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41. 发明申请

US20170348236A1 METHOD FOR PRODUCING MICROPARTICLES 审中-公开
公开(公告)号：US20170348236A1
公开(公告)日：2017-12-07
申请号：US15622816
申请日：2017-06-14
申请人： NRL PHARMA, INC.
发明人： Hidefumi KUWATA
IPC分类号： A61K9/16 , A23P10/30 , A61K9/20 , A61K38/48 , A23K40/30 , A61K38/28 , A61K38/40 , B01J2/04
CPC分类号： A61K9/1652 , A23K40/30 , A23P10/30 , A61K9/1617 , A61K9/1694 , A61K9/2077 , A61K38/28 , A61K38/40 , A61K38/482 , A61K38/488 , B01J2/04 , C12Y304/21 , C12Y304/23001
摘要： The present invention has an object providing microparticles having an average particle size of 100 μm or less.The present invention provides microparticles having an average particle size of 100 μm or less and a method for producing thereof. In addition, the present invention provides medicine, food and feedstuff comprising the microparticles having an average particle size of 100 μm or less.

42. 发明申请

US20160346364A1 MEDICAMENT AND METHOD FOR TREATING INNATE IMMUNE RESPONSE DISEASES 审中-公开
标题翻译：治疗免疫应答疾病的药物和方法
公开(公告)号：US20160346364A1
公开(公告)日：2016-12-01
申请号：US15101630
申请日：2014-12-11
申请人： DSM IP ASSETS B.V.
发明人： Maaike Johanna BRUINS , Luppo EDENS , Lenneke NAN
IPC分类号： A61K38/48 , A23L5/20 , A23L29/00 , A21D8/04 , A61K9/00 , C12N9/62
CPC分类号： A61K38/488 , A21D8/042 , A23L5/25 , A23L29/06 , A23V2002/00 , A61K9/0053 , A61K38/482 , C12C5/004 , C12N9/62 , C12Y304/21026 , C12Y304/23018 , C12Y304/23019 , A61K2300/00
摘要： This invention relates to a medicament or a dietary supplement comprising the Aspergillus niger aspergilloglutamic peptidase that is capable of hydrolyzing plant food allergens, and more particularly, alpha-amylase/trypsin inhibitors, thereby treating diseases due to an innate immune response in humans, and/or allowing to delay the onset of said diseases. The present invention relates to the discovery that the Aspergillus niger aspergilloglutamic peptidase is capable of hydrolyzing alpha-amylase/trypsin inhibitors that are present in wheat and related cereals said inhibitors being strong inducers of innate immune response. Furthermore, the present invention relates to a method for hydrolyzing alpha-amylase/trypsin inhibitors comprising incubating a composition for food consumption comprising alpha-amylase/trypsin inhibitors with the Aspergillus niger aspergilloglutamic peptidase, wherein the inhibitors are hydrolyzed. It also relates to an enzyme composition comprising the Aspergillus niger aspergilloglutamic peptidase and an additional enzyme, and to foodstuff comprising the Aspergillus niger aspergilloglutamic peptidase.
摘要翻译：本发明涉及一种药物或膳食补充剂，其包含能够水解植物食物过敏原的黑曲霉曲霉菌肽酶，更具体地，涉及α-淀粉酶/胰蛋白酶抑制剂，从而治疗由于人的先天免疫应答引起的疾病，和/ 或允许延迟所述疾病的发作。本发明涉及黑曲霉曲霉菌肽酶能够水解存在于小麦和相关谷物中的α-淀粉酶/胰蛋白酶抑制剂的发现，所述抑制剂是先天免疫应答的强诱导剂。此外，本发明涉及水解α-淀粉酶/胰蛋白酶抑制剂的方法，包括将包含α-淀粉酶/胰蛋白酶抑制剂的食物组合物与黑曲霉曲霉菌肽酶一起孵育，其中所述抑制剂被水解。它还涉及包含黑曲霉曲霉菌肽酶和另外的酶的酶组合物，以及包含黑曲霉曲霉菌肽酶的食品。

43. 发明授权

US09101623B2 Treatment of synucleinopathies 有权
标题翻译：治疗突触核蛋白病
公开(公告)号：US09101623B2
公开(公告)日：2015-08-11
申请号：US13782160
申请日：2013-03-01
申请人： The Brigham and Women's Hospital, Inc.
发明人： Michael Schlossmacher , Valerie Cullen , Lamya Shihabuddin , Seng H. Cheng
IPC分类号： A61K38/47 , A61K38/48 , A61K38/17 , A61K31/436 , A61K45/06 , A61K31/00 , A61K31/047 , A61K31/4353 , A61K38/13 , A61K48/00
CPC分类号： A61K38/4873 , A61K31/00 , A61K31/047 , A61K31/4353 , A61K31/436 , A61K31/7088 , A61K38/13 , A61K38/1709 , A61K38/47 , A61K38/488 , A61K45/06 , A61K48/005 , A61K2300/00 , C12Y302/01045 , C12Y304/22041 , C12Y304/23005
摘要： This invention relates generally to treating synucleinopathies in subjects that are not clinically diagnosed with a lysosomal storage disease, as well as associated methods of making medicaments and screening methods.
摘要翻译：本发明一般涉及治疗未临床诊断患有溶酶体贮积病的受试者的突触核蛋白病，以及制备药物和筛选方法的相关方法。

