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41. 发明授权

US07608618B2 Urea or thiourea substituted 1,4-pyrazine compounds useful as anti-cancer agents and for inhibiting Chk1 失效
标题翻译：尿素或硫脲可用作抗癌剂和抑制Chk1的1,4-吡嗪化合物
公开(公告)号：US07608618B2
公开(公告)日：2009-10-27
申请号：US11115993
申请日：2005-04-27
申请人： Edward A. Kesicki , John Joseph Gaudino , Adam Wade Cook , Scott Douglas Cowen , Laurence Edward Burgess
发明人： Edward A. Kesicki , John Joseph Gaudino , Adam Wade Cook , Scott Douglas Cowen , Laurence Edward Burgess
IPC分类号： C07D241/04 , C07D241/20 , C07D413/12 , A61K31/496 , A61K31/4965 , A61K31/497 , A61K31/5377 , C07D241/44 , C07D239/42 , C07D251/42 , C07D253/02 , A61K31/498 , A61K31/506 , A61K31/513 , A61K31/53 , A61P35/04 , A61P35/02 , A61P29/02
CPC分类号： A61K45/06 , A61K31/4965 , A61K31/498 , C07D213/30 , C07D213/40 , C07D213/75 , C07D213/77 , C07D215/34 , C07D231/12 , C07D231/40 , C07D233/56 , C07D239/42 , C07D239/47 , C07D241/12 , C07D241/20 , C07D241/44 , C07D249/08 , C07D251/22 , C07D253/07 , C07D257/06 , C07D277/48 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D453/02 , A61K2300/00
摘要： Compounds of the formula wherein: Y′ is O or S, W′ is optionally substituted, Z′ is selected from the group consisting of wherein Q′ is OR7 and R7 is C1-3alkyleneC3-8heterocycloalkyl useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division also are disclosed.
摘要翻译：下式的化合物其中：Y'是O或S，W'任选被取代，Z'选自其中Q'是OR 7，R 7是可用于治疗疾病和病症的C 1-3亚烷基C 3-8杂环烷基涉及DNA复制中的DNA损伤或病变。还公开了制备化合物的方法及其作为治疗剂的用途，例如用于治疗癌症和其它以DNA复制，染色体分离或细胞分裂缺陷为特征的疾病。

42. 发明申请

US20090062279A1 HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS, IN PARTICULAR AS ANTI-ALZHEIMER AGENTS 有权
标题翻译：杂环化合物，其制备及其用作药物，特别是作为抗病毒剂
公开(公告)号：US20090062279A1
公开(公告)日：2009-03-05
申请号：US11909911
申请日：2006-03-29
申请人： Francis Marsais , Pierre Bohn , Nicolas Le Fur , Vincent Levacher
发明人： Francis Marsais , Pierre Bohn , Nicolas Le Fur , Vincent Levacher
IPC分类号： A61K31/5377 , C07D215/00 , C07D217/00 , A61K31/44 , C07D413/02 , A61K31/47
CPC分类号： C07D211/96 , C07D211/86 , C07D211/90 , C07D215/34 , C07D215/36 , C07D215/54 , C07D217/22 , C07D217/24 , C07D413/04
摘要： The invention is related to compound which comprises at least one radical C═Y, Y being O or S, and an oxidable and non protonable nitrogen atom N wherein the distance (d) between the at least one carbon atom of the radical group C═Y and the nitrogen atom, when oxidized, is comprised between 0.3 and 0.8 nanometers. The invention is related to new heterocyclic compounds defined by formula G, their preparation, to pharmaceutical compositions comprising them and to their use as therapeutic agents, particularly in the treatment of neurodegenerative or Alzheimer disease.
摘要翻译：本发明涉及包含至少一个基团CY，Y为O或S的氧化和不可质子化的氮原子N的化合物，其中基团CY的至少一个碳原子和氮之间的距离（d）当氧化时，原子在0.3和0.8纳米之间。本发明涉及由式G定义的新的杂环化合物，其制备方法，包含它们的药物组合物及其作为治疗剂的用途，特别是用于治疗神经变性或阿尔茨海默病。

43. 发明授权

US07067506B2 Compounds useful for inhibiting Chk1 失效
公开(公告)号：US07067506B2
公开(公告)日：2006-06-27
申请号：US10087715
申请日：2002-03-01
申请人： Kathleen S. Keegan , Edward A. Kesicki , John Joseph Gaudino , Adam Wade Cook , Scott Douglas Cowen , Laurence Edward Burgess
发明人： Kathleen S. Keegan , Edward A. Kesicki , John Joseph Gaudino , Adam Wade Cook , Scott Douglas Cowen , Laurence Edward Burgess
IPC分类号： A61K31/33 , C07D241/00
CPC分类号： A61K45/06 , A61K31/4965 , A61K31/498 , C07D213/30 , C07D213/40 , C07D213/75 , C07D213/77 , C07D215/34 , C07D231/12 , C07D231/40 , C07D233/56 , C07D239/42 , C07D239/47 , C07D241/12 , C07D241/20 , C07D241/44 , C07D249/08 , C07D251/22 , C07D253/07 , C07D257/06 , C07D277/48 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D453/02 , A61K2300/00
摘要： Aryl- and heteroaryl-substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division also are disclosed.

