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    • 54. 发明公开
    • 대장암 과발현 유전자를 이용한 대장암 진단 마커
    • 使用调节基因的结肠癌诊断标记
    • KR1020090063924A
    • 2009-06-18
    • KR1020070131457
    • 2007-12-14
    • 한국생명공학연구원
    • 이희구송은영염영일김선영김영호전호경정경숙원미선김재화윤도영최은화강민아
    • C12Q1/68G01N33/574
    • C12Q1/6886G01N33/57446
    • A specific marker for diagnosing colorectal cancer, which is overexpressed in colorectal cancer cell is provided to use for determining metastasis and prognosis of colorectal cancer and develop anticancer drug. A marker for diagnosing colorectal cancer comprises CHEK1[checkpoint homolog(S.pombe)], MAD2L1[mitotic arrest deficient 2, yeast, human homolog like-1], KRT23[keratin 23] PROX1[prospero-related homeobox 1], SLC7A11[solute carrier family 7, member 11] ASB9[Ankyrin repeat and SOCS box protein 9], ENC1[Ectoderm neural cortex protein 1] PLAU[plasminogen activator, urokinase], RNF183[Ring Finger Protein 183] CSEIL[chromosome segregation 1(yeast homolog)-like], ATAD2[ATPase family, AAA domain containing 2] RAD51AP1[RAD51 associated protein 1], C60RF173[chromosome 6 open reading rfame 173] and CCNB1[cyclin B1] gene. THE CHEK1, MAD2L1, KRT23, PROX1, SLC7A11, ASB9, ENC1, PLAU, RNF183, CSEIL, ATAD2, RAD51AP1, C60RF173 and CCNB1 genes are overexpressed in colorectal cancer cell. The composition comprises a mRNA of CHEK1, MAD2L1, KRT23, PROX1, SLC7A11, ASB9, ENC1, PLAU, RNF183, CSEIL, ATAD2, RAD51AP1, C60RF173 or CCNB1 gene or their primer.
    • 提供了一种用于诊断结直肠癌细胞中过表达的结肠直肠癌的特异性标志物,用于确定结肠直肠癌的转移和预后,并开发抗癌药物。 用于诊断结肠直肠癌的标志物包括CHEK1 [检查点同源物(S.pombe)],MAD2L1 [有丝分裂停滞缺陷2,酵母,人类同源物样-1],KRT23 [角蛋白23] PROX1 [繁荣相关同源异型盒1],SLC7A11 [ 溶质载体家族7,成员11] ASB9 [Ankyrin repeat and SOCS box protein 9],ENC1 [外胚层神经皮质蛋白1] PLAU [纤溶酶原激活剂,尿激酶],RNF183 [环指蛋白183] CSEIL [染色体分离1(酵母同系物 ),ATAD2 [ATPase家族,AAA结构域含2] RAD51AP1 [RAD51相关蛋白1],C60RF173 [6号染色体开放阅读rfame 173]和CCNB1 [细胞周期蛋白B1]基因。 CHEK1,MAD2L1,KRT23,PROX1,SLC7A11,ASB9,ENC1,PLAU,RNF183,CSEIL,ATAD2,RAD51AP1,C60RF173和CCNB1基因在结肠直肠癌细胞中过表达。 该组合物包含CHEK1,MAD2L1,KRT23,PROX1,SLC7A11,ASB9,ENC1,PLAU,RNF183,CSEIL,ATAD2,RAD51AP1,C60RF173或CCNB1基因或其引物的mRNA。
    • 58. 发明公开
    • NDRG2 단백질에 대한 단일클론항체 및 단백질 칩을이용한 정량 측정법
    • 单克隆抗体制备N-MYC下游调控基因2和使用蛋白质芯片确定NDRG2
    • KR1020070059373A
    • 2007-06-12
    • KR1020050118140
    • 2005-12-06
    • 한국생명공학연구원
    • 송은영김재화이희구임종석최승철조미영백경은김진숙김종태윤도영권두한박미영염영일최용경김영준
    • C07K16/00C12N5/12C12Q1/00
    • C07K16/18G01N33/574G01N33/6842G01N2500/00
    • A preparation method of a monoclonal antibody to an N-myc downstream regulated gene 2(NDRG2) protein and a quantitative determination of the NDRG2 protein by using a protein chip are provided to analyze characteristics of dendritic cells, measure presence of NDRG2 protein in cells or tissues, and study on the function of NDRG2 protein in cancer cells. The monoclonal antibody to N-myc downstream regulated gene 2(NDRG2) protein expressed from the dendritic cells which are differentiated from human peripheral monocytes or stem cells of umbilical cord blood is provided, wherein the subclass of the monoclonal antibody is IgG2a; and the monoclonal antibody is produced from a hybridoma cell line NDRG2-19C-4(KCTC 10854BP). The NDRG2 protein is determined quantitatively or qualitatively by treating a reverse-phase protein microarray having biological samples as a protein chip with the monoclonal antibody, wherein the biological sample is tissue, cell, whole blood, serum, plasma, saliva, cerebrospinal fluid or urine.
    • 提供了通过使用蛋白质芯片对N-myc下游调节基因2(NDRG2)蛋白的单克隆抗体的制备方法和NDRG2蛋白质的定量测定,以分析树突状细胞的特征,测定细胞中NDRG2蛋白的存在或 组织,研究NDRG2蛋白在癌细胞中的功能。 提供了从与人周边单核细胞或脐带血干细胞分化的树突状细胞表达的N-myc下游调节基因2(NDRG2)蛋白的单克隆抗体,其中单克隆抗体的亚类为IgG2a; 并且从杂交瘤细胞系NDRG2-19C-4(KCTC 10854BP)产生单克隆抗体。 通过用单克隆抗体处理具有生物样品作为蛋白质芯片的反相蛋白质微阵列来定量或定性测定NDRG2蛋白质,其中生物样品是组织,细胞,全血,血清,血浆,唾液,脑脊髓液或尿液 。