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51. 发明申请

US20100298290A1 Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their Use and Manufacture 失效
标题翻译：苯并西泮作为PI3K / mTOR的抑制剂及其使用和制造方法
公开(公告)号：US20100298290A1
公开(公告)日：2010-11-25
申请号：US12784254
申请日：2010-05-20
申请人： Neel Kumar Anand , Charles M. Blazey , Owen Joseph Bowles , Chris Allen Buhr , Joerg Bussenius , Jeffry Kimo Curtis , Steven Charles DeFina , Larisa Dubenko , Jason R. Harris , Eileen E. Jackson-Ugueto , Anagha Joshi , Angie Inyoung Kim , Amy Lew Tsuhako , Sunghoon Ma , Jean-Claire Limun Manalo , Stephanie Ng , Csaba J. Peto , Kenneth D. Rice , Tsze H. Tsang , Cristiana A. Zaharia
发明人： Neel Kumar Anand , Charles M. Blazey , Owen Joseph Bowles , Chris Allen Buhr , Joerg Bussenius , Jeffry Kimo Curtis , Steven Charles DeFina , Larisa Dubenko , Jason R. Harris , Eileen E. Jackson-Ugueto , Anagha Joshi , Angie Inyoung Kim , Amy Lew Tsuhako , Sunghoon Ma , Jean-Claire Limun Manalo , Stephanie Ng , Csaba J. Peto , Kenneth D. Rice , Tsze H. Tsang , Cristiana A. Zaharia
IPC分类号： A61K31/553 , C07D413/14 , A61P35/00 , A61P35/04
CPC分类号： C07D413/14 , C07D413/04 , C07D417/14 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/08 , C07D495/04 , C07D498/04 , C07D513/04 , C07D519/00
摘要： The invention is directed to Compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.
摘要翻译：本发明涉及式I化合物及其药学上可接受的盐或溶剂合物，以及制备和使用该化合物的方法。

52. 发明申请

US20100121573A1 POSITION CALCULATING METHOD AND POSITION CALCULATING DEVICE 有权
标题翻译：位置计算方法和位置计算装置
公开(公告)号：US20100121573A1
公开(公告)日：2010-05-13
申请号：US12613010
申请日：2009-11-05
申请人： Shigeru IMAFUKU , Kumar ANAND
发明人： Shigeru IMAFUKU , Kumar ANAND
IPC分类号： G01C21/10 , G01C21/18
CPC分类号： G01C21/165 , G01S19/47
摘要： A position calculating method performed by a position calculating device having a sensor unit carried by or mounted on a mobile body and moving with the mobile body, includes: calculating the position of the mobile body; setting a detection value agreement range of the sensor unit for each of the possibility of moving, possibility of uncertainty, and possibility of stopping of the mobile body, and setting the detection value agreement range of the possibility of moving as the widest range to establish a membership function; determining whether the mobile body is in the stopping condition by predetermined fuzzy inference calculation using the membership function; changing an error parameter used for predetermined Kalman filter process to correct the calculated position by the Kalman filter process according to whether the stopping condition of the mobile body is determined or not; and correcting the calculated position by the Kalman filter process.
摘要翻译：由具有由移动体承载或安装在移动体上并与移动体一起移动的传感器单元的位置计算装置执行的位置计算方法包括：计算移动体的位置; 为移动的可能性，不确定性的可能性和移动体的停止的可能性设置传感器单元的检测值协议范围，并且将移动的可能性的检测值协议范围设置为最宽范围，以建立隶属函数; 通过使用隶属函数的预定模糊推理来确定移动体是否处于停止状态; 改变用于预定卡尔曼滤波处理的误差参数，以根据移动体的停止条件是否确定通过卡尔曼滤波处理来校正计算出的位置; 并通过卡尔曼滤波处理校正计算出的位置。

