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41. 发明申请

US20120227469A1 CHROMATOGRAPHY OF POLYOLEFIN POLYMERS 有权
标题翻译：聚烯烃聚合物的色谱法
公开(公告)号：US20120227469A1
公开(公告)日：2012-09-13
申请号：US13512387
申请日：2010-12-21
申请人： William L. Winniford , Rongjuan Cong , Theodore M. Stokich, JR. , Randy J. Pell , Matthew D. Miller , Abhishek Roy , Freddy Van Damme , Alexander W. Degroot , John W. Lyons , David M. Meunier
发明人： William L. Winniford , Rongjuan Cong , Theodore M. Stokich, JR. , Randy J. Pell , Matthew D. Miller , Abhishek Roy , Freddy Van Damme , Alexander W. Degroot , John W. Lyons , David M. Meunier
IPC分类号： G01N30/06
CPC分类号： B01D15/161 , B01D15/166 , B01D15/1878 , B01J20/24 , B01J2220/4825 , G01N30/34 , G01N2030/3076 , G01N2030/885
摘要： The invention provides a method for one-dimensional chromatography of a polyolefin polymer, comprising introducing a solution of the polyolefin polymer into a liquid flowing through a liquid chromatography stationary phase, the liquid chromatography stationary phase comprising graphitic carbon, and wherein the polyolefin polymer emerging from the liquid chromatography stationary phase has a retention factor greater than zero, and wherein the solution introduced into the liquid chromatography stationary phase is subjected to a temperature gradient, and/or the solution is subjected to a solvent gradient. The invention also provides a method for multi-dimensional chromatography of a polyolefin polymer, comprising introducing a solution of the polyolefin polymer into a liquid flowing through a first liquid chromatography stationary phase or a field flow fractionation device, and subsequently flowing the solution through a second liquid chromatography stationary phase, the second liquid chromatography stationary phase comprising graphitic carbon, and wherein the polyolefin polymer emerging from the liquid chromatography stationary phase has a retention factor greater than zero. The invention also provides an apparatus for polyolefin polymer chromatography, comprising a liquid chromatography stationary phase, the liquid chromatography stationary phase comprising graphitic carbon and at least one inert filler.
摘要翻译：本发明提供了聚烯烃聚合物的一维色谱法的方法，包括将聚烯烃聚合物的溶液引入流过液相色谱固定相的液体中，液相色谱固定相包含石墨碳，其中聚烯烃聚合物从液相色谱固定相具有大于零的保留因子，其中引入液相色谱固定相的溶液经受温度梯度，和/或溶液经受溶剂梯度。本发明还提供了聚烯烃聚合物的多维色谱法的方法，包括将聚烯烃聚合物的溶液引入流过第一液相色谱固定相或场流分离装置的液体中，随后使溶液流过第二液相色谱固定相，第二液相色谱固定相包含石墨碳，其中从液相色谱固定相中出现的聚烯烃聚合物具有大于零的保留因子。本发明还提供了一种用于聚烯烃聚合物色谱的装置，包括液相色谱固定相，液相色谱固定相包含石墨碳和至少一种惰性填料。

42. 发明申请

US20100151584A1 MULTI-DIMENSIONAL CHROMATOGRAPHIC METHODS FOR SEPARATING N-GLYCANS 有权
标题翻译：用于分离N-GLYCANS的多维色谱方法
公开(公告)号：US20100151584A1
公开(公告)日：2010-06-17
申请号：US12595937
申请日：2008-04-15
申请人： Ian Christopher Parsons , Ting Zheng , Nur Sibel Gunay , Carlos J. Bosques
发明人： Ian Christopher Parsons , Ting Zheng , Nur Sibel Gunay , Carlos J. Bosques
IPC分类号： G01N30/84 , G01N33/00
CPC分类号： G01N33/6803 , B01D15/166 , B01D15/1864 , B01D15/1878 , B01D15/325 , B01D15/363 , B01D15/426 , C07K1/36 , G01N1/34 , G01N30/463 , G01N33/6854 , G01N2400/00 , G01N2440/38 , Y10T436/14 , Y10T436/142222 , Y10T436/143333 , Y10T436/145555
摘要： A multi-dimensional chromatographic method for the separation of N-glycans. The method comprises providing a glycan preparation that includes at least one negatively charged N-glycan. The glycan preparation is then separated by anion-exchange chromatography and at least one secondary chromatographic technique.
摘要翻译：用于分离N-聚糖的多维色谱方法。该方法包括提供包含至少一个带负电荷的N-聚糖的聚糖制剂。然后通过阴离子交换层析和至少一种二级色谱技术分离聚糖制备物。

