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51. 发明授权

EP1962871B1 ENHANCED DELIVERY OF CELLS 有权
标题翻译：细胞的改进的通讯
公开(公告)号：EP1962871B1
公开(公告)日：2015-01-28
申请号：EP06802090.8
申请日：2006-08-23
申请人： Boston Scientific Scimed, Inc.
发明人： FREYMAN, Toby , PALASIS, Maria , NAIMARK, Wendy
IPC分类号： A61K35/28
CPC分类号： A61M25/10 , A61K31/28 , A61K31/7076 , A61K35/28 , A61K45/00 , A61K45/06 , A61K2300/00 , A61M5/1407 , A61M2025/1052 , A61M2210/125
摘要： The present invention provides a method comprising administering cells by infusion through a blood vessel and administering a vasodilator, a vascular enhancer, or both. In accordance with one embodiment, the delivery of stem cells to the myocardium by intracoronary infusion is improved by administration of one or more vasodilators and/or vascular permeability enhancers prior to or at the time of cell therapy.

52. 发明公开

EP2262566A1 BALLOON CATHETER DEVICES WITH FOLDED BALLOONS 审中-公开
标题翻译：具有折叠的气球的气球导管装置
公开(公告)号：EP2262566A1
公开(公告)日：2010-12-22
申请号：EP09716422.2
申请日：2009-03-06
申请人： Boston Scientific Scimed, Inc.
发明人： KNAPP, David , MICKLEY, Timothy , CHEN, John , SUTERMEISTER, Derek , FREYMAN, Toby , KOCUR, Gordon , HORN, Daniel , ANDERSON, Jim , ARCAND, Ben , RASSAT, Jay , RIZQ, Raed , NAZAROVA, Irina , QUILLIN, Dan , WEBER, Jan , SCHEUERMANN, Torsten
IPC分类号： A61M25/10 , A61L29/00
CPC分类号： A61M25/1029 , A61L29/085 , A61L29/16 , A61L2300/416 , A61M25/0045 , A61M25/10 , A61M2025/0056 , A61M2025/1031 , A61M2025/105 , B29L2009/005 , C08L53/02
摘要： Catheter devices (10) having an expandable balloon (14) for delivering a therapeutic agent to a body site. The balloon has one or more folds (16) which serve as a reservoir for containing the therapeutic agent. The fold may have any of various configurations to hold the therapeutic agent. In some cases, the balloon comprises one or more lobes that forms the fold(s). The therapeutic agent may be provided in various ways. For example, the therapeutic agent may be contained in packets that rupture upon expansion of the balloon, or as a plurality of discrete bulk masses, or sealed within compartments.

53. 发明申请

WO2013066970A1 FOAM AND DELIVERY SYSTEM FOR TREATMENT OF POSTPARTUM HEMORRHAGE 审中-公开
标题翻译：泡沫和输送系统用于治疗血栓形成
公开(公告)号：WO2013066970A1
公开(公告)日：2013-05-10
申请号：PCT/US2012/062732
申请日：2012-10-31
申请人： ARSENAL MEDICAL, INC. , SHARMA, Upma , GITLIN, Irina , ZAMIRI, Parisa , FREYMAN, Toby , BUSOLD, Rany , CORE, Lee , MORTENSEN, Jennifer , KOMATSU, Janet, Chie
发明人： SHARMA, Upma , GITLIN, Irina , ZAMIRI, Parisa , FREYMAN, Toby , BUSOLD, Rany , CORE, Lee , MORTENSEN, Jennifer , KOMATSU, Janet, Chie
IPC分类号： A61L27/14 , A61L27/56 , A61L31/04 , A61L31/14
CPC分类号： A61L24/0015 , A61L24/0036 , A61L24/046 , A61L27/14 , A61L27/56 , A61L31/04 , A61L31/146 , A61L2300/418 , A61L2400/04 , A61L2430/22 , C08L75/04
摘要： Medical implants and methods useful in treating postpartum hemorrhage are disclosed. The implants, in some embodiments, comprise polyurethane foams having advantageous mechanical and other properties selected to promote hemostasis when brought in contact with an inner wall of a uterus. Methods of making and deploying such implants are also disclosed.
摘要翻译：公开了用于治疗产后出血的医疗植入物和方法。在一些实施方案中，植入物包含具有有利的机械和其它性质的聚氨酯泡沫，当与子宫的内壁接触时，其被选择用于促进止血。还公开了制造和部署这种植入物的方法。

