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51. 发明专利

PE20142316A1 DERIVADOS DE SULFONAMIDA COMO AGENTES INDUCTORES DE APOPTOSIS CON SELECTIVIDAD POR Bcl-2 PARA EL TRATAMIENTO DE CANCER Y ENFERMEDADES INMUNES 未知
公开(公告)号：PE20142316A1
公开(公告)日：2015-02-04
申请号：PE2014001365
申请日：2009-12-04
申请人： ABBVIE INC
发明人： BRUNCKO MILAN , DING HONG , DOHERTY GEORGE A , ELMORE STEVEN W , HASVOLD LISA , HEXAMER LAURA , KUNZER AARON R , MANTEI ROBERT A , MCCLELLAN WILLIAM J , PARK CHANG H , PARK CHEOL-MIN , PETROS ANDREW M , SONG XIAOHONG , SOUERS ANDREW J , SULLIVAN GERARD M , TAO ZHI-FU , WANG GARY T , WANG LE , WANG XILU , WENDT MICHAEL D
IPC分类号： C07D405/12 , A61K31/404 , A61P35/00 , C07D209/32 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D235/26 , C07D249/04 , C07D295/125 , C07D295/14 , C07D309/14 , C07D401/12
摘要： REFERIDA A UN COMPUESTO DE FORMULA (I), DONDE: A2, B1, D1, E1 SON H, F, Cl, Br, ENTRE OTROS; Y1 ES H, CN, NO2, ENTRE OTROS; Z1 ES R26, R27, ENTRE OTROS; R26 ES FENILO QUE NO ESTA FUSIONADO O FUSIONADO CON ARENO O HETEROARENO; R27 ES HETEROARENO QUE NO ESTA FUSIONADO O FUSIONADO CON ARENO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 4-(4-((4'-CLORO-1,1'-BIFENIL-2-IL)METIL)PIPERAZIN-1-IL)-2-FENOXI-N-((4-((TETRAHIDRO-2H-PIRAN-4-ILMETIL)AMINO)FENIL)SULFONIL)-2-FENOXIBENZAMIDA, 4-(4-((4'-CLORO-1,1'-BIFENIL-2-IL)METIL)PIPERAZIN-1-IL)-N-((3-NITRO-4-((TETRAHIDRO-2H-PIRAN-4-ILMETIL)AMINO)FENIL)SULFONIL)BENZAMIDA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA ACTIVIDAD DE LAS PROTEINAS ANTI-APOPTOTICAS BCL-2 O BCL-XL Y SON UTILES EN EL TRATAMIENTO DEL CANCER DE VEJIGA, ENTRE OTRAS

52. 发明专利

NZ603284A Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases 未知
公开(公告)号：NZ603284A
公开(公告)日：2015-01-30
申请号：NZ60328411
申请日：2011-05-25
申请人： ABBVIE INC
发明人： CATRON NATHANIEL D , TAO ZHI-FU , WANG XILU , SOUERS ANDREW J , SULLIVAN GERARD
IPC分类号： A01N43/42 , A01N43/38 , A01N43/40 , A61K31/44
摘要： Disclosed herein is a compound of formula (I), (II) or (III), wherein the variables are defined herein, and the use in the treatment of bladder cancer, brain cancer, breast cancer, bone marrow cancer, cervical cancer, chronic lymphocytic leukemia, colorectal cancer, esophageal cancer, hepatocellular cancer, lymphoblastic leukemia, follicular lymphoma, lymphoidmalignancies of T -cell or B-cell origin, melanoma, myelogenous leukemia, myeloma, oral cancer, ovarian cancer, non-small cell lung cancer, chronic lymphocytic leukemia, myeloma, prostate cancer, small cell lung cancer or spleen cancer Embodiments of the compound include the following: (5-{ 5-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-2-[({ 3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl} sulfonyl)carbamoyl] phenoxy} -7H-pyrrolo[2,3-b]pyridin-7-yl)methyldihydrogen phosphate; and trans-4-[(4-{ [4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzoyl]sulfamoyl} -2-nitrophenoxy)methyl]cyclohexyldihydrogen phosphate

