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41. 发明专利

JP3483870B2 Terminal sterilization osteogenic device and its preparation 有权
公开(公告)号：JP3483870B2
公开(公告)日：2004-01-06
申请号：JP2001331607
申请日：2001-10-29
申请人：ストライカー・コーポレーション
发明人：ティー．サンパスクバー , シー．ルーガーデイビッド , エム．タッカーマジョリー
IPC分类号： A61L2/08 , A61L2/00 , A61L27/00 , A61L27/12 , A61L27/20 , A61L27/22 , A61L27/24
CPC分类号： A61L2/007 , A61L2/0011 , A61L2/0035 , A61L27/12 , A61L27/20 , A61L27/227 , A61L27/24 , Y10S530/84 , C08L1/28
摘要： Disclosed are terminally sterilized osteogenic devices for implantation into a mammal. The devices contain a combination of a biologically active osteogenic protein and an insoluble carrier which after being combined are sterilized by exposure to ionizing radiation, for example, by exposure to gamma rays or an electron beam. The terminally sterilized devices of the invention are characterized in that they induce bone formation following implantation into a mammal. Also disclosed is a method for inducing bone formation in a mammal by implanting a terminally sterilized device of the invention into a preselected locus in a mammal. Also disclosed is a method for preparing the terminally sterilized device of the invention.

43. 发明专利

JPS5943361A Vitamin k dependency bone protein position-idiosyncrasy ( special ) measurement 失效
标题翻译：维生素K依赖性蛋白质位置 - 特异性测定
公开(公告)号：JPS5943361A
公开(公告)日：1984-03-10
申请号：JP9163483
申请日：1983-05-26
申请人： Univ California
发明人： REONARUDO JIEI DEFUTOSU , BAYAADO DEII KIYAZAAUTSUDO
IPC分类号： A61K35/32 , A61K38/00 , A61K39/00 , A61K39/395 , A61K51/00 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/78 , C07K16/00 , C07K16/18 , C07K19/00 , C12P21/08 , G01N33/53 , G01N33/68 , G01N33/82
CPC分类号： C07K14/78 , C07K16/18 , G01N33/82 , Y10S530/808 , Y10S530/84

44. 发明申请

WO2004073721A1 A FOOD-SUPPLEMENT COMPOSITION SUITABLE FOR PROMOTING IRON ABSORPTION 审中-公开
标题翻译：适用于促进吸收的食品补充剂组合物
公开(公告)号：WO2004073721A1
公开(公告)日：2004-09-02
申请号：PCT/EP2004/001526
申请日：2004-02-18
申请人： MEDESTEA RESEARCH AND PRODUCTION S.R.L. , MERIZZI, Gianfranco
发明人： MERIZZI, Gianfranco
IPC分类号： A61K33/00
CPC分类号： A61K45/06 , A23L33/10 , A23L33/105 , A23L33/15 , A23L33/16 , A23V2002/00 , A61K31/737 , A61K33/26 , A61K33/30 , A61K36/16 , A61K36/23 , A61K36/87 , Y10S514/814 , Y10S530/84 , A61K2300/00 , A23V2250/2042 , A23V2250/1642 , A23V2250/7056 , A23V2250/21 , A23V2250/712 , A23V2250/1868 , A23V2250/187
摘要： Use of a composition comprising cartilage or chondroitin sulphate and absorbable zinc for the preparation of a food supplement or a drug suitable for promoting iron absorption in patients suffering from lack of iron.
摘要翻译：使用包含软骨或硫酸软骨素和可吸收锌的组合物用于制备食物补充剂或适合于在缺乏铁的患者中促进铁吸收的药物。

45. 发明申请

WO9916406A3 THERAPEUTIC METHOD 审中-公开
标题翻译：治疗方法
公开(公告)号：WO9916406A3
公开(公告)日：1999-07-08
申请号：PCT/NZ9800145
申请日：1998-09-25
申请人： AUCKLAND UNISERVICES LTD , REID IAN REGINALD , CORNISH JILLIAN
发明人： REID IAN REGINALD , CORNISH JILLIAN
IPC分类号： A61K45/00 , A61K38/00 , A61K38/22 , A61P19/08 , A61P43/00 , C07K14/575 , C12N5/077 , A61K38/17 , A61K38/18
CPC分类号： C12N5/0655 , A61K38/00 , C07K14/575 , C12N2500/38 , C12N2501/34 , C12N2501/998 , Y10S530/84
摘要： This invention is directed to new therapeutic uses which involve the stimulation of chondrocyte proliferation. More particularly, it is directed to the use of amylin and adrenomedullin as agents which stimulate chondrocyte proliferation and which therefore have utility in the treatment of cartilage disorders and/or cartilage mediated bone growth.
摘要翻译：本发明涉及涉及刺激软骨细胞增殖的新的治疗用途。更具体地说，涉及使用胰岛淀粉样多肽和肾上腺髓质素作为刺激软骨细胞增殖的试剂，并因此可用于治疗软骨疾病和/或软骨介导的骨生长。

