专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

51. 发明申请

WO2006044680A1 METHODS OF DETECTING COLORECTAL CANCER 审中-公开
标题翻译：检测彩色癌的方法
公开(公告)号：WO2006044680A1
公开(公告)日：2006-04-27
申请号：PCT/US2005/037049
申请日：2005-10-14
申请人： THE CLEVELAND CLINIC FOUNDATION , XU, Yan , XIAO, Yi-Jin
发明人： XU, Yan , XIAO, Yi-Jin
IPC分类号： G01N33/574 , G01N33/92
CPC分类号： G01N33/57419 , G01N33/92
摘要： The present invention is directed to a method of detecting colorectal cancer in an individual comprising determining a level of lysophosphatylcholine (LPC) in the individual, wherein a level of LPC in the individual that is lower than the level of LPC in a control is indicative of colorectal cancer in the individual. The LPC can be, for example, LPC 18:2, LPC 18:1, LPC 16:0 or a combination thereof. In a particular embodiment, the sample the sample (e.g., blood, plasma, lymph and tissue) is obtained from the individual. The level of LPC in the individual can be detected using, for example, a liquid chromatography - mass spectrometry (LC-MS) detection method, an ultraviolet (UV) detection method, an enzymatic detection method and combinations thereof.
摘要翻译：本发明涉及一种检测个体中的结肠直肠癌的方法，包括确定个体中溶血磷脂酰胆碱（LPC）的水平，其中个体中LPC水平低于对照中的LPC水平表示个体结肠直肠癌。 LPC可以是例如LPC 18：2，LPC 18：1，LPC 16：0或它们的组合。在一个具体实施方案中，样品从个体获得样品（例如，血液，血浆，淋巴和组织）。可以使用例如液相色谱 - 质谱（LC-MS）检测方法，紫外线（UV）检测方法，酶检测方法及其组合来检测个体中的LPC水平。

52. 发明申请

WO2005073405A3 CATALYTIC POLYNUCLEOTIDE AND ITS USE FOR DETERMINATION OF ANALYTES 审中-公开
标题翻译：催化多核苷酸及其用于测定分析物的用途
公开(公告)号：WO2005073405A3
公开(公告)日：2006-02-16
申请号：PCT/IL2005000097
申请日：2005-01-27
申请人： YISSUM RES DEV CO , WILLNER ITAMAR , XIAO YI , PAVLOV VALERI , GILL RON , NIAZOV TAMARA
发明人： WILLNER ITAMAR , XIAO YI , PAVLOV VALERI , GILL RON , NIAZOV TAMARA
IPC分类号： C12Q1/68 , C12N15/115
CPC分类号： C12N15/115 , C12Q1/6813 , C12Q1/683 , C12Q2521/543 , C12Q2521/331
摘要： A method for the determination of an analyte in a sample, the method comprising: (a) providing a catalytic polynucleotide; (b) contacting the catalytic polynucleotide with the sample so that the catalytic polynucleotide may bind to the analyte; (c) providing assay conditions such that the catalytic polynucleotide produces an optically detectable signal in the presence of the analyte; and (d) detecting the signal, thereby determining the presence of the analyte in the sample. One application of the method is for the detection of telomerase in a biological sample.
摘要翻译：一种用于测定样品中分析物的方法，所述方法包括：（a）提供催化多核苷酸; （b）使催化多核苷酸与样品接触，使得催化多核苷酸可以结合分析物; （c）提供测定条件，使得催化多核苷酸在分析物存在下产生可光学检测的信号; 和（d）检测信号，从而确定样品中分析物的存在。该方法的一个应用是用于检测生物样品中的端粒酶。

53. 发明申请

WO2004085661A3 PROCESS TO CHIRAL BETA-AMINO ACID DERIVATIVES 审中-公开
标题翻译：酰胺氨基酸衍生物的方法
公开(公告)号：WO2004085661A3
公开(公告)日：2005-03-10
申请号：PCT/US2004008533
申请日：2004-03-19
申请人： MERCK & CO INC , DREHER SPENCER D , IKEMOTO NORIHIRO , NJOLITO EUGENIA , RIVERA NELO R , TELLERS DAVID M , XIAO YI
发明人： DREHER SPENCER D , IKEMOTO NORIHIRO , NJOLITO EUGENIA , RIVERA NELO R , TELLERS DAVID M , XIAO YI
IPC分类号： C07C229/34 , C07D295/185 , C07D487/04 , C07D471/00 , C07C207/00 , C07C229/00 , C07C233/00 , C07C235/00 , C07C237/00 , C07D487/00 , C07D491/00 , C07D495/00
CPC分类号： C07D295/185 , C07B2200/07 , C07C229/34 , C07D487/04
摘要： The present invention relates to a process for the synthesis of chiral beta-amino acid derivatives and in particular to a process for the preparation of enantiomerically enriched beta-amino acid amide inhibitors of dipeptidyl peptidase-IV (DP-IV) which are useful for the treatment of Type 2 diabetes.
摘要翻译：本发明涉及一种合成手性β-氨基酸衍生物的方法，特别涉及制备二肽基肽酶-IV（DP-IV）的对映体富集的β-氨基酸酰胺抑制剂的方法，其可用于治疗2型糖尿病。