54. 发明申请

WO2015031742A9 DELIVERY CATHETERS FOR IN SITU FORMING FOAMS 审中-公开
公开(公告)号：WO2015031742A9
公开(公告)日：2015-03-05
申请号：PCT/US2014/053388
申请日：2014-08-29
申请人： ARSENAL MEDICLA, INC. , FREYMAN, Toby , MORTENSEN, Jennifer , GROOM, Jeffrey
发明人： FREYMAN, Toby , MORTENSEN, Jennifer , GROOM, Jeffrey
IPC分类号： A61M25/00 , A61L31/14
摘要： Delivery catheters for in situ forming foams are provided. The catheters include, in various embodiments, coatings, valves, mixing structures, exit ports and combinations of the same.

55. 发明申请

WO2014152742A2 DELIVERY SYSTEM FOR IN SITU FORMING FOAMS AND METHODS OF USING THE SAME 审中-公开
标题翻译：原位形成泡沫的输送系统及其使用方法
公开(公告)号：WO2014152742A2
公开(公告)日：2014-09-25
申请号：PCT/US2014/027683
申请日：2014-03-14
申请人： ARSENAL MEDICAL, INC. , SHARMA, Upma , BUSOLD, Rany , RAGO, Adam , ZUGATES, Gregory, T. , FREYMAN, Toby , MILLER, Lisette, Manrique
发明人： SHARMA, Upma , BUSOLD, Rany , RAGO, Adam , ZUGATES, Gregory, T. , FREYMAN, Toby , MILLER, Lisette, Manrique
IPC分类号： A61B17/00
CPC分类号： A61B17/00491 , A61B2017/00398 , A61B2017/00495 , A61B2017/00544 , A61B2017/00548 , A61B2017/8838 , A61C9/0026 , A61M5/1409 , A61M5/1452 , A61M5/16804 , A61M5/19 , A61M13/003 , A61M2205/103 , B01F3/04453 , B01F5/0602 , B01F5/0604 , B01F7/00558 , B01F7/00583 , B01F13/0023 , B01F15/00253 , B01F15/00525 , B01F15/0279 , B05B7/0037 , B05B7/2421 , B05B7/2472 , B05C17/00553 , B65D81/325
摘要： Delivery systems for in situ forming foam formulations are provided. The devices may include various actuation mechanisms and may entrain air into fluid formulation components in a variety of ways, including mixing with air and the addition of compressed gas.
摘要翻译：提供了原位形成泡沫配方的输送系统。这些装置可以包括各种致动机构并且可以以各种方式将空气带入流体制剂组分中，包括与空气混合并添加压缩气体。

56. 发明申请

WO2014004160A1 IN-SITU FORMING FOAMS FOR TREATMENT OF ANEURYSMS 审中-公开
标题翻译：治疗原发性疾病的现状
公开(公告)号：WO2014004160A1
公开(公告)日：2014-01-03
申请号：PCT/US2013/046281
申请日：2013-06-18
申请人： ARSENAL MEDICAL, INC. , SHARMA, Upma , ZUGATES, Gregory, T. , BUSOLD, Rany , FREYMAN, Toby
发明人： SHARMA, Upma , ZUGATES, Gregory, T. , BUSOLD, Rany , FREYMAN, Toby
IPC分类号： A61L31/06 , A61L31/14 , C08L75/02
CPC分类号： A61L24/0036 , A61L24/046 , A61L2430/36 , C08G18/7621 , C08G18/7664 , C08G2101/0083 , C08L75/04
摘要： Systems, methods and kits relating to in-situ forming polymer foams for the treatment of aneurysms are disclosed. The systems include an insertable medical device and an in-situ forming foam that is formed from a polymer that reacts in an aqueous environment. When used to treat an aneurysm, the foam is placed into contact with at least a portion of an exterior surface of the medical device and/or the tissue surface of the aneurysm.
摘要翻译：公开了与用于治疗动脉瘤的原位形成聚合物泡沫有关的系统，方法和试剂盒。该系统包括可插入的医疗装置和由在水性环境中反应的聚合物形成的原位成形泡沫。当用于治疗动脉瘤时，将泡沫放置成与医疗装置的外表面的至少一部分和/或动脉瘤的组织表面接触。