43. 发明申请

US20080160629A1 METHODS AND SYSTEMS FOR OFF-LINE MULTIDIMENSIONAL CONCENTRATION AND SEPARATION OF BIOMOLECULES 审中-公开
标题翻译：离线多元浓缩和生物分子分离的方法和系统
公开(公告)号：US20080160629A1
公开(公告)日：2008-07-03
申请号：US11619041
申请日：2007-01-02
申请人： Brian M. Balgley
发明人： Brian M. Balgley
IPC分类号： G01N30/02 , B01D57/02
CPC分类号： G01N30/463 , B01D15/1878 , B01D15/305 , B01D15/322 , B01D15/325 , B01D15/34 , G01N27/44773
摘要： The invention provides a method for performing off-line multi-dimensional separation and analysis of a heterogeneous biomolecular sample. The method includes separating the heterogeneous biomolecular sample into a plurality of fractions using an electrophoresis capillary. The plurality of fractions are then deposited onto one or more structures, which keep each of the plurality of fractions separate from one another. The plurality of fractions are then subjected to non-eluting conditions by titrating the at least one of the plurality of fractions to an acidic pH and adding an ion-pairing reagent to the fractions. At least one of the fractions is then introduced into a capillary reversed-phase electrophoresis capillary. The fraction is then separated in the capillary into a plurality of sub-fractions based on hydrophobicity of the sub-fractions. The sub-fractions are then analyzed to determine their constituent molecules.
摘要翻译：本发明提供了一种用于进行异质生物分子样品的离线多维分离和分析的方法。该方法包括使用电泳毛细管将异质生物分子样品分离成多个级分。然后将多个级分沉积到一个或多个结构上，这些结构将多个级分中的每一个保持彼此分离。然后通过将多个级分中的至少一种滴定至酸性pH并将该离子配对试剂加入到该级分中，使多个馏分经历非洗脱条件。然后将至少一个级分引入毛细管反相电泳毛细管中。然后将该馏分在毛细管中分离成多个基于亚级分的疏水性的亚级分。然后分析子级分以确定其组成分子。

44. 发明授权

US07112453B2 Retentate chromatography and protein chip arrays with applications in biology and medicine 失效
公开(公告)号：US07112453B2
公开(公告)日：2006-09-26
申请号：US10138008
申请日：2002-08-05
申请人： T. William Hutchens , Tai-Tung Yip
发明人： T. William Hutchens , Tai-Tung Yip
IPC分类号： G01N33/553 , B05D3/00
CPC分类号： C40B30/04 , B01D15/1878 , B01D15/305 , B01D15/3809 , B01J20/281 , B01J20/286 , B01J20/3204 , B01J20/3212 , B01J20/3219 , B01J20/3248 , B01J20/3253 , B01J20/3265 , B01J20/3274 , B01J20/3289 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00644 , B01J2219/00659 , B01J2219/00702 , B01J2219/00725 , B01J2220/54 , C12Q1/00 , C40B40/10 , G01N30/00 , G01N30/02 , G01N30/461 , G01N30/463 , G01N30/466 , G01N30/48 , G01N30/482 , G01N30/90 , G01N30/95 , G01N33/531 , G01N33/538 , G01N33/543 , G01N33/54306 , G01N33/54353 , G01N33/54373 , G01N33/54393 , G01N33/566 , G01N33/6803 , G01N33/6845 , G01N33/6851 , G01N2030/008 , G01N2030/009 , Y02A90/26 , Y10S422/906 , Y10S435/803 , Y10S435/81 , Y10S435/814 , Y10S435/815 , Y10S435/97 , Y10S435/973 , Y10S435/975 , Y10S436/808 , Y10S436/809 , Y10S436/811 , Y10S436/813 , Y10S436/824 , Y10S436/825 , Y10T436/24 , Y10T436/25 , Y10T436/25125 , Y10T436/2525 , Y10T436/25375 , Y10T436/255 , B01D15/363 , B01D15/322 , B01D15/327 , B01D15/3804 , B01D15/362 , B01D15/38 , B01D15/26
摘要： This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical diagnostics and drug discovery.