44. 发明申请

US20050245525A1 Compounds useful for inhibiting CHK1 失效
标题翻译：可用于抑制CHK1的化合物
公开(公告)号：US20050245525A1
公开(公告)日：2005-11-03
申请号：US11115993
申请日：2005-04-27
申请人： Kathleen Keegan , Edward Kesicki , John Gaudino , Adam Cook , Scott Cowen , Laurence Burgess
发明人： Kathleen Keegan , Edward Kesicki , John Gaudino , Adam Cook , Scott Cowen , Laurence Burgess
IPC分类号： A61K31/4965 , A61K31/497 , A61K31/498 , A61K31/5377 , A61K45/06 , A61P35/00 , A61P43/00 , C07D213/30 , C07D213/40 , C07D213/75 , C07D213/77 , C07D215/34 , C07D231/40 , C07D239/42 , C07D239/46 , C07D241/12 , C07D241/20 , C07D241/30 , C07D241/44 , C07D241/54 , C07D251/22 , C07D253/06 , C07D253/07 , C07D257/06 , C07D277/48 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D453/02 , C07D521/00 , A61K31/53 , A61K31/50
CPC分类号： A61K45/06 , A61K31/4965 , A61K31/498 , C07D213/30 , C07D213/40 , C07D213/75 , C07D213/77 , C07D215/34 , C07D231/12 , C07D231/40 , C07D233/56 , C07D239/42 , C07D239/47 , C07D241/12 , C07D241/20 , C07D241/44 , C07D249/08 , C07D251/22 , C07D253/07 , C07D257/06 , C07D277/48 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D453/02 , A61K2300/00
摘要： Aryl- and heteroaryl-substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division also are disclosed.
摘要翻译：公开了可用于治疗与DNA复制中的DNA损伤或病变相关的疾病和病症的芳基和杂芳基取代的脲化合物。还公开了制备化合物的方法及其作为治疗剂的用途，例如用于治疗癌症和其它以DNA复制，染色体分离或细胞分裂缺陷为特征的疾病。

45. 发明授权

US3818012A 1,2-dihydro-8-carbamoyloxyquinolines 失效
标题翻译： 1,2-二氢-8-羰基氧杂环戊烷
公开(公告)号：US3818012A
公开(公告)日：1974-06-18
申请号：US17842771
申请日：1971-09-07
申请人： CIBA GEIGY AG
发明人： NIKLES E
IPC分类号： C07D215/26 , C07D215/34 , C07D33/40
CPC分类号： C07D215/26 , C07D215/34
摘要： Heterocyclic compounds of the formula

WHEREIN R1 is hydrogen, C1-C4 alkyl, C3-C5 alkenyl or C3-C5 alkinyl, R2 is hydrogen, C1-C4 alkyl or optionally substituted C1-C6 acyl, R3 is hydrogen, C1-C6 alkyl optionally substituted by C1-C4 alkoxy groups or cyano, C3-C5 alkenyl or C3-C5 alkinyl, R4 and R5 are each hydrogen or C1-C4 alkyl, R6 and R7 are each hydrogen or C1-C4 alkyl or together are a further bond between the C atoms to which they are attached in the heterocyclic ring, and R8 is hydrogen, C1-C4 alkyl or halogen, The compound being in the form of the free base or of an acid addition salt thereof, processes for their manufacture and use as agents for pest control.
摘要翻译：式IV的杂环化合物，其中R 1是氢，C 1 -C 4烷基，C 3 -C 5烯基或C 3 -C 5炔基，R 2是氢，C 1 -C 4烷基或任选取代的C 1 -C 6酰基，R 3是氢，被C 1 -C 4烷氧基或氰基，C 3 -C 5烯基或C 3 -C 5炔基取代，R 4和R 5各自为氢或C 1 -C 4烷基，R 6和R 7各自为氢或C 1 -C 4烷基或一起为在杂环中连接的C原子，R 8为氢，C 1 -C 4烷基或卤素。化合物为游离碱形式或其酸加成盐，其制备方法为虫害防治剂。

