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41. 发明授权

US06737548B2 Process for preparing 1,5-diaminonaphthalene derivative 失效
标题翻译：制备1,5-二氨基萘衍生物的方法
公开(公告)号：US06737548B2
公开(公告)日：2004-05-18
申请号：US10312852
申请日：2003-01-02
申请人： Satoshi Inoki , Yoshio Motoyama
发明人： Satoshi Inoki , Yoshio Motoyama
IPC分类号： C07C20936
CPC分类号： C07C209/52 , C07C201/12 , C07C209/36 , C07C209/40 , C07C209/68 , C07C211/58 , C07C249/02 , C07C249/08 , C07C2602/10 , C07C251/44 , C07C251/20 , C07C205/06 , C07C205/45 , C07C205/56
摘要： In a process where an ortho-alkylnitrobenzene derivative and a vinyl compound as starting materials are used to prepare a 1,5-diaminonaphthalene derivative via a 4-(2-nitrobenzene)propane derivative and a 5-nitro-1-tetralone derivative, the ortho-alkylnitrobenzene derivative and a vinyl compound having an electron withdrawing group such as an acrylonitrile derivative and an acrylate may be reacted in the presence of a base to provide an aromatic nitro compound. An aromatic nitro compound such as 4-(2-nitrobenzene)butanonitrile thus obtained may be cyclized to safely, cost-effectively and selectively provide a 5-nitro-1-tetralone derivative without forming any isomer. Furthermore, from the 5-nitro-1-tetralone derivative, a 1,5-diaminonaphthalene derivative may be prepared without forming any isomer.
摘要翻译：在使用原烷基硝基苯衍生物和乙烯基化合物作为原料的方法中，通过4-（2-硝基苯）丙烷衍生物和5-硝基-1-四氢萘酮衍生物制备1,5-二氨基萘衍生物，正烷基硝基苯衍生物和具有吸电子基团的乙烯基化合物如丙烯腈衍生物和丙烯酸酯可以在碱的存在下反应以提供芳族硝基化合物。如此获得的芳族硝基化合物如4-（2-硝基苯）丁腈可以环化以安全，成本有效地选择性地提供5-硝基-1-四氢萘酮衍生物而不形成任何异构体。此外，从5-硝基-1-四氢萘酮衍生物可以制备1,5-二氨基萘衍生物而不形成任何异构体。

42. 发明授权

US06392010B1 Process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and &agr;&bgr;-unsaturated carboxylic acid and aldehyde compounds 失效
标题翻译：醛，酮，肟，胺，异羟肟酸和字母不饱和羧酸和醛化合物的固相合成方法
公开(公告)号：US06392010B1
公开(公告)日：2002-05-21
申请号：US09469829
申请日：1999-12-22
申请人： Joseph M. Salvino , George C. Morton , Helen J. Mason , Richard F. Labaudiniere
发明人： Joseph M. Salvino , George C. Morton , Helen J. Mason , Richard F. Labaudiniere
IPC分类号： C08J300
CPC分类号： C07D307/33 , C07B2200/11 , C07C45/004 , C07C45/41 , C07C45/45 , C07C45/516 , C07C209/00 , C07C209/40 , C07C209/42 , C07C209/66 , C07C239/08 , C07C259/06 , C07C259/08 , C07C259/10 , C07C315/04 , C07D311/68 , C07D311/82 , C07D313/12 , C08F8/10 , C08F8/12 , C08F8/18 , C08F8/30 , C08F8/34 , C08F2800/20 , C08F2810/30 , C07C49/807 , C07C49/213 , C07C47/55 , C07C47/228 , C07C47/23 , C07C47/277 , C07C317/44 , C08F212/08 , C08F8/02 , C08F8/00
摘要： This invention is directed to a process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and &agr;,&bgr;-unsaturated carboxylic acid and aldehyde compounds and to polymeric hydroxylamine resin compounds useful therefor.
摘要翻译：本发明涉及醛，酮，肟，胺，异羟肟酸和α，β-不饱和羧酸和醛化合物的固相合成方法以及用于其的聚合羟胺树脂化合物的方法。

