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51. 发明授权

US09987636B2 Method and apparatus for use in temperature controlled processing of microfluidic samples 有权
公开(公告)号：US09987636B2
公开(公告)日：2018-06-05
申请号：US14691340
申请日：2015-04-20
申请人： Caliper Life Sciences, Inc.
发明人： Morten J Jensen , Andrea W Chow , Colin B. Kennedy , Stephane Mouradian
IPC分类号： C12Q1/68 , B01L7/00 , B01L3/00
CPC分类号： B01L7/525 , B01L3/5025 , B01L3/5027 , B01L3/502715 , B01L3/502746 , B01L3/50851 , B01L7/5255 , B01L2300/0609 , B01L2300/0816 , B01L2300/0829 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0877 , B01L2300/1822 , B01L2300/1827 , B01L2400/0418 , B01L2400/0487
摘要： Embodiments of the invention comprise microfluidic devices, instrumentation interfacing with those devices, processes for fabricating that device, and methods of employing that device to perform PCR amplification. Embodiments of the invention are also compatible with quantitative Polymerase Chain Reaction (“qPCR”) processes. Microfluidic devices in accordance with the invention may contain a plurality of parallel processing channels. Fully independent reactions can take place in each of the plurality of parallel processing channels. The availability of independent processing channels allows a microfluidic device in accordance with the invention to be used in a number of ways. For example, separate samples could be processed in each of the independent processing channels. Alternatively, different loci on a single sample could be processed in multiple processing channels.

52. 发明授权

US09604945B2 Sydnonimines-specific dopamine reuptake inhibitors and their use in treating dopamine related disorders 有权
公开(公告)号：US09604945B2
公开(公告)日：2017-03-28
申请号：US13851359
申请日：2013-03-27
申请人： Caliper Life Sciences, Inc.
发明人： Hao Chen , Ming Liu , Qi Su , Manish Raisinghani
IPC分类号： C07D271/04 , A61K31/4245
CPC分类号： C07D271/04 , A61K31/4245
摘要： Derivatives of Sydnonimine and its analogues, which bind selectively to dopamine transporter (DAT) proteins are useful for treating and delaying the progression of disorders and illnesses that are alleviated by inhibiting dopamine reuptake.

53. 发明申请

US20170056379A1 METHOD OF USING DOPAMINE REUPTAKE INHIBITORS AND THEIR ANALOGS FOR TREATING DIABETES SYMPTOMS AND DELAYING OR PREVENTING DIABETES-ASSOCIATED PATHOLOGIC CONDITIONS 审中-公开
标题翻译：使用多巴胺复苏抑制剂及其类似物治疗糖尿病症状和延迟或预防糖尿病相关病理状况的方法
公开(公告)号：US20170056379A1
公开(公告)日：2017-03-02
申请号：US15350221
申请日：2016-11-14
申请人： CALIPER LIFE SCIENCES, INC.
发明人： Hao Chen , Ming Liu , Malathi Sathyamoorthy , Qi Su , Lisa Leary , Wayne Shaobin Zhong
IPC分类号： A61K31/4245 , A61K45/06
CPC分类号： A61K31/4245 , A61K45/00 , A61K45/06
摘要： Method of using dopamine reuptake inhibitors, e.g., sydnonimine derivatives, for the management of diabetic symptoms and associated complications or conditions, such as hyperglycemia and diabetic neuropathy.
摘要翻译：使用多巴胺再摄取抑制剂例如sydnonimine衍生物用于治疗糖尿病症状及相关并发症或病症如高血糖症和糖尿病性神经病变的方法。

