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51. 发明申请

WO1995027193A1 PINHOLE DETECTOR 审中-公开
标题翻译： PINHOLE检测器
公开(公告)号：WO1995027193A1
公开(公告)日：1995-10-12
申请号：PCT/JP1995000603
申请日：1995-03-30
申请人： OTSUKA PHARMACEUTICAL FACTORY, INC. , ABE, Hiroshi , ISHIO, Kazuhiko , MURAKAWA, Yoshihiro , YAMAMOTO, Akira
发明人： OTSUKA PHARMACEUTICAL FACTORY, INC.
IPC分类号： G01M03/04
CPC分类号： G01M3/226
摘要： A pinhole detector for accurately and speedily detecting pinholes in a sealed container. The detector comprises a pallet (1) which removably holds gas-filled containers (11) and which has an air inlet (13) closable to keep the pallet sealed; a gas leak detector (2) connected to the air inlet (13) in an examination position, communicating with the interior of the pallet (1) and adapted to generate an analog voltage corresponding to leakage per unit time if the same gas in the container is present; an A/D converter (3) adapted to convert this analog signal into a digital signal; and a first arithmetic unit (4) adapted to determine on the basis of this signal the gradient of a linear regression line representative of the relation between voltage and time, calculate a difference between this gradient and a maximum value of the gradient which has been inputted in advance of a linear regression line in the air the above-mentioned gas and output an abnormality signal when this difference is out of a permissible range.
摘要翻译：针孔检测器，用于准确，快速地检测密封容器中的针孔。该检测器包括可移除地保持充气容器（11）的托盘（1），该托盘具有可关闭的空气入口（13）以保持托盘密封; 在检查位置连接到进气口（13）的气体泄漏检测器（2），与托盘（1）的内部连通并且适于产生对应于每单位时间的泄漏的模拟电压，如果容器中的相同气体存在; 适于将该模拟信号转换为数字信号的A / D转换器（3）; 以及第一算术单元（4），其适于基于该信号确定表示电压和时间之间的关系的线性回归线的梯度，计算该梯度与已经输入的梯度的最大值之间的差在上述气体的空气中的线性回归线之前，当该差超出允许范围时，输出异常信号。

52. 发明申请

WO1995024410A1 PHOSPHONIC DIESTER DERIVATIVE 审中-公开
公开(公告)号：WO1995024410A1
公开(公告)日：1995-09-14
申请号：PCT/JP1995000303
申请日：1995-02-27
申请人： OTSUKA PHARMACEUTICAL FACTORY, INC. , KUROKI, Yasuhisa , MIYATA, Kazuyoshi , TSUDA, Yoshihiko , INOUE, Yasuhide , KANAYA, Jun , SATO, Keigo
发明人： OTSUKA PHARMACEUTICAL FACTORY, INC.
IPC分类号： C07F09/6512
CPC分类号： C07F9/65128
摘要： A phosphonic diester derivative represented by general formula (1) and useful as a remedy and preventive for hyperlipidemia, hypertension, diabetes, and so forth. In formula (1) R , R , R and R represent each independently hydrogen, lower alkyl, halogen, nitro, etc.; R represents phenyl, lower alkyl, phenylalkyl, etc.; R represents lower alkyl; R represents lower alkoxy, hydroxy, phenyl, or phenylated lower alkoxy or lower alkylamino wherein the phenyl group may be halogenated; X and X represent each oxygen or sulfur; A represents oxygen or a single bond; and Z represents lower alkylene.
摘要翻译：由通式（1）表示的膦酸二酯衍生物，可用作高脂血症，高血压，糖尿病等的补救和预防。在式（1）中，R 1，R 2，R 3和R 6各自独立地表示氢，低级烷基，卤素，硝基等; R 4表示苯基，低级烷基，苯基烷基等; R 5表示低级烷基; R 7表示低级烷氧基，羟基，苯基或苯基的低级烷氧基或低级烷基氨基，其中苯基可以被卤化; X 1和X 2代表每个氧或硫; A代表氧或单键; Z表示低级亚烷基。

