专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

51. 发明申请

US20150225462A1 PICORNAVIRUS-LIKE PARTICLE PRODUCTION IN PLANTS 审中-公开
标题翻译： PICORNAVIRUS-like颗粒生产在植物
公开(公告)号：US20150225462A1
公开(公告)日：2015-08-13
申请号：US14426019
申请日：2013-08-29
申请人： MEDICAGO INC.
发明人： Marc-Andre D'Aoust , Pierre-Olivier Lavoie , Manon Couture , Lucie Poulin , Louis-Philippe Vezina
IPC分类号： C07K14/005 , C07K16/10 , A61K39/125 , C12N7/00 , A61K39/13
CPC分类号： C07K14/005 , A61K39/125 , A61K39/13 , C07K16/1009 , C07K2317/10 , C12N7/00 , C12N15/8258 , C12N2770/32322 , C12N2770/32323 , C12N2770/32351 , C12N2770/32623 , C12N2770/32634 , C12N2800/22
摘要： A method of producing a picornavirus-like particle (PVLP) in a plant is provided. The method comprises introducing a first nucleic acid and a second nucleic acid into the plant, portion of the plant, or a plant cell. The first nucleic acid comprising a first regulatory region active in the plant operatively linked to a nucleotide sequence encoding a polyprotein. The second nucleic acid comprises a second regulatory region active in the plant and operatively linked to a nucleotide sequence encoding one or more protease. The plant, portion of the plant, or plant cell is incubated under conditions that permit the expression of the nucleic acids, thereby producing the PVLP. A PVLP comprising the polyprotein is also provided.
摘要翻译：提供了一种在植物中生产小核糖核酸病毒样颗粒（PVLP）的方法。该方法包括将第一核酸和第二核酸引入植物，植物部分或植物细胞中。所述第一核酸包含在植物中活性的第一调节区，其与编码多蛋白的核苷酸序列有效连接。第二核酸包含在植物中有活性的第二调控区，并可操作地连接于编码一种或多种蛋白酶的核苷酸序列。植物，植物部分或植物细胞在允许核酸表达的条件下温育，从而产生PVLP。还提供了包含多蛋白的PVLP。

52. 发明申请

US20140120578A1 PLANTS FOR PRODUCTION OF THERAPEUTIC PROTEINS 审中-公开
标题翻译：用于生产治疗性蛋白质的植物
公开(公告)号：US20140120578A1
公开(公告)日：2014-05-01
申请号：US14068731
申请日：2013-10-31
申请人： Medicago Inc. , Cellectis SA
发明人： Luc Mathis , Daniel F. Voytas , Jin Li , Feng Zhang , Thomas Stoddard , Marc-André D'Aoust
IPC分类号： C12N15/82 , C12N15/01 , C12P21/00
摘要： Materials and Methods are provided for making plants (e.g., Nicotiana varieties) that are suitable for producing therapeutic polypeptides suitable for administration to humans and animals, particularly by making TAL effector endonuclease-induced mutations in genes encoding xylosyltransferases and fucosyltransferases.
摘要翻译：提供材料和方法用于制备适于产生适于施用于人和动物的治疗性多肽的植物（例如烟草属），特别是通过在编码木糖基转移酶和岩藻糖基转移酶的基因中产生TAL效应子内切核酸酶诱导的突变。

53. 发明申请

WO2020181354A1 ENDOGENOUS PLANT EXPRESSION ENHANCER 审中-公开
公开(公告)号：WO2020181354A1
公开(公告)日：2020-09-17
申请号：PCT/CA2019/050319
申请日：2019-03-14
申请人： MITSUBISHI TANABE PHARMA CORPORATION , MEDICAGO INC. , NATIONAL UNIVERSITY CORPORATION NARA INSTITUTE OF SCIENCE AND TECHNOLOGY
发明人： LAVOIE, Pierre-Olivier , D'AOUST, Marc-Andre , KATO, Ko , YAMASAKI, Shotaro
IPC分类号： C12N15/113 , A01H5/00 , C07K14/08 , C07K14/11 , C12N15/13 , C12N15/40 , C12N15/44 , C12N15/82 , C12N5/10 , C12P21/02
摘要： An isolated expression enhancer active in a plant, portion of a plant or plant cell, the expression enhancer is provided. The isolated expression enhancer may be selected from the group consisting of nbEPI42 (SEQ ID NO:1); nbSNS46 (SEQ ID NO:2); nbCSY65 (SEQ ID NO:3); nbHEL40 (SEQ ID NO:4); and nbSEP44 (SEQ ID NO:5). Methods for using the isolated expression enhancer are also provided.

