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51. 发明申请

WO2015173417A1 HAND-HELD TEST METER WITH BODY PORTION PROXIMITY SENSOR MODULE 审中-公开
标题翻译：手持式测试仪带有身体部位接近传感器模块
公开(公告)号：WO2015173417A1
公开(公告)日：2015-11-19
申请号：PCT/EP2015/060801
申请日：2015-05-15
申请人： LIFESCAN SCOTLAND LIMITED
发明人： GUTHRIE, Brian , ELDER, David , YOUNG, John , CARNEY, Ciaran , LLOYD, Timothy
IPC分类号： G01N33/487 , H03K17/945
CPC分类号： G01N27/3273 , G01N33/48785 , H03K17/955
摘要： A hand-held test meter (100) for use with an analytical test strip (TS, for example, an electrochemical-based analytical test strip) in the determination of an analyte (such as glucose) in a bodily fluid sample (e.g., a whole blood sample) includes a housing (110), a micro-controller (112) disposed in the housing (110), a body portion proximity sensor module (107) disposed at least partially in the housing (110), and a strip port connector (106) configured to operationally receive an analytical test strip (TS). The body portion proximity sensor module (107) of the analytical test strip is configured to sense presence of a user's body portion (e.g., a user's finger, forearm or palm) within a predetermined distance of the strip port connector (106) and, upon sensing the presence of such a body portion, transmit a signal to the micro-controller (110) indicating the presence of such a body portion. Such signal is used to switch the test meter (100) from a low-power standby mode to a high-power active mode.
摘要翻译：用于测定体液样品中的分析物（例如葡萄糖）的分析测试条（TS，例如基于电化学的分析测试条）的手持式测试仪（100）全血样本）包括壳体（110），设置在壳体（110）中的微控制器（112），至少部分地设置在壳体（110）中的主体部分接近传感器模块（107）连接器（106）被配置为可操作地接收分析测试条（TS）。分析测试条的主体部分接近传感器模块（107）被配置为在带状端口连接器（106）的预定距离内感测用户身体部分（例如，用户的手指，前臂或手掌）的存在，并且在感测到这样的身体部分的存在，向微控制器（110）发送指示这样的身体部分的存在的信号。这种信号用于将测试仪（100）从低功率待机模式切换到高功率活动模式。

52. 发明申请

WO2015036400A1 PHASE-DIFFERENCE DETERMINATION USING TEST METER 审中-公开
标题翻译：使用测试仪进行相位差测定
公开(公告)号：WO2015036400A1
公开(公告)日：2015-03-19
申请号：PCT/EP2014/069192
申请日：2014-09-09
申请人： LIFESCAN SCOTLAND LIMITED
发明人： ELDER, David , LLOYD, Tim , FORLANI, Christian , MASSARI, Rossano , POZZI, Emanuele
IPC分类号： A61B5/145 , G01N27/327
CPC分类号： G01N33/49 , A61B5/14532 , A61B5/14535 , A61B5/1486 , A61B5/7225 , A61B2560/0209 , A61B2562/0295 , G01N27/3273 , G01N27/3274
摘要： A hand-held test meter includes a strip port connector to receive a test strip. A signal-measurement circuit applies a periodic voltage signal across a sample applied to the strip and detects a resulting current signal. The circuit provides data of the current signal at a digitizing frequency and a selected phase with respect to the voltage signal. A processor records one or more value(s) of the data and then alters the selected phase. Value(s) are thus recorded at each of a plurality of phases. The processor determines a phase difference of the current signal with respect to the voltage signal using the respective sets of value(s). A method for employing a test meter and a test strip is also disclosed, and includes measuring a respective plurality of points for each of a plurality of different measurement phases and determining a phase difference of a fluid sample therefrom.
摘要翻译：手持测试仪包括用于接收测试条的条形端口连接器。信号测量电路在施加到条上的样本上施加周期性电压信号，并检测结果电流信号。该电路以数字化频率和相对于电压信号的选定相位提供电流信号的数据。处理器记录一个或多个数据值，然后改变所选择的阶段。因此，在多个相位中的每一个处记录值。处理器使用相应的一组值来确定电流信号相对于电压信号的相位差。还公开了一种采用测试仪和测试条的方法，包括测量多个不同测量阶段中的每一个的相应多个点，并确定流体样本的相位差。