43. 发明授权

US06307103B1 Process for the preparation of 1,1,1-trifluoro-2-aminoalkanes 失效
标题翻译：制备1,1,1-三氟-2-氨基烷烃的方法
公开(公告)号：US06307103B1
公开(公告)日：2001-10-23
申请号：US09537910
申请日：2000-03-28
申请人： Hans-Peter Niedermann , Dieter Gutheil
发明人： Hans-Peter Niedermann , Dieter Gutheil
IPC分类号： C07C20940
CPC分类号： C07C209/40 , C07C211/15
摘要： An improved process for the preparation of a 1,1,1-trifluoro-2-aminoalkane of formula I wherein R1 represents an optionally substituted alkyl group; which comprises hydrogenating the corresponding oxime of formula II wherein R1 has the meaning given above and the winding line indicates that the hydroxy group may be in the (E)- or (Z)-position with respect to the trifluoromethyl group, in the presence of Raney nickel and a diluent; the improvement wherein is, that said reaction is carried out in a diluent selected from an alkanol, a cyclic ether and an aromatic hydrocarbon.
摘要翻译：用于制备式I的1,1,1-三氟-2-氨基烷烃的改进方法，其中R1表示任选取代的烷基;其包括氢化相应的式II的肟，其中R1具有上述含义，并且绕组线表示在阮内镍和稀释剂的存在下，羟基可以在相对于三氟甲基的（E） - 或（Z） - 位置中;改进之处在于，所述反应是在选自链烷醇，环醚和芳族烃。

44. 发明授权

US6034274A Process for preparing a naphtalenamine derivative 失效
标题翻译：制备萘胺衍生物的方法
公开(公告)号：US6034274A
公开(公告)日：2000-03-07
申请号：US319879
申请日：1999-07-27
申请人： Krisztina Vukics , Tamas Fodor , Janos Fischer , Iren Fellegvari , Sandor Levai
发明人： Krisztina Vukics , Tamas Fodor , Janos Fischer , Iren Fellegvari , Sandor Levai
IPC分类号： C07C45/51 , C07C49/697 , C07C209/40 , C07C211/42 , C07C291/02 , C07C211/00
CPC分类号： C07C291/02 , C07C209/40 , C07C45/512 , C07C49/697 , C07C2102/10
摘要： The present invention relates to a proccss for preparing cis-(1S)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphtalenamine and its acid addition salts wherein N-methyl-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-naphtalene-1-en]-amine-N-oxide is hydrogenated in an inert solvent in the presence of a catalyst, then the resulting mixture is treated with alcanolic solution of a mineral acid, the resulting cis-racemic acid addition salt is converted to the free base by known methods, resolved and the resulting cis-(+)-base of formula (II) is converted to an acid addition salt. N-methyl-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-naphtalene-1-en]amine-N-oxide is also disclosed.
摘要翻译： PCT No.PCT / HU97 / 00083 Sec。 371日期：1999年7月27日 102（e）日期1997年7月27日PCT 1997年12月15日PCT公布。第WO98 / 27050号公报日期：1998年6月25日本发明涉及制备顺式 - （1S）-N-甲基-4-（3,4-二氯苯基）-1,2,3,4-四氢-1-萘胺及其酸其中N-甲基 - [4-（3,4-二氯苯基）-1,2,3,4-四氢 - 萘-1] - 胺-N-氧化物的加成盐在惰性溶剂中在催化剂，然后将所得混合物用无机酸的无水溶液处理，所得顺式 - 外消旋酸加成盐通过已知方法转化为游离碱，分离并得到式（II）的顺式 - （+） - 基）转化成酸加成盐。还公开了N-甲基 - [4-（3,4-二氯苯基）-1,2,3,4-四氢 - 萘-1]胺-N-氧化物。

45. 发明授权

US5675038A Lithium and amine dissolving metal reduction 失效
标题翻译：锂和胺溶解金属还原
公开(公告)号：US5675038A
公开(公告)日：1997-10-07
申请号：US685902
申请日：1996-07-18
申请人： Lloyd J. Dolby , Nestor A. Fedoruk , Shervin Esfandiari , Natalie C. Chamberlain , Michael E. Garst
发明人： Lloyd J. Dolby , Nestor A. Fedoruk , Shervin Esfandiari , Natalie C. Chamberlain , Michael E. Garst
IPC分类号： C07B31/00 , C07C5/11 , C07C13/48 , C07C29/132 , C07C31/137 , C07C41/18 , C07C41/20 , C07C43/188 , C07C45/41 , C07C45/62 , C07C47/32 , C07C209/40 , C07C209/44 , C07C209/48 , C07C209/50 , C07C209/52 , C07C211/07 , C07C211/17 , C07C211/35 , C07C211/48 , C07C231/08 , C07C231/12 , C07C233/05 , C07C319/02 , C07C319/06 , C07C321/26 , C07D233/06 , C07D233/10 , C07D403/06 , C07C291/00
CPC分类号： C07C5/11 , C07B31/00 , C07C209/40 , C07C209/48 , C07C209/50 , C07C209/52 , C07C231/08 , C07C231/12 , C07C29/132 , C07C319/02 , C07C319/06 , C07C41/18 , C07C45/41 , C07C45/62 , C07D233/06 , C07D233/10 , C07C2101/16 , C07C2102/10 , C07C2103/74
摘要： The invention is directed to a process for reducing or reductively cleaving an organic compound susceptible to dissolving metal reduction comprising exposing the organic compound to a solution of lithium in a polyamine including at least two amino groups, selected from the group consisting of primary and secondary amino groups and mixtures thereof, e.g. ethylenediamine and R--NH.sub.2, optionally containing a lower alkyl alcohol, wherein R is chosen from the group consisting of ethyl, propyl, and butyl, including all straight and branched chain isomers thereof, for a time sufficient to effect reduction.
摘要翻译：本发明涉及减少或还原性裂解易溶解金属还原的有机化合物的方法，其包括将有机化合物暴露于含有至少两个氨基的多胺中的锂溶液，所述多胺选自伯和仲氨基基团及其混合物，例如乙二胺和R-NH 2，任选地含有低级烷基醇，其中R选自乙基，丙基和丁基，包括其所有直链和支链异构体在足以实现还原的时间。