53. 发明专利

NZ603463A Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases 未知
公开(公告)号：NZ603463A
公开(公告)日：2014-11-28
申请号：NZ60346310
申请日：2010-11-22
申请人： ABBVIE INC
发明人： HANSEN TODD M , KUNZER AARON R , DING HONG , WENDT MICHAEL , MANTEI ROBERT , HASVOLD LISA , SULLIVAN GERARD , WANG LE , DOHERTY GEORGE , ELMORE STEVEN , SONG XIAOHONG , SOUERS ANDREW J , BRUNCKO MILAN , WANG GARY T , HEXAMER LAURA , WANG XILU , TAO ZHI-FU
IPC分类号： C07D471/04 , A61K31/437 , A61K35/00
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein. In one embodiment the compound is N-(4-{ [4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzoyl]sulfamoyl} -2-nitrophenyl)-4-cyanopiperidine-1-carboxamide.

55. 发明专利

CA2903538A1 PYRROLOPYRIMINDINE CDK9 KINASE INHIBITORS 未知
公开(公告)号：CA2903538A1
公开(公告)日：2014-10-02
申请号：CA2903538
申请日：2014-03-13
申请人： ABBVIE INC
发明人： FLORJANCIC ALAN S , TONG YUNSONG , PENNING THOMAS , SOUERS ANDREW J , GOSWAMI RAJEEV , TAO ZHI-FU
IPC分类号： C07D487/04 , A61K31/519 , A61K35/00
摘要： Disclosed are compound of Formula (Ia), wherein R1, R2, and R3 are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds may be used as agents in the treatment of diseases, including cancer. Also provided are pharmaceutical compositions, comprising one or more compounds of Formula (Ia).

56. 发明专利

CA2899041A1 APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 未知
公开(公告)号：CA2899041A1
公开(公告)日：2014-10-02
申请号：CA2899041
申请日：2014-02-21
申请人： ABBVIE INC
发明人： TAO ZHI-FU , WANG XILU , WENDT MICHAEL D , SOUERS ANDREW J , JUDD ANDREW S , KUNZER AARON , SULLIVAN GERARD
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
摘要： Disclosed herein are compounds that inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases using the compounds.

57. 发明专利

CA2905935A1 PYRROLO[2,3-B]PYRIDINE CDK9 KINASE INHIBITORS 未知
公开(公告)号：CA2905935A1
公开(公告)日：2014-09-25
申请号：CA2905935
申请日：2014-03-13
申请人： ABBVIE INC
发明人： GONG JIANCHUN , TAO ZHI-FU , TONG YUNSONG , ZHU GUIDONG , PENNING THOMAS , SOUERS ANDREW J
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
摘要： Disclosed are compounds of Formula (IIIa), wherein R1, R2, R3, X1, X2, X3, X4, X5, have any of the values defined therefore in the specification, and pharmaceutically acceptable salts thereof. The compounds may be used as agents in the treatment of diseases, including cancer. Also provided are pharmaceutical compositions comprising one or more compounds of Formula (IIIa).

58. 发明专利

NZ602055A Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases 未知
公开(公告)号：NZ602055A
公开(公告)日：2014-08-29
申请号：NZ60205511
申请日：2011-03-10
申请人： ABBVIE INC
发明人： HEXAMER LAURA , SOUERS ANDREW J , WENDT MICHAEL , PARK CHEOL-MIN , DING HONG , ELMORE STEVEN , KUNZER AARON R , SULLIVAN GERARD
IPC分类号： C07D295/112 , A61K31/18 , A61K31/451 , A61K31/495 , A61P35/00 , C07C311/51 , C07D211/58 , C07D295/195 , C07D417/04
摘要： Disclosed herein are sulfonyl benzamide compounds, and the use thereof in the treatment of bladder cancer, brain cancer, breast cancer, bone marrow cancer, cervical cancer, chronic lymphocytic leukmia, colorectal cancer, esophageal cancer, hepatocellular cancer, lymphoblastic leukemia, follicular lymphoma, lymphoid malignancies of T -cell or B-cell origin, melanoma, myelogenous leukemia, myeloma, oral cancer, ovarian cancer, non-small cell lung cancer, chronic lymphocytic leukemia, myeloma, prostate cancer, small cell lung cancer or spleen cancer. In one embodiment the compound is N-({ 4-[(cyclohexylmethyl)amino]-3-nitrophenyl} sulfonyl)-3’-{ [(1S,2S,3S,5R)-2,6,6-trimethylbicyclo[3.1.1]hept-3-yl]amino} biphenyl-4-carboxamide.