53. 发明申请

WO2014195480A1 ELECTROCHEMICAL-BASED ANALYTICAL TEST STRIP WITH A SOLUBLE ELECTROCHEMICALLY-ACTIVE COATING OPPOSITE A BARE ELECTRODE 审中-公开
标题翻译：基于电化学的分析测试条带可溶电化学活性涂层对苯二甲酸丁酯电极
公开(公告)号：WO2014195480A1
公开(公告)日：2014-12-11
申请号：PCT/EP2014/061881
申请日：2014-06-06
申请人： LIFESCAN SCOTLAND LIMITED
发明人： COOPER, Alexander , RODGERS, James Iain , MACFIE, Gavin
IPC分类号： G01N27/327 , C12Q1/00
CPC分类号： G01N27/3272 , C12Q1/001 , C12Q1/004
摘要： Electrochemical-based analytical test strip with a soluble electrochemically-active coating opposite a bare electrode An electrochemical-based analytical test strip (EBATS) for the determination of an analyte in a bodily fluid sample includes an electrically insulating base layer, a patterned electrically conductive layer disposed on the electrically insulating base layer and including a plurality of electrodes, and an enzymatic reagent layer disposed on a portion of the patterned conductor layer and defining a bare electrode(s) and a plurality of enzymatic reagent covered electrodes from the plurality of electrodes. The EBATS also includes a patterned spacer layer, a top layer having an underside surface (USS), and a soluble electrochemically-active coating (SEAC) disposed on the USS of the top layer. In addition, at least the patterned spacer layer and top layer define a sample-receiving chamber within the EBATS. Furthermore, the SEAC is disposed on the USS of the top layer within at least a portion the sample-receiving chamber and in an opposing relationship to the bare electrodes.
摘要翻译：具有与裸露电极相对的可溶电化学活性涂层的基于电化学的分析测试条用于测定体液样品中的分析物的基于电化学的分析测试条（EBATS）包括电绝缘基底层，图案化导电层设置在所述电绝缘基底层上并且包括多个电极，以及设置在所述图案化导体层的一部分上并且从所述多个电极限定裸电极和多个酶试剂覆盖电极的酶试剂层。 EBATS还包括图案化间隔层，具有下表面（USS）的顶层和设置在顶层的USS上的可溶电化学活性涂层（SEAC）。此外，至少图案化间隔层和顶层限定EBATS内的样品接收室。此外，SEAC设置在至少部分样品接收室内的顶层的USS上，并且与裸露电极相对的关系。

