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51. 发明申请

US20070208239A1 Living body light measuring device 有权
标题翻译：活体光测量装置
公开(公告)号：US20070208239A1
公开(公告)日：2007-09-06
申请号：US11646468
申请日：2006-12-28
申请人： Hiroki Sato , Atsushi Maki
发明人： Hiroki Sato , Atsushi Maki
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B5/14535 , A61B5/14553 , A61B5/6814 , A61B5/7264 , A61B5/742 , A61B2562/0233 , A61B2562/046
摘要： At each of measurement sites, changes in plural biological data (such as an oxy-Hb signal species and a deoxy-Hb signal species) in a predetermined period are statistically tested independently of each other. By combining results of the plural biological data, the measurement sites are each classified into one out of plural categories. The classified results are each displayed in a single chart. Effective is also a method of setting different activity periods correspondingly to plural Hb signal species, deciding whether or not each of the signal species shows activity or estimating the strength of the signal species, and displaying classification results based on combination of activities of the plural Hb signal species in a single chart. A living body light measuring device using the brain activity analyzing method and displaying method of the invention makes it possible to detect sites where brain activity is generated with a high precision.
摘要翻译：在每个测量位置，在预定时间段内的多个生物数据（例如氧基-Hb信号物质和脱氧-Hb信号物质）中的变化被彼此独立地进行统计学测试。通过组合多个生物数据的结果，将测量点分类为多个类别中的一个。分类结果分别显示在单个图表中。有效还是对应于多个Hb信号种类设定不同活动期的方法，决定每个信号种类是否显示活动或估计信号种类的强度，以及基于多个Hb的活动的组合来显示分类结果信号种类在一个单一的图表。使用本发明的脑活动分析方法和显示方法的生物体光测量装置可以高精度地检测产生脑活动的部位。

52. 发明申请

US20070055136A1 Inspection apparatus using magnetic resonance 审中-公开
标题翻译：使用磁共振的检查装置
公开(公告)号：US20070055136A1
公开(公告)日：2007-03-08
申请号：US11471708
申请日：2006-06-21
申请人： Yukari Yamamoto , Atsushi Maki
发明人： Yukari Yamamoto , Atsushi Maki
IPC分类号： A61B5/05
CPC分类号： G01R33/48 , A61B5/055 , A61B5/417 , A61B5/4509
摘要： A means to predict bone density reduction before it actually begins will be provided. This invention provides a method to detect abnormalities in the bone marrow hemopoietic cells which precede the bone density reduction, by obtaining a nuclear magnetic resonance image containing a flat bone or an a long bone epiphysis, and evaluating the signal intensity in the red marrow area.
摘要翻译：将提供在实际开始之前预测骨密度降低的手段。本发明提供一种检测骨密度降低前的骨髓造血细胞异常的方法，通过获得含有平骨或长骨骨ysis的核磁共振图像，评价红髓区域的信号强度。

53. 发明申请

US20070038154A1 Living body inspection apparatus 有权
标题翻译：生活检查仪器
公开(公告)号：US20070038154A1
公开(公告)日：2007-02-15
申请号：US11455191
申请日：2006-06-19
申请人： Akihiko Kandori , Tsuyoshi Miyashita , Kuniomi Ogata , Atsushi Maki , Daisuke Suzuki
发明人： Akihiko Kandori , Tsuyoshi Miyashita , Kuniomi Ogata , Atsushi Maki , Daisuke Suzuki
IPC分类号： A61B5/103 , A61B5/117
CPC分类号： A61B5/1125 , A61B5/1126 , A61B5/6825 , A61B5/6826 , A61B5/6838
摘要： A living body inspection apparatus which quantitatively evaluates timings of movements (bending and stretching) of fingers. The apparatus includes: a movement sensor including a transmitter coil for generating a magnetic field and a plurality of receiver coils for receiving the generated magnetic field from the transmitter coil; analyzing means which analyzes time-series waveform data acquired from the movement sensor; and display means which displays a result of analysis made by the analyzing means. For comparison of waveform data, the analyzing means includes distance waveform generating means for generating distance waveforms corresponding to the waveform data, and standard point generating means for generating standard points based on standard distances in the distance waveforms.
摘要翻译：生物体检查装置，其定量地评价手指的移动（弯曲和伸展）的定时。该装置包括：运动传感器，包括用于产生磁场的发射器线圈和用于从发射器线圈接收所产生的磁场的多个接收器线圈; 分析装置，其分析从所述运动传感器获取的时间序列波形数据; 以及显示装置，显示由分析装置进行的分析结果。为了比较波形数据，分析装置包括用于产生与波形数据对应的距离波形的距离波形发生装置，以及用于根据距离波形中的标准距离产生标准点的标准点产生装置。

