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51. 发明授权

US06462332B1 Particle optical apparatus 有权
标题翻译：粒子光学仪器
公开(公告)号：US06462332B1
公开(公告)日：2002-10-08
申请号：US09689059
申请日：2000-10-12
申请人： Petrus Hubertus Franciscus Trompenaars , Bernardus Hendrikus Wilhelmus Hendriks , Jarig Politiek
发明人： Petrus Hubertus Franciscus Trompenaars , Bernardus Hendrikus Wilhelmus Hendriks , Jarig Politiek
IPC分类号： H01S100
CPC分类号： H01J37/026 , H01J2237/0045 , H01J2237/2522 , H01J2237/31701
摘要： A particle optical apparatus, such as an ion implantation apparatus, an Auger electron spectrometer, an XPS analysis apparatus, and the like, is provided with a radiation source by means of which a wafer or substrate brought into the apparatus can be bombarded by radiation providing for at least a positively charged surface layer of the wafer or substrate. The apparatus further comprises a charge neutralization device with means for providing secondary electron emission and transport means for transporting secondary electrons. This transport means device is provided with a hollow insulating structure for controlled electron transport based on secondary electron emission, particularly in the form of an electron fibre with electrodes at the entrance and exit. The exit of the electron fibre forms a clean secondary electron source.
摘要翻译：诸如离子注入装置，俄歇电子能谱仪，XPS分析装置等的粒子光学装置设置有辐射源，通过该辐射源，被带入设备中的晶片或衬底可以被辐射提供用于晶片或衬底的至少带正电的表面层。该装置还包括具有用于提供用于传输二次电子的二次电子发射和传输装置的装置的电荷中和装置。该输送装置具有中空绝缘结构，用于基于二次电子发射的受控电子传输，特别是具有在入口和出口处具有电极的电子束的形式。电子束的出口形成清洁的二次电子源。

52. 发明授权

US10105057B2 Apparatus for optical analysis of an associated tissue 有权
公开(公告)号：US10105057B2
公开(公告)日：2018-10-23
申请号：US13995967
申请日：2011-12-22
申请人： Bernardus Hendrikus Wilhelmus Hendriks , Rami Nachabe , Gerhardus Wilhelmus Lucassen , Adrien Emmanuel Desjardins , Theodoor Jacques Marie Ruers
发明人： Bernardus Hendrikus Wilhelmus Hendriks , Rami Nachabe , Gerhardus Wilhelmus Lucassen , Adrien Emmanuel Desjardins , Theodoor Jacques Marie Ruers
IPC分类号： A61B6/00 , A61B5/00 , A61B1/00 , G01N21/25 , A61B18/18
摘要： The present invention relates to an apparatus 100 and, a method and a computer program for determining a parameter indicative of a tissue type of an associated tissue 116. In particular, the invention relates to an apparatus 100 comprising a spectrometer 102, which spectrometer comprises a light source 104 and a detector 106, 108 arranged to measure an optical spectrum. This enables determination of a first parameter being indicative of a bile concentration. As the inventors of the present invention have made the insight that bile concentration may serve as a discriminative feature for different tissue types, the apparatus is arranged to determine a second parameter indicative of a tissue type based on a concentration of bile. According to a specific embodiment, the apparatus further comprises an interventional device 112.

53. 发明授权

US09980698B2 Re-calibration of pre-recorded images during interventions using a needle device 有权
公开(公告)号：US09980698B2
公开(公告)日：2018-05-29
申请号：US13321189
申请日：2010-05-07
申请人： Levinus Pieter Bakker , Bernardus Hendrikus Wilhelmus Hendriks , Adrian Emmanuel Desjardins
发明人： Levinus Pieter Bakker , Bernardus Hendrikus Wilhelmus Hendriks , Adrian Emmanuel Desjardins
IPC分类号： A61B19/00 , G06T7/00 , A61B5/00 , A61B6/12 , A61B8/08 , A61B6/00 , A61B17/34 , A61B8/00 , A61B90/00
CPC分类号： A61B8/0841 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/0071 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/6848 , A61B6/12 , A61B6/5247 , A61B8/00 , A61B8/5238 , A61B17/34 , A61B17/3403 , A61B17/3417 , A61B2090/3614 , A61B2090/374 , A61B2090/376 , A61B2090/378 , A61B2090/3784
摘要： Re-calibration of pre-recorded images during interventions uses an interventional system including an imaging device providing images of an object, a needle device, and a processing device. The needle device includes a sensor for providing data corresponding to tissue properties. The processing device is configured to perform an overlay registration of pre-recorded images and live images provided by the imaging device, utilizing the data from the sensor. Thus, the accuracy of an overlay of images is increased.

