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51. 发明授权

US08047206B2 Magnetic devices, systems, and methods placed in or on a tongue 有权
标题翻译：放置在舌头中或舌上的磁性装置，系统和方法
公开(公告)号：US08047206B2
公开(公告)日：2011-11-01
申请号：US11404631
申请日：2006-04-14
申请人： Ryan P. Boucher , Joe Paraschac , Edward M. Gillis , Eric N. Doelling , Craig A. Purdy
发明人： Ryan P. Boucher , Joe Paraschac , Edward M. Gillis , Eric N. Doelling , Craig A. Purdy
IPC分类号： A61F13/00
CPC分类号： A61F5/566 , A61F5/56 , Y10S602/902
摘要： Magnetic structures develop a magnetic force between a tongue and a posterior pharyngeal wall to stabilize an orientation of the tongue. The magnetic structures include magnetic materials that are sized, configured, and arranged on at least one of the first and second magnetic structures, to maintain a substantially mutually repelling orientation between the first and second magnetic structures during a native range of movement of the tongue relative to the pharyngeal wall, i.e., during swallowing and/or drinking/and or speech.
摘要翻译：磁性结构在舌头和后咽壁之间产生磁力，以稳定舌头的取向。磁性结构包括磁性材料，其尺寸，构造和布置在第一和第二磁性结构中的至少一个上，以在舌形相对的自然运动范围内在第一和第二磁性结构之间保持基本相互排斥的取向到咽壁，即在吞咽和/或饮酒和/或言语期间。

52. 发明授权

US08020560B2 Devices, systems and methods using magnetic force systems affecting the tongue or hyoid muscles in the upper airway 有权
标题翻译：使用磁力系统的装置，系统和方法影响上呼吸道中的舌头或hy肌
公开(公告)号：US08020560B2
公开(公告)日：2011-09-20
申请号：US11592637
申请日：2006-11-03
申请人： Joe Paraschac , Ryan P. Boucher , Edward M. Gillis , Octavian Iancea , Andrew W. Kramer , Brian K. McCollum , Scott A. McGill , Lionel M. Nelson , Andres D. Tomas
发明人： Joe Paraschac , Ryan P. Boucher , Edward M. Gillis , Octavian Iancea , Andrew W. Kramer , Brian K. McCollum , Scott A. McGill , Lionel M. Nelson , Andres D. Tomas
IPC分类号： A61F5/56
CPC分类号： A61F5/566 , A61F5/56 , Y10S602/902
摘要： Systems and methods are provided for resisting posterior movement of the tongue during sleep, thereby keeping an airway open. The systems and methods employ a first structure that can be placed either in or on a tongue within an oral cavity and/or in a region of hyoid muscle. The first structure includes a ferromagnetic material. The systems and methods employ a second structure that can be placed either in or on external tissue outside the oral cavity and/or in or on external tissue outside the oral cavity in a desired relationship with the first structure. The second structure includes a magnetic material that magnetically interacts with the ferromagnetic material by attracting the ferromagnetic material, thereby resisting posterior movement of the tongue.
摘要翻译：提供了系统和方法，用于抵抗睡眠期间舌头的后运动，从而保持呼吸道畅通。该系统和方法采用可以放置在口腔内和/或舌骨区域内或舌上的第一结构。第一结构包括铁磁材料。该系统和方法采用第二结构，该第二结构可以以与第一结构的期望的关系置于口腔外部和/或外部组织外部和/或外部组织中或外部组织中。第二结构包括通过吸引铁磁材料与铁磁材料磁性相互作用的磁性材料，从而抵抗舌头的后部运动。

53. 发明授权

US06014579A Endocardial mapping catheter with movable electrode 失效
标题翻译：具有可动电极的心内膜导管
公开(公告)号：US06014579A
公开(公告)日：2000-01-11
申请号：US897657
申请日：1997-07-21
申请人： Mark L. Pomeranz , Susan M. Pietroski , Harold A. Heitzmann , Robert F. Bencini , Edward M. Gillis
发明人： Mark L. Pomeranz , Susan M. Pietroski , Harold A. Heitzmann , Robert F. Bencini , Edward M. Gillis
IPC分类号： A61B5/042 , A61B5/0408 , A61N1/05
CPC分类号： A61B5/6858 , A61B5/0422 , A61B2562/0209 , A61B2562/043
摘要： An endocardial mapping catheter for introduction into a chamber of a heart formed by a wall. The flexible elongate tubular member has proximal and distal extremities and extends along a longitudinal axis. A plurality of longitudinally-extending spaced-apart members are carried by the distal extremity of the flexible elongate tubular member and have proximal extremities and interconnected distal extremities. Certain of the plurality of longitudinally-extending members are arms of a basket-like assembly and are movable between contracted positions and expanded positions in which the arms bow outwardly from the longitudinal axis. A plurality of longitudinally spaced-apart electrodes are carried by each of the arms. Electrical conductors extend through the flexible elongate tubular member and are connected to the electrodes for performing electrical functions with respect to the electrodes. At least one additional electrode is slidably mounted on one of the longitudinally-extending members.
摘要翻译：用于引入由壁形成的心脏室的心内膜定位导管。柔性细长管状构件具有近端和远端，并且沿着纵向轴线延伸。多个纵向延伸的间隔开的构件由柔性细长管状构件的远端承载并且具有近端和相互连接的远端。多个纵向延伸的构件中的某些是篮状组件的臂，并且可以在收缩位置和扩展位置之间移动，在该位置中臂从纵向轴线向外伸出。多个纵向间隔开的电极由每个臂承载。电导体延伸穿过柔性细长管状构件并且连接到电极以相对于电极执行电功能。至少一个附加电极可滑动地安装在一个纵向延伸部件上。