53. 发明申请

WO1995022456A1 MULTILAYER FILM AND CONTAINER 审中-公开
标题翻译：多层膜和容器
公开(公告)号：WO1995022456A1
公开(公告)日：1995-08-24
申请号：PCT/JP1994000245
申请日：1994-02-17
申请人： OTSUKA PHARMACEUTICAL FACTORY, INC. , WATANABE, Katsushi , OKAMOTO, Hideshi , TANIGUCHI, Hirohisa
发明人： OTSUKA PHARMACEUTICAL FACTORY, INC.
IPC分类号： B32B27/32
CPC分类号： B32B27/08 , B32B7/02 , B32B27/32 , B32B27/322 , B32B2250/05 , B32B2250/242 , B32B2307/718 , B32B2309/105 , B32B2439/80 , Y10T428/1352 , Y10T428/24992 , Y10T428/27 , Y10T428/31909
摘要： A multilayer film according to the present invention is a 5-layer film consisting of ethylene alpha -olefin copolymer, and the densities of resin constituting the layers are as follows starting with the outermost: first layer: 0.935-0.950 g/cm , second layer: not more than 0.920 g/cm , third layer: 0.925-0.950 g/cm , fourth layer: not more than 0.920 g/cm , fifth layer: 0.925-0.940 g/cm . A container according to the present invention is molded by using this multilayer film and has high thermal resistance, blocking resistance, tensile strength, flexibility and transparency. Therefore, the multilayer film and container according to the present invention are suitably used for medical purposes.
摘要翻译：根据本发明的多层膜是由乙烯α-烯烃共聚物组成的5层膜，构成层的树脂密度如下：最外层：第一层：0.935-0.950g / cm 3 ，第二层：不大于0.920g / cm 3，第三层：0.925-0.950g / cm 3，第四层：不大于0.920g / cm 3，第五层：0.925-0.940g / 厘米<3>。根据本发明的容器通过使用该多层膜成型并具有高耐热性，抗粘连性，拉伸强度，柔韧性和透明性。因此，根据本发明的多层膜和容器适合用于医疗目的。

54. 发明申请

WO1994007598A1 ADSORBENT FOR CELLULAR FIBRONECTIN, SEPARATION AND PURIFICATION OF FIBRONECTIN, AND PURIFICATION OF BLOOD 审中-公开
标题翻译：细胞纤维蛋白的吸收，纤维蛋白的分离和纯化，血液的纯化
公开(公告)号：WO1994007598A1
公开(公告)日：1994-04-14
申请号：PCT/JP1993001366
申请日：1993-09-22
申请人： OTSUKA PHARMACEUTICAL FACTORY, INC. , NISSHINBO INDUSTRIES, INC. , KOMAI, Takashi , TAKENISHI, Soichiro , MIYASHITA, Keiichi , SAKASHITA, Eiji , KAMOGAWA, Hiroshi , INOUE, Fujio
发明人： OTSUKA PHARMACEUTICAL FACTORY, INC. , NISSHINBO INDUSTRIES, INC.
IPC分类号： B01J20/24
CPC分类号： B01J20/24 , Y10S530/829
摘要： A selective adsorbent for cellular fibronectin (cFN) utilizing a nonwoven cellulose sulfate fiber fabric, and a method of separation and purification of FN in which an FN-containing material containing plasma fibronectin (pFN) and the cFN is brought into contact with the non-woven fabric to separate the pFN from the cFN. According to this method, the cFN can be separated from the pFN efficiently by a simple operation, and high purity pFN and cFN can be recovered at a high yield.
摘要翻译：使用非织造纤维素硫酸纤维织物的细胞纤维连接蛋白（cFN）的选择性吸附剂以及分离和纯化FN的方法，其中含有含有血浆纤连蛋白（pFN）和cFN的含FN材料与非接触式非织造织物接触，编织物将pFN与cFN分开。根据该方法，可以通过简单的操作将cFN与pFN进行有效分离，可以高产率回收高纯度的pFN和cFN。

55. 发明申请

WO1994006396A1 DRUG-PACKING POLYOLEFINIC MATERIAL, PROCESS FOR PRODUCING THE SAME, AND CONTAINER FOR DRUG PACKING 审中-公开
标题翻译：药物包装用聚合物材料，其制造方法和用于药物包装的容器
公开(公告)号：WO1994006396A1
公开(公告)日：1994-03-31
申请号：PCT/JP1993001257
申请日：1993-09-06
申请人： OTSUKA PHARMACEUTICAL FACTORY, INC. , MITSUI PETROCHEMICAL INDUSTRIES, LTD. , INOUE, Fujio , IZUMI, Masamitsu , KASHIYAMA, Shigetoshi , TANAKA, Hiroshi
发明人： OTSUKA PHARMACEUTICAL FACTORY, INC. , MITSUI PETROCHEMICAL INDUSTRIES, LTD.
IPC分类号： A61J01/00
CPC分类号： C08F6/005 , A61J1/10 , C08J5/18 , C08J2323/08 , C08L23/0815 , C08L23/12 , C08L23/00 , C08L2666/06
摘要： A drug-packing polyolefinic material containing at most 150 ppm of C12-C26 substances and being extremely reduced in the risk of adversely affecting the drugs packed therein.
摘要翻译：含有至多150ppm C12-C26物质的药物包装聚烯烃材料，并且极度降低其中包装的药物的不利影响的风险。