46. 发明申请

WO1996005851A1 USE OF TASTELESS, HYDROLYSED COLLAGEN AND AGENT CONTAINING THE SAME 审中-公开
标题翻译：味道适中，水解胶原蛋白的使用和代理含有该
公开(公告)号：WO1996005851A1
公开(公告)日：1996-02-29
申请号：PCT/EP1995003304
申请日：1995-08-19
申请人： DGF STOESS AG , MILAN, Adam , EGGERSGLÜSS, Bernd , BRÄUMER, Klaus , SCHRIEBER, Reinhard
发明人： DGF STOESS AG
IPC分类号： A61K38/01
CPC分类号： A61K38/014 , A61K38/23 , Y10S514/801 , Y10S514/808 , Y10S514/825 , Y10S530/84 , A61K38/01 , A61K31/57 , A61K33/06 , A61K2300/00
摘要： The invention concerns the use of tasteless, hydrolysed collagen from gelatine, of gelatine or collagenic animal connective tissue with an average molecular weight of 1 to 40 kD for preparing osteoporosis treatment agents. It can be combined with conventional agents for combatting osteoporosis, such as calcitonin, calcium salts and/or progesterone.
摘要翻译：从明胶，明胶或胶原动物结缔组织无味水解胶原蛋白为1〜40kD的平均分子量在制备的剂治疗骨质疏松症。它可以与骨质疏松症的控制如降钙素，钙盐和/或孕酮常规方法进行组合。

47. 发明申请

WO1995000166A1 PHARMACEUTICAL COMPOSITIONS FOR STIMULATING RECONSTRUCTION OF HEMOPOIETIC MICROENVIRONMENT 审中-公开
标题翻译：用于刺激重建微生态环境的药物组合物
公开(公告)号：WO1995000166A1
公开(公告)日：1995-01-05
申请号：PCT/GB1994001309
申请日：1994-06-17
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY , GOLDIN, Douglas, Michael , BAB, Itai , MUHLRAD, Andras , CHOREV, Michael , SHTEYER, Arie , SLAVIN, Shimon , MANSUR, Nura , GUREVITCH, Olga
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY , GOLDIN, Douglas, Michael
IPC分类号： A61K37/36
CPC分类号： C07K14/51 , A61K38/00 , Y10S530/84 , Y10S530/841
摘要： The invention relates to a pharmaceutical composition for stimulating reconstruction of hemopoietic microenvironment comprising a therapeutically effective amount of a peptide having an amino acide sequence Ala-Leu-Lys-Arg-Gln-Gly-Arg-Thr-Leu-Try-Gly-Phe-Gly-Gly- (OGP), or conservative amino acid substitution or deletion thereof, or an oligopeptide having molecular weight of from 200 to 2,000 wherein the four C-terminal amino acid residues are identical with those of the said OGP, with the penultimate Gly optionally replaced by His, or a mixture thereof and a pharmaceutically acceptable carrier. A method of stimulating reconstruction of hemopoietic microenvironment in a mammal which comprises administering to said mammal a therapeutically effective amount of a peptide having an amino acid sequence Ala-Leu-Lys-Arg-Gln-Gly-Arg-Thr-Leu-Tyr-Gly-Phe-Gly-Gly (OGP), or conservative amino acid substitution or deletion thereof, or an oligopeptide having molecular weight of from 200 to 2,000 wherein the four C-terminal amino acid residues are identical with those of said OGP, with the penultimates Gly optionally replaced by His, or a mixture thereof.
摘要翻译：本发明涉及用于刺激造血微环境重建的药物组合物，其包含治疗有效量的具有氨基酸序列Ala-Leu-Lys-Arg-Gln-Gly-Arg-Thr-Leu-Try-Gly-Phe- Gly-Gly-（OGP）或其保守氨基酸取代或缺失，或分子量为200至2,000的寡肽，其中四个C-末端氨基酸残基与所述OGP的氨基酸残基相同，其中倒数第二任选地被His替代，或其混合物和药学上可接受的载体。一种刺激哺乳动物造血微环境重建的方法，其包括向所述哺乳动物施用治疗有效量的具有氨基酸序列Ala-Leu-Lys-Arg-Gln-Gly-Arg-Thr-Leu-Tyr-Gly -Phe-Gly-Gly（OGP）或其保守氨基酸取代或缺失，或分子量为200至2,000的寡肽，其中四个C末端氨基酸残基与所述OGP的氨基酸残基相同， Gly任选被His取代，或其混合物。