54. 发明申请

WO2020000101A1 INFLUENZA VIRUS HEMAGGLUTININ MUTANTS 审中-公开
公开(公告)号：WO2020000101A1
公开(公告)日：2020-01-02
申请号：PCT/CA2019/050893
申请日：2019-06-27
申请人： MEDICAGO INC.
发明人： LAVOIE, Pierre-Olivier , LORIN, Aurélien , DOUCET, Alain , D'AOUST, Marc-André , COUTURE, Manon
IPC分类号： C12N15/44 , A01H5/00 , A61K39/145 , A61P31/16 , A61P37/04 , C07K14/11 , C07K16/10 , C12N15/82 , C12N5/10 , C12N7/00 , C12N7/01
摘要： The present invention relates to the production of modified influenza viral proteins in plants. More specifically, the present invention relates to producing and increasing influenza virus-like particle (VLP) production in plants, wherein the VLPs comprise the modified influenza viral proteins, such as modified influenza hemagglutinin (HA). The HA protein may comprising an amino acid sequence comprising at least one substitution when compared to a corresponding wildtype amino acid sequence. Further provided are nucleic acid encoding the modified HA protein. Furthermore methods of producing an influenza virus like particle (VLP) and methods of increasing yield of production of an influenza virus like particle (VLP) in a plant, portion of a plant, or a plant cell, are also provided.

55. 发明申请

WO2011035422A1 METHOD OF PREPARING PLANT-DERIVED VLPS 审中-公开
标题翻译：制备植物衍生VLPS的方法
公开(公告)号：WO2011035422A1
公开(公告)日：2011-03-31
申请号：PCT/CA2010/001488
申请日：2010-09-21
申请人： MEDICAGO INC. , VEZINA, Louis-Philippe , COUTURE, Manon , PAQUET, Dany , DARGIS, Michele , D'AOUST, Marc-Andre
发明人： VEZINA, Louis-Philippe , COUTURE, Manon , PAQUET, Dany , DARGIS, Michele , D'AOUST, Marc-Andre
IPC分类号： C12N7/02 , A61K39/12 , A61K39/145 , A61P31/16 , A61P37/04 , C12N7/00
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/517 , A61K2039/5258 , C12N7/00 , C12N15/8203 , C12N15/8257 , C12N15/8258 , C12N2760/16123 , C12N2760/16134
摘要： Methods of preparing plant-derived virus like particles (VLPs) are provided. The method may comprise obtaining a plant, or plant matter comprising apoplast-localized VLPs, producing a protoplast/spheroplast fraction and apoplast fraction from the plant or plant matter, and recovering the apoplast fraction. The apoplast fraction comprises plant-derived VLPs. Alternatively, VLPs may be obtained from plant or plant matter comprising plant-derived VLPs by digesting the plant matter using a cell wall degrading enzyme composition to produced a digested fraction. The digested fraction is filtered to produced a filtered fraction, and the plant- derived VLPs are recovered from the filtered fraction.
摘要翻译：提供了植物来源的病毒样颗粒（VLPs）的制备方法。该方法可以包括获得植物或包含原生质体定位的VLP的植物物质，从植物或植物物质产生原生质体/原生质体级分和原生质体级分，以及回收载脂蛋白级分。载脂蛋白级分包含植物来源的VLP。或者，VLP可以通过使用细胞壁降解酶组合物消化植物物质从包含植物来源的VLP的植物或植物物质获得，以产生消化部分。将消化的馏分过滤以产生过滤的馏分，并从过滤的馏分中回收来自植物的VLP。

