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51. 发明申请

WO2003016865A2 CALIBRATOR 审中-公开
公开(公告)号：WO2003016865A2
公开(公告)日：2003-02-27
申请号：PCT/US2002/026190
申请日：2002-08-15
申请人： OPTISCAN BIOMEDICAL CORPORATION , BRAIG, James, R. , RULE, Peter , STERLING, Bernhard, B. , SMITH, Heidi, M. , CORTELLA, Julian, M. , GABLE, Jennifer, H.
发明人： BRAIG, James, R. , RULE, Peter , STERLING, Bernhard, B. , SMITH, Heidi, M. , CORTELLA, Julian, M. , GABLE, Jennifer, H.
IPC分类号： G01N
CPC分类号： A61B5/1495 , A61B5/14532 , A61B5/1455 , A61B5/1491
摘要： A method calibrates a monitor (100) that comprises a non-invasive blood constituent monitor (102) and a traditional measurement system (116). The non-invasive blood constituent monitor includes a thermal gradient inducing element (110) an analyzer window (108). A traditional monitor output representing a property of a blood constituent is generated by the traditional measurement system. A non-invasive monitor output representing the property of the whole blood constituent is generated by the non-invasive constituent monitor. The traditional monitor output and the non-invasive monitor output are compared to estimate an amount of error. The non-invasive monitor output is corrected by the amount of error.
摘要翻译：一种校准包括非侵入性血液成分监测器（102）和传统测量系统（116）的监测器（100）。非侵入性血液成分监测器包括热梯度诱导元件（110）分析器窗口（108）。由传统的测量系统产生代表血液成分属性的传统监视器输出。代表全血成分的性质的非侵入性监测输出是由非侵入性成分监测器产生的。将传统的监视器输出和非侵入式监视器输出进行比较，以估计误差量。非侵入性监视器输出由误差量校正。

52. 发明申请

WO2003013352A1 DEVICE FOR ISOLATING REGIONS OF LIVING TISSUE 审中-公开
标题翻译：用于分离生活组织区域的设备
公开(公告)号：WO2003013352A1
公开(公告)日：2003-02-20
申请号：PCT/US2002/025368
申请日：2002-08-08
申请人： OPTISCAN BIOMEDICAL CORPORATION , RULE, Peter , BRAIG, James, R. , GOLDBERGER, Daniel, S. , CORTELLA, Julian, M. , AGOSTINO, Mark, D.
发明人： RULE, Peter , BRAIG, James, R. , GOLDBERGER, Daniel, S. , CORTELLA, Julian, M. , AGOSTINO, Mark, D.
IPC分类号： A61B5/00
CPC分类号： A61B5/6841 , A61B5/061 , A61B5/14532 , A61B5/1455
摘要： A device and method are provided for use with a non-invasive optical measurement system. A site selector (100) is secured to a patient's forearm, such as by a fastening strap (112), thereby isolating a measurement site on the patient's skin for determination of blood glucose levels. The site selector attaches to a thermal mass window of the spectrometer and thus forms an interface between the patient's skin and the thermal mass window. Protrusions (108, 108') and raised sections (110, 110') can facilitate the attachment. When the spectrometer must be temporarily removed from the patient's skin the site selector is left secured to the forearm so as to maintain a consistent measurement site on the skin. When the spectrometer is later reattached to the patient, the site selector will again form an interface between the gradient spectrometer and the same location of skin as before.
摘要翻译：提供了一种用于非侵入式光学测量系统的装置和方法。站点选择器（100）例如通过紧固带（112）固定到患者的前臂，从而隔离患者皮肤上的测量部位以确定血糖水平。站点选择器连接到光谱仪的热质量窗口，从而形成患者皮肤和热质量窗口之间的界面。突起（108,108'）和凸起部分（110,110'）可以便于附接。当光谱仪必须临时从患者皮肤上取出时，将位置选择器固定在前臂上，以保持皮肤上一致的测量位置。当光谱仪后来重新连接到患者时，站点选择器将再次形成梯度光谱仪和与之前相同的皮肤位置之间的界面。