54. 发明申请

US20070038067A1 Living body inspection apparatus 审中-公开
标题翻译：生活检查仪器
公开(公告)号：US20070038067A1
公开(公告)日：2007-02-15
申请号：US11480518
申请日：2006-07-05
申请人： Akihiko Kandori , Tsuyoshi Miyashita , Kuniomi Ogata , Atsushi Maki
发明人： Akihiko Kandori , Tsuyoshi Miyashita , Kuniomi Ogata , Atsushi Maki
IPC分类号： A61B5/05
CPC分类号： A61B5/04005 , A61B5/1124 , A61B5/1126 , A61B5/6826 , G01R33/0354
摘要： Living body inspection apparatus which concurrently carries out proper measurement of movement of a living body and measurement of a magnetic field emanating from the living body. It includes a movement sensor which includes magnetic field generating means for generating a magnetic field and magnetic field receiving means attached to a living body for receiving the magnetic field and measures movement of the living body based on the magnetic field emitted from the magnetic field generating means and received by the magnetic field receiving means. It also includes: a SQUID magnetometer which receives a biomagnetic field emanating from the living body; analyzing means which analyzes measurement data obtained by the movement sensor and the SQUID magnetometer; and display means which outputs a result of analysis made by the analyzing means. The magnetic field generating means is fixed in a prescribed position relative to the SQUID magnetometer.
摘要翻译：生物体检查装置同时进行生物体的运动的适当的测量以及从生物体发出的磁场的测量。其包括运动传感器，其包括用于产生磁场的磁场产生装置和附接到生物体的磁场接收装置，用于接收磁场，并且基于从磁场产生装置发射的磁场来测量活体的运动并由磁场接收装置接收。它还包括：SQUID磁力计，其接收从生物体发出的生物磁场; 分析装置，分析由运动传感器和SQUID磁力计获得的测量数据; 以及显示装置，其输出由分析装置进行的分析结果。磁场产生装置相对于SQUID磁力计固定在规定位置。

55. 发明申请

US20060100525A1 Biological optical measurement system 有权
公开(公告)号：US20060100525A1
公开(公告)日：2006-05-11
申请号：US11205160
申请日：2005-08-17
申请人： Takusige Katura , Naoki Tanaka , Hiroki Sato , Akiko Obata , Atsushi Maki
发明人： Takusige Katura , Naoki Tanaka , Hiroki Sato , Akiko Obata , Atsushi Maki
IPC分类号： A61B6/00
CPC分类号： A61B5/6814 , A61B5/0059 , A61B5/024 , A61B5/14553
摘要： A typical task assigned for measuring a brain activity signal lasts from 10 to 30 seconds. The frequency band of the Mayer wave noise signal is very close to the frequency bands of brain activity signals, a result, it is difficult to reduce the Mayer wave noise signal using a bandpass filter or a bandcut filter. Light irradiating units and light detecting units for detecting the emitted light that has been passed through or reflected within the tissue are provided. A biological signal measuring unit measures at least one of the pulsation, breathing, blood pressure, and temperature. The relationship between an optical signal obtained by the light detecting unit and a biological signal using non-linear analysis; and a computation for separating the biological noise signal from the optical signal on the basis of the obtained relationship.

56. 发明授权

US07022083B2 Measurement system for living bodies 失效
标题翻译：活体测量系统
公开(公告)号：US07022083B2
公开(公告)日：2006-04-04
申请号：US10457478
申请日：2003-06-10
申请人： Naoki Tanaka , Atsushi Maki , Masashi Kiguchi
发明人： Naoki Tanaka , Atsushi Maki , Masashi Kiguchi
IPC分类号： A61B5/02 , A61B5/00
CPC分类号： A61B5/486 , A61B5/0086 , A61B5/1455
摘要： A satisfactory averaged signal can be obtained with only a small number of repetitions of measurement in the measurement of responses to a stimulus given to a living body. A low-frequency biological fluctuation is extracted and a stimulus is presented to the living body in synchronism with the phase of the extracted fluctuation.
摘要翻译：在对给予生物体的刺激的响应的测量的测量中，可以仅获得少量的测量重复来获得满意的平均信号。提取低频生物波动，并且与提取的波动的相位同步地向生物体提供刺激。