59. 发明专利

AU2011229862B2 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases 未知
公开(公告)号：AU2011229862B2
公开(公告)日：2014-07-24
申请号：AU2011229862
申请日：2011-03-10
申请人： ABBVIE INC
发明人： DING HONG , ELMORE STEVEN , HEXAMER LAURA , KUNZER AARON R , PARK CHEOL-MIN , SOUERS ANDREW J , SULLIVAN GERARD , WENDT MICHAEL
IPC分类号： C07D295/112 , A61K31/18 , A61K31/451 , A61K31/495 , A61P35/00 , C07C311/51 , C07D211/58 , C07D295/195 , C07D417/04
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti apoptotic Bcl-2 protein.

60. 发明专利

NZ600084A Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases 未知
公开(公告)号：NZ600084A
公开(公告)日：2014-05-30
申请号：NZ60008410
申请日：2010-06-01
申请人： ABBVIE INC
发明人： BRUNCKO MILAN , DAI YUJIA , DING HONG , DOHERTY GEORGE A , ELMORE STEVEN W , HASVOLD LISA , HEXAMER LAURA , KUNZER AARON , MANTEI ROBERT A , MCCLELLAN WILLIAM J , PARK CHANG H , PARK CHEOL-MIN , PETROS ANDREW M , SONG XIAOHONG , SOUERS ANDREW J , SULLIVAN GERARD M , TAO ZHI-FU , WANG GARY T , WANG LE , WANG XILU , WENDT MICHAEL D , HANSEN TODD M
IPC分类号： C07D209/08 , A61K31/404 , A61K31/416 , A61K31/4166 , A61K31/4184 , A61K31/444 , A61K31/496 , C07D211/58 , C07D213/61 , C07D213/65 , C07D213/73 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D235/26 , C07D277/24 , C07D295/155 , C07D309/04 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04
摘要： 600084 Disclosed are 2-(1H-indol-5-yloxy) / 2-(1H-indazol-4-yloxy) / 2-[(3-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-4-yl)oxy and 2-[(6-amino-5-chloropyridin-3-yl)oxy] N-({ pyridin-3-yl / phenyl} sulfonyl)benzamide derivatives as represented by the general formula (I), wherein the compounds are N-({ 3-chloro-4-[(4-fluorotetrahydro-2H-pyran-4-yl)methoxy]phenyl} sulfonyl)-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-2-[(6-fluoro-1H-indol-5-yl)oxy]benzamide; N-({ 3-chloro-4-[(4-fluorotetrahydro-2H-pyran-4-yl)methoxy]phenyl} sulfonyl)-4-(4-{ [4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-2H-pyran-3-yl]methyl} piperazin-1-yl)-2-[(6-fluoro-1Hindol-5-yl)oxy]benzamide; N-({ 5-chloro-6-[(trans-4-hydroxycyclohexyl)methoxy]pyridin-3-yl} sulfonyl)-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-2-[(6-fluoro-1H-indazol-4-yl)oxy]benzamide; N-({ 5-chloro-6-[(4-fluorotetrahydro-2H-pyran-4-yl)methoxy]pyridin-3-yl} sulfonyl)-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-2-[(6-fluoro-1H-indazol-4-yl)oxy]benzamide; tert-butyl 5-[(4-{ 4-[({ 5-chloro-6-[(4-fluorotetrahydro-2H-pyran-4-yl)methoxy]pyridin-3-yl} sulfonyl)carbamoyl]-3-[(6-fluoro-1H-indol-5-yl)oxy]phenyl} piperazin-1-yl)methyl]-4-(4-chlorophenyl)-3,6-dihydropyridine-1(2H)-carboxylate; N-({ 5-chloro-6-[(4-fluorotetrahydro-2H-pyran-4-yl)methoxy]pyridin-3-yl} sulfonyl)-4-(4-{ [4-(4-chlorophenyl)-1-(1,3-difluoropropan-2-yl)-1,2,5,6-tetrahydropyridin-3-yl]methyl} piperazin-1-yl)-2-[(6-fluoro-1H-indol-5-yl)oxy]benzamide; 4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-2-[(6-fluoro-1H-indazol-4-yl)oxy]-N-[(4-{ [(4-fluorotetrahydro-2H-pyran-4-yl)methyl]amino} -3-nitrophenyl)sulfonyl]benzamide; N-({ 5-chloro-6-[(trans-4-hydroxycyclohexyl)methoxy]pyridin-3-yl} sulfonyl)-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-2-[(7-fluoro-1H-indazol-4-yl)oxy]benzamide; N-({ 5-chloro-6-[(4-fluorotetrahydro-2H-pyran-4-yl)methoxy]pyridin-3-yl} sulfonyl)-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-2-[(7-fluoro-1H-indazol-4-yl)oxy]benzamide; 