54. 发明授权

US09131846B2 Optical scanning probe assembly 有权
标题翻译：光学扫描探头组件
公开(公告)号：US09131846B2
公开(公告)日：2015-09-15
申请号：US13125392
申请日：2009-10-19
申请人： Franciscus Martinus Antonius Maria Van Gaal , Bernardus Hendrikus Wilhelmus Hendriks , Augustinus Laurentius Braun , Cornelius Antonius Hezemans , Waltherus Cornelis Jozef Bierhoff
发明人： Franciscus Martinus Antonius Maria Van Gaal , Bernardus Hendrikus Wilhelmus Hendriks , Augustinus Laurentius Braun , Cornelius Antonius Hezemans , Waltherus Cornelis Jozef Bierhoff
IPC分类号： A61B6/00 , A61B5/00 , G02B23/24 , G02B26/10
CPC分类号： A61B5/0062 , A61B5/0084 , G02B23/2461 , G02B26/103
摘要： An optical scanning probe assembly for microscopic guide optic scanning and inspection of tissues includes an outer housing having a spring element for a scanning motor. The spring element is formed as a hollow tube configured to receive an optical guide, where the hollow tube has a mechanical stiffness larger than the optical guide to be received. The assembly further includes a lens system and a deflector configured to deflect the distal end of the hollow tube in directions transverse to the longitudinal extension of the hollow tube, so as to form an optical scan pattern.
摘要翻译：用于微小导向光学扫描和组织检查的光学扫描探针组件包括具有用于扫描电机的弹簧元件的外壳。弹簧元件形成为构造成接收光导的中空管，其中中空管具有比要接收的光导更大的机械刚度。组件还包括透镜系统和偏转器，其被配置为使中空管的远端沿垂直于中空管的纵向延伸的方向偏转，以形成光学扫描图案。

55. 发明授权

US09107694B2 Examination apparatus 有权
标题翻译：检查仪器
公开(公告)号：US09107694B2
公开(公告)日：2015-08-18
申请号：US13146223
申请日：2010-01-25
申请人： Bernardus Hendrikus Wilhelmus Hendriks , Adrien Emmanuel Desjardins , Martin Franciscus McKinney
发明人： Bernardus Hendrikus Wilhelmus Hendriks , Adrien Emmanuel Desjardins , Martin Franciscus McKinney
IPC分类号： G01N23/04 , H05G1/08 , A61B17/34 , A61B6/12 , A61B6/00 , G06F19/00 , H05B33/08 , A61B19/00 , A61B17/00
CPC分类号： A61B17/3403 , A61B6/12 , A61B6/463 , A61B6/464 , A61B6/467 , A61B34/25 , A61B90/30 , A61B2017/00035 , A61B2017/00061 , A61B2017/00084 , A61B2017/00128 , A61B2034/107 , A61B2034/254 , A61B2090/372 , A61B2090/376 , G06F19/00 , G06F19/321 , H05B33/0803
摘要： The present invention relates to an examination apparatus for providing information about an object and a method for providing information about an object of interest. In order to improve the visual reception of information relating to the object, an examination apparatus is provided that comprises an examination arrangement and a control unit with at least a first interface and a second interface. The examination arrangement is adapted to detect object data from at least one region of interest of an object and to provide the object data to the control unit. Further, the control unit is adapted to compute object data into object information and to transform at least a part of the object information into image data (32, 36). Further, the control unit is arranged to extract pre-determined indicative data from the object information and to transform the indicative data into graphical advisory data (40). The first interface is configured such to provide the image data to a display unit (20) in order to display the image data (32, 36) to the user. The second interface is configured such to provide a signal for an ambient advice display arrangement in order to provide the graphical advisory data (40) to the user.
摘要翻译：本发明涉及一种用于提供关于对象的信息的检查装置和用于提供关于感兴趣对象的信息的方法。为了改善与对象有关的信息的视觉接收，提供一种检查装置，其包括检查装置和具有至少第一接口和第二接口的控制单元。检查装置适于从对象的至少一个感兴趣区域检测对象数据，并将对象数据提供给控制单元。此外，控制单元适于将对象数据计算为对象信息并将对象信息的至少一部分转换为图像数据（32,36）。此外，控制单元被布置成从对象信息提取预定指示数据，并将指示性数据变换成图形咨询数据（40）。第一接口被配置为将图像数据提供给显示单元（20），以便向用户显示图像数据（32,36）。第二接口被配置为提供用于环境咨询显示装置的信号，以向用户提供图形咨询数据（40）。