54. 发明申请

US20160228079A1 INTEGRATED MICROTOMOGRAPHY AND OPTICAL IMAGING SYSTEMS 有权
标题翻译：综合微电影和光学成像系统
公开(公告)号：US20160228079A1
公开(公告)日：2016-08-11
申请号：US15098819
申请日：2016-04-14
申请人： Caliper Life Sciences, Inc.
发明人： Daniel G. Stearns , David G. Nilson , Bradley W. Rice
IPC分类号： A61B6/00 , A61B6/04 , A61B6/03
CPC分类号： A61B6/4417 , A61B5/0035 , A61B5/0073 , A61B6/032 , A61B6/035 , A61B6/0457 , A61B6/4405 , A61B6/508 , A61B6/5247 , A61B2503/40 , G01N21/763 , G01N23/046 , G01N2223/419
摘要： An integrated microtomography and optical imaging system includes a rotating table that supports an imaging object, an optical stage, and separate optical and microtomography imaging systems. The table rotates the imaging object about a vertical axis running therethrough to a plurality of different rotational positions during a combined microtomography and optical imaging process. The optical stage can be a trans-illumination, epi-illumination or bioluminescent stage. The optical imaging system includes a camera positioned vertically above the imaging object. The microtomography system includes an x-ray source positioned horizontally with respect to the imaging object. Optical and x-ray images are both obtained while the imaging object remains in place on the rotating table. The stage and table are included within an imaging chamber, and all components are included within a portable cabinet. Multiple imaging objects can be imaged simultaneously, and side mirrors can provide side views of the object to the overhead camera.
摘要翻译：集成的微影像学和光学成像系统包括支持成像对象的旋转台，光学平台以及单独的光学和微影像成像系统。在组合的微影像学和光学成像过程期间，桌子将成像对象围绕其穿过的垂直轴旋转到多个不同的旋转位置。光学舞台可以是反照，外照明或生物发光阶段。光学成像系统包括垂直地位于成像对象上方的照相机。微图像系统包括相对于成像对象水平定位的x射线源。当成像对象保持在旋转台上的适当位置时，都获得光学和X射线图像。舞台和桌子包括在成像室内，所有组件都包含在便携式机柜中。可以同时对多个成像对象进行成像，并且侧视镜可以向顶置摄像机提供对象的侧视图。

55. 发明授权

US09278354B2 Control of operation conditions within fluidic systems 有权
公开(公告)号：US09278354B2
公开(公告)日：2016-03-08
申请号：US14660337
申请日：2015-03-17
申请人： Caliper Life Sciences, Inc.
发明人： J. Wallace Parce , Yung-Mae M. Yao , Donald J Morrissey
IPC分类号： G01N1/10 , B01L3/00 , G01N27/447 , G01N35/08 , B01L3/02 , G01N35/00 , G01N35/10
CPC分类号： B01L3/502784 , B01L3/5027 , B01L3/502746 , B01L2200/0673 , B01L2200/0684 , B01L2200/141 , B01L2300/0816 , B01L2300/105 , B01L2300/14 , B01L2400/0415 , B01L2400/0487 , B01L2400/049 , B01L2400/084 , G01N27/44791 , G01N35/08 , G01N2035/00237 , G01N2035/1034 , Y10T137/0324 , Y10T137/0391 , Y10T436/2575
摘要： The invention provides methods of controlling environmental conditions within a fluidic system, where such environmental conditions can affect the operation of the system in its desired function, and fluidic channels, devices, and systems that are used in practicing these methods. Such methods are generally directed to environmental control fluids, the movement of such fluids through these systems, and the interaction of these fluids with other components of the system, e.g., other fluids or solid components of the system.

56. 发明申请

US20160040226A1 MANIPULATION OF MICROPARTICLES IN MICROFLUIDIC SYSTEMS 审中-公开
标题翻译：微流控系统中微生物的操作
公开(公告)号：US20160040226A1
公开(公告)日：2016-02-11
申请号：US14823571
申请日：2015-08-11
申请人： Caliper Life Sciences, Inc.
发明人： Tammy Burd Mehta , Anne R. Kopf-Sill , J. Wallace Parce , Andrea W. Chow , Luc J. Bousse , Michael R. Knapp , Theo T. Nikiforov , Steve Gallagher
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , B01F13/0059 , B01J2219/00317 , B01J2219/00459 , B01J2219/00468 , B01L3/5027 , B01L3/502715 , B01L3/502761 , B01L2200/0668 , B01L2400/0409 , B01L2400/0415 , B01L2400/043 , B01L2400/0487 , C07H21/02 , C07H21/04 , C12Q1/6869 , C40B60/14 , G01N27/44756 , G01N35/0098 , G01N2035/00574 , Y10T436/143333 , C12Q2565/629 , C12Q2535/101 , C12Q2563/173 , C12Q2525/186 , C12Q2527/125
摘要： An array of transportable particle sets is used in a microfluidic device for performing chemical reactions in the microfluidic device. The microfluidic device comprises a main channel and intersecting side channels, the main channel and side channels forming a plurality of intersections. The array of particle sets is disposed in the main channel, and the side channels are coupled to reagents. As the particle sets are transported through the intersections of the main channel and the side channels, reagents are flowed through the side channels into contact with each array member (or selected array members), thereby providing a plurality of chemical reactions in the microfluidic system.
摘要翻译：在微流体装置中使用可移动颗粒组的阵列，用于在微流体装置中进行化学反应。微流体装置包括主通道和相交的侧通道，主通道和侧通道形成多个交叉点。颗粒组的阵列设置在主通道中，并且侧通道与试剂偶联。当颗粒组通过主通道和侧通道的交叉点传输时，试剂通过侧通道流动与每个阵列构件（或选定的阵列构件）接触，从而在微流体系统中提供多个化学反应。