53. 发明申请

WO2011140389A3 MEMBRANE ELECTROLYZER AND HEMODIALYSIS SYSTEM USING THE SAME 审中-公开
标题翻译：使用相同的膜电解质和血液透析系统
公开(公告)号：WO2011140389A3
公开(公告)日：2012-05-10
申请号：PCT/US2011035419
申请日：2011-05-05
申请人： TECH BIOMEDICAL INC C , BRAIG JAMES
发明人： BRAIG JAMES
IPC分类号： A61M1/16 , A61M1/34
CPC分类号： B01D61/44 , A61M1/1696
摘要： A sorbent hemodialysis system includes a dialyzer configured to receive a flow of clean dialysate from a reservoir and to output an unclean dialysate flow. The system also includes a sorbent component having a urease section and a sorbent section through which the unclean dialysate flow from the dialyzer passes, wherein the sorbent component removes urea from the dialysate. The system further comprises a membrane electrolyzer that receives at least a portion of said clean dialysate flow and separates the dialysate flow into an acidic component flow and a base component flow. A mixing conduit combines the base component flow from the membrane electrolyzer and an output dialysate solution from the urease section of the sorbent component to separate the dialysate solution into an ammonia gas amount and ammonia liquid amount. A gas vent is used to vent the ammonia gas amount, and the sorbent section with a suitable amount of zirconium phosphate (ZrP) removes the ammonia liquid amount from the unclean dialysate flow before flowing the clean dialysate to the reservoir. The system can further include a second mixing conduit upstream of the sorbent section of the sorbent component, the second mixing conduit combining the acidic component flow and the ammonia liquid amount in the dialysate solution to increase the pH of the dialysate solution to about 7.5 prior to returning to the reservoir.
摘要翻译：吸附剂血液透析系统包括透析器，其构造成从储存器接收干净的透析液流并输出不洁净的透析液流。该系统还包括具有尿素酶部分和吸附剂部分的吸附剂组分，来自透析器的不洁透析液流过该吸附剂部分，其中吸附剂组分从透析液中除去尿素。所述系统还包括膜电解器，其接收所述清洁透析液流的至少一部分，并将透析液流分离成酸性组分流和碱组分流。混合导管结合来自膜电解器的基础组分流和来自吸附剂组分的脲酶部分的输出透析液，将透析液分离成氨气量和氨液量。使用排气口排出氨气量，并且使用适量的磷酸锆（ZrP）的吸附剂部分从清洁的透析液流中除去氨液体量，然后将清洁的透析液流入储存器。该系统还可以包括在吸附剂组分的吸附剂部分上游的第二混合管道，第二混合管道将酸性组分流和氨液体量结合在透析液中，以将透析液的pH值增加至约7.5，然后回到水库。

54. 发明申请

WO2006127724A2 SPECTROSCOPIC ANALYSIS OF A BIOLOGICAL FLUID REACTED WITH AN ENZYME 审中-公开
标题翻译：用酶反应的生物流体的光谱分析
公开(公告)号：WO2006127724A2
公开(公告)日：2006-11-30
申请号：PCT/US2006/019952
申请日：2006-05-23
申请人： OPTISCAN BIOMEDICAL CORPORATION , BRAIG, James R. , WITTE, Kenneth G. , MAGARIAN, Margaret , SHEILL, Jane J. , STERLING, Bernhard B.
发明人： BRAIG, James R. , WITTE, Kenneth G. , MAGARIAN, Margaret , SHEILL, Jane J. , STERLING, Bernhard B.
CPC分类号： C12Q1/26 , C12Q1/32 , C12Q1/52 , C12Q1/54
摘要： An apparatus is presented for estimating the concentration of an analyte using a combined enzyme-spectroscopic method. Examples are provided for the detection of glucose and lactate. A sample of biological fluid is mixed or contacted with an enzyme specific to the analyte of interest, and the reacting fluid is probed with an optical system at wavelengths that includes at least one wavelength that is sensitive to the analyte concentration and at least one wavelength that is not sensitive to the analyte concentration. The optical system measures properties, such as optical density, and relates the measurements to concentration through a calibration of the system. A method is also provided for analyzing the data obtained from optical measurements of reactions of enzymes with biological fluids. These technologies may be applied to continuous or periodic patient sampling systems or to test strip type devices.
摘要翻译：提出了使用组合酶分光法估计分析物浓度的装置。提供葡萄糖和乳酸盐检测的实例。将生物流体的样品与特定于目的分析物的酶混合或接触，并且用包括至少一种对分析物浓度和至少一种波长的波长的波长的光学系统探测反应流体，对分析物浓度不敏感。光学系统测量诸如光密度的特性，并通过校准系统将测量值与浓度相关联。还提供了一种用于分析从酶与生物流体的反应的光学测量获得的数据的方法。这些技术可以应用于连续或周期性的患者采样系统或测试条型设备。