53. 发明申请

US20090243920A1 POSITIONING METHOD, PROGRAM, AND POSITIONING APPARATUS 审中-公开
标题翻译：定位方法，程序和定位装置
公开(公告)号：US20090243920A1
公开(公告)日：2009-10-01
申请号：US12413076
申请日：2009-03-27
申请人： Kumar ANAND , Rama SANJAY
发明人： Kumar ANAND , Rama SANJAY
IPC分类号： G01S5/14
CPC分类号： G01S19/42
摘要： A positioning method adapted to perform interactive mixing model calculation (IMM calculation) for combining outputs of a plurality of Kalman filter processes while applying weighting of given model probabilities to the outputs in a positioning apparatus, includes the steps of (a) calculating a first likelihood index value of a first Kalman filter process, (b) calculating a second likelihood index value of a second Kalman filter process, (c) calculating a relative value of the first and second likelihood index values, (d) calculating a first model probability corresponding to the first Kalman filter process and a second model probability corresponding to the second Kalman filter process using the relative value, and (e) combining outputs of the first and second Kalman filter processes using the first and second model probabilities to execute the positioning.
摘要翻译：一种适于执行交互式混合模型计算（IMM计算）的定位方法，包括以下步骤：（a）计算第一可能性（b）计算第二卡尔曼滤波处理的第二似然指标值，（c）计算第一和第二似然指数值的相对值，（d）计算第一模型概率对应使用所述相对值对应于所述第一卡尔曼滤波处理和对应于所述第二卡尔曼滤波处理的第二模型概率，以及（e）使用所述第一和第二模型概率组合所述第一和第二卡尔曼滤波处理的输出以执行所述定位。

54. 发明申请

US20090156576A1 Azetidines as MEK Inhibitors for the Treatment of Proliferative Diseases 有权
标题翻译： Azetidines作为MEK抑制剂治疗增殖性疾病
公开(公告)号：US20090156576A1
公开(公告)日：2009-06-18
申请号：US11995928
申请日：2006-10-05
申请人： Naing Aay , Neel Kumar Anand , Charles M. Blazey , Owen Joseph Bowles , Joerg Bussenius , Simona Costanzo , Jeffry Kimo Curtis , Steven Charles DeFina , Larisa Dubenko , Anagha Abhijit Joshi , Abigail R. Kennedy , Angie Inyoung Kim , Elena S. Koltun , Jean-Claire Limun Manalo , Csaba J. Peto , Kenneth D. Rice , Tsze H. Tsang
发明人： Naing Aay , Neel Kumar Anand , Charles M. Blazey , Owen Joseph Bowles , Joerg Bussenius , Simona Costanzo , Jeffry Kimo Curtis , Steven Charles DeFina , Larisa Dubenko , Anagha Abhijit Joshi , Abigail R. Kennedy , Angie Inyoung Kim , Elena S. Koltun , Jean-Claire Limun Manalo , Csaba J. Peto , Kenneth D. Rice , Tsze H. Tsang
IPC分类号： A61K31/397 , C07D205/04 , C07D401/14 , C07D403/06 , C07D471/04 , C07D413/06
CPC分类号： C07D205/04 , C07D205/06 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/06 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
摘要： Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer.
摘要翻译：公开了式（I）的化合物及其药学上可接受的盐和溶剂化物。这些化合物是MEK抑制剂，可用于治疗增殖性疾病如癌症。还公开了含有这些化合物的药物组合物以及使用本发明化合物和组合物治疗癌症的方法。

55. 发明申请

US20060242113A1 Cybernetic search with knowledge maps 有权
标题翻译：用知识图进行控制论搜索
公开(公告)号：US20060242113A1
公开(公告)日：2006-10-26
申请号：US11406209
申请日：2006-04-18
申请人： Kumar Anand , Nori Vithal , Mandaleeka Guru Lakshmi Narayana
发明人： Kumar Anand , Nori Vithal , Mandaleeka Guru Lakshmi Narayana
IPC分类号： G06F17/30
CPC分类号： G06F17/30533
摘要： A precision information collating device is disclosed. The device comprises means for inputting keywords and key phrases and defining level of traverse for establishing interlinks and interdependencies between keywords and key phrases entered and using previously stored interlinks and interdependencies to form a map. The device facilitates searching for keywords and key phrases and filtering out unwanted results, indexing, rating and posting of the result obtained and means for browsing the result.
摘要翻译：公开了一种精密信息整理装置。该设备包括用于输入关键词和关键短语的装置，并且定义用于建立交互链接的遍历水平和关键词与输入的关键短语之间的相互依赖性以及使用先前存储的互连和相互依赖以形成地图的装置。该设备便于搜索关键词和关键短语，并过滤掉不必要的结果，索引，评估和发布所获得的结果以及浏览结果的方法。

