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51. 发明申请

WO2011015522A3 PROCESS FOR THE MANUFACTURE OF PHARMACEUTICALLY ACTIVE COMPOUNDS 审中-公开
标题翻译：制药活性化合物的制备方法
公开(公告)号：WO2011015522A3
公开(公告)日：2011-04-07
申请号：PCT/EP2010061079
申请日：2010-07-30
申请人： HOFFMANN LA ROCHE , HILDBRAND STEFAN , MAIR HANS-JUERGEN , RADINOV ROUMEN NIKOLAEV , REN YI , WRIGHT JAMES ANDERSON
发明人： HILDBRAND STEFAN , MAIR HANS-JUERGEN , RADINOV ROUMEN NIKOLAEV , REN YI , WRIGHT JAMES ANDERSON
IPC分类号： C07D213/73 , A61K31/437 , C07D471/04
CPC分类号： C07D471/04 , C07D213/73 , Y10T436/145555
摘要： According to the present invention there are provided novel processes for the manufacture of the compound of formula (1) as well as novel synthesis routes for key intermediates used in those processes.
摘要翻译：根据本发明，提供了制备式（1）化合物的新方法以及用于这些方法的关键中间体的新型合成路线。

52. 发明申请

WO2009133464A9 OXIDATION PROCESS 审中-公开
标题翻译：氧化工艺
公开(公告)号：WO2009133464A9
公开(公告)日：2011-01-20
申请号：PCT/IB2009005738
申请日：2009-04-30
申请人： DANISCO , MIKKELSEN JOERN DALGAARD , KRAGH KARSTEN MATHIAS , MIKKELSEN RENE , DERKX PATRICK MARIA FRANCISCUS , YU SHUKUN , MULDER HARM , NIKOLAEV IGOR
发明人： MIKKELSEN JOERN DALGAARD , KRAGH KARSTEN MATHIAS , MIKKELSEN RENE , DERKX PATRICK MARIA FRANCISCUS , YU SHUKUN , MULDER HARM , NIKOLAEV IGOR
IPC分类号： C12N9/04 , C12P19/04
CPC分类号： C12N11/14 , C12N9/0006 , C12P19/00
摘要： A method of oxidising a saccharide, by contacting the saccharide with an alcohol dehydrogenase (ADH) enzyme selected from a quinone redox cofactor-dependent ADH, a nicotinamide adenine dinucleotide (NAD+) redox cofactor-dependent ADH, a nicotinamide adenine dinucleotide phosphate (NADP+) redox cofactor-dependent ADH, and any combination thereof is described. An oxidised saccharide obtainable by the method and products, in particular food products and paper products, containing the oxidised saccharide, are also described.
摘要翻译：通过使糖与选自醌氧化还原辅因子ADH，烟酰胺腺嘌呤二核苷酸（NAD +）氧化还原辅因子依赖性ADH，烟酰胺腺嘌呤二核苷酸磷酸（NADP +）的NADP +）的醇脱氢酶（ADH）酶接触来进行氧化糖的方法，描述了氧化还原辅因子依赖性ADH及其任何组合。还描述了通过该方法获得的氧化糖，特别是含有氧化糖的食品和纸制品。

53. 发明申请

WO2010105853A1 VERTIKAL KONTAKTIERTES ELEKTRONISCHES BAUELEMENT SOWIE VERFAHREN ZUR HERSTELLUNG EINES SOLCHEN 审中-公开
标题翻译：垂直接触的电子元件和用于制备这种
公开(公告)号：WO2010105853A1
公开(公告)日：2010-09-23
申请号：PCT/EP2010/001792
申请日：2010-03-22
申请人： MICROGAN GMBH , DAUMILLER, Ingo , HEINLE, Ulrich , KUNZE, Mike , NIKOLAEV, Dmitry
发明人： DAUMILLER, Ingo , HEINLE, Ulrich , KUNZE, Mike , NIKOLAEV, Dmitry
IPC分类号： H01L23/31 , H01L23/00
CPC分类号： H01L24/04 , H01L23/3114 , H01L23/3171 , H01L23/3192 , H01L23/562 , H01L2224/05599 , H01L2224/85399 , H01L2924/00014 , H01L2924/01005 , H01L2924/01006 , H01L2924/01013 , H01L2924/01014 , H01L2924/0102 , H01L2924/01022 , H01L2924/01023 , H01L2924/01033 , H01L2924/01068 , H01L2924/01072 , H01L2924/01074 , H01L2924/014 , H01L2924/05042 , H01L2924/12032 , H01L2224/45099 , H01L2924/00
摘要： Die Erfindung betrifft ein elektronisches Bauelement mit zumindest einer in einer Kontaktebene liegenden Kontaktoberfläche, zumindest einer oberhalb der Kontaktebene angeordneten isolierenden Schicht, zumindest einer auf der isolierenden Schicht angeordneten stabilisierenden Schicht zur Erhöhung einer mechanischen Stabilität des Bauelementes, sowie zumindest einem Bond- und/oder Lötkontakt, wobei die isolierende Schicht und die stabilisierende Schicht zumindest eine Öffnung aufweisen, die sich in einer der Kontaktoberfläche abgewandten Oberseite der stabilisierenden Schicht öffnet und sich durch die stabilisierende Schicht und die isolierende Schicht hindurch bis zur Kontaktoberfläche erstreckt, und wobei sich der Bond- und/oder Lötkontakt über die stabilisierende Schicht erstreckt und durch die Öffnung die Kontaktoberfläche berührt.
摘要翻译：本发明涉及一种具有至少一个位于一接触平面接触表面的电子装置，至少一个接触平面上方布置绝缘层，至少一个设置在所述绝缘层的稳定层，以提高器件的机械稳定性，并且至少一个键和/或焊料接触其中所述绝缘层，并具有至少一个开口的稳定层，打开稳定层背向在接触表面中的一个，并通过稳定层和所述绝缘层通过所述接触表面延伸的顶部，且其中所述键和/ 或稳定化层上焊料接触延伸，并通过开口的接触表面接触。

