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51. 发明申请

US20060151921A1 Medical device balloons with improved strength properties and processes for producing the same 审中-公开
标题翻译：具有改善的强度特性的医疗装置气球及其制造方法
公开(公告)号：US20060151921A1
公开(公告)日：2006-07-13
申请号：US11356522
申请日：2006-02-17
申请人： Lixiao Wang , John Chen , Jeffrey Lindquist , Nao Lee , Douglas Devens
发明人： Lixiao Wang , John Chen , Jeffrey Lindquist , Nao Lee , Douglas Devens
IPC分类号： H05B6/00
CPC分类号： A61L31/06 , A61L31/125 , A61M25/1029 , B29C48/022 , B29C48/09 , B29C48/832 , B29C48/86 , B29C48/865 , B29C48/919 , B29L2031/7542 , Y10T428/1086
摘要： A tubular parison for forming a medical device balloon. The parison is formed of a polymeric material, for instance a thermoplastic elastomer. The parison has an elongation at break which is not more than 80% of the elongation of the bulk polymeric material. The elongation of the parison is controlled by altering extrusion conditions. Balloons prepared from the parisons provide higher wall strength and/or higher inflation durability than balloons prepared from conventional parisons of the same material.
摘要翻译：一种用于形成医疗装置气囊的管形型坯。型坯由聚合物材料形成，例如热塑性弹性体。型坯的断裂伸长率不大于本体聚合材料的伸长率的80％。通过改变挤出条件来控制型坯的伸长率。从型坯制备的气球比从相同材料的常规型坯制备的气球提供更高的壁强度和/或更高的充气耐久性。

52. 发明授权

US07056466B2 Method of manufacture medical devices employing microwave energy 失效
公开(公告)号：US07056466B2
公开(公告)日：2006-06-06
申请号：US10212926
申请日：2002-08-06
申请人： Lixiao Wang , Jan Weber
发明人： Lixiao Wang , Jan Weber
IPC分类号： B29C35/08
CPC分类号： B29C49/78 , A61M25/1027 , A61M25/1029 , A61M25/1036 , B29C33/06 , B29C45/14655 , B29C47/0026 , B29C47/003 , B29C47/0071 , B29C47/86 , B29C47/862 , B29C47/8805 , B29C47/8835 , B29C47/90 , B29C47/903 , B29C47/907 , B29C47/908 , B29C49/0042 , B29C49/783 , B29C2035/0855 , B29C2049/0089 , B29K2105/258 , B29L2022/022 , B29L2031/7542 , H05B6/80
摘要： An apparatus and method for molding balloon catheters is disclosed. The balloon may be molded by providing a polymeric tube within a mold having an interior cavity in the shape of the desired balloon. Microwave energy, which may be generated by a gyrotron, may then be directed toward the mold, to heat the polymeric material without heating the mold. Once heated, pressurized fluid may be injected into the tube to blow the polymeric material against the interior cavity whereupon the material can cool to form the balloon or can be further heatset by additional microwave energy and be cooled to form the balloon. In accordance with one embodiment, microwave energy can also be used without a mold to form a medical device.

53. 发明授权

US07037318B2 Catheter for controlled stent delivery 有权
标题翻译：用于受控支架输送的导管
公开(公告)号：US07037318B2
公开(公告)日：2006-05-02
申请号：US09740101
申请日：2000-12-18
申请人： Lixiao Wang
发明人： Lixiao Wang
IPC分类号： A61M29/00
CPC分类号： A61F2/958 , A61F2002/9583 , A61F2250/0039 , A61M25/1002 , A61M29/02 , A61M2025/1059
摘要： A catheter having a catheter shaft and a medical balloon mounted thereon. The medical balloon having a non-inflated state and being inflatable to an inflated state. The medical balloon having a stent mounting region, with a stent being disposed about at least a portion of the stent mounting region. The stent mounting region having a middle portion, a first end portion adjacent to the middle portion and a second end portion adjacent to the middle portion. The middle portion having a middle portion diameter, the first end portion having a first end portion diameter, the second end portion having a second end portion diameter. In the non-inflated state the middle portion diameter being different from the first end portion diameter and the second end portion diameter, in the inflated state the middle portion diameter being substantially the same as the first end portion diameter and the second end portion diameter.
摘要翻译：具有安装在其上的导管轴和医用气囊的导管。该医用气囊具有非充气状态并可膨胀至充气状态。所述医疗气囊具有支架安装区域，支架围绕所述支架安装区域的至少一部分设置。支架安装区域具有中间部分，与中间部分相邻的第一端部部分和与中间部分相邻的第二端部部分。中间部具有中间部分直径，第一端部具有第一端部直径，第二端部具有第二端部直径。在非充气状态下，中间部分直径与第一端部直径和第二端部部分直径不同，在膨胀状态下，中间部分直径与第一端部直径和第二端部部分直径基本相同。

