光来照亮样品。照明源可以与启用时间门控检测的门控元件同步。

59. 发明申请

US20060155195A1 Method of chemical imaging to determine tissue margins during surgery 有权
公开(公告)号：US20060155195A1
公开(公告)日：2006-07-13
申请号：US11361256
申请日：2006-02-24
申请人： John Maier , Shona Stewart , Jeffrey Cohen , Matthew Nelson
发明人： John Maier , Shona Stewart , Jeffrey Cohen , Matthew Nelson
IPC分类号： A61B6/00 , G01J3/44 , A61B18/18 , G01J3/40 , A61B5/00 , A61B5/05
CPC分类号： G01N21/65 , A61B5/0075 , A61B5/0084 , G01N2021/6484 , G01N2021/656 , G01N2201/08
摘要： A method and system to differentiate a tissue margins during various medical procedures. A region containing a biological tissue is irradiated, with a substantially monochromatic light. Raman spectroscopic data is obtained from the irradiated region. A boundary between a neoplastic portion and a non-neoplastic portion, in the region containing the biological tissue, is differentiated by evaluating the Raman spectroscopic data for at least one Raman spectroscopic value characteristic of either the neoplastic portion or the non-neoplastic portion. The neoplastic portion is selected for physical manipulation based on the differentiation of the boundary between the neoplastic portion and the non-neoplastic portion.

60. 发明授权

US09382554B2 Methods for isoprene and pinene production in cyanobacteria 有权
标题翻译：蓝细菌中异戊二烯和蒎烯生产方法
公开(公告)号：US09382554B2
公开(公告)日：2016-07-05
申请号：US13952071
申请日：2013-07-26
申请人： Toivo Kallas , Matthew Nelson , Eric Singsaas
发明人： Toivo Kallas , Matthew Nelson , Eric Singsaas
IPC分类号： C12P5/02 , C12P5/00 , C12N9/88 , C12N9/90
CPC分类号： C12P5/007 , C12N9/88 , C12N9/90 , C12P5/002 , C12P5/026 , C12Y205/01001 , C12Y402/03015 , C12Y402/03027 , C12Y503/03002 , Y02P20/52
摘要： Methods of isoprenoid production are provided by the present invention. In particular, transgenic Synechococcus sp. PCC 7002 cyanobacteria and methods for producing isoprene and pinene using a host transgenic Synechococcus sp. PCC 7002 cyanobacterium are provided.
摘要翻译：异戊二烯生产方法由本发明提供。特别是转基因聚球藻 PCC 7002蓝细菌和使用宿主转基因聚球藻生产异戊二烯和蒎烯的方法。提供PCC 7002蓝藻。

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