54. 发明授权

US09439801B2 Systems and methods for treatment of sleep apnea 有权
标题翻译：用于治疗睡眠呼吸暂停的系统和方法
公开(公告)号：US09439801B2
公开(公告)日：2016-09-13
申请号：US13539081
申请日：2012-06-29
申请人： Edward M. Gillis , Csaba Truckai , Paul J. Buscemi
发明人： Edward M. Gillis , Csaba Truckai , Paul J. Buscemi
IPC分类号： A61F5/56 , A61F2/00
CPC分类号： A61F5/566 , A61F2/00 , A61F2210/0004 , A61F2250/0018 , Y10T29/49826
摘要： Methods of maintaining airway patency in an airway of a patient. A method includes the steps of wrapping a bioerodable material at least partway around an axis to create a wound bioerodable implant, and coupling two points on the bioerodable material to each other. The invention also provides systems for maintaining airway patency in an airway of a patient that may be used with the methods.
摘要翻译：维持患者气道通气通畅的方法。一种方法包括以下步骤：将至少一部分可生物侵蚀的材料缠绕在轴线周围以产生缠绕的可生物侵蚀的植入物，并将可生物侵蚀的材料上的两个点彼此连接。本发明还提供了可以与该方法一起使用的用于维持患者气道中的气道通畅的系统。

55. 发明申请

US20150202074A1 PARTIALLY ERODABLE SYSTEMS FOR TREATMENT OF OBSTRUCTIVE SLEEP APNEA 审中-公开
标题翻译：用于治疗阻塞性睡眠的部分可清除系统
公开(公告)号：US20150202074A1
公开(公告)日：2015-07-23
申请号：US14674986
申请日：2015-03-31
申请人： Edward M. GILLIS , Octavian IANCEA
发明人： Edward M. GILLIS , Octavian IANCEA
IPC分类号： A61F5/56
CPC分类号： A61F5/56 , A61F5/566
摘要： A method of maintaining airway patency in an airway of a patient which includes the steps of implanting a device into tissue adjacent an airway, the device having a bioerodable material wound around a resiliently deformable body to temporarily maintain the deformable body in a stretched, deformed state, and permitting the bioerodable material of the device to bioerode to apply a force to maintain airway patency. The invention also provides devices for practicing the method.
摘要翻译：一种在患者气道中保持气道通畅的方法，其包括将装置植入邻近气道的组织中的步骤，所述装置具有缠绕在弹性可变形体上的生物可蚀塑料，以暂时将变形体保持在拉伸变形状态并且允许该装置的生物可蚀塑料进行生化代谢以施加力以维持气道通畅。本发明还提供了用于实施该方法的装置。

56. 发明授权

US08590537B2 Devices, systems and methods using magnetic force systems in the tongue 失效
标题翻译：在舌头中使用磁力系统的装置，系统和方法
公开(公告)号：US08590537B2
公开(公告)日：2013-11-26
申请号：US11404598
申请日：2006-04-14
申请人： Joe Paraschac , Ryan P. Boucher , Edward M. Gillis , Eric N. Doelling , Craig A. Purdy , Ronald G. Lax
发明人： Joe Paraschac , Ryan P. Boucher , Edward M. Gillis , Eric N. Doelling , Craig A. Purdy , Ronald G. Lax
IPC分类号： A61F5/37 , A61F13/00 , A61B17/52 , A61N2/00
CPC分类号： A61F2/00 , A61F5/56 , A61F5/566 , A61F2210/009
摘要： Magnetic structures develop a magnetic force between a tongue and a posterior pharyngeal wall to stabilize an orientation of the tongue.
摘要翻译：磁性结构在舌头和后咽壁之间产生磁力，以稳定舌头的取向。