54. 发明授权

US07004963B2 Conformable balloons 有权
公开(公告)号：US07004963B2
公开(公告)日：2006-02-28
申请号：US09952397
申请日：2001-09-14
申请人： Yiqun Bruce Wang , John Jianhua Chen , Lixiao Wang , Jason Todd Lenz
发明人： Yiqun Bruce Wang , John Jianhua Chen , Lixiao Wang , Jason Todd Lenz
IPC分类号： A61M29/00
CPC分类号： A61F2/958
摘要： An inflatable medical balloon for multiple procedures, including angioplasty procedures, procedures for delivering medical devices, such as stents, and a method of making the catheter systems. The catheter system employs a balloon having a plurality of flexible portions and a combination of hard and soft portions.

55. 发明授权

US06939593B2 Medical devices utilizing melt-processible poly(tetrafluoroethylene) 失效
标题翻译：利用可熔融加工的聚（四氟乙烯）
公开(公告)号：US06939593B2
公开(公告)日：2005-09-06
申请号：US09940558
申请日：2001-08-27
申请人： Lixiao Wang
发明人： Lixiao Wang
IPC分类号： A61L29/00 , A61L29/04 , A61L31/00 , A61L31/04 , A61M25/00 , B32B1/08 , B32B27/30 , A61M25/01 , A61M25/10 , B32B27/08 , F16L11/04
CPC分类号： A61L29/041 , A61L31/041 , Y10T29/49885 , Y10T428/139 , Y10T428/1393 , Y10T428/31544 , C08L27/18
摘要： This invention relates to medical devices containing melt-processible polytetrafluoro-ethylene (PTFE) and methods of making same.
摘要翻译：本发明涉及含有可熔融加工的聚四氟乙烯（PTFE）的医疗装置及其制造方法。

56. 发明授权

US06911038B2 Matched balloon to stent shortening 有权
标题翻译：匹配气球支架缩短
公开(公告)号：US06911038B2
公开(公告)日：2005-06-28
申请号：US09850815
申请日：2001-05-08
申请人： Steven P. Mertens , Fernando DiCaprio , Brian Brown , Lixiao Wang
发明人： Steven P. Mertens , Fernando DiCaprio , Brian Brown , Lixiao Wang
IPC分类号： A61M25/00 , A61F2/06 , A61F2/84 , A61M29/00
CPC分类号： A61F2/958
摘要： A catheter for delivery of a prosthesis comprises an expandable member which includes a portion which foreshortens longitudinally upon radial expansion of the expandable member.
摘要翻译：用于输送假体的导管包括可扩张构件，其包括在可扩张构件的径向膨胀时纵向缩短的部分。

57. 发明申请

US20050131528A1 Biodegradable drug delivery vascular stent 有权
公开(公告)号：US20050131528A1
公开(公告)日：2005-06-16
申请号：US11041027
申请日：2005-01-21
申请人： Paul Buscemi , Elizabeth Stejskal , Donald Palme , Lixiao Wang
发明人： Paul Buscemi , Elizabeth Stejskal , Donald Palme , Lixiao Wang
IPC分类号： A61F2/00 , A61F2/02 , A61F2/82 , A61F2/88 , A61L31/14 , A61L31/16 , A61F2/06
CPC分类号： A61F2/82 , A61F2/88 , A61F2/958 , A61F2210/0004 , A61F2210/0023 , A61F2250/0067 , A61F2250/0068 , A61L31/041 , A61L31/044 , A61L31/047 , A61L31/148 , A61L31/16 , A61L2300/42 , A61L2300/604 , A61L2300/606 , A61L2300/622 , Y10S623/901 , C08L67/04
摘要： A stent includes a main body of a generally tubular shape for insertion into a lumen of a vessel of a living being. The tubular main body includes a substantially biodegradable matrix having collagen IV and laminin that enclose voids within the matrix. The tubular main body also includes a biodegradable strengthening material in contact with the matrix to strengthen the matrix. The tubular main body is essentially saturated with drugs.