46. 发明授权

US3384538A Combatting insects with omicron-[-2-lower alkyl-quinolyl-(8)]n-methyl carbamates 失效
标题翻译：将昆虫与二甲基 - [ - 2-低级烷基 - 喹啉基 - （8）]甲基氨基甲酸酯
公开(公告)号：US3384538A
公开(公告)日：1968-05-21
申请号：US46051565
申请日：1965-06-01
申请人： GEIGY CHEM CORP
发明人： ERNEST HODEL
IPC分类号： C07D215/34
CPC分类号： C07D215/34

47. 发明授权

US3362960A O-quinolyl-(8)-n-methyl carbamic acid esters 失效
标题翻译： O-喹啉基 - （8） - 甲基氨基甲酸酯
公开(公告)号：US3362960A
公开(公告)日：1968-01-09
申请号：US63330467
申请日：1967-04-24
申请人： GEIGY CHEM CORP
发明人： ERNST HODEL
IPC分类号： A01N47/22 , C07D215/34 , C07D215/38
CPC分类号： C07D215/38 , A01N47/22 , C07D215/34

48. 发明公开

KR1020030078957A 방사선 증감제 및 화학적 감작제로서 유용한 아릴, 및헤테로아릴 우레아 ＣＨＫ１ 억제제 失效
标题翻译：芳基和杂芳基脲CHK1抑制剂，可用作辐射敏化剂和化学敏化剂
公开(公告)号：KR1020030078957A
公开(公告)日：2003-10-08
申请号：KR1020037011393
申请日：2002-03-01
申请人： 이코스 코포레이션
发明人： 키간카트린에스 , 케식키에드워드에이 , 가우디노죤죠셉 , 쿡아담웨이드 , 코웬스코트더글라스 , 불게스로렌스에드워드
IPC分类号： C07D241/20
CPC分类号： A61K45/06 , A61K31/4965 , A61K31/498 , C07D213/30 , C07D213/40 , C07D213/75 , C07D213/77 , C07D215/34 , C07D231/12 , C07D231/40 , C07D233/56 , C07D239/42 , C07D239/47 , C07D241/12 , C07D241/20 , C07D241/44 , C07D249/08 , C07D251/22 , C07D253/07 , C07D257/06 , C07D277/48 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D453/02 , A61K2300/00
摘要： 본 발명은 DNA 손상 또는 DNA 복제의 병변과 관련된 질환 및 증상의 치료에 유용한 화학식 1의 아릴 치환, 및 헤테로아릴 치환된 우레아 화합물에 관한 것이다. 또한, 본 발명은 상기 화합물의 제조 방법, 예를 들어 암, 그리고 DNA 복제, 염색체 분리 또는 세포 분화의 결함을 특징으로 하는 다른 질환의 치료에 있어 치료제로서의 상기 화합물의 용도에 관한 것이다.
화학식 1

상기 식 중, W'는 2개 이상의 질소원자와 경우에 따라 청구범위에 정의된 바와 같은 치환기를 포함하는 6원의 방향족 고리이고, Z'는 청구범위에 정의된 바와 같이 5원 또는 6원의 방향족 또는 헤테로방향족 고리이며, Y'는 O 또는 S이다.

49. 发明公开

KR1019970001328A 치환된 퀴놀린 제초제 중간체 및 이의 제조 방법 无效
标题翻译：取代的喹啉除草剂中间体及其制备方法
公开(公告)号：KR1019970001328A
公开(公告)日：1997-01-24
申请号：KR1019960019816
申请日：1996-06-04
申请人： 와이어쓰 홀딩스 엘엘씨
发明人： 웬-쥬우
IPC分类号： C07D215/14
CPC分类号： C07D215/26 , C07D215/32 , C07D215/34
摘要： 본발명은제초제 2―(4―이소프로필―메틸―5―옥소―2―이미다졸리디닐)―5―메톡시메틸니코틴산의합성에유용한치환된퀴놀린중간체및 제초제중간체 3―메특시메틸―7―또는 8―히드록시퀴놀린의제조방법에관한것이다.

50. 发明授权

EP1868998B1 NEW HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS, IN PARTICULAR AS ANTI-ALZHEIMER AGENTS 有权转让
标题翻译：新的杂环化合物，其制备及其作为药物，尤其是作为一种手段，抗阿尔茨海默氏病
公开(公告)号：EP1868998B1
公开(公告)日：2016-05-25
申请号：EP06742673.4
申请日：2006-03-29
申请人： VFP Therapies
发明人： MARSAIS, Francis , BOHN, Pierre , LEVACHER, Vincent , LE FUR, Nicolas
IPC分类号： C07D211/84 , C07D413/04 , C07D211/82 , C07D211/86
CPC分类号： C07D211/96 , C07D211/86 , C07D211/90 , C07D215/34 , C07D215/36 , C07D215/54 , C07D217/22 , C07D217/24 , C07D413/04

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