54. 发明申请

WO2014096826A1 ELECTRICAL CONNECTOR FOR SUBSTRATE HAVING CONDUCTIVE TRACKS 审中-公开
标题翻译：具有导电轨道的基座的电气连接器
公开(公告)号：WO2014096826A1
公开(公告)日：2014-06-26
申请号：PCT/GB2013/053354
申请日：2013-12-19
申请人： LIFESCAN SCOTLAND LIMITED
发明人： CARROLL, Gary , CONFIELD, Ivan , VALSECCHI, Luca , SALA, Michele , VOLPE, Maurizio , BERETTA, Roberto , NELSON, John
IPC分类号： G01N33/487
CPC分类号： H01R12/613 , G01N33/48771 , H01R12/714 , H01R13/6683 , H01R2201/12 , H01R2201/20
摘要： An electrical connector (110) can receive a substrate (351) having conductive tracks (341, 342, 343, 344, 345). The connector includes a housing (120) with a port (129) and at least one alignment feature (121, 321) that together define a direction of insertion (125). At least three function pins (131, 132, 133, 134, 135) mounted to the housing each include contacts (141, 142, 143, 144, 145) that electrically connect to one of the conductive tracks of a substrate inserted in the connector. A sense pin (139) mounted to the housing has a contact (149) that electrically connects to at least one of the conductive tracks of an inserted substrate. The sense pin can include a plurality of electrically-connected segments, each segment extending substantially parallel or substantially perpendicular to the direction of insertion of the substrate. Systems and methods for detecting an analyte in a bodily-fluid sample are also described.
摘要翻译：电连接器（110）可以接收具有导电轨迹（341,342,343,344,345）的基底（351）。连接器包括具有端口（129）的壳体（120）和一起限定插入方向（125）的至少一个对准特征（121,321）。安装到壳体的至少三个功能销（131,132,133,134,135）包括电连接到插入连接器中的基板的导电轨道中的一个的触点（141,142,143,144,145）。安装到壳体的感测针（139）具有电连接到插入的衬底的至少一个导电轨道的触点（149）。感测引脚可以包括多个电连接的段，每个段基本上平行或基本垂直于衬底的插入方向延伸。还描述了用于检测体液样品中的分析物的系统和方法。

55. 发明申请

WO2013190270A1 ANALYTICAL TEST STRIP WITH CAPILLARY SAMPLE-RECEIVING CHAMBERS SEPARATED BY A PHYSICAL BARRIER ISLAND 审中-公开
标题翻译：带有毛细管样本接收板的分析测试条由物理障碍物岛分离
公开(公告)号：WO2013190270A1
公开(公告)日：2013-12-27
申请号：PCT/GB2013/051552
申请日：2013-06-13
申请人： LIFESCAN SCOTLAND LIMITED
发明人： WHYTE, Lynsey , SLOSS, Scott , MCCOLL, David , WHITEHEAD, Neil , SMITH, Antony
IPC分类号： B01L3/00 , G01N27/327
CPC分类号： G01N27/3272 , B01L3/502 , B01L2300/0825 , G01N27/3274 , G01N33/492
摘要： An analytical test strip for the determination of an analyte (such as glucose and/or hematocrit) in a bodily fluid sample (such as a whole blood sample) includes a first capillary sample-receiving chamber, a second capillary sample-receiving chamber, and a physical barrier island disposed between the first and second capillary sample-receiving chambers. Moreover, the physical island barrier is disposed such that bodily fluid sample flow between the first capillary sample-receiving chamber and the second capillary sample-receiving chamber is prevented during use of the analytical test strip.
摘要翻译：用于测定体液样品（例如全血样品）中的分析物（例如葡萄糖和/或血细胞比容）的分析测试条包括第一毛细管样品接收室，第二毛细管样品接收室和设置在第一和第二毛细管样品接收室之间的物理屏障岛。此外，物理岛屏障设置成在分析测试条的使用期间防止了体液样品在第一毛细管样品接收室和第二毛细管样品接收室之间流动。