56. 发明申请

WO2010148511A8 CHIMERIC INFLUENZA VIRUS-LIKE PARTICLES COMPRISING HEMAGGLUTININ 审中-公开
标题翻译：含有HEMAGGLUTININ的CHIMERIC INFLUENZA病毒颗粒
公开(公告)号：WO2010148511A8
公开(公告)日：2011-03-10
申请号：PCT/CA2010000983
申请日：2010-06-25
申请人： MEDICAGO INC , COUTURE MANON , DARGIS MICHELE , LAVOIE PIERRE-OLIVIER , VEZINA LOUIS-PHILIPPE , D AOUST MARC-ANDRE
发明人： COUTURE MANON , DARGIS MICHELE , LAVOIE PIERRE-OLIVIER , VEZINA LOUIS-PHILIPPE , D AOUST MARC-ANDRE
IPC分类号： C07K14/11 , A01H5/00 , A61K39/145 , A61P31/16 , C07K19/00 , C12N7/00 , C12N7/01 , C12N15/44 , C12N15/82
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5258 , C07K14/005 , C07K2319/00 , C07K2319/02 , C12N15/8257 , C12N2760/16122 , C12N2760/16123 , C12N2760/16134 , C12N2760/16222 , C12N2760/16223 , C12N2760/16234
摘要： A method for synthesizing chimeric influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of chimeric influenza HA in a plant or a portion of a plant. The invention is also directed towards a VLP comprising chimeric influenza HA protein and plants lipids. The invention is also directed to a nucleic acid encoding chimeric influenza HA as well as vectors. The VLPs may be used to formulate influenza vaccines, or may be used to enrich existing vaccines.
摘要翻译：提供了一种在植物或植物的一部分内合成嵌合型流感病毒样颗粒（VLP）的方法。该方法包括在植物或植物的一部分中表达嵌合流感HA。本发明还涉及包含嵌合流感HA蛋白和植物脂质的VLP。本发明还涉及编码嵌合流感HA以及载体的核酸。 VLP可用于制定流感疫苗，或可用于丰富现有疫苗。

57. 发明申请

WO2008151440A8 MODIFYING GLYCOPROTEIN PRODUCTION IN PLANTS 审中-公开
标题翻译：修改植物中的糖蛋白生产
公开(公告)号：WO2008151440A8
公开(公告)日：2010-03-04
申请号：PCT/CA2008001139
申请日：2008-06-13
申请人： MEDICAGO INC , CENTRE NAT RECH SCIENT , D AOUST MARC-ANDRE , MARQUET-BLOUIN ESTELLE , BARDOR MURIEL , BUREL CAROLE , FAYE LOIC , LEROUGE PATRICE , VEZINA LOUIS-PHILIPPE , GOMORD VERONIQUE , AQUIN STEPHANIE , RIHOUEY CHRISTOPHE , PACCALET THOMAS , SOURROUILLE CHRISTOPHE , UNIV ROUEN
发明人： D AOUST MARC-ANDRE , MARQUET-BLOUIN ESTELLE , BARDOR MURIEL , BUREL CAROLE , FAYE LOIC , LEROUGE PATRICE , VEZINA LOUIS-PHILIPPE , GOMORD VERONIQUE , AQUIN STEPHANIE , RIHOUEY CHRISTOPHE , PACCALET THOMAS , SOURROUILLE CHRISTOPHE
IPC分类号： C12N15/62 , A01H5/00 , A01H5/10 , C07K19/00 , C12N5/10 , C12N9/10 , C12N15/54 , C12N15/82 , C12P21/02 , C12P21/08
CPC分类号： C12N15/8257 , C12N9/1051 , C12N15/8216 , C12N15/8218 , C12N15/8245 , C12N15/8258
摘要： A method for synthesizing a protein of interest with a modified N-glycosylation profile within a plant, a portion of a plant, or a plant cell is provided. The method comprises co-expressing within a plant a nucleotide sequence encoding a first nucleotide sequence encoding a hybrid protein (GNTl-GaIT) comprising a CTS domain of N-acetylglucosaminyl transferase (GNTl) fused to a catalytic domain of beta-l,4galactosyltransferase (GaIT), the first nucleotide sequence operatively linked with a first regulatory region that is active in the plant, and a second nucleotide sequence for encoding the protein of interest, the second nucleotide sequence operatively linked with a second regulatory region that is active in the plant. The first and second nucleotide sequences are co-expressed to synthesize a protein of interest comprising glycans with the modified N-glycosylation profile within the plant, the portion of the plant, or the plant cell.
摘要翻译：提供了在植物，植物的一部分或植物细胞内合成具有修饰的N-糖基化谱的目的蛋白质的方法。该方法包括在植物内共表达编码编码杂合蛋白（GNT1-GalT）的第一核苷酸序列的核苷酸序列，所述第一核苷酸序列包含融合到β-1,4galactosyltransferase的催化结构域的N-乙酰葡糖胺基转移酶（GNT1）的CTS结构域 GaIT），与在植物中有活性的第一调节区可操作地连接的第一核苷酸序列和用于编码目标蛋白的第二核苷酸序列，第二核苷酸序列与在植物中有活性的第二调节区可操作地连接。共表达第一和第二核苷酸序列以合成目标蛋白，其包含在植物，植物部分或植物细胞内具有修饰的N-糖基化谱的聚糖。