57. 发明申请

US20050171440A1 Optical system for measuring metabolism in a body and imaging method 有权
公开(公告)号：US20050171440A1
公开(公告)日：2005-08-04
申请号：US11037338
申请日：2005-01-19
申请人： Atsushi Maki , Hideaki Koizumi , Fumio Kawaguchi , Yuichi Yamashita , Yoshitoshi Ito
发明人： Atsushi Maki , Hideaki Koizumi , Fumio Kawaguchi , Yuichi Yamashita , Yoshitoshi Ito
IPC分类号： A61B5/00 , A61B5/05 , A61B5/055 , A61B5/18 , A61B6/00 , A61B6/03
CPC分类号： A61B5/0059 , A61B5/0042 , A61B5/055 , A61B5/14552 , A61B5/14553 , A61B5/18 , A61B5/6814 , A61B5/7207 , A61B5/7228 , A61B6/03 , A61B6/507 , A61B2562/0219 , A61B2562/0233 , A61B2562/046
摘要： In an optical measurement system and imaging method adapted to measure in vivo information in a living body without harming the living body, light rays of a plurality of wavelengths which are modulated in intensity with a plurality of different frequencies are irradiated on a plurality of irradiation positions on the surface of a living body, and time-variable changes in living body transmitting light intensity levels corresponding to the respective wavelengths and the respective irradiation positions are measured at different positions on the surface of the living body. Light is utilized to image the results of the measurements, in which the measuring time is shortened by estimating fluctuation attributable to the living body, and the presence or absence of a change in measured signal can be decided easily by displaying an estimation signal and a measured signal at a time.

58. 发明授权

US06640133B2 Optical measurement instrument for living body 有权
标题翻译：生物体光学测量仪器
公开(公告)号：US06640133B2
公开(公告)日：2003-10-28
申请号：US09849409
申请日：2001-05-07
申请人： Yuichi Yamashita , Atsushi Maki , Hideaki Koizumi
发明人： Yuichi Yamashita , Atsushi Maki , Hideaki Koizumi
IPC分类号： A61B505
CPC分类号： A61B5/0059 , A61B5/055 , A61B5/14546 , A61B5/14552 , A61B5/14553 , A61B5/18 , A61B5/6814 , A61B6/03 , A61B2562/0233 , A61B2562/0242 , A61B2562/046 , G01N21/35 , G01N21/4795
摘要： A control device for a living body including an input device having a launcher for launching light into the living body from at least one light incident position on a surface of the living body, a collector for collecting light obtained by causing the light incident from the light incident position to pass through the living body, at at least one light detection position on the surface of the living body, a detector for detecting an intensity of the transmitted light collected by the collector, an operator for determining a type of output signal, based on the intensity of the transmitted light, which has been detected by the detector and pre-stored reference data and for outputting a signal indicative thereof. External equipment is provided for using the signal outputted as an input signal and for executing a functional operation according to a type of the input signal.
摘要翻译：一种生物体的控制装置，具有：输入装置，具有从生物体的表面上的至少一个光入射位置向所述生物体射出光的发射器，收集从所述光入射的光所得到的光的收集体在生物体的表面上的至少一个光检测位置通过活体的入射位置，用于检测由收集器收集的透射光的强度的检测器，用于确定输出信号的类型的操作者关于由检测器检测到的透射光的强度，以及预先存储的参考数据，并输出指示其的信号。提供外部设备，用于使用作为输入信号输出的信号，并根据输入信号的类型执行功能操作。

