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    • 52. 发明申请
    • Powered actuating device for a closure panel of a vehicle
    • 用于车辆闭合面板的动力驱动装置
    • US20070261310A1
    • 2007-11-15
    • US11657713
    • 2007-01-25
    • Alex PoratSalvatore VitaleStephen MitchellEduard VasilescuPeter OxleyGordon PatonJason NiskanenAndrew DanielsDragan Mrkovic
    • Alex PoratSalvatore VitaleStephen MitchellEduard VasilescuPeter OxleyGordon PatonJason NiskanenAndrew DanielsDragan Mrkovic
    • E05F15/12
    • E05F1/1091E05F15/622E05Y2201/11E05Y2600/40E05Y2800/29E05Y2900/548
    • An actuating device is provided for moving a closure panel between an open position spaced apart from a vehicle body and a closed position abutting the vehicle body to close an access opening thereof. The actuating device includes a telescopic arm having a first member coupled to one of the closure panel and the vehicle body and a second member coupled to the other of the closure panel and the vehicle body. The first and second members are slidable relative to one another to move the actuating device between a retracted position corresponding with the closed position and an extended position corresponding with the open position. A screw is rotatable relative to the first member. The screw includes a cavity formed therewithin. A nut is secured to the second member and threadingly engages the screw such that rotation of the screw moves the second member towards and away from the first member to move the actuating device between the respective retracted and extended positions. A gas spring is at least partially disposed within the cavity of the screw for urging the actuating device into the extended position to move the closure panel into the open position.
    • 提供一种致动装置,用于在与车身间隔开的打开位置和邻近车体的关闭位置之间移动闭合面板以关闭其进入开口。 所述致动装置包括伸缩臂,所述伸缩臂具有联接到所述闭合面板和所述车体中的一个的第一构件和联接到所述闭合面板和所述车体中的另一个的第二构件。 第一和第二构件可相对于彼此滑动以使致动装置在对应于关闭位置的缩回位置与对应于打开位置的延伸位置之间移动。 螺杆可相对于第一构件旋转。 螺杆包括在其中形成的空腔。 螺母固定到第二构件并螺纹地接合螺钉,使得螺钉的旋转使第二构件朝向和远离第一构件移动,以使致动装置在相应的缩回位置和延伸位置之间移动。 气体弹簧至少部分地设置在螺钉的空腔内,用于将致动装置推进伸出位置,以将封闭板移动到打开位置。
    • 53. 发明申请
    • Novel serpentine transmembrane antigens expressed in human cancers and uses thereof
    • 在人类癌症中表达的新型蛇纹石跨膜抗原及其用途
    • US20060147951A1
    • 2006-07-06
    • US11225661
    • 2005-09-12
    • Daniel AfarRene HubertKahan LeongArthur RaitanoDouglas SaffranStephen Mitchell
    • Daniel AfarRene HubertKahan LeongArthur RaitanoDouglas SaffranStephen Mitchell
    • C12Q1/68G01N33/574C07H21/04C12P21/06C07K14/82C07K16/30
    • C07K14/4748C07K14/705C07K14/723C07K16/28C07K16/3069C07K2317/34C07K2319/00Y10T436/143333
    • Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STRAP” Serpentine TRansmembrane Antigens of the Prostate). Four particular human STRAPs are described and characterized herein. The human STRAPs exhibit a high degree of structural conservation among them but show no significant structural homology to any known human proteins. The prototype member of the STRAP family, STRAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STRAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and Intracellular N- and C-termini, suggesting that It folds In a “serpentine” manner Into three extracellular and two intracellular loops. STRAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STRAP-1 is highly over-expressed In certain other human cancers.
    • 描述了一种新型的细胞表面蛇纹石跨膜抗原家族。 这个家族中的两个蛋白质完全或主要地在前列腺中表达,以及在前列腺癌中,因此该家族的成员被称为前列腺的“STRAP”蛇纹石TRANmembrane抗原。 本文描述和表征了四种特定的人类STRAP。 人类STRAP在其中表现出高度的结构保守性,但与任何已知的人类蛋白质没有显着的结构同源性。 STRAP家族STRAP-1的原型成员似乎是主要在正常人体组织中的前列腺细胞中表达的IIIa型膜蛋白。 在结构上,STRAP-1是一种339个氨基酸的蛋白质,其特征在于六个跨膜结构域和细胞内N-和C-末端的分子拓扑结构,表明它以“蛇纹石”方式折叠成三个细胞外和两个细胞内环。 STRAP-1蛋白表达在前列腺癌的各个阶段保持在高水平。 此外,STRAP-1在某些其他人类癌症中高度过度表达。
    • 54. 发明授权
    • Drillhole blasting
    • 钻孔爆破
    • US07052092B2
    • 2006-05-30
    • US10432405
    • 2001-11-19
    • Stephen Mitchell CollinsworthNils Alberto HeinkeRoger Dean Skaggs
    • Stephen Mitchell CollinsworthNils Alberto HeinkeRoger Dean Skaggs
    • F24D1/08E21C37/16
    • F42D3/00E21C37/16F42D1/00
    • A blasting arrangement (10) includes drillholes (30) in a rock mass (20). Blind ends (32) are drilled to a desired level and, if necessary, are adjusted as shown at (62) to said level. Each hole (30) is plugged by means of a plug (42), which is protected by non flammable buffer material (44), at a level (40) spaced from the end (32). Explosive (50) is charged above the level (40) and the hole is tamped, shown at (60). The holes are detonated desirably by detonators (52), forcing the plugs (42) downwardly and compressing air in chambers (34) above the ends (32). The weakest part of each hole, around the end (32), is split causing a three dimensional zone of weakness at the level of the ends (32). Air forced into the zone of weakness causes a fracture zone (70) at that level, inhibiting propagation of blasting shock waves and protecting the material underneath the level of the ends (32).