54. 发明申请

WO2009152463A3 METHOD FOR SCREENING FOR COMPOUNDS THAT INHIBIT NEURODEGENERATION 审中-公开
公开(公告)号：WO2009152463A3
公开(公告)日：2009-12-17
申请号：PCT/US2009/047255
申请日：2009-06-12
申请人： GENENTECH, INC. , NIKOLAEV, Anatoly , TESSIER-LAVIGNE, Marc
发明人： NIKOLAEV, Anatoly , TESSIER-LAVIGNE, Marc
IPC分类号： G01N33/50 , G01N33/15 , C12Q1/02
摘要： Methods for screening for compounds that inhibit neurodegeneration are presented. Shedding of APP can be a useful marker for neurodegeneration and compounds that inhibit shedding of APP are useful as inhibitors of neurodegeneration. Such compounds may be useful in treatment and/or prevention of various neurological diseases, disorders and neuronal damage and may enhance growth, regeneration or survival of mammalian neuronal cells or tissue.

55. 发明申请

WO2009133462A2 PROTEINS 审中-公开
标题翻译：蛋白质
公开(公告)号：WO2009133462A2
公开(公告)日：2009-11-05
申请号：PCT/IB2009005629
申请日：2009-04-30
申请人： DANISCO , DERKX PATRICK MARIA FRANCISCUS , MULDER HARM , NIKOLAEV IGOR
发明人： DERKX PATRICK MARIA FRANCISCUS , MULDER HARM , NIKOLAEV IGOR
IPC分类号： C12N9/04
CPC分类号： C12N11/14 , C12N9/0006 , C12P19/00
摘要： An amino acid sequence is described. The amino acid comprises a signal sequence that is SEQ ID No. 1a (or a variant or homologue or derivative or fragment thereof) that is expressed as a fusion protein that comprisies a protein of interest. The signal sequence directs secretion of the protein of interest. The protein of interest may be a heterologous protein. Secretion of the fusion protein aids purification.
摘要翻译：描述了氨基酸序列。氨基酸包含被表达为包含感兴趣蛋白质的融合蛋白的SEQ ID No.1a（或其变体或同系物或衍生物或片段）的信号序列。信号序列指导目标蛋白的分泌。感兴趣的蛋白质可以是异源蛋白质。融合蛋白的分泌有助于净化。

56. 发明申请

WO2009048488A1 GLUCOAMYLASE VARIANTS WITH ALTERED PROPERTIES 审中-公开
标题翻译：具有更改属性的葡萄糖酶变体
公开(公告)号：WO2009048488A1
公开(公告)日：2009-04-16
申请号：PCT/US2008/004574
申请日：2008-04-08
申请人： DANISCO US, INC., GENENCOR DIVISION , AEHLE, Wolfgang , BOTT, Richard, R. , NIKOLAEV, Igor , SCHEFFERS, Martijn , VAN SOLINGEN, Piet , VROEMEN, Casper
发明人： AEHLE, Wolfgang , BOTT, Richard, R. , NIKOLAEV, Igor , SCHEFFERS, Martijn , VAN SOLINGEN, Piet , VROEMEN, Casper
IPC分类号： C12N9/34 , C07K14/37 , C12N15/56 , C12N15/31 , C12R1/885 , C12N15/62
CPC分类号： C12N9/2428 , Y02E50/17
摘要： The present invention relates to variant glucoamylases wherein the variant has altered properties (e.g., improved thermostability and/or specific activity) compared to a corresponding parent glucoamylase. The present invention also relates to enzyme compositions comprising a variant glucoamylase (e.g., starch hydrolyzing compositions); DNA constructs comprising polynucleotides encoding the variants and methods of producing the variant glucoamylases in host cells
摘要翻译：本发明涉及变体葡糖淀粉酶，其中与相应的母体葡糖淀粉酶相比，变体具有改变的性质（例如改善的热稳定性和/或比活性）。本发明还涉及包含变体葡糖淀粉酶（例如淀粉水解组合物）的酶组合物; 包含编码变体的多核苷酸的DNA构建体和在宿主细胞中产生变体葡糖淀粉酶的方法