55. 发明申请

WO2006088785A1 ANALYTE DETECTION SYSTEM WITH DISTRIBUTED SENSING 审中-公开
标题翻译：分布式感知分析检测系统
公开(公告)号：WO2006088785A1
公开(公告)日：2006-08-24
申请号：PCT/US2006/005005
申请日：2006-02-13
申请人： OPTISCAN BIOMEDICAL CORPORATION , BRAIG, James, R. , WITTE, Kenneth, G. , WECHSLER, Mark , RULE, Peter , KEENAN, Richard
发明人： BRAIG, James, R. , WITTE, Kenneth, G. , WECHSLER, Mark , RULE, Peter , KEENAN, Richard
IPC分类号： A61B5/15 , A61M1/36
CPC分类号： A61B5/14546 , A61B5/145 , A61B5/14532 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150755 , A61B5/150862 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/4839 , A61M5/14212 , A61M2230/20 , G01N35/1095
摘要： In certain embodiments, a sampling assembly is for use with a main analyzer. The main analyzer is configured to sense an analyte in a body fluid obtained from a patient through a first fluid passageway extending from the main analyzer. The sampling assembly includes an instrument portion separate from the main analyzer and including at least one sensor. The instrument portion is removably engaged with the first fluid passageway. The at least one sensor is in sensing engagement with the first fluid passageway such that the at least one sensor can sense a property of a fluid within the first fluid passageway.
摘要翻译：在某些实施例中，采样组件用于主分析器。主分析器构造成通过从主分析器延伸的第一流体通道感测从患者获得的体液中的分析物。采样组件包括与主分析器分离并且包括至少一个传感器的仪器部分。仪器部分可移除地与第一流体通道接合。所述至少一个传感器与第一流体通道感应接合，使得至少一个传感器可感测第一流体通道内的流体的特性。

56. 发明申请

WO2005111580A1 SAMPLE ELEMENT WITH FRINGING-REDUCTION CAPABILITIES 审中-公开
标题翻译：具有减少能力的样品元件
公开(公告)号：WO2005111580A1
公开(公告)日：2005-11-24
申请号：PCT/US2005/015888
申请日：2005-05-06
申请人： OPTISCAN BIOMEDICAL CORPORATION , WECHSLER, Mark , WHITE, Kenneth, G. , KEENAN, Rich , LI, Ken, I. , SMITH, Andrew, C. , BRAIG, James, R.
发明人： WECHSLER, Mark , WHITE, Kenneth, G. , KEENAN, Rich , LI, Ken, I. , SMITH, Andrew, C. , BRAIG, James, R.
IPC分类号： G01N21/03
CPC分类号： B01L3/502715 , B01L3/502707 , B01L2200/025 , B01L2300/045 , B01L2300/0825 , B01L2300/0887 , B01L2400/0406 , G01N21/03 , G01N21/0303 , G01N21/0332 , G01N21/31 , G01N2021/0346 , G01N2021/036 , G01N2021/0389
摘要： A sample element configured to hold a material sample for determining a concentration of an analyte in the material sample. The sample element comprises a first window, a sample chamber partially defined by the first window, and a second, moveable window substantially aligned with the first window and the sample chamber. The second window is moveable from a first position in which the second window is spaced from the sample chamber, to a second position in which the second window covers and at least partially encloses the sample chamber.
摘要翻译：样品元件，构造成保持材料样品以确定材料样品中分析物的浓度。样品元件包括第一窗口，部分地由第一窗口限定的样品室和与第一窗口和样品室基本对齐的第二可移动窗口。第二窗口可从第二窗口与样品室间隔开的第一位置移动到第二位置，在第二位置，第二窗口覆盖并且至少部分地包围样品室。