45. 发明授权

US06730228B2 Methods and apparatus for characterization of polymers using multi-dimensional liquid chromatography with regular second-dimension sampling 失效
标题翻译：使用具有常规二维采样的多维液相色谱法表征聚合物的方法和装置
公开(公告)号：US06730228B2
公开(公告)日：2004-05-04
申请号：US10230863
申请日：2002-08-28
申请人： Miroslav Petro , Son Hoai Nguyen , Eric D. Carlson
发明人： Miroslav Petro , Son Hoai Nguyen , Eric D. Carlson
IPC分类号： B01D1508
CPC分类号： G01N30/463 , B01D15/1878 , B01D15/265 , B01D15/325 , B01D15/34 , B01D15/424 , B01J19/0046 , B01J2219/00283 , B01J2219/00286 , B01J2219/00308 , B01J2219/00315 , B01J2219/00317 , B01J2219/00389 , B01J2219/00585 , B01J2219/00599 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00704 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01J2219/00736 , G01N30/02 , G01N30/20 , G01N30/46 , G01N30/461 , G01N30/8651 , G01N33/44 , G01N2030/027 , G01N2030/324 , G01N30/16
摘要： Methods and apparatus for characterizing a polymer sample and in preferred embodiments, libraries of polymer samples, in a comprehensive, directly-coupled multi-dimensional liquid chromatography system are disclosed. The first and second dimensions are preferably high-performance liquid chromatography dimensions, such as for example, a first dimension adapted for determining composition (e.g. adapted for mobile-phase gradient elution chromatography, including reverse phase chromatography, adsorption chromatography and the like), and a second dimension adapted for determining molecular weight or particle size (e.g., adapted for size exclusion chromatography, including gel permeation chromatography).
摘要翻译：公开了在综合的直接耦合的多维液相色谱系统中用于表征聚合物样品的方法和装置，并且在优选实施方案中，聚合物样品的文库。第一和第二维度优选是高效液相色谱尺寸，例如适于测定组成的第一维度（例如适用于流动相梯度洗脱色谱法，包括反相色谱法，吸附色谱法等），和适于确定分子量或粒度的第二维度（例如，适于尺寸排阻色谱法，包括凝胶渗透色谱法）。