56. 发明申请

WO1993023374A1 INDOLE DERIVATIVE 审中-公开
公开(公告)号：WO1993023374A1
公开(公告)日：1993-11-25
申请号：PCT/JP1993000560
申请日：1993-04-28
申请人： OTSUKA PHARMACEUTICAL FACTORY, INC. , INAI, Masatoshi , SHIBUTANI, Tadanao , KANAYA, Jun , MORITAKE, Masako , TANAKA, Akie
发明人： OTSUKA PHARMACEUTICAL FACTORY, INC.
IPC分类号： C07D209/10
CPC分类号： C07D401/12 , C07D209/10
摘要： An indole derivative represented by general formula (1). It has a potent antiestrogenic effect and hence is useful for treating estrogen-dependent diseases such as anovular infertility, prostatomegaly, osteoporosis, breast cancer, endometrial cancer and melanoma.
摘要翻译：由通式（1）表示的吲哚衍生物。它具有有效的抗雌激素作用，因此可用于治疗雌激素依赖性疾病，如无性生殖不全，前列腺肥大，骨质疏松症，乳腺癌，子宫内膜癌和黑素瘤。

57. 发明申请

WO2023081336A2 METHODS FOR THE CHEMOENZYMATIC SYNTHESIS OF LOW MOLECULAR WEIGHT HEPARIN FROM LOW MOLECULAR WEIGHT HEPAROSAN 审中-公开
公开(公告)号：WO2023081336A2
公开(公告)日：2023-05-11
申请号：PCT/US2022/048928
申请日：2022-11-04
申请人： RENSSELAER POLYTECHNIC INSTITUTE , OTSUKA PHARMACEUTICAL FACTORY, INC. , LINHARDT, Robert, John , DORDICK, Jonathan, Seth , YU, Yanlei , FU, Li , HE, Peng , XIA, Ke , VARGHESE, Sony , ZHANG, Fuming , WANG, Hong
发明人： LINHARDT, Robert, John , DORDICK, Jonathan, Seth , YU, Yanlei , FU, Li , HE, Peng , XIA, Ke , VARGHESE, Sony , ZHANG, Fuming , WANG, Hong
IPC分类号： C08B37/00 , C08B37/08 , C08L5/10 , C12P19/26 , C12N9/10 , C12P19/04
摘要： Low molecular weight heparin (LMWH) suitable for equivalent use to USP enoxaparin sodium is prepared from a starting material isolated from engineered E. coli K5 capsular polysaccharide, e.g., E. coli K5 heparosan. The E. Coli CPS is treated with acids to remove 3-deoxy-D-manno oct-2-ulosonic acid (Kdo) residues, and further hydrolyzed via alkali treatment to form low molecular weight N-sulfo, N-acetyl heparosan (LMW-NSNAH) having molecular weight and N-acetylation comparable to enoxaparin. The LMW-NSNAH is converted to LMWH via a series of enzymatic modifications by C5-epimerase, 2-O-, 6-O-, and 3-O-sulfotransferases. Compositions including the LMWH are prepared without the use of porcine-derived heparin, and thus benefit from better source material availability, better control of manufacturing processes, reduced concerns about contamination, adulteration or animal virus, or impurities. Further, the LMWH product is demonstrated to be structurally and functionally comparable traditional pharmaceutical LMWHs.

58. 发明申请

WO2021201282A1 METHOD FOR PRODUCING SULFATED POLYSACCHARIDE AND METHOD FOR PRODUCING PAPS 审中-公开
公开(公告)号：WO2021201282A1
公开(公告)日：2021-10-07
申请号：PCT/JP2021/014337
申请日：2021-04-02
申请人： RENSSELAER POLYTECHNIC INSTITUTE , OTSUKA PHARMACEUTICAL FACTORY, INC. , KIRIN BIOMATERIALS CO., LTD.
发明人： FUKUNAGA Kenta , NISHIBARA Aki , KATO Ryosuke , KURATSU Masahiro , HAYASHI Mikiro , HASHIMOTO Shin-ichi
IPC分类号： C12P19/32
摘要： An object of the present invention is to provide a method for easily producing sulfated polysaccharides by reacting a PAPS production/regeneration system utilizing the metabolic activity of a microorganism or a treated matter thereof with a microorganism expressing a sulfation enzyme or a treated matter or extract thereof upon mixing of inexpensive raw materials such as magnesium sulfate. Another object of the present invention is to provide a practical method for producing PAPS from inexpensive raw materials. The present invention relates to a method for producing a sulfated polysaccharide and a method for producing PAPS, the methods comprising a step of preparing a transformant (a) of a bacterium of the genus Corynebacterium, which comprises at least a gene encoding an ATP sulfurylase and a gene encoding an APS kinase which are introduced thereinto in an expressible manner, and in which a cell plasma membrane of the transformant (a) is substance-permeable, or a treated matter of the transformant (a); and a step of conducting a reaction for producing PAPS by using a reaction solution containing ATP or an ATP source, a sulfate ion source, and the transformant (a) or the treated matter thereof.