48. 发明申请

WO1993002718A1 UTILISATION OF CROSS-LINKED COLLAGEN FOR THE FABRICATION OF A STITCHABLE, BIOCOMPATIBLE, SLOW RESORPTION MEMBRANE 审中-公开
标题翻译：用于制造可缝合，生物易吸收的缓冲膜的交联胶原的使用
公开(公告)号：WO1993002718A1
公开(公告)日：1993-02-18
申请号：PCT/FR1992000750
申请日：1992-07-30
申请人： COLETICA , ABDUL-MALAK, Nabil , FOURCART, Jean , HUC, Alain
发明人： COLETICA
IPC分类号： A61L31/00
CPC分类号： A61L31/044 , A61F2310/00365 , A61L27/24 , Y10S128/08 , Y10S530/84 , Y10S530/842 , Y10S602/90
摘要： The invention relates to the utilization of cross-linked collagen for the fabrication of a stitchable, biocompatible, slow resorption membrane. The collagen used, may be native collagen particularly of type I or type III, atelocollagen or a mixture of collagen or atelocollagen with glycosaminoglycan. Said membrane is stitchable, biocompatible and slow resorbing, thereby enabling its use for guided tissue regeneration.

49. 发明申请

WO1992018142A1 OSTEOINDUCTIVE PROTEIN MIXTURES AND PURIFICATION PROCESSES 审中-公开
标题翻译： OSTEOINDUCTIVE蛋白质混合物和纯化方法
公开(公告)号：WO1992018142A1
公开(公告)日：1992-10-29
申请号：PCT/US1992003295
申请日：1992-04-21
申请人： INTERMEDICS ORTHOPEDICS/DENVER, INC.
发明人： INTERMEDICS ORTHOPEDICS/DENVER, INC. , POSER, James, William , BENEDICT, James, John
IPC分类号： A61K37/00
CPC分类号： C07K14/51 , A61F2/28 , A61F2/32 , A61F2/38 , A61F2/4455 , A61F2002/30011 , A61F2002/30062 , A61F2210/0004 , A61F2250/0023 , A61K38/1875 , A61L27/025 , A61L27/227 , Y10S530/84 , A61K2300/00
摘要： A method for purifying bone-derived osteoinductive factors including an ultrafiltration process, an anion exchange process, a cation exchange process, and a reverse phase HPLC process. The ultrafiltration process preferably includes a first ultrafiltration step using a membrane having a nominal molecular weight cutoff of approximately 100 kilodaltons (kD) and a second ultrafiltration step employing a membrane having a nominal molecular weight cutoff of approximately 10 kD. For the anion exchange process, a strongly cationic resin is used, preferably having quaternary amine functional groups. Typically, the eluant for the anion exchange process has a conductivity from about 10,260 micromhos (νmhos) (1.026 x 10-2 siemens (S)) to about 11,200 νmhos (1.120 x 10-2 S). For the cation exchange process, a strongly anionic resin is used, preferably having sulfonic acid functional groups. The eluant for the cation exchange process typically has a conductivity from about 39,100 νmhos (3.91 x 10-2 S) to about 82,700 νmhos (8.27 x 10-2 S) or more. The HPLC process typically utilizes a column containing hydrocarbon-modified silica packing material. The osteoinductive proteins can be eluted from the HPLC column with an acetonitrile solution in combination with aqueous trifluoracetic acid. The purification processes yield osteoinductively active protein mixtures.

50. 发明申请

WO1990010018A1 BONE COLLAGEN MATRIX FOR IMPLANTS 审中-公开
标题翻译：用于植入物的骨胶原基质
公开(公告)号：WO1990010018A1
公开(公告)日：1990-09-07
申请号：PCT/US1990000912
申请日：1990-02-22
申请人： CREATIVE BIOMOLECULES, INC.
发明人： CREATIVE BIOMOLECULES, INC. , KUBERASAMPATH, Thangavel , RIDGE, Richard, J.
IPC分类号： C07K15/00
CPC分类号： C07K14/51 , A61C8/0006 , A61F2310/00365 , A61K9/0024 , A61K38/00 , A61L27/227 , A61L27/24 , A61L27/34 , A61L27/3608 , A61L27/56 , A61L2430/02 , Y10S128/08 , Y10S530/84 , Y10S623/923 , C08L89/06
摘要： A matrix for implantation in a mammalian host comprising biocompatible, mineral-free, insoluble Type-I bone collagen which may be allogenic or xenogenic to the host, and which, when implanted in the host, is biodegradable. The collagen is treated with a collagen fibril modifying substance such as acidified acetonitrile, chloroform, or dichloromethane, or by heating in an aqueous environment to a temperature of 37 DEG -65 DEG C. The treated material undergoes a change in morphology involving a significant increase in its surface area as measured by various methods. Under the scanning electron microscope the material has an ''oyster shell'' appearance with many pits and micropores.
摘要翻译：用于植入哺乳动物宿主中的基质，其包含可能与宿主同种异体或异源的生物相容性，无矿物质的不溶性I型骨胶原，并且当植入宿主时，其可生物降解。用胶原原纤维改性物质如酸化的乙腈，氯仿或二氯甲烷或通过在含水环境中加热至37-65℃的温度来处理胶原。经处理的材料经历形态变化，其显着增加在其表面积通过各种方法测量。在扫描电子显微镜下，该材料具有许多凹坑和微孔的“牡蛎壳”外观。

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