59. 发明授权

US06282438B1 Optical system for measuring metabolism in a body and imaging method 失效
标题翻译：用于测量身体代谢的光学系统和成像方法
公开(公告)号：US06282438B1
公开(公告)日：2001-08-28
申请号：US09203610
申请日：1998-12-02
申请人： Atsushi Maki , Hideaki Koizumi , Fumio Kawaguchi , Yuichi Yamashita , Yoshitoshi Ito
发明人： Atsushi Maki , Hideaki Koizumi , Fumio Kawaguchi , Yuichi Yamashita , Yoshitoshi Ito
IPC分类号： A61B600
CPC分类号： A61B5/0059 , A61B5/0042 , A61B5/055 , A61B5/14552 , A61B5/14553 , A61B5/18 , A61B5/6814 , A61B5/7207 , A61B5/7228 , A61B6/03 , A61B6/507 , A61B2562/0219 , A61B2562/0233 , A61B2562/046
摘要： Light rays of a plurality of wavelengths which are modulated in intensity with a plurality of different frequencies are irradiated on a plurality of irradiation positions on the surface of a living body, and time-variable changes in living body transmitting light intensity levels corresponding to the respective wavelengths and the respective irradiation positions are measured at different positions on the surface of the living body. After completion of the measurement or during the measurement, changes in concentration values of absorbers in the living body are determined from the living body transmitting light intensity levels of the plurality of wavelengths detected at the respective detection points and a measuring point is set on a perpendicular extending through an intermediate point between the incident point and each detection point so as to image a function of the living body. In living body optical measurement system and method, the measuring time is shortened by estimating fluctuation attributable to the living body, the presence or absence of a change in measured signal can be decided easily by displaying an estimation signal and a measured signal at a time, and a local change in. hemodynamic movement can be measured by detecting light rays transmitting through the interior of the living body by the two light detectors disposed at different two sites (equidistant from the light incident point) on a subject and by separating only the local change in hemodynamic movement from an overall change in hemodynamic movement in the living body in accordance with a logarithmic difference between the two detection signals.
摘要翻译：以多个不同频率强度调制的多个波长的光线照射在生物体的表面上的多个照射位置上，并且生物体的时间变化透射与各个相对应的光强度水平波长和各个照射位置在生物体的表面上的不同位置处被测量。在测量完成之后或在测量期间，生物体中的吸收体的浓度值的变化是根据在各个检测点处检测到的多个波长的光强度水平来发射的，并且将测量点设定在垂直方向延伸穿过入射点和每个检测点之间的中间点，以便对活体的功能进行成像。在生物体光学测量系统和方法中，通过估计归因于生物体的波动来缩短测量时间，通过一次显示估计信号和测量信号可以容易地确定测量信号的变化是否存在，并且可以通过检测设置在被摄体上不同的两个位置（等于光入射点的位置）的两个光检测器检测通过生物体的内部的光线，并且仅分离本地根据两个检测信号之间的对数差异，从生物体的血液动力学运动的总体变化中改变血流动力学运动。

60. 发明授权

US08311600B2 Optical measurement instrument for living body 有权
标题翻译：生物体光学测量仪器
公开(公告)号：US08311600B2
公开(公告)日：2012-11-13
申请号：US11954627
申请日：2007-12-12
申请人： Takusige Katura , Naoki Tanaka , Atsushi Maki
发明人： Takusige Katura , Naoki Tanaka , Atsushi Maki
IPC分类号： A61B5/1455
CPC分类号： A61B5/0059 , A61B5/02028 , A61B5/6814 , A61B5/7207 , G06K9/6243
摘要： An optical measurement instrument for living body includes: a plurality of light irradiation means for irradiating an object being tested with light; a plurality of light reception means for detecting the light that is irradiated to the object being tested and propagates inside the object being tested; and a calculation unit for calculating hemodynamics of a plurality of factors inside the object being tested from the detection signal detected by the light reception means, wherein the calculation unit includes a separation calculation unit for separating a plurality of signals from the detection signals; a selection unit for calculating a correlation coefficient between a plurality of the signals separated to select a signal in which a correlation coefficient is a predetermined value or greater as a noise signal; and a reconstruction calculation unit for reconfiguring the detection signal excluding the noise signal selected by the selection unit.
摘要翻译：一种用于生物体的光学测量仪器包括：多个光照射装置，用于用光照射被测物体; 多个光接收装置，用于检测照射到被测试物体上的光并在待测物体的内部传播; 以及计算单元，用于根据由光接收装置检测的检测信号计算被测物体内的多个因子的血液动力学，其中所述计算单元包括分离计算单元，用于从所述检测信号中分离出多个信号; 选择单元，用于计算分离以选择其中相关系数为预定值或更大的信号的多个信号之间的相关系数作为噪声信号; 以及重建计算单元，用于重新配置除了由选择单元选择的噪声信号之外的检测信号。

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