57. 发明申请

WO2012027138A1 IN SITU FORMING HEMOSTATIC FOAM IMPLANTS 审中-公开
标题翻译：在现场形成HEMOSTATIC泡沫植入物
公开(公告)号：WO2012027138A1
公开(公告)日：2012-03-01
申请号：PCT/US2011/047615
申请日：2011-08-12
申请人： ARSENAL MEDICAL, INC. , SHARMA, Upma , GITLIN, Irina , ZUGATES, Greg , RAGO, Adam , ZAMIRI, Parisa , BUSOLD, Rany , FREYMAN, Toby
发明人： SHARMA, Upma , GITLIN, Irina , ZUGATES, Greg , RAGO, Adam , ZAMIRI, Parisa , BUSOLD, Rany , FREYMAN, Toby
IPC分类号： A61B17/03
CPC分类号： A61L24/043 , A61L24/0036 , A61L2400/06 , A61M31/002 , C08L75/04 , C08L71/02
摘要： Systems and methods related to polymer foams are generally described. Some embodiments relate to compositions and methods for the preparation of polymer foams, and methods for using the polymer foams. The polymer foams can be applied to a body cavity and placed in contact with, for example, tissue, injured tissue, internal organs, etc. In some embodiments, the polymer foams can be formed within a body cavity (i.e., in situ foam formation). In addition, the foamed polymers may be capable of exerting a pressure on an internal surface of a body cavity and preventing or limiting movement of a bodily fluid (e.g., blood, etc.).
摘要翻译：通常描述与聚合物泡沫有关的系统和方法。一些实施方案涉及用于制备聚合物泡沫的组合物和方法，以及使用聚合物泡沫体的方法。聚合物泡沫可以施加到体腔并且与例如组织，损伤的组织，内部器官等接触。在一些实施例中，聚合物泡沫可以在体腔内形成（即，原位泡沫形成）。此外，发泡聚合物可能能够在体腔的内表面上施加压力，并且能够防止或限制体液（例如血液等）的移动。

58. 发明申请

WO2005037359A1 MADICAL DEVICE GUIDANCE FROM AN ANATOMICAL REFERENCE 审中-公开
标题翻译：来自解剖学参考的植物装置指南
公开(公告)号：WO2005037359A1
公开(公告)日：2005-04-28
申请号：PCT/US2004/031376
申请日：2004-09-27
申请人： SCIMED LIFE SYSTEMS, INC. , FREYMAN, Toby , MICKLEY, Timothy, J.
发明人： FREYMAN, Toby , MICKLEY, Timothy, J.
IPC分类号： A61M25/01
CPC分类号： A61M25/01 , A61B5/061 , A61M25/0105
摘要： A system and method for simply and reliably determining the location and orientation of a medical device within a patient's body. A medical device, such as a catheter (1), has bending indicators (13) on or imbedded in its wall (7), and passes through an anatomical reference (11) of known orientation relative to a target site within the patient. Information from the tube bending indicators permits determination of the orientation of a feature, such as an orifice, at the distal end (3) of the medical device relative to the anatomical reference. From the known orientation of the anatomical reference, and information on the location and orientation of the distal end of the medical device obtained from fluoroscopic imaging from a single direction, the physician may reliably determine the orientation of the distal feature relative to the target site, eliminating the need for imaging from multiple directions.
摘要翻译：一种用于简单且可靠地确定患者体内的医疗装置的位置和方向的系统和方法。诸如导管（1）的医疗装置在其壁（7）上或嵌入其中的弯曲指示器（13），并且相对于患者内的目标部位通过已知取向的解剖参考（11）。来自管弯曲指示器的信息允许在医疗装置的远端（3）处相对于解剖参考确定诸如孔的特征的取向。从已知的解剖学参考方向，以及关于从单一方向从透视成像获得的医疗装置的远端的位置和方位的信息，医师可以可靠地确定远侧特征相对于目标部位的方向，消除了从多个方向进行成像的需要。

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