56. 发明申请

WO2013190072A1 ELECTROCHEMICAL-BASED ANALYTICAL TEST STRIP WITH INTERSECTING SAMPLE-RECEIVING CHAMBERS 审中-公开
标题翻译：基于电化学分析测试条带接口采样样品
公开(公告)号：WO2013190072A1
公开(公告)日：2013-12-27
申请号：PCT/EP2013/062950
申请日：2013-06-20
申请人： LIFESCAN SCOTLAND LIMITED
发明人： WHYTE, Lynsey , SLOSS, Scott , WHITEHEAD, Neil , MCCOLL, David , SMITH, Antony
IPC分类号： C12Q1/00
CPC分类号： G01N27/327 , C12Q1/004 , C12Q1/006
摘要： An electrochemical-based analytical test strip for the determination of an analyte (such as glucose) in a bodily fluid sample (for example, a whole blood sample) and/or a characteristic of the bodily fluid sample (for example, hematocrit) includes a first sample-receiving chamber with first and second sample-application openings, and first and second electrodes. The first and second electrodes are disposed in the first sample-receiving chamber between the first and second sample-application openings. The electrochemical-based analytical test strip also includes a second sample-receiving chamber and a plurality of electrodes disposed in the second sample-receiving chamber. In addition, the second sample-receiving chamber intersects the first sample-receiving chamber between the first and second electrodes, thereby defining a chamber intersection.
摘要翻译：用于测定体液样品（例如全血样品）中的分析物（例如葡萄糖）和/或体液样品的特性（例如，血细胞比容）的基于电化学的分析测试条包括第一样品接收室，其具有第一和第二样品施加开口，以及第一和第二电极。第一和第二电极设置在第一和第二样品施加开口之间的第一样品接收室中。基于电化学的分析测试条还包括第二样品接收室和设置在第二样品接收室中的多个电极。此外，第二样本接收室在第一和第二电极之间与第一样本接收室相交，由此限定腔室交叉。

57. 发明申请

WO2013144617A1 BATTERY STATUS DETECTION AND STORAGE METHOD AND SYSTEM IN MEDICAL MONITORING 审中-公开
标题翻译：电池状态检测和存储方法和系统在医学监测
公开(公告)号：WO2013144617A1
公开(公告)日：2013-10-03
申请号：PCT/GB2013/050796
申请日：2013-03-27
申请人： LIFESCAN SCOTLAND LIMITED
发明人： GUTHRIE, Brian , MACRAE, Allan
IPC分类号： A61B5/145
CPC分类号： H01M10/425 , A61B5/14532 , A61B2560/0214 , A61B2560/0431 , G01R31/36 , G01R31/362 , G06F19/00 , H01M6/5083 , H01M10/42 , H01M10/4285 , H01M10/48 , H01M2220/30
摘要： Described herein are systems and methods to determine when a new or fresh battery has been replaced in a medical monitoring device and store a record of such battery replacement so that the battery records of the medical monitoring device can be reliably kept over the life of the monitoring device.
摘要翻译：这里描述了确定何时在医疗监视装置中更换新的或新鲜电池的系统和方法，并且存储这种电池更换的记录，使得医疗监视装置的电池记录可以在监视的整个使用寿命期间被可靠地保持设备。

58. 发明申请

WO2013049510A1 ANALYTICAL TEST STRIP WITH BODILY FLUID PHASE-SHIFT MEASUREMENT ELECTRODES 审中-公开
标题翻译：分析测试条与液体相变相测量电极
公开(公告)号：WO2013049510A1
公开(公告)日：2013-04-04
申请号：PCT/US2012/057828
申请日：2012-09-28
申请人： LIFESCAN SCOTLAND LIMITED , LUGO JIMENEZ, Gustavo C.
发明人： LUGO JIMENEZ, Gustavo C.
IPC分类号： G01N27/327
CPC分类号： G01N27/3272 , G01N27/3274
摘要： An analytical test strip ("ATS") for use with a hand-held test meter ("HHTM") in the determination of an analyte in a bodily fluid sample ("BFS") includes a first patterned conductive layer with a working electrode and a reference electrode, as well as a method for determining an analyte in BFS. The ATS also includes an enzymatic reagent layer disposed on the working electrode, a patterned spacer layer disposed over the first patterned conductive layer and configured to define a sample chamber ("SC") within the ATS, and a second patterned conductive layer disposed above the first patterned conductive layer. The second patterned conductive layer includes a first phase-shift measurement electrode and a second phase-shift measurement electrode, which electrodes are disposed in the SC and are configured to measure, along with the HHTM, a phase shift of an electrical signal forced through a BFS introduced into the SC during the ATS' use.
摘要翻译：在用于测定体液样品（“BFS”）中的分析物的手持测试仪（“HHTM”）中使用的分析测试条（“ATS”）包括具有工作电极的第一图案化导电层和参考电极，以及用于确定BFS中分析物的方法。 ATS还包括设置在工作电极上的酶试剂层，设置在第一图案化导电层之上并构造成在ATS内限定样品室（“SC”）的图案化间隔层，以及设置在ATS上方的第二图案化导电层第一图案化导电层。第二图案化导电层包括第一相移测量电极和第二相移测量电极，这些电极设置在SC中，并且被配置为与HHTM一起测量强制通过 BFS在ATS使用期间引入了SC。