57. 发明申请

US20150211045A1 MICROFLUIDIC METHOD AND SYSTEM FOR ENZYME INHIBITION ACTIVITY SCREENING 审中-公开
标题翻译：用于酶抑制活性筛选的微流化方法和系统
公开(公告)号：US20150211045A1
公开(公告)日：2015-07-30
申请号：US14682996
申请日：2015-04-09
申请人： Caliper Life Sciences, Inc.
发明人： Jude A. Dunne , Javier A. Farinas , Irina G. Kazakova , Esther Huang , Raphaele Gerber , Roger Dettloff , Thi Ngoc Vy Trinh , Coleen Hacker
IPC分类号： C12Q1/48 , B01L3/00
CPC分类号： C12Q1/485 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L2200/10 , B01L2200/16 , B01L2300/0829 , B01L2300/0838 , B01L2300/14 , B01L2400/0415 , B01L2400/0487 , C12Q1/42 , G01N30/88 , G01N2500/04 , G01N2500/20
摘要： Methods for screening a compound for enzyme inhibition activity include providing at least one sample mixture to a microfluidic device, applying vacuum pressure to the sample mixture, flowing the sample mixture along a microchannel of the microfluidic device, separating at least two components of the sample mixture based upon a net charge difference between the product and at least one other material to produce separated material, detecting at least one of the separated materials, and determining enzyme inhibition activity based on the detection of the separated material. Kits for screening a compound for enzyme inhibition activity include a first multiwell plate having a specific plurality of enzymes disposed within a first plurality of wells and a second multiwell plate having a plurality of enzyme substrates disposed with a second plurality of wells, a phosphate source and a cofactor disposed within each well of the second plate.
摘要翻译：用于筛选化合物用于酶抑制活性的方法包括向微流体装置提供至少一个样品混合物，向样品混合物施加真空压力，沿着微流体装置的微通道流动样品混合物，分离样品混合物的至少两个组分基于产物与至少一种其它材料之间的净电荷差异来产生分离的材料，检测至少一种分离的材料，以及基于分离的材料的检测来确定酶抑制活性。用于筛选化合物用于酶抑制活性的试剂盒包括具有设置在第一多个孔内的特定多个酶的第一多孔板和具有多个设置有第二多个孔的酶底物的第二多孔板，磷酸盐源和配置在第二板的每个孔内的辅因子。

58. 发明申请

US20140151229A1 MANIPULATION OF OBJECTS IN MICROFLUIDIC DEVICES USING EXTERNAL ELECTRODES 审中-公开
标题翻译：使用外部电极处理微流体装置中的物体的操作
公开(公告)号：US20140151229A1
公开(公告)日：2014-06-05
申请号：US13705670
申请日：2012-12-05
申请人： CALIPER LIFE SCIENCES, INC.
发明人： Joshua I. Molho , Daniel G. Stearns , I-Jane Chen , Danh Tran , Bradley W. Rice , Tobias Daniel Wheeler
IPC分类号： B01L3/00
CPC分类号： B01L3/50273 , B01L3/502715 , B01L3/502792 , B01L2200/0647 , B01L2300/0645 , B01L2300/0816 , B01L2300/0819 , B01L2400/0424 , B01L2400/0427 , B01L2400/0487 , B03C5/005 , B03C5/026 , B03C2201/26
摘要： The invention provides microfluidic devices, systems, and methods for manipulating an object within a channel of a microfluidic device using an external electrode. The device has a channel disposed within the device, the channel having no included electrodes. The channel has a wall, at least a portion of which is penetrable by an electric field generated external to the device, the wall being penetrable such that the electric field extends through the wall portion and into a region within the channel. The system includes the microfluidic device and an electrode external to and not bonded to the device. In the method, the external electrode is placed adjacent to the device and energized to generate an electric field that extends through the wall of the device and into the channel, thereby manipulating an object within the channel.
摘要翻译：本发明提供了使用外部电极来操纵微流体装置的通道内的物体的微流体装置，系统和方法。该装置具有设置在该装置内的通道，该通道不包括电极。通道具有壁，其至少一部分可由在该装置外部产生的电场穿透，该壁可穿透，使得电场延伸通过该壁部并进入通道内的区域。该系统包括微流体装置和外部并未结合到装置的电极。在该方法中，外部电极被放置在与器件相邻并被激励以产生延伸穿过器件的壁并进入通道的电场，从而操纵通道内的物体。

