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51. 发明申请

WO2011008108A1 A SKATEBOARD AND TRUCK 审中-公开
标题翻译：滑板和卡车
公开(公告)号：WO2011008108A1
公开(公告)日：2011-01-20
申请号：PCT/NZ2009/000144
申请日：2009-07-16
申请人： INSTINCT (2008) LIMITED , COLLINS, Peter Roger
发明人： COLLINS, Peter Roger
IPC分类号： A63C17/00
CPC分类号： A63C17/012 , A63C17/015
摘要： A skateboard truck base includes a base, a hanger coupling interface and a truck coupling for retaining the base within a skateboard deck. Two tapered volume of revolution mounting protrusions extending from the base and are configured to be received within the skateboard deck. The protrusions are to be received within the skateboard deck to transmit shear forces between the base and skateboard deck. According to an alternative aspect a skateboard truck includes a base and a hanger. A resiliently deformable member is disposed between the base and the hanger. The resiliently deformable member facilitates all practical relative movement between the base and the hanger. Also presented are travel stops and braking systems for skateboards.
摘要翻译：一个滑板卡车底座包括一个底座，一个衣架耦合接口和一个卡车连接器，用于将基座保持在滑板甲板内。两个锥形体积的旋转安装突起从基部延伸并被构造成容纳在滑板甲板内。这些突起将被接收在滑板甲板内以在基座和滑板甲板之间传递剪切力。根据替代方面，滑板卡车包括底座和衣架。可弹性变形的构件设置在基座和吊架之间。可弹性变形的构件有助于基座和衣架之间的所有实际的相对移动。还提供了滑板的行驶停止和制动系统。

52. 发明申请

WO2010142592A1 USER INTERFACE FOR INSPECTION OF PHOTOGRAPHS 审中-公开
标题翻译：用于摄影摄影的用户界面
公开(公告)号：WO2010142592A1
公开(公告)日：2010-12-16
申请号：PCT/EP2010/057762
申请日：2010-06-03
申请人： 3D LABS INC., LTD , MURAVEYNYK, Oleg , EWIN, Jon , COLLINS, Peter Daniel , MURPHY, Nicholas, J. N.
发明人： MURAVEYNYK, Oleg , EWIN, Jon , COLLINS, Peter Daniel , MURPHY, Nicholas, J. N.
IPC分类号： G06F3/048
CPC分类号： G06F3/04883 , G06F3/0481 , G06F2203/04805
摘要： A method of displaying images on the display screen of a portable electronic device includes presenting the overall image according to a first magnification level and a selected region in accordance with a second magnification level. The second region is superimposed over the overall image and is activated by a user input.
摘要翻译：在便携式电子设备的显示屏幕上显示图像的方法包括根据第二放大级别根据第一放大级别和所选择的区域呈现整体图像。第二区域叠加在整个图像上并由用户输入激活。