2-[(6-amino-5-chloropyridin-3-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-{ [3-nitro-4-({ [4-(oxetan-3-yl)morpholin-2-yl]methyl} amino)phenyl]sulfonyl} benzamide; 4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-2-[(6-fluoro-1H-indol-5-yl)oxy]-N-{ [3-nitro-4-({ [4-(oxetan-3-yl)morpholin-2-yl]methyl} amino)phenyl]sulfonyl} benzamide; 4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-2-[(7-fluoro-1H-indazol-4-yl)oxy]-N-[(4-{ [(4-fluorotetrahydro-2H-pyran-4-yl)methyl]amino} -3-nitrophenyl)sulfonyl]benzamide; N-({ 5-chloro-6-[(trans-4-hydroxy-4-methylcyclohexyl)methoxy]pyridin-3-yl} sulfonyl)-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-2-[(6-fluoro-1Hindazol-4-yl)oxy]benzamide; 4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-{ [5-chloro-6-(tetrahydro-2H-pyran-4-ylmethoxy)pyridin-3-yl]sulfonyl} -2-[(3-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-4-yl)oxy]benzamide; 4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-({ 4-[(4-fluorotetrahydro-2H-pyran-4-yl)methoxy]-3-nitrophenyl} sulfonyl)-2-[(3-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-4-yl)oxy]benzamide; 4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-[(4-{ [(trans-4-methoxycyclohexyl)methyl]amino} -3-nitrophenyl)sulfonyl]-2-[(3-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-4-yl)oxy]benzamide; 2-[(3-amino-1H-indazol-4-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-[(4-{ [(4-fluorotetrahydro-2H-pyran-4-yl)methyl]amino} -3-nitrophenyl)sulfonyl]benzamide; 2-[(3-amino-1H-indazol-4-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-({ 4-[(4-fluorotetrahydro-2H-pyran-4-yl)methoxy]-3-nitrophenyl} sulfonyl)benzamide; 2-[(3-amino-1H-indazol-4-yl)oxy]-N-({ 5-chloro-6-[(4-fluorotetrahydro-2H-pyran-4-yl)methoxy]pyridin-3-yl} sulfonyl)-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)benzamide; 2-[(3-amino-1H-indazol-4-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-({ 3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl} sulfonyl)benzamide; 2-[(6-amino-5-chloropyridin-3-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-[(4-{ [4-fluoro-1-(oxetan-3-yl)piperidin-4-yl]methoxy} -3-nitrophenyl)sulfonyl]benzamide; 4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-2-[(6-fluoro-1H-indazol-4-yl)oxy]-N-({ 4-[(4-fluorotetrahydro-2H-pyran-4-yl)methoxy]-3-nitrophenyl} sulfonyl)benzamide; 2-[(6-amino-5-chloropyridin-3-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-[(4-{ [(trans-4-hydroxy-4-methylcyclohexyl)methyl]amino} -3-nitrophenyl)sulfonyl]benzamide; 2-[(3-amino-1H-indazol-4-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-[(4-{ [(trans-4-methoxycyclohexyl)methyl]amino} -3-nitrophenyl)sulfonyl]benzamide; 2-[(6-amino-5-chloropyridin-3-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-({ 4-[(cis-4-hydroxy-4-methylcyclohexyl)methoxy]-3-nitrophenyl} sulfonyl)benzamide; 2-[(6-amino-5-chloropyridin-3-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-[(4-{ [(cis-4-hydroxy-4-methylcyclohexyl)methyl]amino} -3-nitrophenyl)sulfonyl]benzamide; 4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-{ [3-chloro-4-(tetrahydro-2H-pyran-4-ylmethoxy)phenyl]sulfonyl} -2-[(3-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-4-yl)oxy]benzamide; 4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-[(4-{ [(4-cyclopropylmorpholin-2-yl)methyl]amino} -3-nitrophenyl)sulfonyl]-2-[(3-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-4-yl)oxy]benzamide; 2-[(6-amino-5-chloropyridin-3-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-{ [3-nitro-4-(2-oxaspiro[3.5]non-7-ylmethoxy)phenyl]sulfonyl} benzamide; 2-[(6-amino-5-chloropyridin-3-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-({ 4-[(trans-4-hydroxy-4-methylcyclohexyl)methoxy]-3-nitrophenyl} sulfonyl)benzamide; 2-[(6-amino-5-chloropyridin-3-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-{ [4-({ [(2S)-4-cyclopropylmorpholin-2-yl]methyl} amino)-3-nitrophenyl]sulfonyl} benzamide; 2-[(6-amino-5-chloropyridin-3-yl)oxy]-N-({ 5-chloro-6-[(trans-1-fluoro-4-hydroxy-4-methylcyclohexyl)methoxy]pyridin-3-yl} sulfonyl)-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)benzamide; 2-[(6-amino-5-chloropyridin-3-yl)oxy]-N-({ 5-chloro-6-[(cis-1-fluoro-4-hydroxy-4-methylcyclohexyl)methoxy]pyridin-3-yl} sulfonyl)-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)benzamide; 2-[(3-amino-1H-indazol-4-yl)oxy]-N-({ 5-chloro-6-[(trans-4-hydroxy-4-methylcyclohexyl)methoxy]pyridin-3-yl} sulfonyl)-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)benzamide; N-({ 5-chloro-6-[(trans-4-hydroxy-4-methylcyclohexyl)methoxy]pyridin-3-yl} sulfonyl)-2-[(3-chloro-1H-indazol-4-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)benzamide; 2-[(6-amino-5-chloropyridin-3-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-[(4-{ [(cis-4-ethyl-4-hydroxycyclohexyl)methyl]amino} -3-nitrophenyl)sulfonyl]benzamide; 2-[(6-amino-5-chloropyridin-3-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-{ [3-nitro-4-({ [(2S)-4-(oxetan-3-yl)morpholin-2-yl]methyl} amino)phenyl]sulfonyl} benzamide; 2-[(6-amino-5-chloropyridin-3-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-({ 5-nitro-6-[(tetrahydro-2H-pyran-4-ylmethyl)amino]pyridin-3-yl} sulfonyl)benzamide; 2-[(6-amino-5-chloropyridin-3-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-({ 3-nitro-4-[(2-oxaspiro[3.5]non-7-ylmethyl)amino]phenyl} sulfonyl)benzamide; 2-[(6-amino-5-chloropyridin-3-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-{ [4-({ [trans-4-(morpholin-4-yl)cyclohexyl]methyl} amino)-3-nitrophenyl]sulfonyl} benzamide; 2-[(6-amino-5-chloropyridin-3-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-[(4-{ [cis-4-(morpholin-4-yl)cyclohexyl]amino} -3-nitrophenyl)sulfonyl]benzamide; 4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-({ 5-cyano-6-[(trans-4-hydroxy-4-methylcyclohexyl)methoxy]pyridin-3-yl} sulfonyl)-2-[(6-fluoro-1Hindazol-4-yl)oxy]benzamide; 2-[(6-amino-5-chloropyridin-3-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-{ [4-({ [4-({ [4-(methoxymethyl)cyclohexyl]methyl} amino)-3-nitrophenyl]sulfonyl} amino)-3-nitrophenyl]sulfonyl} benzamide; 2-[(6-amino-5-chloropyridin-3-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-[(3-nitro-4-{ [(3R)-1-(oxetan-3-yl)pyrrolidin-3-yl]amino} phenyl)sulfonyl]benzamide; 2-[(6-amino-5-chloropyridin-3-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-N-[(3-nitro-4-{ [(3S)-1-(oxetan-3-yl)pyrrolidin-3-yl]amino} phenyl)sulfonyl]benzamide; N-[4-({ 2-[(6-amino-5-chloropyridin-3-yl)oxy]-4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)benzoyl} sulfamoyl)-2-nitrophenyl]morpholine-4-carboxami

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