57. 发明申请

WO2009027063A2 MUTANT DOUBLE CYCLIZED RECEPTOR PEPTIDES INHIBITING ß1-ADRENOCEPTOR ANTIBODIES 审中-公开
标题翻译：突变型双循环受体肽抑制ß1-亚单位抗体
公开(公告)号：WO2009027063A2
公开(公告)日：2009-03-05
申请号：PCT/EP2008006932
申请日：2008-08-22
申请人： UNIV WUERZBURG J MAXIMILIANS , JAHNS ROLAND , JAHNS VALERIE , LOHSE MARTIN , NIKOLAEV VIACHESLAV
发明人： JAHNS ROLAND , JAHNS VALERIE , LOHSE MARTIN , NIKOLAEV VIACHESLAV
IPC分类号： C07K7/64 , A61K38/12 , A61K38/16 , C07K14/705
CPC分类号： C07K7/64 , A61K38/00 , G01N33/6854
摘要： The present invention relates to novel ß-AR homologous cyclopeptide-mutants comprising only two cysteine residues able to form an intramolecular linkage, to linear peptides that can form these cyclopeptide-mutants and to nucleic acid molecules encoding these cyclopeptide-mutants and linear peptides. Moreover, vectors and recombinant host cells comprising said nucleic acid molecule and a method for producing the disclosed cyclopeptide-mutants are provided. Further provided is a composition comprising the peptides, nucleic acid molecules, vectors or host cells of the invention. The present invention also relates to therapeutic and diagnostic means, methods and uses taking advantage of the peptides of the invention and to means, methods and uses for detecting anti-ß-adrenergic receptor antibodies like anti-ßradrenergic receptor antibodies.
摘要翻译：本发明涉及包含仅能形成分子内连锁的两个半胱氨酸残基的新型β-AR同源环肽突变体，可形成这些环肽突变体的线性肽和编码这些环肽突变体和线性肽的核酸分子。此外，提供了包含所述核酸分子的载体和重组宿主细胞以及用于制备所公开的环肽突变体的方法。还提供了包含本发明的肽，核酸分子，载体或宿主细胞的组合物。本发明还涉及利用本发明的肽的治疗和诊断手段，方法和用途以及用于检测抗β肾上腺素能受体抗体（如抗 - 肾上腺素能受体抗体）的手段，方法和用途。

58. 发明申请

WO2008080045A3 DR6 ANTIBODIES INHIBITING THE BINDING OF DR6 TO APP, AND USES THEREOF IN TREATING NEUROLOGICAL DISORDERS 审中-公开
标题翻译： DR6抗体阻止DR6与APP的结合，以及其在治疗神经疾病中的应用
公开(公告)号：WO2008080045A3
公开(公告)日：2008-09-12
申请号：PCT/US2007088521
申请日：2007-12-21
申请人： GENENTECH INC , NIKOLAEV ANATOLY , TESSIER-LAVIGNE MARC
发明人： NIKOLAEV ANATOLY , TESSIER-LAVIGNE MARC
IPC分类号： C07K16/28 , C07K14/705 , C12N15/113
CPC分类号： C07K16/18 , A61K38/00 , C07K14/70578 , C07K16/2878 , C07K2317/76 , C07K2319/02 , C07K2319/30 , C07K2319/61 , C12N15/1138 , C12N2310/14
摘要： Methods and compositions comprising DR6 antagonists for use in treating neurological disorders, including Alzheimer's disease, are provided. The DR6 antagonists include anti-APP antibodies, anti-DR6 antibodies, DR6 immunoadhesins and DR6 variants (and fusion proteins thereof) which enhance growth, regeneration or survival of mammalian neuronal cells or tissue.
摘要翻译：提供了包含用于治疗神经障碍（包括阿尔茨海默病）的DR6拮抗剂的方法和组合物。 DR6拮抗剂包括增强哺乳动物神经细胞或组织的生长，再生或存活的抗APP抗体，抗DR6抗体，DR6免疫粘附素和DR6变体（及其融合蛋白）。