53. 发明申请

WO2010003032A3 RECOMBINANT HUMAN PARAINFLUENZA TYPE 1 VIRUSES (HPIV1S) CONTAINING MUTATIONS IN OR DELETION OF THE C PROTEIN ARE ATTENUATED IN AFRICAN GREEN MONKEYS AND IN CILIATED HUMAN AIRWAY EPITHELIAL CELLS AND ARE POTENTIAL VACCINE CANDIDATES FOR HPIV1 审中-公开
标题翻译：包含突变或缺失C蛋白的重组人类嗜血菌1型病毒（HPIV1S）在非洲绿色猴子和人类睫状体上皮细胞中减毒并且是HPIV1的潜在疫苗候选者
公开(公告)号：WO2010003032A3
公开(公告)日：2010-08-12
申请号：PCT/US2009049461
申请日：2009-07-01
申请人： US GOV HEALTH & HUMAN SERV , BARTLETT EMMALENE , COLLINS PETER L , SKIADOPOULOS MARIO H , MURPHY BRIAN R
发明人： BARTLETT EMMALENE , COLLINS PETER L , SKIADOPOULOS MARIO H , MURPHY BRIAN R
IPC分类号： C07K14/005
CPC分类号： C12N7/00 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/543 , C12N2760/18634 , C12N2760/18661
摘要： Two recently characterized live attenuated HPIV1 vaccine candidates, rHPIV1-CR84G/ ?170HNT553ALY942A and rHPIV1-CR84G/? 170HNT553AL? 1710-11, which contain temperature sensitive (ts) attenuating (att) and non-ts att mutations, were evaluated in a Human Airway Epithelium (HAE) model culture system and in vivo in African Green monkeys (AGM). The vaccine candidates were highly restricted in growth in HAE at permissive (32 o C) and restrictive (37 o C) temperatures. The viruses grew slightly better at 37 o C than at 32 oC, and rHPIV1-CR84G/ ?170HNT553ALY942A was less attenuated than rHPIV1-CR84G/ ?170HNT553AL ?1710-11. The level of replication in HAE correlated with that observed in African Green monkeys, suggesting that the HAE model is useful as a tool for pre-clinical evaluation of HPIV1 vaccines. A live attenuated HPIV1 vaccine candidate having a normal P/C gene structure of overlapping P and C open reading frames, but does not express any functional C protein, is found to highly attenuated in AGMs, and provides a significant immune response in AGMs.
摘要翻译：最近有两种特征性活减毒HPIV1候选疫苗，rHPIV1-CR84G /？170HNT553ALY942A和rHPIV1-CR84G /？ 170HNT553AL？在人类呼吸道上皮细胞（HAE）模型培养系统中和体内非洲绿猴（AGM）中评估含有温度敏感性（ts）减弱（att）和非ts att突变的1710-11。候选疫苗高度限制HAE在宽容（32℃）和限制性（37℃）温度下的生长。病毒在37℃时比在32℃时稍微好些，rHPIV1-CR84G /Δ170HNT553ALY942A比rHPIV1-CR84G /Δ170HNT553ALΔ1710-11弱。 HAE中的复制水平与在非洲绿猴中观察到的复制水平相关，表明HAE模型可用作HPIV1疫苗的临床前评估的工具。发现具有重叠的P和C开放阅读框但不表达任何功能性C蛋白的正常P / C基因结构的活的减毒HPIV1疫苗候选物在AGM中高度减毒，并且在AGM中提供显着的免疫应答。

54. 发明申请

WO2005110906A2 SYSTEM FOR GAP SCANNING 审中-公开
标题翻译：差距扫描系统
公开(公告)号：WO2005110906A2
公开(公告)日：2005-11-24
申请号：PCT/GB2005/001788
申请日：2005-05-10
申请人： AIRDRI LIMITED , COLLINS, Peter, Ralph
发明人： COLLINS, Peter, Ralph
IPC分类号： B66B13/26
CPC分类号： B66B13/26
摘要： A gap scanning system for a variable sized gap bounded on a first side by a first member and on the other side to the first side by a second member movable relative to the first member wherein a plurality of emitters of a beams of electromagnetic radiation, such as of infra red, are directed from one side of the gap of variable size to the other side to the one side where a beam from one emitter in the plurality can be received by a complementary receiver in a plurality thereof; characterised in that the number of emitters in the plurality thereof differs substantially from the number of receivers in the plurality thereof and the plurality containing the greater number of emitters or receivers is located on the first side of the gap. The invention further includes a lift door system incorporating a gap scanning system as aforesaid.
摘要翻译：一种间隙扫描系统，用于可变尺寸的间隙，其在第一侧由第一构件限定，并且在另一侧通过相对于第一构件可移动的第二构件在另一侧上限定，其中多个电磁辐射束的发射器从红外线，从可变尺寸的间隙的一侧向另一侧引导到多个中的来自一个发射器的波束可以被多个互补接收器接收的一侧; 其特征在于，多个发射器的数量与其多个中的接收器的数量基本不同，并且包含更多数量的发射器或接收器的多个位于间隙的第一侧。本发明还包括如上所述的包括间隙扫描系统的电梯门系统。

55. 发明申请

WO2005072528A1 ANTICANCER GLYCOSIDE COMPOUNDS 审中-公开
标题翻译：抗癌甘油化合物
公开(公告)号：WO2005072528A1
公开(公告)日：2005-08-11
申请号：PCT/US2005/003101
申请日：2005-01-27
申请人： NORTHWESTERN UNIVERSITY , ADRIAN, Thomas, E. , COLLINS, Peter
发明人： ADRIAN, Thomas, E. , COLLINS, Peter
IPC分类号： A01N43/04
CPC分类号： A61K31/704
摘要： The present invention relates to new classes of anti-cancer compounds. In particular, the present invention provides glycoside compounds as anti-cancer agent, alone, or in combination with other anti-cancer agents or therapies.
摘要翻译：本发明涉及新类型的抗癌化合物。特别地，本发明提供作为抗癌剂的糖苷化合物，单独使用或与其它抗癌剂或疗法组合。