46. 发明授权

US5200561A Process for producing optically active amines 失效
标题翻译：生产光活性胺的方法
公开(公告)号：US5200561A
公开(公告)日：1993-04-06
申请号：US771569
申请日：1991-10-07
申请人： Naoto Konya , Yukio Yoneyoshi , Yoji Sakito , Shinji Nishii , Gohfu Suzukamo , Hiroko Sakane
发明人： Naoto Konya , Yukio Yoneyoshi , Yoji Sakito , Shinji Nishii , Gohfu Suzukamo , Hiroko Sakane
IPC分类号： C07B53/00 , C07C209/40 , C07C209/52 , C07C211/03 , C07C211/27
CPC分类号： C07C209/40
摘要： Disclosed is a process for producing an optically active amine represented by the formula (IV) ##STR1## wherein R.sub.7 and R.sub.8 each denote an alkyl group, aryl group or aralkyl group, providing that they do not denote the same group at the same time, and * indicates an asymmetric carbon atom, which comprises reacting an asymmetric reducing agent obtained from (1) an optically active amine derivative represented by the formula (I) ##STR2## wherein R.sub.1 denotes an alkyl group, aryl group or aralkyl group; R.sub.2 denotes a hydrogen atom, alkyl group or aralkyl group; R.sub.3 denotes an aryl group or a substituent represented by the formula (II) ##STR3## wherein R.sub.4 and R.sub.5 each denote a hydrogen atom, aryl group or aralkyl group, and * is as defined above, (2) a metal borohydride and (3) sulfuric acid, with either the syn-isomer or the anti-isomer of an oxime derivative represented by the formula (III) or with a mixture rich in either one of the two isomers ##STR4## wherein R.sub.6 denotes an alkyl group, aralkyl group or alkyl-substituted silyl group, and R.sub.7 and R.sub.8 are as defined above.The optically active amine obtained can be used as a resolving agent for preparing medicinal agents, agricultural chemicals, or intermediates thereof.

47. 发明授权

US4404401A Process for the preparation of para-amino-diphenylamine 失效
标题翻译：对氨基二苯胺的制备方法
公开(公告)号：US4404401A
公开(公告)日：1983-09-13
申请号：US14672
申请日：1979-02-23
申请人： Hans G. Zengel , Manfred Bergfeld
发明人： Hans G. Zengel , Manfred Bergfeld
IPC分类号： C07C83/02
CPC分类号： C07C209/40
摘要： An improved process for the preparation of para-amino diphenylamine in which para-nitroso-diphenylhydroxylamine is catalytically hydrogenated in the presence of an organic solvent and one or more metal components selected from the group consisting of ruthenium, rhodium, palladium, osmium, iridium, and platinum, and their sulfidic compounds, at temperatures from 20.degree. to 200.degree. C., is disclosed. The improvement comprises utilizing as the organic solvent one or more members of the group consisting of aniline and aniline derivatives containing ring-alkyl groups, N-alkyl groups, or a combination thereof, wherein the ring-alkyl groups contain a total of 1 to 6 carbon atoms and the N-alkyl groups contain from 1 to 6 carbon atoms.
摘要翻译：一种改进的对氨基二苯胺的制备方法，其中对 - 亚硝基 - 二苯基羟胺在有机溶剂和一种或多种选自钌，铑，钯，锇，铱的金属组分的存在下催化氢化，和铂，以及它们的硫化合物在20℃至200℃的温度下进行了公开。改进之处在于使用作为有机溶剂的一种或多种由苯胺和含有环烷基的苯胺衍生物，N-烷基或其组合组成的组，其中环烷基含有总共1至6个碳原子和N-烷基含有1至6个碳原子。