    • 爆破装置(10)包括岩体(20)中的钻孔(30)。 将盲端(32)钻到所需的水平面上,如果需要,将其调整为(62)所示的水平。 每个孔(30)通过由不可燃缓冲材料(44)保护的塞子(42)在与端部(32)间隔开的水平(40)处堵塞。 爆炸物(50)被充电到水平面(40)上,孔被夯实,如(60)所示。 这些孔期望地由引爆器(52)引爆,迫使塞子(42)向下并压缩在端部(32)上方的腔室(34)中的空气。 每个孔的最弱部分(32)围绕端部(32)被分裂,导致端部(32)的水平处的三维弱点区域。 被迫进入弱化区的空气导致在该水平的断裂带(70),从而抑制爆破冲击波的传播并保护端部(32)的下方的材料。
    • 55. 发明申请
    • Liquid dispenser
    • 液体分配器
    • US20050155983A1
    • 2005-07-21
    • US10504614
    • 2003-02-14
    • David RobinsonStephen Mitchell
    • David RobinsonStephen Mitchell
    • B67D3/00B67D5/60
    • B67D3/0029
    • Dispensing apparatus is provided which includes a reservoir for containing a liquid therein which is supported by support means in use. The reservoir has an opening into which valve means are located. The valve means are movable between an open condition, wherein a user can dispense the liquid from the reservoir, and a closed condition, wherein the opening is closed. The valve means are a spaced distance from and separate to the support means. In addition, the reservoir is provided with means to allow releasable engagement with the support means, thereby allowing the reservoir to be located with and removed from the support means as and when required.
    • 提供分配装置,其包括用于容纳其中的液体的储存器,其在使用中由支撑装置支撑。 储存器具有阀装置所在的开口。 阀装置可以在打开状态之间移动,在打开状态下,使用者可以从储存器中分配液体和关闭状态,其中开口被关闭。 阀装置与支撑装置隔开距离并分离。 此外,储存器设置有允许与支撑装置可释放地接合的装置,从而允许储存器在需要时与支撑装置一起定位并从支撑装置移除。
    • 56. 发明授权
    • System and method for computerized status monitor and use in a telephone network
    • 用于电话网络中计算机化状态监视和使用的系统和方法
    • US06430289B1
    • 2002-08-06
    • US09291693
    • 1999-04-13
    • Stephen Mitchell Liffick
    • Stephen Mitchell Liffick
    • H04M100
    • H04M3/436H04M1/57H04M7/0015H04M7/0018H04M7/0021H04M7/0027H04M7/0033Y10S379/90
    • A telecommunication system combines telephone technology and computer. network technology to monitor a caller and callee's computer activity and to access call processing criteria selected by the caller and callee and stored on the computer network. A component of the telephone system, such as a central office switch, accesses the caller and callee call processing criteria. The system evaluates the call processing criteria and, when conditions for both caller and callee are met, the telephone system initiates a telephone call between the caller and callee. The call processing criteria may include accepting all calls, no calls, or calls only from specified parties. In addition, the call processing criteria can vary in accordance with the time of day or an individual's personal preferences, or status, such as when an individual is in a meeting. A user's computer activity may also be monitored and the computer status as idle or active may be reported to the computer network as part of the call processing criteria.
    • 电信系统结合了电话技术和电脑。 网络技术来监视呼叫者和受理者的计算机活动,并访问由呼叫者和被呼叫者选择并存储在计算机网络上的呼叫处理标准。 诸如中心局交换机的电话系统的组件访问呼叫者和被叫方呼叫处理标准。 系统评估呼叫处理标准,并且当满足呼叫者和被叫方的条件时,电话系统发起呼叫者和被叫方之间的电话呼叫。 呼叫处理标准可以包括仅接收来自指定方的所有呼叫,不呼叫或呼叫。 此外,呼叫处理标准可以根据一天中的时间或个人的个人偏好或状态(例如个人在会议中)而变化。 还可以监视用户的计算机活动,并且作为呼叫处理标准的一部分,可以将计算机状态作为空闲或活动报告给计算机网络。