57. 发明申请

US20120132214A1 SYSTEMS AND METHODS FOR TREATMENT OF SLEEP APNEA 审中-公开
标题翻译：用于治疗睡眠APNEA的系统和方法
公开(公告)号：US20120132214A1
公开(公告)日：2012-05-31
申请号：US13308449
申请日：2011-11-30
申请人： Edward M. Gillis , John H. Shadduck , Csaba Truckai
发明人： Edward M. Gillis , John H. Shadduck , Csaba Truckai
IPC分类号： A61F5/56
CPC分类号： A61F5/566
摘要： An implant for treating an obstructive airway disorder includes an elongate implant body configured for implanting in airway-interface tissue. The implant body has a medial portion extending between first and second anchoring end portions. The medial portion of the implant body is axially compliant and the end portions are axially non-compliant. Methods of treating an airway disorder comprising implanting an axially-extending implant in an airway-interface tissue are also provided.
摘要翻译：用于治疗阻塞性气道障碍的植入物包括构造成用于植入气道界面组织中的细长植入体。植入体具有在第一和第二锚固端部之间延伸的中间部分。植入物主体的中间部分是轴向柔性的，并且端部轴向不顺应。还提供了治疗气道障碍的方法，包括在气道 - 界面组织中植入轴向延伸的植入物。

58. 发明授权

US07721740B2 Devices, systems, and methods using magnetic force systems in or on tissue 有权
标题翻译：在组织中或组织上使用磁力系统的装置，系统和方法
公开(公告)号：US07721740B2
公开(公告)日：2010-05-25
申请号：US11397744
申请日：2006-04-04
申请人： Ryan P. Boucher , Edward M. Gillis , Joe Paraschac , Scott A. McGill , Charles R. Rampersaud , Craig A. Purdy
发明人： Ryan P. Boucher , Edward M. Gillis , Joe Paraschac , Scott A. McGill , Charles R. Rampersaud , Craig A. Purdy
IPC分类号： A61F5/56
CPC分类号： A61F5/566 , A61F5/56 , Y10S602/902
摘要： Systems and methods include magnetic structures for placement in or on tissues in an airway. The magnetic structures carry sources of magnetism, which generate magnetic fields having directions. The magnetic fields interact to provide magnetic forces that provide a desired therapeutic effect, e.g., maintaining separation between the soft palate and/or tongue and the posterior pharyngeal wall. The systems and methods size and configure the directions of the magnetic fields to provide stability, which makes possible the achievement of the desired therapeutic effect in a straightforward and elegant manner.
摘要翻译：系统和方法包括用于放置在气道中或组织中的磁性结构。磁结构带有磁场，其产生具有方向的磁场。磁场相互作用以提供提供所需治疗效果的磁力，例如维持软腭和/或舌与咽后壁之间的分离。系统和方法规定和配置磁场的方向以提供稳定性，这使得可以以直观和优雅的方式实现期望的治疗效果。

59. 发明授权

US06468264B1 Closed exchange system 失效
标题翻译：封闭交换系统
公开(公告)号：US06468264B1
公开(公告)日：2002-10-22
申请号：US09416588
申请日：1999-10-12
申请人： Edward M. Gillis , Timothy Scott Nelson
发明人： Edward M. Gillis , Timothy Scott Nelson
IPC分类号： A61K922
CPC分类号： A61M37/00 , A61B17/3468 , A61B90/40 , A61N5/1007
摘要： The invention provides a means of closed exchange of implanted medical device components. An exchanger is brought into contact with the implanted medical device in situ. The component is withdrawn from the implanted device and brought into a closed chamber of the exchanger. Without breaking the contact between implanted device and exchanger, the replacement component is then moved from its position in the exchanger, and inserted into the correct position in the implanted device. The surfaces of the implanted device are not brought into contact with the outside environment, thereby minimizing the possibility of introducing contaminants into the body during the exchange process. The invention is particularly useful for devices that are difficult to position and re-position, thus making it advantageous to exchange only an expended component, rather than the entire device.
摘要翻译：本发明提供了一种植入式医疗装置部件的闭合交换装置。交换器与植入的医疗装置原位接触。组件从植入装置中取出并进入交换器的封闭室。在不破坏植入装置和交换器之间的接触的情况下，更换部件然后从其在交换器中的位置移动，并插入植入装置中的正确位置。植入装置的表面不会与外部环境接触，从而最小化在交换过程中将污染物引入身体的可能性。本发明对于难以定位和重新定位的装置特别有用，因此使得只有交换部件而不是整个装置才是有利的。

60. 发明授权

US06368315B1 Composite drug delivery catheter 有权
公开(公告)号：US06368315B1
公开(公告)日：2002-04-09
申请号：US09339465
申请日：1999-06-23
申请人： Edward M. Gillis , Felix Theeuwes
发明人： Edward M. Gillis , Felix Theeuwes
IPC分类号： A61M2500
CPC分类号： A61M25/0026 , A61M25/0032 , A61M2025/0036 , A61M2025/0056 , A61M2025/0063
摘要： The present invention features a composite catheter comprising an elongate outer member and an elongate inner member positioned within the outer member so that the inner and outer members define an interstitial space. The outer member has a size and other characteristics that facilitate handling and implantation of the composite catheter, while the inner diameter of the inner member has the size and other characteristics suitable for delivery of a drug through a lumen of the inner member. The interstitial space imparts flexibility to the composite catheter by, for example, removing material from the cross-sectional area that would otherwise provide additional stiffness to the catheter, and/or by accommodating movement of the outer member relative to the inner member.

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