54. 发明申请

WO2004085378A1 PROCESS FOR THE PREPARATION OF CHIRAL BETA AMINO ACID DERIVATIVES BY ASYMMETRIC HYDROGENATION 审中-公开
标题翻译：通过不对称加氢制备乳酸氨基酸衍生物的方法
公开(公告)号：WO2004085378A1
公开(公告)日：2004-10-07
申请号：PCT/US2004/007793
申请日：2004-03-15
申请人： MERCK & CO. INC. , XIAO, Yi , ARMSTRONG, Joseph, D., III , KRSKA, Shane, W. , NJOLITO, Eugenia , RIVERA, Nelo, R. , SUN, Yongkui , ROSNER, Thorsten
发明人： XIAO, Yi , ARMSTRONG, Joseph, D., III , KRSKA, Shane, W. , NJOLITO, Eugenia , RIVERA, Nelo, R. , SUN, Yongkui , ROSNER, Thorsten
IPC分类号： C07C209/52
CPC分类号： B01J31/2295 , B01J31/24 , B01J31/2409 , B01J2231/645 , B01J2531/0263 , B01J2531/0286 , B01J2531/822 , B01J2531/842 , C07C227/16 , C07C231/12 , C07C231/18 , C07D487/04 , C07C237/20
摘要： The present invention relates to a process for the efficient preparation of enantiomerically enriched beta amino acid derivatives which are useful in the asymmetric synthesis of biologically active molecules. The process comprises an enantioselective hydrogenation of a prochiral beta amino acrylic acid derivative substrate in the presence of a transition metal precursor complexed with a chiral ferrocenyl diphosphine ligand.
摘要翻译：本发明涉及有效制备对映体富集的β氨基酸衍生物的方法，其可用于生物活性分子的不对称合成。该方法包括在与手性二茂铁基二膦配体配合的过渡金属前体存在下的前手性β-氨基丙烯酸衍生物底物的对映选择性氢化。

55. 发明申请

WO9749653A3 SOLID PHASE TYRPHOSTIN LIBRARY LINKED TO MATRICES WITH MEMORIES 审中-公开
标题翻译：与相关记录相关的固体相型蛋白酶图谱
公开(公告)号：WO9749653A3
公开(公告)日：1998-02-26
申请号：PCT/US9711035
申请日：1997-06-24
申请人： IRORI , XIAO XIAO YI , SHI SHUHAO , PARANDOOSH ZAHRA , NOVA MICHAEL P
发明人： XIAO XIAO-YI , SHI SHUHAO , PARANDOOSH ZAHRA , NOVA MICHAEL P
IPC分类号： B01J19/00 , C07B61/00 , C07H21/00 , C07K1/04 , C40B40/06 , C40B40/10 , C40B60/14 , C40B70/00 , G01N15/14 , G01N35/00 , B01L3/14 , C07C255/41 , C07C255/60 , C07C323/32 , C07D213/40 , C07D307/52 , C07D317/58 , C07D333/20 , C12Q1/48 , G06K19/06
CPC分类号： G01N35/00732 , B01J19/0046 , B01J2219/00283 , B01J2219/00295 , B01J2219/00299 , B01J2219/00308 , B01J2219/00333 , B01J2219/00344 , B01J2219/00461 , B01J2219/00463 , B01J2219/005 , B01J2219/00542 , B01J2219/00547 , B01J2219/00549 , B01J2219/00551 , B01J2219/00554 , B01J2219/00563 , B01J2219/00567 , B01J2219/00569 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00689 , B01J2219/00695 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00948 , B01L2300/0609 , C07H21/00 , C07K1/047 , C40B40/06 , C40B40/10 , C40B60/14 , C40B70/00 , G01N35/00871 , G01N2015/149 , G01N2035/00782 , G01N2333/9121 , G01N2500/00
摘要： Combinations, called matrices with memories, of matrix materials with memories that are remotely addressable or remotely programmable recording devices or are associated with imprinted symbology are provided. In particular, combinations of matrix materials, memories, and linked molecules that are tyrphostin analogs are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The matrix materials may additionally include fluophors or other luminescent moieties to produce luminescing matrices with memories. The memories include electronic and optical storage media and also include optical memories, such as bar codes and other machine-readable codes. By virtue of this combination, molecules and biological particles, such as the tyrphostin compounds, that are in proximity or in physical contact with the matrix combination can be labeled by programming the memory with identifying information and can be identified by retrieving the stored information. The tyrphostin compounds, as well as methods of preparing the compounds, are also provided.
摘要翻译：提供了具有存储器的组合，具有可远程寻址的存储器或远程可编程记录装置或与压印符号系统相关联的矩阵材料。特别地，提供了酪氨酸磷酸酯类似物的基质材料，记忆和连接分子的组合。基质材料是在固相化学和生物化学合成，免疫测定和杂交反应中用作载体的基质材料。基质材料还可以包括荧光体或其它发光部分以产生具有记忆的发光基质。存储器包括电子和光学存储介质，并且还包括诸如条形码和其他机器可读代码的光学存储器。通过这种组合，可以通过用识别信息对存储器进行编程来标记与基质组合接近或物理接触的分子和生物颗粒，例如酪氨酸磷酸化合物，并且可以通过检索所存储的信息来鉴定。还提供了酪氨酸磷酸酯化合物，以及制备化合物的方法。