48. 发明申请

WO2015178847A1 PROCESS FOR THE PREPARATION OF CHIRAL AMINES BY ASYMMETRIC HYDROGENATION OF PROCHIRAL OXIMES 审中-公开
标题翻译：通过不对称加氢处理来制备丙烯酰胺的方法
公开(公告)号：WO2015178847A1
公开(公告)日：2015-11-26
申请号：PCT/SE2015/050582
申请日：2015-05-20
申请人： SP PROCESS DEVELOPMENT AB
发明人： RYBERG, Per , BERG, Robert
IPC分类号： C07B43/04 , C07B53/00 , C07C209/40 , B01J23/46 , B01J31/22 , B01J31/24 , C07C211/27 , C07C211/29 , C07C211/30
CPC分类号： C07B43/04 , B01J31/2409 , B01J31/2495 , B01J2231/643 , B01J2531/007 , B01J2531/0266 , B01J2531/821 , B01J2531/822 , B01J2531/827 , C07B53/00 , C07C209/40 , C07C213/02 , C07C211/29 , C07C211/27 , C07C211/30 , C07C217/58
摘要： There is provided a method for the preparation of an enantiomerically enriched amine by asymmetric hydrogenation of a prochiral oxime.
摘要翻译：提供了通过前手iral肟的不对称氢化制备对映异构体富集的胺的方法。

49. 发明申请

WO2012128515A3 POLYMER SUPPORTED REAGENTS AND METHODS OF REDUCING AROMATIC NITRO COMPOUNDS BY USING THE SAME 审中-公开
标题翻译：聚合物支持的试剂及其使用方法减少芳族硝基化合物
公开(公告)号：WO2012128515A3
公开(公告)日：2013-02-07
申请号：PCT/KR2012001928
申请日：2012-03-16
申请人： LG CHEMICAL LTD , IUCF HYU , HAN YANG-KYOO , CHO JIN , LEE SANG-MI , SHIN SEUNG-HOON
发明人： HAN YANG-KYOO , CHO JIN , LEE SANG-MI , SHIN SEUNG-HOON
IPC分类号： C08F20/54 , B01J27/26 , C07C245/00 , C08F12/08 , C08F20/56
CPC分类号： C07C291/08 , B01J31/06 , B01J2231/641 , C07C201/04 , C07C207/02 , C07C209/36 , C07C209/38 , C07C209/40 , C07C213/02 , C07C245/08 , C08F20/54 , C08F212/08 , C08F220/56 , Y02P20/582 , C08F220/54 , C08F212/36 , C07C211/46 , C07C211/47
摘要： The present invention relates to a polymer supported reagent comprising a novel crosslinked mesoporous polymer, enabling a simple and easy production of an azoxy compound or an azo compound from an aromatic nitro compound, and a method of selectively reducing an aromatic nitro compound by using the same. The polymer supported reagent comprises a certain acrylamide mesoporous crosslinked polymer.
摘要翻译：本发明涉及包含新颖的交联介孔聚合物的聚合物负载型试剂，能够简单且容易地从芳族硝基化合物制备偶氮化合物或偶氮化合物，以及通过使用其来选择还原芳族硝基化合物的方法。聚合物负载的试剂包括某种丙烯酰胺介孔交联聚合物。

50. 发明申请

WO2012128515A2 POLYMER SUPPORTED REAGENTS AND METHODS OF REDUCING AROMATIC NITRO COMPOUNDS BY USING THE SAME 审中-公开
标题翻译：聚合物支持的试剂和使用相同的方法减少芳香硝基化合物
公开(公告)号：WO2012128515A2
公开(公告)日：2012-09-27
申请号：PCT/KR2012/001928
申请日：2012-03-16
申请人： LG CHEM, LTD. , IUCF-HYU (INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY) , HAN, Yang-Kyoo , CHO, Jin , LEE, Sang-Mi , SHIN, Seung-Hoon
发明人： HAN, Yang-Kyoo , CHO, Jin , LEE, Sang-Mi , SHIN, Seung-Hoon
IPC分类号： C08F20/54 , C08F20/56 , C08F12/08 , C07C245/00 , B01J27/26
CPC分类号： C07C291/08 , B01J31/06 , B01J2231/641 , C07C201/04 , C07C207/02 , C07C209/36 , C07C209/38 , C07C209/40 , C07C213/02 , C07C245/08 , C08F20/54 , C08F212/08 , C08F220/56 , Y02P20/582 , C08F220/54 , C08F212/36 , C07C211/46 , C07C211/47
摘要： The present invention relates to a polymer supported reagent comprising a novel crosslinked mesoporous polymer, enabling a simple and easy production of an azoxy compound or an azo compound from an aromatic nitro compound, and a method of selectively reducing an aromatic nitro compound by using the same. The polymer supported reagent comprises a certain acrylamide mesoporous crosslinked polymer.
摘要翻译：本发明涉及一种包含新型交联中孔聚合物的聚合物载体试剂，其能够简单且容易地由芳族硝基化合物制备氧化偶氮化合物或偶氮化合物，以及选择性还原通过使用它们的芳香族硝基化合物。聚合物载体试剂包含特定的丙烯酰胺中孔交联聚合物。

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