56. 发明授权

US06233916B1 Method of using fuel gas expander in power generating plants 失效
公开(公告)号：US06233916B1
公开(公告)日：2001-05-22
申请号：US09661641
申请日：2000-09-13
申请人： Ashok Kumar Anand , Raub Warfield Smith
发明人： Ashok Kumar Anand , Raub Warfield Smith
IPC分类号： F02G300
CPC分类号： F02C3/22 , F02C1/00 , Y02E20/16
摘要： In a power generating plant which utilizes fuel gas for combustion at a predetermined pressure to drive a primary load, and where the fuel gas is supplied at a pressure higher than the predetermined pressure, an improvement is provided wherein a fuel gas expander is located downstream of a source of the fuel gas and upstream of a combustor for decreasing the pressure of the fuel gas, and wherein excess energy from the expander is used to drive a secondary load.

57. 发明授权

US06170263B2 Method and apparatus for converting low grade heat to cooling load in an integrated gasification system 失效
标题翻译：在一体化气化系统中将低等级热量转换为冷负荷的方法和装置
公开(公告)号：US06170263B2
公开(公告)日：2001-01-09
申请号：US09311098
申请日：1999-05-13
申请人： Cedric Chow , Ashok Kumar Anand , Jatila Ranasinghe , David Andrew Stats
发明人： Cedric Chow , Ashok Kumar Anand , Jatila Ranasinghe , David Andrew Stats
IPC分类号： F01K2506
CPC分类号： F01K23/068 , Y02E20/16 , Y02E20/18 , Y02P80/152
摘要： Low grade heat recovered from various sections of an integrated gasification system is used to drive an absorption chilling cycle. In an exemplary embodiment, the recovered low grade heat is used to heat a two component working solution that is pumped through a closed cycle absorption chilling system. The heated working solution is separated into a rich stream and a lean stream. The rich stream is condensed to produce a liquid rich stream that is throttled to reduce its temperature and then evaporated to produce a cooling load. The cooling load may be used for auxiliary cooling needs in the integrated gasification system. The rich vapor stream produced by the evaporating step is mixed with the lean stream to produce a mixed stream, which is cooled in an absorber to produce the working solution for the cycle to be repeated.
摘要翻译：使用从综合气化系统的各个部分回收的低等级热量来驱动吸收冷却循环。在示例性实施例中，回收的低等级热量用于加热泵送通过封闭循环吸收冷却系统的双组分工作溶液。加热的工作溶液被分离成富流和贫流。浓缩的物流被冷凝以产生液体丰富的物流，其被节流以降低其温度，然后蒸发以产生冷却负荷。冷却负荷可用于集成气化系统中的辅助冷却需求。通过蒸发步骤产生的富蒸气流与贫流混合以产生混合流，其在吸收器中冷却以产生用于重复循环的工作溶液。