56. 发明申请

WO2004077947A1 PESTICIDAL COMPOSITION AND PROCESS FOR PRODUCING COATED SOLID PESTICIDES 审中-公开
标题翻译：农药组合物和生产涂层固体杀虫剂的方法
公开(公告)号：WO2004077947A1
公开(公告)日：2004-09-16
申请号：PCT/EP2004/002294
申请日：2004-03-05
申请人： SYNGENTA PARTICIPATIONS AG , HASEGAWA, Hiroshi , MATSUBARA, Takahiro , KOHNOSU, Shigeru , SUDA, Yukiko , KINGSBURY, Lee, Paul , COLLINS, Peter
发明人： HASEGAWA, Hiroshi , MATSUBARA, Takahiro , KOHNOSU, Shigeru , SUDA, Yukiko , KINGSBURY, Lee, Paul , COLLINS, Peter
IPC分类号： A01N25/26
CPC分类号： A01N25/26 , A01N51/00 , A01N43/90 , A01N2300/00
摘要： The instant invention relates to a pesticidal composition and to a process for producing coated solid pesticides. Said pesticidal composition and process for the coating of a solid pesticide formulation with thermoplastic polymers comprise the steps of a) charging said solid pesticide formulation into the drum of a pan coater equipped with at least one spraying nozzle, with at least one gas inlet and with at least one gas outlet b) spraying a mixture of at least one solvent and at least one thermoplastic polymer emulsified therein through said spraying nozzle during the operation of the pan coater and simultaneously blowing a gas through said gas inlet into the drum. The process according to the instant invention enables the production of coated solid pesticides in a very simple process, without requiring any manual intervention during the operation, and yields coated solid pesticides with excellently uniform coating layers and having extraordinarily well controlled release property of active ingredients.
摘要翻译：本发明涉及一种农药组合物和一种生产包衣固体杀虫剂的方法。用热塑性聚合物涂覆固体农药制剂的所述杀虫组合物和方法包括以下步骤：a）将所述固体农药制剂装入装有至少一个喷雾嘴的平底锅涂布机的滚筒中，至少一个气体入口和至少一个气体出口b）在盘式涂布机的操作期间喷射至少一种溶剂和至少一种在其中乳化的热塑性聚合物的混合物，同时将气体通过所述气体入口吹入滚筒。根据本发明的方法能够以非常简单的方法生产涂覆的固体杀虫剂，而不需要在操作期间进行任何手动干预，并且产生具有优异均匀涂层的涂覆固体杀虫剂并且具有非常好的控制活性成分释放性能。

57. 发明申请

WO03043587A2 RECOVERY OF RECOMBINANT HUMAN PARAINFLUENZA VIRUS TYPE 1 (HPIVI) FROM CDNA AND USE OF RECOMBINANT HPIVI IN IMMUNOGENIC COMPOSITIONS AND AS VECTORS TO ELICIT IMMUNE RESPONSES AGAINST PIV AND OTHER HUMAN PATHOGENS 审中-公开
标题翻译：从CDNA恢复重组人淋巴瘤病毒1型（HPIVI）和在免疫组化中使用重组HPIVI和作为向量的免疫应答对抗PIV和其他人类病原体的免疫反应
公开(公告)号：WO03043587A2
公开(公告)日：2003-05-30
申请号：PCT/US0237688
申请日：2002-11-21
申请人： US SECRETARY DEPT OF HEALTH AN , MURPHY BRIAN R , COLLINS PETER L , SKIADOPOULOS MARIO H , NEWMAN JASON T
发明人： MURPHY BRIAN R , COLLINS PETER L , SKIADOPOULOS MARIO H , NEWMAN JASON T
IPC分类号： A61K20060101 , A61K35/76 , A61K39/155 , A61P31/14 , C07K14/115 , C12N7/00 , C12N7/01 , C12N7/04 , C12N15/45 , C12N15/86 , C12P21/04 , A61K
CPC分类号： C07K14/005 , A61K2039/525 , C12N7/00 , C12N15/86 , C12N2760/18622 , C12N2760/18643 , C12N2760/18661
摘要： Recombinant human parainfluenza virus type I (HPIVI) composiitions, formulations, and methods are provided. The recombinant HPIVI viruses and HPIVI chimeric and chimeric vector viruses provided according to the invention are infectious and attenuated in permissive mammalian subjects, including humans, are useful in immunogenic composition s for eliciting an immune responses against one or more PIVs, against one or more non-PIV pathogens, or against a PIV and a non-PIV pathogen. Also provided are isolated polynucleotide molecules and vectors incorporating a recombinant HPIVI genome or antigenome.
摘要翻译：提供重组人副流感病毒I型（HPIVI）组合物，制剂和方法。根据本发明提供的重组HPIVI病毒和HPIVI嵌合和嵌合载体病毒在许可哺乳动物受试者（包括人）中是感染性和减毒性的，可用于针对一种或多种非免疫原性引发针对一种或多种PIV的免疫应答的免疫原性组合物 -PIV病原体，或针对PIV和非PIV病原体。还提供了分离的多核苷酸分子和掺入重组HPIVI基因组或反基因组的载体。