59. 发明申请

WO2021199445A1 METHOD FOR PRODUCING SULFATED POLYSACCHARIDE AND METHOD FOR PRODUCING PAPS 审中-公开
公开(公告)号：WO2021199445A1
公开(公告)日：2021-10-07
申请号：PCT/JP2020/015388
申请日：2020-04-03
申请人： RENSSELAER POLYTECHNIC INSTITUTE , OTSUKA PHARMACEUTICAL FACTORY, INC. , KIRIN BIOMATERIALS CO., LTD.
发明人： FUKUNAGA Kenta , NISHIBARA Aki , KATO Ryosuke , KURATSU Masahiro , HAYASHI Mikiro , HASHIMOTO Shin-ichi
IPC分类号： C12P19/32
摘要： An object of the present invention is to provide a method for easily producing sulfated polysaccharides by reacting a PAPS production/regeneration system utilizing the metabolic activity of a microorganism or a treated matter thereof with a microorganism expressing a sulfation enzyme or a treated matter or extract thereof upon mixing of inexpensive raw materials such as magnesium sulfate. Another object of the present invention is to provide a practical method for producing PAPS from inexpensive raw materials. The present invention relates to a method for producing a sulfated polysaccharide and a method for producing PAPS, the methods comprising a step of preparing a transformant (a) of a bacterium of the genus Corynebacterium, which comprises at least a gene encoding an ATP sulfurylase and a gene encoding an APS kinase which are introduced thereinto in an expressible manner, and in which a cell plasma membrane of the transformant (a) is substance-permeable, or a treated matter of the transformant (a); and a step of conducting a reaction for producing PAPS by using a reaction solution containing ATP or an ATP source, a sulfate ion source, and the transformant (a) or the treated matter thereof.

60. 发明申请

WO2003097355A1 MULTI-LAYER FILM AND MEDICINE CONTAINER USING THE SAME 审中-公开
标题翻译：多层薄膜和医用容器
公开(公告)号：WO2003097355A1
公开(公告)日：2003-11-27
申请号：PCT/JP2003/005808
申请日：2003-05-09
申请人： OTSUKA PHARMACEUTICAL FACTORY, INC. , MANABE, Yuki , OKAMOTO, Hideshi , KAWAKAMI, Keiichi
发明人： MANABE, Yuki , OKAMOTO, Hideshi , KAWAKAMI, Keiichi
IPC分类号： B32B27/32
CPC分类号： B32B27/322 , A61J1/05 , B32B1/02
摘要： ABSTRACT Disclosed is a multi-layer film comprising: a surface layer having a thickness of 10 to 50 ƒÊm made of an ethylene-ƒ¿-olefin copolymer having a density of 0.935 to 0.950 g/cm3, a flexible layer having a thickness of 100 to 200 ƒÊm made of an ethylene-ƒ¿-olefin copolymer having a density of 0.860 to 0.930 g/cm3, a barrier layer having a thickness of 10 to 80 ƒÊm made of a mixed resin containing 60 to 95% by weight of a cyclic olefin polymer and 5 to 40% by weight of an ethylene-ƒ¿-olefin copolymer having a density of 0.900 to 0.965 g/cm3, and a seal layer having a thickness of 5 to 80 ƒÊm made of an ethylene-ƒ¿-olefin copolymer having a density of 0.910 to 0.950 g/cm3. This multi-layer film is suited for use as a material for production of a medicine container 10 because it suppresses adsorption of a medicine by the barrier layer and is also superior in strength and flexibility.
摘要翻译：摘要公开了一种多层膜，包括：具有密度为0.935至0.950g / cm 3的乙烯 - 烯烃共聚物制成的厚度为10至50埃的表层，厚度为100埃的柔性层至200密耳，由密度为0.860至0.930g / cm3的乙烯 - 烯烃共聚物制成，厚度为10至80的阻挡层由含有60至95重量％的环状烯烃聚合物和5至40重量％的密度为0.900至0.965g / cm 3的乙烯 - 烯烃共聚物，以及由乙烯 - 烯烃制成的厚度为5-80的密封层共聚物，其密度为0.910〜0.950g / cm 3。这种多层膜适合用作药物容器10的制造原料，因为它抑制了阻挡层吸收药物，而且强度和柔软性也优异。

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