58. 发明授权

US6101983A Modified gas turbine system with advanced pressurized fluidized bed combustor cycle 失效
标题翻译：改进型燃气轮机系统采用先进的加压流化床燃烧器循环
公开(公告)号：US6101983A
公开(公告)日：2000-08-15
申请号：US371169
申请日：1999-08-11
申请人： Ashok Kumar Anand , Ralph R. Boericke
发明人： Ashok Kumar Anand , Ralph R. Boericke
IPC分类号： F01K23/06 , F02C3/20 , F02C6/04
CPC分类号： F01K23/067 , F01K23/062 , F02C3/205 , Y02E20/18
摘要： A modified gas turbine system is provided that adapts an advanced pressurized fluidized bed combustor cycle for use with existing combustion turbine technology. To accommodate current combustion turbine technology, the air extracted from the compressor discharge is limited, e.g. to about 20% of the total. The additional air required for the APFBC cycle is provided by an auxiliary source of compressed air. The compressor discharge air that is not extracted is used for combustion of the fuel gas produced by the carbonizer and also provides internal cooling as required by conventional combustion turbine design. A separate expander turbine is used to recover energy from the vitiated air from the PFBC. Energy from the vitiated air may further be recovered by directing the expander exhaust to an HRSG.
摘要翻译：提供了一种改进的燃气轮机系统，其适应先进的加压流化床燃烧器循环以与现有燃气轮机技术一起使用。为了适应目前的燃气轮机技术，从压缩机排放物抽出的空气是有限的。至约20％。 APFBC循环所需的额外空气由辅助压缩空气源提供。未提取的压缩机排出空气用于由碳化器生产的燃料气体的燃烧，并且还根据常规燃气轮机设计的要求提供内部冷却。单独的膨胀机涡轮机用于从PFBC中的空气中回收能量。来自膨胀空气的能量可以通过将膨胀机排气引导至HRSG进一步回收。

59. 发明申请

US20190064301A1 METHOD AND SYSTEM OF FREQUENCY CONSTRAINED GRADIENT WAVEFORM PRODUCTION 审中-公开
公开(公告)号：US20190064301A1
公开(公告)日：2019-02-28
申请号：US15690795
申请日：2017-08-30
申请人： Andrew Thomas Curtis , Christopher Kumar Anand , Chad Tyler Harris , Jeff Alan Stainsby , Phil J. Beatty
发明人： Andrew Thomas Curtis , Christopher Kumar Anand , Chad Tyler Harris , Jeff Alan Stainsby , Phil J. Beatty
IPC分类号： G01R33/565 , G01R33/389
CPC分类号： G01R33/56509 , G01R33/3854 , G01R33/389
摘要： The present disclosure provides a method and system of magnetic resonance imaging using a constrained gradient waveform. The constrained gradient waveform is designed to have only predetermined frequencies, for example excluding one or more identified resonant frequencies associated with the MRI system. The application of such a constrained gradient waveform during imaging may aid in reducing noise, vibration and/or heating of the MRI system during imaging.

60. 发明授权

US08697737B2 Raf modulators and methods of use 有权
标题翻译： Raf调节剂和使用方法
公开(公告)号：US08697737B2
公开(公告)日：2014-04-15
申请号：US12903031
申请日：2010-10-12
申请人： Neel Kumar Anand , Charles M. Blazey , Owen Joseph Bowles , Joerg Bussenius , Simona Costanzo , Jeffry Kimo Curtis , Larisa Dubenko , Abigail R. Kennedy , Steven Charles Defina , Angie I. Kim , Jean-Claire L. Manalo , Csaba J. Peto , Kenneth D. Rice , Tsze H. Tsang , Anagha Abhijit Joshi
发明人： Neel Kumar Anand , Charles M. Blazey , Owen Joseph Bowles , Joerg Bussenius , Simona Costanzo , Jeffry Kimo Curtis , Larisa Dubenko , Abigail R. Kennedy , Steven Charles Defina , Angie I. Kim , Jean-Claire L. Manalo , Csaba J. Peto , Kenneth D. Rice , Tsze H. Tsang , Anagha Abhijit Joshi
IPC分类号： A01N43/56 , A61K31/415 , C07D231/56
CPC分类号： C07D413/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention relates to compounds of the Formula I, wherein G, A, X1, X2, X3, Z, E, Y, and X are defined herein. The compounds modulate protein kinase enzymatic activity to modulate cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Raf. Methods of using and preparing the compounds, and pharmaceutical compositions thereof, to treat kinase-dependent diseases and conditions are also an aspect of the invention.
摘要翻译：本发明涉及式I化合物，其中G，A，X 1，X 2，X 3，Z，E，Y和X如本文所定义。该化合物调节蛋白激酶酶活性以调节细胞活性，如增殖，分化，程序性细胞死亡，迁移和化学侵袭。本发明的化合物抑制，调节和/或调节激酶，特别是Raf。使用和制备化合物的方法及其药物组合物治疗激酶依赖性疾病和病症也是本发明的一个方面。

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