56. 发明申请

WO2013135304A1 BLIND DECODING 审中-公开
标题翻译： BLIND解码
公开(公告)号：WO2013135304A1
公开(公告)日：2013-09-19
申请号：PCT/EP2012/054669
申请日：2012-03-16
申请人： NOKIA SIEMENS NETWORKS OY , WANG, Xiao Yi , FREDERIKSEN, Frank
发明人： WANG, Xiao Yi , FREDERIKSEN, Frank
IPC分类号： H04L5/00
CPC分类号： H04W72/042 , H04L5/001 , H04L5/0023 , H04L5/0051 , H04L5/0053 , H04L5/006 , H04L5/0064 , H04L5/0098 , H04W72/04 , H04W76/00
摘要： A technique, comprising: in a system in which a communication device searches for unscheduled transmissions of downlink control information for said communication device: selecting a combination of search spaces for unscheduled transmissions of downlink control information for a communication device by a plurality of transmission techniques: and transmitting an indication of the result of the selected combination to said communication device.
摘要翻译：一种技术，包括：在通信设备搜索用于所述通信设备的下行链路控制信息的未调度传输的系统中：通过多种传输技术为通信设备的下行链路控制信息的非预定传输选择搜索空间的组合：以及将所选择的组合的结果的指示发送到所述通信设备。

57. 发明申请

WO2012058528A3 DROUGHT TOLERANT PLANTS AND RELATED CONSTRUCTS AND METHODS INVOLVING GENES ENCODING DTP6 POLYPEPTIDES 审中-公开
标题翻译：耐旱植物及相关建议及涉及编码DTP6多肽的基因的方法
公开(公告)号：WO2012058528A3
公开(公告)日：2012-08-02
申请号：PCT/US2011058273
申请日：2011-10-28
申请人： DU PONT , PIONEER HI BRED INT , ALLEN STEPHEN M , BROTHERS JASON L , DESHMUKH KRUPA , LAFITTE HONOR RENEE , LI XIAO YI , LU CHENG , LUCK STANLEY , MULLEN JEFFREY , SAKAI HAJIME , SAYLOR JAMES J , TINGEY SCOTT V , WILLIAMS ROBERT WAYNE
发明人： ALLEN STEPHEN M , BROTHERS JASON L , DESHMUKH KRUPA , LAFITTE HONOR RENEE , LU CHENG , LUCK STANLEY , MULLEN JEFFREY , SAKAI HAJIME , SAYLOR JAMES J , TINGEY SCOTT V , WILLIAMS ROBERT WAYNE
IPC分类号： C12N15/82 , A01H5/10 , C12Q1/68
CPC分类号： C12N15/8274 , A01H5/10 , C12N15/8261 , C12N15/8273 , G06F19/20
摘要： Isolated polynucleotides and polypeptides and recombinant DNA constructs useful for conferring drought tolerance, compositions (such as plants or seeds) comprising these recombinant DNA constructs, and methods utilizing these recombinant DNA constructs. The recombinant DNA construct comprises a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotide encodes a DTP6 polypeptide.
摘要翻译：用于赋予耐旱性的分离的多核苷酸和多肽和重组DNA构建体，包含这些重组DNA构建体的组合物（例如植物或种子），以及利用这些重组DNA构建体的方法。重组DNA构建体包含可操作地连接于在植物中有功能的启动子的多核苷酸，其中所述多核苷酸编码DTP6多肽。