56. 发明授权

US08842208B2 Optical fiber scanning probe 有权
标题翻译：光纤扫描探头
公开(公告)号：US08842208B2
公开(公告)日：2014-09-23
申请号：US13127242
申请日：2009-11-09
申请人： Bernardus Hendrikus Wilhelmus Hendriks
发明人： Bernardus Hendrikus Wilhelmus Hendriks
IPC分类号： H04N5/225 , G02B26/10 , A61B1/00 , A61B1/07 , G02B23/24
CPC分类号： G02B23/2423 , A61B1/00096 , A61B1/00172 , A61B1/07 , G02B23/2469 , G02B26/103
摘要： Optical probes are provided for miniature applications, e.g. medical inspections and procedures or in industrial inspections. The probe comprises an optical guide, a first lens system mounted on a distal end portion of the optical guide for focusing light from the optical guide, an actuator for displacing the distal end portion and the first lens system to enable optical scanning, and a second lens system fixed inside the probe to receive radiation from the first lens system. The second lens system is selected to enable a deflection of radiation from the first lens system in a direction corresponding to a direction of displacement of the first lens system by the actuator. The second lens system can be a cheap negative lens, and the invention is thereby particularly useful for increasing the field of view (FOV) of cheap, disposable optical probes.
摘要翻译：提供光学探针用于微型应用，例如医疗检查和程序或工业检查。探针包括光导，安装在光导的远端部分上的第一透镜系统，用于聚焦来自光导的光;用于移位远端部分和第一透镜系统以使光学扫描的致动器，以及第二透镜系统透镜系统固定在探头内部以接收来自第一透镜系统的辐射。选择第二透镜系统以使得能够在与致动器的第一透镜系统的位移方向相对应的方向上偏转来自第一透镜系统的辐射。第二透镜系统可以是便宜的负透镜，因此本发明特别有助于增加便宜的一次性光学探针的视野（FOV）。

57. 发明申请

US20140200459A1 APPARATUS FOR OPTICAL ANALYSIS OF AN ASSOCIATED TISSUE 审中-公开
标题翻译：用于相关组织的光学分析的装置
公开(公告)号：US20140200459A1
公开(公告)日：2014-07-17
申请号：US13995967
申请日：2011-12-22
申请人： Bernardus Hendrikus Wilhelmus Hendriks , Rami Nachabe , Gerhardus Wilhelmus Lucassen , Adrien Emmanuel Desjardins , Theodoor Jacques Marie Ruers
发明人： Bernardus Hendrikus Wilhelmus Hendriks , Rami Nachabe , Gerhardus Wilhelmus Lucassen , Adrien Emmanuel Desjardins , Theodoor Jacques Marie Ruers
IPC分类号： A61B5/00 , A61B18/18
CPC分类号： A61B5/0075 , A61B1/00 , A61B5/0084 , A61B5/4836 , A61B18/18 , G01N21/25
摘要： The present invention relates to an apparatus 100 and, a method and a computer program for determining a parameter indicative of a tissue type of an associated tissue 116. In particular, the invention relates to an apparatus 100 comprising a spectrometer 102, which spectrometer comprises a light source 104 and a detector 106, 108 arranged to measure an optical spectrum. This enables determination of a first parameter being indicative of a bile concentration. As the inventors of the present invention have made the insight that bile concentration may serve as a discriminative feature for different tissue types, the apparatus is arranged to determine a second parameter indicative of a tissue type based on a concentration of bile. According to a specific embodiment, the apparatus further comprises an interventional device 112.
摘要翻译：本发明涉及一种用于确定指示相关组织116的组织类型的参数的装置100和方法和计算机程序。特别地，本发明涉及一种包括分光计102的装置100，该分光计包括：光源104和被布置成测量光谱的检测器106,108。这使得能够确定指示胆汁浓度的第一参数。本发明的发明人已经认识到胆汁浓度可以用作不同组织类型的鉴别特征，该装置被设置为基于胆汁的浓度来确定指示组织类型的第二参数。根据具体实施例，该装置还包括介入装置112。

58. 发明授权

US08717654B2 Optical probe with feedback correction 失效
标题翻译：具有反馈校正的光学探头
公开(公告)号：US08717654B2
公开(公告)日：2014-05-06
申请号：US13320601
申请日：2010-05-10
申请人： Cornelius Antonius Hezemans , Bernardus Hendrikus Wilhelmus Hendriks , Waltherus Cornelis Jozef Bierhoff , Augustinus Laurentius Braun , Nenad Mihajlovic
发明人： Cornelius Antonius Hezemans , Bernardus Hendrikus Wilhelmus Hendriks , Waltherus Cornelis Jozef Bierhoff , Augustinus Laurentius Braun , Nenad Mihajlovic
IPC分类号： G02B26/08 , A61B5/05
CPC分类号： A61B5/6848 , A61B5/0068 , A61B5/0084 , G02B21/0012 , G02B21/0036 , G02B23/2423 , G02B23/26 , G02B26/103
摘要： The present invention relates to an optical probe (1) suitable for miniature applications. An example application is a fiber-based confocal miniaturized microscope. The optical probe comprises a coil-based actuation system (9, 10) comprising drive coils (9) capable of displacing the distal end (3) of an optical guide (2) housed (4) by the optical probe. The probe makes use of a feedback loop which alternate between driving the displacement of the optical guide by driving a current through the drive coils and switching off the current through the drive coils, and while the drive current being switched off, measure the speed of the distal end of the optical guide. The measured speed is compared to the set-point speed, and if a difference is detected, the drive current is adjusted to eliminate, or at least bring down, this difference.
摘要翻译：本发明涉及适合于微型应用的光学探头（1）。一个示例应用是基于光纤的共聚焦微型显微镜。光探头包括基于线圈的致动系统（9,10），其包括驱动线圈（9），该驱动线圈能够移动由光学探头容纳（4）的光导（2）的远端（3）。探头利用反馈回路，通过驱动通过驱动线圈的电流驱动光导的位移和切断通过驱动线圈的电流之间的交替，并且当驱动电流被切断时，测量速度光导的远端。将测量的速度与设定点速度进行比较，并且如果检测到差异，则调节驱动电流以消除或至少降低该差异。