58. 发明申请

WO2008151440A4 MODIFYING GLYCOPROTEIN PRODUCTION IN PLANTS 审中-公开
标题翻译：修改植物中的糖蛋白生产
公开(公告)号：WO2008151440A4
公开(公告)日：2009-02-26
申请号：PCT/CA2008001139
申请日：2008-06-13
申请人： MEDICAGO INC , CENTRE NAT RECH SCIENT , D AOUST MARC-ANDRE , MARQUET-BLOUIN ESTELLE , BARDOR MURIEL , BUREL CAROLE , FAYE LOIC , LEROUGE PATRICE , VEZINA LOUIS-PHILIPPE , GOMORD VERONIQUE , AQUIN STEPHANIE , RIHOUEY CHRISTOPHE , PACCALET THOMAS , SOURROUILLE CHRISTOPHE
发明人： D AOUST MARC-ANDRE , MARQUET-BLOUIN ESTELLE , BARDOR MURIEL , BUREL CAROLE , FAYE LOIC , LEROUGE PATRICE , VEZINA LOUIS-PHILIPPE , GOMORD VERONIQUE , AQUIN STEPHANIE , RIHOUEY CHRISTOPHE , PACCALET THOMAS , SOURROUILLE CHRISTOPHE
IPC分类号： C12N15/62 , A01H5/00 , A01H5/10 , C07K19/00 , C12N5/10 , C12N9/10 , C12N15/54 , C12N15/82 , C12P21/02 , C12P21/08
CPC分类号： C12N15/8257 , C12N9/1051 , C12N15/8216 , C12N15/8218 , C12N15/8245 , C12N15/8258
摘要： A method for synthesizing a protein of interest with a modified N-glycosylation profile within a plant, a portion of a plant, or a plant cell is provided. The method comprises co-expressing within a plant a nucleotide sequence encoding a first nucleotide sequence encoding a hybrid protein (GNTl-GaIT) comprising a CTS domain of N-acetylglucosaminyl transferase (GNTl) fused to a catalytic domain of beta-l,4galactosyltransferase (GaIT), the first nucleotide sequence operatively linked with a first regulatory region that is active in the plant, and a second nucleotide sequence for encoding the protein of interest, the second nucleotide sequence operatively linked with a second regulatory region that is active in the plant. The first and second nucleotide sequences are co-expressed to synthesize a protein of interest comprising glycans with the modified N-glycosylation profile within the plant, the portion of the plant, or the plant cell.
摘要翻译：提供了在植物，植物的一部分或植物细胞内合成具有修饰的N-糖基化谱的目的蛋白质的方法。该方法包括在植物内共表达编码编码杂合蛋白（GNT1-GalT）的第一核苷酸序列的核苷酸序列，所述第一核苷酸序列包含融合到β-1,4galactosyltransferase的催化结构域的N-乙酰葡糖胺基转移酶（GNT1）的CTS结构域 GaIT），与在植物中有活性的第一调节区可操作地连接的第一核苷酸序列和用于编码目标蛋白的第二核苷酸序列，第二核苷酸序列与在植物中有活性的第二调节区可操作地连接。共表达第一和第二核苷酸序列以合成目标蛋白，其包含在植物，植物部分或植物细胞内具有修饰的N-糖基化谱的聚糖。