46. 发明申请

US20030070988A1 Rapid characterization of polymers 失效
标题翻译：快速表征聚合物
公开(公告)号：US20030070988A1
公开(公告)日：2003-04-17
申请号：US10231317
申请日：2002-08-28
发明人： Miroslav Petro , Son Hoai Nguyen , Eric D. Carlson
IPC分类号： B01D015/08
CPC分类号： G01N35/085 , B01D15/166 , B01D15/1878 , B01D15/325 , B01D15/34 , B01J19/0046 , B01J19/26 , B01J2219/00274 , B01J2219/00585 , B01J2219/00587 , B01J2219/00707 , B01J2219/00722 , C40B40/14 , G01N15/0205 , G01N30/02 , G01N30/20 , G01N30/24 , G01N30/30 , G01N30/463 , G01N30/54 , G01N30/8651 , G01N33/44 , G01N35/1097 , G01N2015/0288 , G01N2015/0294 , G01N2030/027 , G01N2030/324 , Y10T436/25 , Y10T436/2575
摘要： Methods and apparatus for characterizing a polymer sample and in preferred embodiments, libraries of polymer samples, in a comprehensive, directly-coupled multi-dimensional liquid chromatography system are disclosed. The first and second dimensions are preferably high-performance liquid chromatography dimensions, such as for example, a first dimension adapted for determining composition (e.g. adapted for mobile-phase gradient elution chromatography, including reverse phase chromatography, adsorption chromatography and the like), and a second dimension adapted for determining molecular weight or particle size (e.g., adapted for size exclusion chromatography, including gel permeation chromatography).
摘要翻译：公开了在综合的直接耦合的多维液相色谱系统中用于表征聚合物样品的方法和装置，并且在优选实施方案中，聚合物样品的文库。第一和第二维度优选是高效液相色谱尺寸，例如适于测定组成的第一维度（例如适用于流动相梯度洗脱色谱法，包括反相色谱法，吸附色谱法等），和适于确定分子量或粒度的第二维度（例如，适于尺寸排阻色谱法，包括凝胶渗透色谱法）。

47. 发明申请

US20020155509A1 Retentate chromatography and protein chip arrays with applications in biology 有权
公开(公告)号：US20020155509A1
公开(公告)日：2002-10-24
申请号：US10150587
申请日：2002-05-17
申请人： CIPHERGEN BIOSYSTEMS, INC.
发明人： T. William Hutchens , Tai-Tung Yip
IPC分类号： G01N033/53 , G01N033/542 , G01N033/537 , G01N033/543
CPC分类号： C40B30/04 , B01D15/1878 , B01D15/305 , B01D15/3809 , B01J20/281 , B01J20/286 , B01J20/3204 , B01J20/3212 , B01J20/3219 , B01J20/3248 , B01J20/3253 , B01J20/3265 , B01J20/3274 , B01J20/3289 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00644 , B01J2219/00659 , B01J2219/00702 , B01J2219/00725 , B01J2220/54 , C12Q1/00 , C40B40/10 , G01N30/00 , G01N30/02 , G01N30/461 , G01N30/463 , G01N30/466 , G01N30/48 , G01N30/482 , G01N30/90 , G01N30/95 , G01N33/531 , G01N33/538 , G01N33/543 , G01N33/54306 , G01N33/54353 , G01N33/54373 , G01N33/54393 , G01N33/566 , G01N33/6803 , G01N33/6845 , G01N33/6851 , G01N2030/008 , G01N2030/009 , Y02A90/26 , Y10S422/906 , Y10S435/803 , Y10S435/81 , Y10S435/814 , Y10S435/815 , Y10S435/97 , Y10S435/973 , Y10S435/975 , Y10S436/808 , Y10S436/809 , Y10S436/811 , Y10S436/813 , Y10S436/824 , Y10S436/825 , Y10T436/24 , Y10T436/25 , Y10T436/25125 , Y10T436/2525 , Y10T436/25375 , Y10T436/255 , B01D15/363 , B01D15/322 , B01D15/327 , B01D15/3804 , B01D15/362 , B01D15/38 , B01D15/26
摘要： This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical diagnostics and drug discovery.