59. 发明申请

US20130026367A1 DETERMINATION OF A LIPID WATER RATIO 有权
标题翻译：脂肪水比的测定
公开(公告)号：US20130026367A1
公开(公告)日：2013-01-31
申请号：US13641229
申请日：2011-04-18
申请人： Bernardus Hendrikus Wilhelmus Hendriks , Jeroen Jan Lambertus Horikx , Gerhardus Wilhelmus Lucassen , Rami Nachabe , Marjolein Van Der Voort
发明人： Bernardus Hendrikus Wilhelmus Hendriks , Jeroen Jan Lambertus Horikx , Gerhardus Wilhelmus Lucassen , Rami Nachabe , Marjolein Van Der Voort
IPC分类号： G01N21/59 , G01N21/49
CPC分类号： A61B5/0059 , A61B5/4869 , G01N21/359
摘要： The present invention relates to an apparatus, a method and a computer program for determining a lipid-water ratio and a scattering parameter of a sample. In particular, the invention relates to an apparatus comprising a light source and a detector arranged to measure an optical parameter at various wavelengths, where the wavelengths are selected so that at two of the wavelengths the absorption coefficients for both water and lipids are substantially identical. This enables determination of a scattering parameter. A further measurement at a third wavelength enables determination of a water-lipid ratio. According to a specific embodiment, the light source and the detector are arranged in relation to an interventional device, so as to be able to examine a tissue in terms of lipid-water ratio and scattering during an intervention.
摘要翻译：本发明涉及一种用于确定样品的脂质 - 水比和散射参数的装置，方法和计算机程序。具体地，本发明涉及一种包括光源和检测器的设备，其被布置成测量各种波长的光学参数，其中选择波长使得在两个波长处，水和脂质的吸收系数基本相同。这使得能够确定散射参数。在第三波长处的进一步测量使得能够测定水 - 油比。根据具体实施例，光源和检测器相对于介入装置布置，以便能够在干预期间根据脂质 - 水比和散射来检查组织。

60. 发明申请

US20120059251A1 RE-CALIBRATION OF PRE-RECORDED IMAGES DURING INTERVENTIONS USING A NEEDLE DEVICE 有权
标题翻译：使用针头装置进行干预时预先记录的图像重新校准
公开(公告)号：US20120059251A1
公开(公告)日：2012-03-08
申请号：US13321189
申请日：2010-05-07
申请人： Levinus Pieter Bakker , Bernardus Hendrikus Wilhelmus Hendriks , Adrian Emmanuel Desjardins
发明人： Levinus Pieter Bakker , Bernardus Hendrikus Wilhelmus Hendriks , Adrian Emmanuel Desjardins
IPC分类号： A61B5/05 , G06K9/00
CPC分类号： A61B8/0841 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/0071 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/6848 , A61B6/12 , A61B6/5247 , A61B8/00 , A61B8/5238 , A61B17/34 , A61B17/3403 , A61B17/3417 , A61B2090/3614 , A61B2090/374 , A61B2090/376 , A61B2090/378 , A61B2090/3784
摘要： Re-calibration of pre-recorded images during interventions is proposed, utilizing an interventional system comprising an imaging device providing images of an object, a needle device, and a processing device. The needle device comprises a sensor for providing data corresponding to tissue properties. The processing device is adapted to perform an overlay registration of pre-recorded images and live images provided by the imaging device, utilizing the data from the sensor. Thus, the accuracy of an overlay of images is increased.
摘要翻译：提出了在干预期间重新校准预先记录的图像，利用包括提供物体，针装置和处理装置的图像的成像装置的介入系统。针装置包括用于提供对应于组织性质的数据的传感器。处理装置适用于利用来自传感器的数据来执行由成像装置提供的预先记录的图像和实况图像的重叠登记。因此，图像的重叠的精度增加。

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