59. 发明申请

WO2006051418A3 TRANSCRIPTION FACTOR OF THE ZN BINUCLEAR CLUSTER FAMILY OF FUNGAL REGULATORS 审中-公开
标题翻译：真菌调节因子ZN BINUCLEAR CLUSTER FERMIL的转录因子
公开(公告)号：WO2006051418A3
公开(公告)日：2006-08-24
申请号：PCT/IB2005003600
申请日：2005-11-10
申请人： DANISCO , NIKOLAEV IGOR , MADRID SUSAN MAMPUSTI
发明人： NIKOLAEV IGOR , MADRID SUSAN MAMPUSTI
IPC分类号： C07K14/37 , C07K14/38 , C12N1/15 , C12N1/21 , C12N5/10 , C12N15/63 , C12N15/80
CPC分类号： C07K14/38 , C12N15/80 , C12N2501/60
摘要： The present invention relates to an isolated nucleic acid sequence coding for a PntR transcription factor comprising a nucleotide sequence that is the same as, or is complementary to, or contains any suitable codon substitutions for any of those of SEQ ID NOs: 1, 3 or 5 or comprises a sequence which has at least 60% sequence homology with any of SEQ ID NOs: 1, 3 or 5, as well as corresponding polypeptides, vector systems and host cells comprising the same. In particular, the invention relates to sequences which are obtained from an Aspergillus, Trichoderma or Penicillium cell. The invention further relates to methods for disrupting PntR expression in a cell as well as methods for expression or production of a POI in a host cell in which PntR expression has been disrupted.
摘要翻译：本发明涉及编码PntR转录因子的分离的核酸序列，所述核酸序列包含与SEQ ID NO：1,3或任何SEQ ID NO：1,3中任一个相同或互补的任何合适的密码子取代的核苷酸序列或或包含与SEQ ID NO：1,3或5中任一个具有至少60％序列同源性的序列，以及相应的多肽，载体系统和包含该序列的宿主细胞。特别地，本发明涉及从曲霉属，木霉属或青霉属细胞获得的序列。本发明还涉及破坏细胞中PntR表达的方法以及在PntR表达被破坏的宿主细胞中表达或产生POI的方法。

60. 发明申请

WO1997038555A1 FLEXIBLE FLAT HEATER AND METHOD FOR REALISING THE SAME 审中-公开
标题翻译：柔性平板加热器及其实现方法
公开(公告)号：WO1997038555A1
公开(公告)日：1997-10-16
申请号：PCT/RU1997000107
申请日：1997-04-09
申请人： SMOLYANINOV, Andrei Nikolaevich , GORDEEV, Sergei Konstantinovich , ZHUKOV, Sergei Germanovich , NIKOLAEV, Alexandr Nikolaevich , PAUTOV, Dmitry Mikhailovich
发明人： SMOLYANINOV, Andrei Nikolaevich
IPC分类号： H05B03/36
CPC分类号： H05B3/145 , H05B3/36 , H05B2203/009 , H05B2203/017
摘要： The present invention pertains to the field of electrotechnology and more precisely to low-energy resistive heating devices. The flexible and flat heater consists of a multilayered packet comprising a fuel element between dielectric layers, wherein at least one side of said layers is in contact with the fuel element through a polymer layer. The fuel element consists of a carbon-based cloth having a resistance in a square-section fragment thereof, along and across the cloth fibres of said fragment, ranging from 0.1 to 30 Ohms. This invention also relates to a method for producing the flexible flat heater, which comprises the steps of preparing a fuel element from a carbon-based cloth previously made rigid and having a resistance in a square-section fragment thereof, along and across the fibres of said fragment, ranging from 0.1 to 30 Ohms; placing the fuel element between layers of a dielectric which on at least one of its sides is in contact with a polymer layer; and bonding the layers of the packet thus obtained by thermal treatment under pressure.
摘要翻译：本发明涉及电技术领域，更准确地涉及低能量电阻加热装置。柔性和扁平加热器由包括介电层之间的燃料元件的多层包装组成，其中所述层的至少一侧通过聚合物层与燃料元件接触。燃料元件由沿着和穿过所述碎片的布纤维的横截面片段中具有阻力的碳基布组成，范围为0.1至30欧姆。本发明还涉及一种柔性扁平加热器的制造方法，该方法包括以下步骤：从预先制成刚性的碳基布制备燃料元件，并且沿着和横过纤维的方形截面片段具有阻力所述片段为0.1至30欧姆; 将所述燃料元件放置在其至少一个侧面上与聚合物层接触的电介质层; 并且通过在压力下的热处理将由此获得的包粘合。

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