59. 发明申请

WO2013045950A1 HAND-HELD TEST METER WITH PHASE-SHIFT-BASED HEMATOCRIT MEASUREMENT CIRCUIT 审中-公开
标题翻译：手持式测试仪，具有基于相位移位的测量电路
公开(公告)号：WO2013045950A1
公开(公告)日：2013-04-04
申请号：PCT/GB2012/052421
申请日：2012-10-01
申请人： LIFESCAN SCOTLAND LIMITED , KRAFT, Ulrich , ELDER, David , KERMANI, Mahyar
发明人： KRAFT, Ulrich , ELDER, David , KERMANI, Mahyar
IPC分类号： G01N27/327
CPC分类号： G01N27/3274 , G01N27/3273 , Y10T436/144444
摘要： A hand-held test meter for use with an analytical test strip in the determination of an analyte in a bodily fluid sample includes a housing (110); a microcontroller block (112) disposed in the housing; and a phase-shift-based hematocrit measurement block (114). The phase- shift-based hematocrit measurement block includes a signal generation sub-block (120), a low pass filter sub-block (122), an analytical test strip sample cell interface sub-block (124), a transimpedance amplifier sub-block (128), and a phase detector sub-block (130). In addition, the phase-shift-based hematocrit measurement block and microcontroller block are configured to measure the phase shift of a bodily fluid sample in a sample cell of an analytical test strip inserted in the hand-held test meter and the microcontroller block is configured to compute the hematocrit of the bodily fluid sample based on the measured phase shift.
摘要翻译：用于测定体液样品中的分析物的分析测试条的手持式测试仪包括壳体（110）; 设置在所述壳体中的微控制器模块（112）和基于相移的血细胞比容测量块（114）。基于相移的血细胞比容测量块包括信号生成子块（120），低通滤波器子块（122），分析测试条样本单元接口子块（124），跨阻放大器子块块（128）和相位检测器子块（130）。此外，基于相移的血细胞比容测量块和微控制器块被配置为测量插入在手持测试仪中的分析测试条的样本池中的体液样本的相移，并且配置微控制器块以根据所测量的相移计算体液样品的血细胞比容。

60. 发明申请

WO2013030375A1 Hematocrit Corrected Glucose Measurements for Electrochemical Test Strip Using Time Differential of the Signals 审中-公开
标题翻译：血细胞比容校正葡萄糖测量电化学测试条使用信号的时间差异
公开(公告)号：WO2013030375A1
公开(公告)日：2013-03-07
申请号：PCT/EP2012/067028
申请日：2012-08-31
申请人： LIFESCAN SCOTLAND LIMITED , MCCOLL, David , SMITH, Antony , FARMAHAN, Mandip
发明人： MCCOLL, David , SMITH, Antony , FARMAHAN, Mandip
IPC分类号： G01N27/327
CPC分类号： G01N27/3274
摘要： Various embodiments that allow for determination of hematocrit by a time differential between the input and output signals such that a glucose measurement for a blood sample can be corrected by the measured hematocrit of the blood sample.
摘要翻译：允许通过输入和输出信号之间的时间差确定血细胞比容的各种实施例，使得可以通过测量的血液样本的血细胞比容校正血液样本的葡萄糖测量。

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