59. 发明申请

US20130315781A1 AUTOMATED SYSTEM FOR HANDLING MICROFLUIDIC DEVICES 审中-公开
标题翻译：用于处理微流体装置的自动化系统
公开(公告)号：US20130315781A1
公开(公告)日：2013-11-28
申请号：US13953572
申请日：2013-07-29
申请人： CALIPER LIFE SCIENCES, INC.
发明人： Michael Greenstein , Colin B. Kennedy , James C. Mikkelsen, JR.
IPC分类号： G01N35/00
CPC分类号： G01N35/00584 , B01L3/5027 , B01L3/502715 , B01L9/527 , B01L2300/0819 , G01N21/05 , G01N21/11 , G01N21/13 , G01N35/04 , G01N35/1095 , G01N2021/0346 , G01N2021/058
摘要： The present invention is an automated microfluidic chip processing apparatus that includes a deck for holding at least one microfluidic chip and capable of being accessed by a liquid handling system, a fluid control system, and a detection system, wherein a chip handling device transports the chip from the deck to the fluid control system and the detection system. The present invention also includes a chip for use with an automated microfluidic chip processing apparatus, and a method for processing a microfluidic chip using such an apparatus.
摘要翻译：本发明是一种自动化微流体芯片处理装置，其包括用于保持至少一个微流体芯片并能够被液体处理系统，流体控制系统和检测系统访问的甲板，其中，芯片处理装置将芯片从甲板到流体控制系统和检测系统。本发明还包括用于自动微流控芯片处理装置的芯片，以及使用这种装置处理微流控芯片的方法。

60. 发明申请

US20040228770A1 Microfluidic devices and systems incorporating cover layers 有权
标题翻译：微流体装置和包含覆盖层的系统
公开(公告)号：US20040228770A1
公开(公告)日：2004-11-18
申请号：US10792020
申请日：2004-03-03
申请人： Caliper Life Sciences, Inc.
发明人： Khushroo Gandhi , Gilbert T. Tong
IPC分类号： G01N001/10
CPC分类号： B29C66/322 , B01L3/502707 , B01L3/502715 , B01L3/5085 , B01L2200/025 , B01L2200/027 , B01L2200/0605 , B01L2200/0689 , B01L2300/0681 , B01L2300/0887 , B01L2300/16 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , B29C65/48 , B29C65/4845 , B29C65/4895 , B29C66/54 , B29C66/71 , B29C66/723 , B29C66/72321 , B29C66/72325 , B29C66/72326 , B29L2031/756 , G01N27/44791 , G01N2035/00148 , Y10T436/25 , Y10T436/25625 , Y10T436/2575 , B29K2083/00 , B29K2081/06 , B29K2069/00 , B29K2055/02 , B29K2033/12 , B29K2027/18 , B29K2027/16 , B29K2027/06 , B29K2025/06 , B29K2023/38 , B29K2023/18 , B29K2023/12 , B29K2023/06
摘要： The present invention provides microfluidic devices that comprise a body structure comprising at least a first microscale channel network disposed therein. The body structure has a plurality of ports or wells disposed in the body structure, where each port is in fluid communication with one or more channels in the first channel network. The devices also include a cover layer comprising a plurality of apertures disposed through the cover layer. The cover layer is mated with the body structure whereby each of the apertures is aligned with a separate one of the plurality of ports. First and second rings are preferentially disposed between the cover layer and the body structure and located circumferentially around each of the apertures of the cover layer. An annular groove is also preferentially disposed between the ring structures to help further minimize the leakage of adhesive or other bonding material into the ports or wells of the device when the cover layer is mated to the body structure.
摘要翻译：本发明提供了包括主体结构的微流体装置，其包括至少设置在其中的第一微量通道网络。身体结构具有设置在体结构中的多个端口或孔，其中每个端口与第一通道网络中的一个或多个通道流体连通。这些装置还包括覆盖层，其包括穿过覆盖层设置的多个孔。覆盖层与主体结构配合，由此每个孔与多个端口中的单独一个对准。第一和第二环优选地设置在覆盖层和主体结构之间并且周向地围绕覆盖层的每个孔定位。环形槽也优先设置在环结构之间，以帮助进一步最小化当覆盖层与主体结构配合时粘合剂或其它结合材料向装置的端口或孔中的泄漏最小化。

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