58. 发明授权

US06719748B2 Low profile metal/polymer tubes 失效
标题翻译：薄型金属/聚合物管
公开(公告)号：US06719748B2
公开(公告)日：2004-04-13
申请号：US10448988
申请日：2003-05-30
申请人： Lixiao Wang
发明人： Lixiao Wang
IPC分类号： A61M2500
CPC分类号： A61M25/0009 , A61M25/0043 , A61M25/0662 , A61M25/104 , A61M2025/0063 , A61M2025/0183
摘要： The present invention relates generally to elongate support members, preferably for use with a catheter for performing medical procedures including percutaneous transluminal coronary angioplasty. An elongate support member, comprising a proximal end, a distal end, is disclosed. The proximal end of the elongate support member, is formed to define a plurality of flanges. A linkage connects the flanges, and a lumen within the shaft defined by connecting the flanges. The elongate support member comprises an improved catheter shaft design that maintains pushability, flexibility, and torquability while limiting the kinking.
摘要翻译：本发明一般涉及细长的支撑构件，优选用于与用于执行包括经皮腔内冠状动脉血管成形术在内的医疗程序的导管一起使用。公开了一种细长的支撑构件，其包括近端，远端。细长支撑构件的近端形成为限定多个凸缘。连杆连接凸缘，以及通过连接法兰限定的内腔。细长支撑构件包括改进的导管轴设计，其在限制扭结的同时保持推压性，柔性和扭矩。

59. 发明授权

US06656156B2 Dual surface protection coating for drug delivery balloon catheters and stents 失效
标题翻译：用于药物输送气囊导管和支架的双表面保护涂层
公开(公告)号：US06656156B2
公开(公告)日：2003-12-02
申请号：US10154186
申请日：2002-05-22
申请人： Dachuan Yang , Joel Stanslaski , Lixiao Wang
发明人： Dachuan Yang , Joel Stanslaski , Lixiao Wang
IPC分类号： A61M2900
CPC分类号： A61L31/16 , A61F2/0077 , A61F2/91 , A61F2/915 , A61F2/958 , A61F2002/91541 , A61F2002/91558 , A61F2250/0067 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/416 , A61L2300/608 , A61L2420/08
摘要： The invention relates to a medical device, such as a stent or a balloon catheter that includes an expandable body portion which has an exterior surface that contacts a vessel wall during treatment. The medical device includes a first coating disposed over at least a portion of the exterior surface. The first coating includes a therapeutic substance that is intended for controlled release from the exterior surface. The medical device further includes a second coating overlaying at least a substantial portion of the first coating. The second coating includes a material that is generally impervious to elution of the therapeutic substance therethrough when the body portion is inserted into the vessel lumen. The material of the second coating is relatively inelastic so that the second coating fractures during expansion of the body portion to allow elution of the therapeutic substance through fissures formed in the second coating.
摘要翻译：本发明涉及医疗装置，例如支架或气囊导管，其包括在治疗期间具有与血管壁接触的外表面的可扩张体部分。医疗装置包括设置在外表面的至少一部分上的第一涂层。第一涂层包括旨在从外表面控制释放的治疗物质。医疗装置还包括覆盖第一涂层的至少大部分的第二涂层。第二涂层包括当主体部分插入血管内腔时通常不能透过治疗物质洗脱的材料。第二涂层的材料相对无弹性，使得第二涂层在体部膨胀期间断裂，以允许通过在第二涂层中形成的裂缝洗脱治疗物质。

60. 发明授权

US06610035B2 Hydrophilic lubricity coating for medical devices comprising a hybrid top coat 有权
标题翻译：用于医疗装置的亲水性润滑性涂层，包括混合面漆
公开(公告)号：US06610035B2
公开(公告)日：2003-08-26
申请号：US09822973
申请日：2001-03-30
申请人： Dachuan Yang , Lixiao Wang , Joel Stanslaski , Liguang Tang
发明人： Dachuan Yang , Lixiao Wang , Joel Stanslaski , Liguang Tang
IPC分类号： A61M2500
CPC分类号： A61L29/145 , A61L29/085 , A61L29/12 , C08L83/04
摘要： The present invention relates to a medical device for insertion into the body wherein the device has at least one surface which periodically comes into contact with a second surface. The first surface comprises an improved lubricious coating having a first hydrogel layer and a second hydrophobic top coating which prevents the hydrogel coating from prematurely absorbing too much moisture. The hydrophobic top coating comprises at least one hydrophilic surfactant which acts as a carrier to facilitate removal of the hydrophobic top coating upon entry into an aqueous environment.
摘要翻译：本发明涉及用于插入体内的医疗装置，其中装置具有周期性地与第二表面接触的至少一个表面。第一表面包括改进的润滑涂层，其具有第一水凝胶层和第二疏水性顶涂层，其防止水凝胶涂层过早吸收太多的水分。疏水性顶涂层包含至少一种作为载体的亲水性表面活性剂，以便在进入水性环境时有助于除去疏水性顶涂层。

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