48. 发明授权

US06225047B1 Use of retentate chromatography to generate difference maps 失效
标题翻译：使用渗余色谱法生成差异图
公开(公告)号：US06225047B1
公开(公告)日：2001-05-01
申请号：US09100302
申请日：1998-06-19
申请人： T. William Hutchens , Tai-Tung Yip
发明人： T. William Hutchens , Tai-Tung Yip
IPC分类号： G01N33543
CPC分类号： C40B30/04 , B01D15/1878 , B01D15/305 , B01D15/3809 , B01J20/281 , B01J20/286 , B01J20/3204 , B01J20/3212 , B01J20/3219 , B01J20/3248 , B01J20/3253 , B01J20/3265 , B01J20/3274 , B01J20/3289 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00644 , B01J2219/00659 , B01J2219/00702 , B01J2219/00725 , B01J2220/54 , C12Q1/00 , C40B40/10 , G01N30/00 , G01N30/02 , G01N30/461 , G01N30/463 , G01N30/466 , G01N30/48 , G01N30/482 , G01N30/90 , G01N30/95 , G01N33/531 , G01N33/538 , G01N33/543 , G01N33/54306 , G01N33/54353 , G01N33/54373 , G01N33/54393 , G01N33/566 , G01N33/6803 , G01N33/6845 , G01N33/6851 , G01N2030/008 , G01N2030/009 , Y02A90/26 , Y10S422/906 , Y10S435/803 , Y10S435/81 , Y10S435/814 , Y10S435/815 , Y10S435/97 , Y10S435/973 , Y10S435/975 , Y10S436/808 , Y10S436/809 , Y10S436/811 , Y10S436/813 , Y10S436/824 , Y10S436/825 , Y10T436/24 , Y10T436/25 , Y10T436/25125 , Y10T436/2525 , Y10T436/25375 , Y10T436/255 , B01D15/363 , B01D15/322 , B01D15/327 , B01D15/3804 , B01D15/362 , B01D15/38 , B01D15/26
摘要： This is invention is directed to methods of identifying analytes that are differentially present between two samples. The methods involve determining retention data by desorption spectrometry for analytes in different samples using the same selectivity conditions, comparing the data, and identifying analytes that are differentially retained.
摘要翻译：本发明涉及鉴定两个样品之间差异存在的分析物的方法。这些方法涉及通过解吸光谱法确定不同样品中分析物的保留数据，使用相同的选择性条件，比较数据和鉴定差异保留的分析物。

49. 发明授权

US12055526B2 Sample handling and dispatching individual sample packages for fluid processing 有权
公开(公告)号：US12055526B2
公开(公告)日：2024-08-06
申请号：US17045756
申请日：2019-04-05
申请人： Agilent Technologies, Inc.
发明人： Stephan Buckenmaier , Konstantin Shoykhet
IPC分类号： G01N30/20 , G01N30/02 , G01N30/46 , G01N30/82 , G01N30/84 , B01D15/18
CPC分类号： G01N30/20 , G01N30/463 , G01N30/465 , G01N30/82 , B01D15/1878 , G01N2030/027 , G01N2030/202 , G01N2030/208 , G01N2030/8411
摘要： A sampling unit for handling a sample fluid includes a sample container having a length and being configured for receiving and storing the sample fluid, and a sample segment dispatching unit configured for providing a plurality of individual sample packages of the fluidic sample, each contained in a respective volume segment along the length of the sample container, and for individually dispatching each of the plurality of individual sample packages for further processing in a fluid processing unit. The sample unit may be utilized, for example, for injecting the sample packages into a mobile phase stream for transporting to a sample separating unit such as a chromatography column.

50. 发明授权

US09683975B2 Volumetric flow regulation in multi-dimensional liquid analysis systems 有权
公开(公告)号：US09683975B2
公开(公告)日：2017-06-20
申请号：US14620924
申请日：2015-02-12
申请人： IDEX Health & Science LLC
发明人： Carl Sims
IPC分类号： G01N30/32 , B01D15/08 , B01D15/42 , G01N30/20 , G01N30/46
CPC分类号： G01N30/32 , B01D15/08 , B01D15/1878 , B01D15/22 , B01D15/424 , G01N30/20 , G01N30/465 , G01N2030/027 , G01N2030/207 , G01N2030/208 , G01N2030/324
摘要： A multi-dimensional liquid analysis system includes a first dimension system and a second dimension system, wherein outflow from the first dimension system is separated at a flow splitter under controlled conditions. The flow splitter separates the first dimension outflow into first and second split outlet flows, with one of the split outlet flows being metered to a designated flow rate with a flow metering device disposed downstream from the flow splitter. The flow metering device selectively closes or opens an outlet flow path to define a volumetric flow rate along that outlet flow path, so that the other split outlet flow is correspondingly controlled.

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