57. 发明申请

WO2005051188A1 METHOD AND APPARATUS FOR ESTIMATION OF RESTING RESPIRATORY QUOTIENT 审中-公开
标题翻译：用于估计呼吸呼吸量的方法和装置
公开(公告)号：WO2005051188A1
公开(公告)日：2005-06-09
申请号：PCT/US2004/039141
申请日：2004-11-22
申请人： BRAIG, James, R.
发明人： BRAIG, James, R.
IPC分类号： A61B5/00
CPC分类号： A61B5/083
摘要： A method and apparatus for determining a user's Respiratory Quotient (RQ) using just measured O 2 and CO 2 concentrations without use of a flow meter. The RQ is determined by measuring the user's real-time inspired O 2 concentration (INS O2) and end tidal O 2 concentration (ETO2) and measuring the user's real-time inspired CO 2 concentration (INS CO2) and end tidal CO 2 concentration (ETCO2), and then determining the user's RQ from the measured INS O2, ETO2, INS CO2, and ETCO2 values in accordance with the following equation: RQ= (ETCO2 - INS CO2) / (INS O2 - ETO2). In order to avoid error introduced by the flow rate, the measurement steps are preferably performed while the user is in a resting condition. Also, ETCO2 is preferably measured as the maximum CO 2 value in a breath cycle of the user, while INS CO2 is preferably measured as the minimum CO 2 value in a breath cycle of the user. Similarly, ETO2 is preferably measured as the minimum O 2 value within a breath cycle of the user, while INS O2 is measured as the maximum O 2 value within a breath cycle of the user. On the other hand, the values of INS CO2 and ETCO2 also may be determined in accordance with the invention by analysis of a CO 2 waveform of a breath cycle of the user and the values of INS O2 and ETO2 determined by synchronizing timing of the O 2 waveform of a breath cycle of the user with the CO 2 waveform and sampling INS O2 and ETO2 values simultaneously with sampling of complementary CO 2 values determined by analysis of the CO 2 waveform. The RQ measuring device may include the oxygen and CO 2 sensors in a mainstream or sidestream configuration.
摘要翻译：一种使用仅测量的O 2和CO 2浓度而不使用流量计来确定用户呼吸商（RQ）的方法和装置。 RQ通过测量用户实时启发的O2浓度（INS O2）和结束潮汐O2浓度（ETO2）和测量用户的实时启发CO2浓度（INS CO2）和最终潮汐CO 2浓度（ETCO2）来确定，以及然后根据以下等式从测量的INS O2，ETO2，INS CO2和ETCO2值确定用户的RQ：RQ =（ETCO2-INS CO2）/（INSO2-ETO2）。为了避免由流量引入的误差，优选在用户处于静止状态的同时进行测量步骤。此外，ETCO2优选地被测量为使用者的呼吸周期中的最大CO 2值，而INS CO 2优选地被测量为用户的呼吸周期中的最小CO 2值。类似地，ETO2优选地被测量为用户呼吸周期内的最小O2值，而INS O2被测量为用户呼吸周期内的最大O2值。另一方面，也可以根据本发明通过分析用户的呼吸周期的二氧化碳波形和通过同步O 2波形的时间确定的INS O2和ETO2的值来确定INS CO 2和ETCO 2的值的呼吸循环用户的CO2波形，并采样INS O2和ETO2值与通过分析CO2波形确定的互补CO 2值的采样同时进行。 RQ测量装置可以包括主流或侧流配置中的氧气和二氧化碳传感器。

58. 发明申请

WO2004016171A9 DEVICE AND METHOD FOR IN VITRO DETERMINATION OF ANALYTE CONCENTRATIONS WITHIN BODY FLUIDS 审中-公开
标题翻译：用于体内测定体内分析物浓度的装置和方法
公开(公告)号：WO2004016171A9
公开(公告)日：2005-03-17
申请号：PCT/US0325352
申请日：2003-08-12
申请人： OPTISCAN BIOMEDICAL CORP , BRAIG JAMES R , RULE PETER , HARTSTEIN PHILIP C
发明人： BRAIG JAMES R , RULE PETER , HARTSTEIN PHILIP C
IPC分类号： G01N33/483 , A61B5/00 , A61B5/145 , A61B5/1455 , A61B5/15 , A61B5/151 , A61B5/157 , G01N21/03 , G01N21/35 , G01N33/49 , G01N33/493 , G01N33/50
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/150022 , A61B5/150061 , A61B5/150213 , A61B5/150274 , A61B5/150358 , A61B5/150412 , A61B5/150458 , A61B5/150755 , A61B5/15087 , A61B5/151 , A61B5/15136 , A61B5/1514 , A61B5/157 , A61B2562/0295 , G01N21/35
摘要： A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.
摘要翻译：能够在患者附近部署的无试剂全血分析物检测系统具有能够发射包括光谱带的辐射束的源。全血系统还具有光束的光路中的检测器。全血系统还具有容纳源和检测器的壳体。全血系统还具有位于束的光路中的样品元件。样品元件具有不消除光谱带中的辐射束的透射率的样品池和样品池壁。