58. 发明申请

WO2011123536A1 POLYCYCLIC TETRACYCLINE COMPOUNDS 审中-公开
标题翻译：多环四环化合物
公开(公告)号：WO2011123536A1
公开(公告)日：2011-10-06
申请号：PCT/US2011/030532
申请日：2011-03-30
申请人： TETRAPHASE PHARMACEUTICALS, INC. , XIAO, Xiao-yi , CLARK, Roger , HUNT, Diana , RÖNN, Magnus , PLAMONDON, Louis , HE, Minsheng , SUTCLIFFE, Joyce , GROSSMAN, Trudy
发明人： XIAO, Xiao-yi , CLARK, Roger , HUNT, Diana , RÖNN, Magnus , PLAMONDON, Louis , HE, Minsheng , SUTCLIFFE, Joyce , GROSSMAN, Trudy
IPC分类号： C07D209/58 , C07D221/18 , C07D243/10 , C07D405/04 , C07D405/06 , C07D487/04 , A61K31/551 , A61K31/473 , A61K31/403 , A61P31/00
CPC分类号： C07D209/58 , C07D221/18 , C07D243/10 , C07D403/06 , C07D405/04 , C07D405/06 , C07D471/04 , C07D487/04 , C07D498/04
摘要： The present invention is directed to a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I) and its therapeutic use.
摘要翻译：本发明涉及由结构式（I）表示的化合物或其药学上可接受的盐。结构式（I）的变量在本文中定义。还描述了包含结构式（I）的化合物及其治疗用途的药物组合物。

59. 发明申请

WO2011025982A3 TETRACYCLINE COMPOUNDS 审中-公开
标题翻译：四环素化合物
公开(公告)号：WO2011025982A3
公开(公告)日：2011-09-22
申请号：PCT/US2010047035
申请日：2010-08-27
申请人： TETRAPHASE PHARMACEUTICALS INC , DENG YONGHONG , PLAMONDON LOUIS , SUN CUIXIANG , XIAO XIAO-YI , ZHOU JINGYE , SUTCLIFFE JOYCE A , RONN MAGNUS P
发明人： DENG YONGHONG , PLAMONDON LOUIS , SUN CUIXIANG , XIAO XIAO-YI , ZHOU JINGYE , SUTCLIFFE JOYCE A , RONN MAGNUS P
IPC分类号： C07C237/26 , A61K31/165 , A61K31/18 , A61K31/397 , A61K31/401 , A61K31/4164 , A61K31/4453 , A61P31/04 , C07C311/21 , C07D207/04 , C07D211/54 , C07D213/82 , C07D233/60 , C07D295/088 , C07D307/10
CPC分类号： C07C311/08 , C07C237/26 , C07C307/10 , C07C311/09 , C07C311/13 , C07C311/21 , C07C311/29 , C07C311/44 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2101/14 , C07C2103/40 , C07C2103/44 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2603/40 , C07C2603/44 , C07C2603/46 , C07D205/04 , C07D207/12 , C07D207/16 , C07D209/44 , C07D209/52 , C07D211/54 , C07D211/60 , C07D213/70 , C07D213/74 , C07D213/82 , C07D223/06 , C07D231/18 , C07D233/60 , C07D233/84 , C07D295/15 , C07D307/64
摘要： The present invention is directed to a compound represented by Structural Formula (1): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I) and its therapeutic use.
摘要翻译：本发明涉及由结构式（1）表示的化合物或其药学上可接受的盐。结构式（I）的变量在本文中定义。还描述了包含结构式（I）的化合物及其治疗用途的药物组合物。

60. 发明申请

WO2010043563A2 GAS TURBINE MODEL AND A METHOD FOR THE MODELING OF A GAS TURBINE 审中-公开
标题翻译：气体涡轮机模型和气体涡轮机建模方法
公开(公告)号：WO2010043563A2
公开(公告)日：2010-04-22
申请号：PCT/EP2009/063175
申请日：2009-10-09
申请人： ALSTOM Technology Ltd. , ZHANG, Xiao-Yi , NEMET, Anton
发明人： ZHANG, Xiao-Yi , NEMET, Anton
IPC分类号： G05B17/02
CPC分类号： G05B17/02
摘要： The invention relates to numerical gas turbine models. The object of the present invention is to propose a gas turbine model and a method for the modeling of a gas turbine, which permits transient modeling with high precision and at the same time numerically efficient means for modeling a gas turbine. The present invention is based on a gas turbine model, which consists of a plurality of sub models. These sub models are either purely dynamic or static, which allows significant simplifications in the numerical solution of the overall model. System parts, which simulate the effects of volumes, metal masses, of actuators, and of measuring systems are regarded as dynamic. The remaining system parts are regarded as static over a time characteristic.
摘要翻译：本发明涉及数值燃气轮机模型。本发明的目的是提出一种用于燃气轮机建模的燃气轮机模型和方法，其允许高精度的瞬时建模，并且同时具有用于对燃气轮机进行建模的数字有效的装置。本发明基于由多个子模型组成的燃气轮机模型。这些子模型是纯动态或静态的，这允许在整个模型的数值解中显着简化。模拟体积，金属质量，致动器和测量系统的影响的系统部件被认为是动态的。剩余的系统部件在时间特性上被视为静态的。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式