58. 发明申请

WO0202605A3 ATTENUATED HUMAN-BOVINE CHIMERIC PARAINFLUENZA VIRUS (PIV) VACCINES 审中-公开
标题翻译：衰老人类血液流行性感冒病毒（PIV）疫苗
公开(公告)号：WO0202605A3
公开(公告)日：2003-01-09
申请号：PCT/US0121527
申请日：2001-07-05
申请人： US HEALTH , SKIADOPOULOS MARIO H , COLLINS PETER L , MURPHY BRIAN R , SCHMIDT ALEXANDER C
发明人： SKIADOPOULOS MARIO H , COLLINS PETER L , MURPHY BRIAN R , SCHMIDT ALEXANDER C
IPC分类号： A61K39/155 , C12N7/04 , C12N15/45 , C07K14/115 , C12N7/00
CPC分类号： C12N7/00 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/5256 , A61K2039/543 , A61K2039/544 , C12N2760/18634 , C12N2760/18661
摘要： Chimeric human-bovine parainfluenza viruses (PIVs) are infectious and attenuated in humans and other mammals and useful individually or in combination in vaccine formulations for eliciting an anti-PIV immune response. Also provided are isolated polynucleotide molecules and vectors incorporating a chimeric PIV genome or antigenome which includes a partial or complete human or bovine PIV "background" genome or antigenome combined or integrated with one or more heterologous gene(s) or genome segment(s) of a different PIV. Chimeric human-bovine PIV of the invention include a partial or complete "background" PIV genome or antigenome derived from or patterned after a human or bovine PIV virus combined with one or more heterologous gene(s) or genome segment(s) of a different PIV virus to form the human-bovine chimeric PIV genome or antigenome. In certain aspects of the invention, chimeric PIV incorporate a partial or complete human PIV background genome or antigenome combined with one or more heterologous gene(s) or genome segment(s) from a bovine PIV, whereby the resultant chimeric virus is attenuated by virtue of host-range restriction. In alternate embodiments, human-bovine chimeric PIV incorporate a partial or complete bovine PIV background genome or antigenome combined with one or more heterologous gene(s) or genome segment(s) from a human PIV gene that encode a human PIV immunogenic protein, protein domain or epitope, for example encoded by PIV HN and/or F glycoprotein gene(s) or genome segment(s). Human-bovine chimeric PIV of the invention are also useful as vectors for developing vaccines against other pathogens. A variety of additional mutations and nucleotide modifications are provided within the human-bovine chimeric PIV of the invention to yield desired phenotypic and structural effects.
摘要翻译：嵌合人 - 牛副流感病毒（PIV）在人类和其他哺乳动物中具有感染性和减毒性，并且在疫苗制剂中单独使用或组合用于引发抗PIV免疫应答。还提供了分离的多核苷酸分子和掺入嵌合PIV基因组或抗原组的载体，其包括部分或完整的人或牛PIV“背景”基因组或反基因组，其与一个或多个异源基因或基因组片段组合或整合，不同的PIV。本发明的嵌合人牛PIV包括部分或完整的“背景”PIV基因组或反义基因组，其衍生自或构图在人或牛PIV病毒与一个或多个异源基因或不同基因组的基因组片段组合 PIV病毒形成人 - 牛嵌合PIV基因组或抗原组。在本发明的某些方面，嵌合PIV包含与牛PIV的一个或多个异源基因或基因组片段组合的部分或完整的人PIV背景基因组或反向异构体，由此得到的嵌合病毒被减弱的主机范围限制。在替代实施方案中，人 - 牛嵌合PIV掺入部分或完整的牛PIV背景基因组或与来自编码人PIV免疫原性蛋白质的蛋白质的人PIV基因的一个或多个异源基因或基因组片段组合的反义基因组结构域或表位，例如由PIV HN和/或F糖蛋白基因或基因组片段编码。本发明的人 - 牛嵌合PIV也可用作开发针对其他病原体的疫苗的载体。在本发明的人 - 牛嵌合PIV内提供了各种另外的突变和核苷酸修饰，以产生所需的表型和结构效果。