59. 发明申请

WO2008151440A1 MODIFYING GLYCOPROTEIN PRODUCTION IN PLANTS 审中-公开
标题翻译：修改植物中的糖蛋白生产
公开(公告)号：WO2008151440A1
公开(公告)日：2008-12-18
申请号：PCT/CA2008/001139
申请日：2008-06-13
申请人： MEDICAGO, INC. , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , D'AOUST, Marc-Andre , MARQUET-BLOUIN, Estelle , BARDOR, Muriel , BUREL, Carole , FAYE, Loic , LEROUGE, Patrice , VEZINA, Louis-Philippe , GOMORD, Véronique , AQUIN, Stéphanie , RIHOUEY, Christophe , PACCALET, Thomas , SOURROUILLE, Christophe
发明人： D'AOUST, Marc-Andre , MARQUET-BLOUIN, Estelle , BARDOR, Muriel , BUREL, Carole , FAYE, Loic , LEROUGE, Patrice , VEZINA, Louis-Philippe , GOMORD, Véronique , AQUIN, Stéphanie , RIHOUEY, Christophe , PACCALET, Thomas , SOURROUILLE, Christophe
IPC分类号： C12N15/62 , A01H5/00 , A01H5/10 , C07K19/00 , C12N15/54 , C12N15/82 , C12N5/10 , C12N9/10 , C12P21/02 , C12P21/08
CPC分类号： C12N15/8257 , C12N9/1051 , C12N15/8216 , C12N15/8218 , C12N15/8245 , C12N15/8258
摘要： A method for synthesizing a protein of interest with a modified N-glycosylation profile within a plant, a portion of a plant, or a plant cell is provided. The method comprises co-expressing within a plant a nucleotide sequence encoding a first nucleotide sequence encoding a hybrid protein (GNTl-GaIT) comprising a CTS domain of N-acetylglucosaminyl transferase (GNTl) fused to a catalytic domain of beta-l,4galactosyltransferase (GaIT), the first nucleotide sequence operatively linked with a first regulatory region that is active in the plant, and a second nucleotide sequence for encoding the protein of interest, the second nucleotide sequence operatively linked with a second regulatory region that is active in the plant. The first and second nucleotide sequences are co-expressed to synthesize a protein of interest comprising glycans with the modified N-glycosylation profile within the plant, the portion of the plant, or the plant cell.
摘要翻译：提供了在植物，植物的一部分或植物细胞内合成具有修饰的N-糖基化谱的目的蛋白质的方法。该方法包括在植物内共表达编码编码杂合蛋白（GNT1-GalT）的第一核苷酸序列的核苷酸序列，所述第一核苷酸序列包含融合到β-1,4galactosyltransferase的催化结构域的N-乙酰葡糖胺基转移酶（GNT1）的CTS结构域 GaIT），与在植物中有活性的第一调节区可操作地连接的第一核苷酸序列和用于编码目标蛋白的第二核苷酸序列，第二核苷酸序列与在植物中有活性的第二调节区可操作地连接。共表达第一和第二核苷酸序列以合成目标蛋白，其包含在植物，植物部分或植物细胞内具有修饰的N-糖基化谱的聚糖。

60. 发明申请

WO2008006224A1 MEDICAGENIC ACID SAPONIN AND USES THEREOF 审中-公开
标题翻译：药用酸皂苷及其用途
公开(公告)号：WO2008006224A1
公开(公告)日：2008-01-17
申请号：PCT/CA2007/001255
申请日：2007-07-13
申请人： Medicago, Inc , PELLETIER, Joelle , VEZINA, Louis-Philippe , LANDRY, Nathalie , SAVARD, Sylvain
发明人： VEZINA, Louis-Philippe , LANDRY, Nathalie , SAVARD, Sylvain
IPC分类号： A61K31/704 , A23L1/30 , A61K31/575 , A61P3/06
CPC分类号： A61K31/575 , A23L33/105 , A61K31/704
摘要： A cholesterol-lowering preparation comprising medicagenic acid saponin is disclosed. The amount of medicagenic acid saponin in the preparation is greater than 50% by weight to produce the cholesterol-lowering effect in an animal. A method of purifying a preparation of at least 30% medicagenic acid saponin is also disclosed. The preparation may be purified from alfalfa plants and used as a treatment for lowering cholesterol and triglycerides in an animal, in particular a human.
摘要翻译：公开了一种包含姬松茸酸皂苷的降胆固醇制剂。为了在动物体内产生降胆固醇效果，制剂中的致acid酸皂苷的量大于50重量％。还公开了纯化至少30％的致acid酸皂苷的制剂的方法。该制剂可以从苜蓿植物中纯化出来并用作降低动物，特别是人类中的胆固醇和甘油三酯的处理剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式