59. 发明申请

WO2004062493A1 WEARABLE DEVICE FOR MEASURING ANALYTE CONCENTRATION 审中-公开
标题翻译：用于测量分析仪浓度的可测装置
公开(公告)号：WO2004062493A1
公开(公告)日：2004-07-29
申请号：PCT/US2003/041579
申请日：2003-12-30
申请人： OPTISCAN BIOMEDICAL CORPORATION , RULE, Peter , BRAIG, James, R. , HERRERA, Roger, O. , WITTE, Kenneth, G. , MUNROW, Michael, A. , HARTSTEIN, Philip, C.
发明人： RULE, Peter , BRAIG, James, R. , HERRERA, Roger, O. , WITTE, Kenneth, G. , MUNROW, Michael, A. , HARTSTEIN, Philip, C.
IPC分类号： A61B5/00
CPC分类号： A61B5/14546 , A61B5/0059 , A61B5/14532 , A61B5/1455
摘要： An analyte detection system includes a first wearable module, a detector, and a processor. The first wearable module has an optical input through which electromagnetic radiation may enter said first wearable module. The first wearable module is configured to be worn on and engage a living wearer’s body such that electromagnetic radiation omitted by the body of the wearer can enter the first wearable module via the optical input. The detector is in optical communication with the optical input. The processor is in communication with the detector. The processor is configured to estimate the concentration of an analyte in the wearer’s tissue based on the emitted electromagnetic radiation.
摘要翻译：分析物检测系统包括第一耐磨模块，检测器和处理器。第一可佩戴模块具有光学输入，电磁辐射可通过该输入进入所述第一可穿戴模块。第一可穿戴模块被配置为佩戴在活体佩戴者的身体上并使其接合，使得佩戴者的身体省略的电磁辐射可经由光学输入进入第一佩戴模块。检测器与光学输入端光学通信。处理器与检测器通信。处理器被配置为基于发射的电磁辐射来估计穿着者组织中的分析物的浓度。

60. 发明申请

WO03037178A9 WINDOW ASSEMBLY FOR THERMAL GRADIENT SPECTROMETER 审中-公开
公开(公告)号：WO03037178A9
公开(公告)日：2003-08-28
申请号：PCT/US0234657
申请日：2002-10-29
申请人： OPTISCAN BIOMEDICAL CORP , HERRERA ROGER O , CORREIA DAVE , CORTELLA JULIAN , BRAIG JAMES , SCHULENBERGER ARTHUR , LI KEN
发明人： HERRERA ROGER O , CORREIA DAVE , CORTELLA JULIAN , BRAIG JAMES , SCHULENBERGER ARTHUR , LI KEN
IPC分类号： A61B5/00 , G01J3/02 , G01J5/06 , G01N21/03 , G01N21/35 , G01N21/71
CPC分类号： A61B5/1455 , A61B5/01 , A61B5/14532 , G01J3/02 , G01J5/061 , G01N21/03 , G01N21/0332 , G01N21/35
摘要： An analyte detection system for non-invasively determining the concentration of an analyte in a sample is described. The detection system includes a window assembly consisting of a main layer adapted to allow electromagnetic radiation to pass therethrough, and a heater layer adapted to exchange heat to the sample. The system also includes a detector adapted to detect electromagnetic radiation emitted by the sample and passed through the window assembly. The analyte detection system also includes a control system in electrical communication with the heater layer and adapted to cause the heater layer to exchange heat to the sample. The main layer of the window assembly may be made from a variety of materials such as germanium, silicon, and chemical vapor deposited diamond.

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