59. 发明申请

WO2002092771A3 SPECIFIC BINDING PROTEINS AND USES THEREOF 审中-公开
公开(公告)号：WO2002092771A3
公开(公告)日：2002-11-21
申请号：PCT/US2002/015185
申请日：2002-05-13
申请人： LUDWIG INSTITUTE FOR CANCER RESEARCH , OLD, Lloyd, J. , JOHNS, Terrance, Grant , PANOUSIS, Con , SCOTT, Andrew, Mark , RENNER, Christoph , RITTER, Gerd , JUNGBLUTH, Achim , STOCKERT, Elisabeth , COLLINS, Peter , CAVENEE, Webster, K. , HUANG, Huei-Jen , BURGESS, Anthony, Wilks , NICE, Edouard, collins
发明人： OLD, Lloyd, J. , JOHNS, Terrance, Grant , PANOUSIS, Con , SCOTT, Andrew, Mark , RENNER, Christoph , RITTER, Gerd , JUNGBLUTH, Achim , STOCKERT, Elisabeth , COLLINS, Peter , CAVENEE, Webster, K. , HUANG, Huei-Jen , BURGESS, Anthony, Wilks , NICE, Edouard, collins
IPC分类号： A61K39/395
摘要： The invention relates to specific binding members, particularly antibodies and active fragments thereof, which recognize an aberrant post-translationally modified, particularly an aberrant glycosylated form of the EGFR. The binding members, particularly antibodies and fragments thereof, of the invention do not bind to EGFR on normal cells in the absence of amplification of the wild- type gene and are capable of binding the de2-7 EGFR at an epitope which is distinct from the junctional peptide. Antibodies of this type are exemplified by the novel antibody 806 whose VH and VL sequences are illustrated as SEQ ID Nos: 2 and 4 and chimeric antibodies thereof as exemplified by ch806.

60. 发明申请

WO1998002530A1 PRODUCTION OF ATTENUATED RESPIRATORY SYNCYTIAL VIRUS VACCINES FROM CLONED NUCLEOTIDE SEQUENCES 审中-公开
标题翻译：从克隆核苷酸序列产生减毒的呼吸道病毒疫苗
公开(公告)号：WO1998002530A1
公开(公告)日：1998-01-22
申请号：PCT/US1997012269
申请日：1997-07-15
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE DEPARTMENT OF HEALTH AND HUMAN SERVICES , MURPHY, Brian, R. , COLLINS, Peter, L. , WHITEHEAD, Stephen, S. , BUKREYEV, Alexander A. , JUHASZ, Katalin , TENG, Michael, N.
发明人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
IPC分类号： C12N07/04
CPC分类号： C07K14/005 , A61K39/00 , C12N7/00 , C12N2760/18522 , C12N2760/18561
摘要： Attenuated respiratory syncytial virus (RSV) and vaccine compositions thereof are produced by introducing specific mutations associated with attenuating phenotypes into wild-type or RSV which is incompletely attenuated by cold-passage or introduction of mutations which produce virus having a temperature sensitive ( ts ) or cold adapted ( ca ) phenotype. Alternatively, recombinant RSV and vaccine compositions thereof incorporate attenuating and other mutations specifying desired structural and or phenotypic characteristics in an infectious RSV. Recombinant RSV incorporate desired mutations specified by insertion, deletion, substitution or rearrangement of a selected nucleotide sequence, gene, or gene segment in an infectious RSV clone. The immune system of an individual is stimulated to induce protection against natural RSV infection, or multivalently against infection by RSV and another pathogen, such as PIV, by administration of attenuated, biologically derived or recombinant RSV.
摘要翻译：减毒的呼吸道合胞病毒（RSV）及其疫苗组合物通过将与减毒表型有关的特异性突变引入野生型或RSV，通过冷通道或引入产生具有温度敏感性的病毒的突变（ ts）或冷适应（ ca）表型。或者，重组RSV及其疫苗组合物结合了在感染性RSV中指定所需结构和/或表型特征的减毒和其它突变。重组RSV包含通过在感染性RSV克隆中选择的核苷酸序列，基因或基因片段的插入，缺失，取代或重排而指定的所需突变。通过施用减毒的，生物衍生的或重组的RSV，刺激个体的免疫系统以诱导针对天然RSV感染的保护，或多重抗RSV和另一种病原体如PIV的感染。

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