44. 发明申请

US20140140980A1 TREATMENT OF GLUTEN INTOLERANCE AND RELATED CONDITIONS 有权
标题翻译：治疗葡萄糖不耐症及相关情况
公开(公告)号：US20140140980A1
公开(公告)日：2014-05-22
申请号：US13912077
申请日：2013-06-06
申请人： David Schriemer
发明人： David Schriemer
IPC分类号： A61K38/48 , A23L1/30
CPC分类号： C12N9/63 , A23L29/06 , A23L33/10 , A23L33/105 , A23V2002/00 , A61K38/00 , A61K38/488 , C12Y304/23012 , A23V2200/304 , A23V2250/5486
摘要： Provided herein are compositions, foods comprising nepenthesin or a derivative thereof and methods of using nepenthesin or a derivative thereof for modulating gluten intolerance and related conditions, such as celiac disease.
摘要翻译：本文提供了组合物，包含楝素或其衍生物的食品和使用楝素或其衍生物调节麸质不耐症和相关病症如乳糜泻的方法。

45. 发明申请

US20130085461A1 Method for Pre-Debriding Treatment of Non-Viable Skin Tissue and Compositions and System Thereof 审中-公开
标题翻译：预先治疗非活动性皮肤组织及其组合物及其系统的方法
公开(公告)号：US20130085461A1
公开(公告)日：2013-04-04
申请号：US13645150
申请日：2012-10-04
申请人： BIOMEDICAL CONCEPTS LLC , DERMAL THERAPY (BARBADOS) INC.
发明人： Donald H. LEAMAN , Alan Lorne PERLMUTTER
IPC分类号： B65D25/04 , A61K31/7004 , A61K38/46 , A61M37/00 , A61P17/00 , A61P31/04 , A61P29/00 , A61K31/17 , A61P17/02
CPC分类号： A61K31/17 , A61F7/034 , A61K31/167 , A61K31/192 , A61K31/194 , A61K31/7004 , A61K38/48 , A61K38/488 , A61K45/06 , A61M35/00 , A61K2300/00
摘要： A pre-debriding composition comprises a chaotropic agent, preferably urea, and, preferably, exfoliating and analgesic agents. The pre-debriding composition reduces the collagen denaturation temperature, Tm, at the site of a wound. Use of the composition along with a supply of heat increases the effectiveness of a subsequent enzymatic debriding treatment. A dressing and heating system is also provided for use with the pre-debriding composition. An “instant activated” debriding composition and package is provided comprising a gel composition and a powdered debriding zymogen composition, wherein mixing of the two compositions results in an activated enzymatic debriding composition. 22290368.1
摘要翻译：预清除组合物包含离液剂，优选尿素，优选去角质和止痛剂。预清除组合物降低伤口部位的胶原变性温度Tm。使用组合物与热量供应增加随后的酶清除治疗的有效性。还提供了与预清洁组合物一起使用的敷料和加热系统。提供即时活化的清创组合物和包装，其包含凝胶组合物和粉末化的清创酶原组合物，其中两种组合物的混合产生活化的酶清除组合物。 22290368.1

46. 发明授权

US08333961B2 Natural liniment for treatment of skin cancers 失效
标题翻译：天然搽剂治疗皮肤癌
公开(公告)号：US08333961B2
公开(公告)日：2012-12-18
申请号：US11773034
申请日：2007-07-03
申请人： James R. Privitera
发明人： James R. Privitera
IPC分类号： A61K38/54 , A61K38/43 , A61K38/00 , A61K31/00 , A61P35/00
CPC分类号： A61K35/413 , A61K31/07 , A61K31/205 , A61K33/30 , A61K36/48 , A61K38/465 , A61K38/47 , A61K38/4873 , A61K38/488 , A61K2300/00
摘要： A liniment composition for reversing or retarding the growth of cancerous skin tumors comprising primarily, pancreatin, pepsin, betaine HCL, emulsified vitamin A, and zinc, pancrelipase, fenugreek, papain, amylase and ox bile extract, with optional trace amounts of other ingredients.
摘要翻译：用于逆转或延缓癌性皮肤肿瘤生长的搽剂组合物，其主要包括胰酶，胃蛋白酶，甜菜碱HCL，乳化维生素A和锌，胰脂酶，葫芦巴，木瓜蛋白酶，淀粉酶和牛胆汁提取物，以及任选的微量其它成分。

47. 发明申请

US20120264190A1 Decellularized and Delipidized Extracellular Matrix and Methods of Use 审中-公开
标题翻译：脱细胞和脱脂细胞外基质和使用方法
公开(公告)号：US20120264190A1
公开(公告)日：2012-10-18
申请号：US13489567
申请日：2012-06-06
申请人： Karen L. Christman , D. Adam Young
发明人： Karen L. Christman , D. Adam Young
IPC分类号： C12N5/07 , C12N9/50
CPC分类号： A61K31/00 , A61K9/0019 , A61K9/06 , A61K31/715 , A61K35/35 , A61K38/39 , A61K38/488 , A61K45/06 , A61K2300/00
摘要： Compositions comprising decellularized and delipidized extracellular matrix derived from adipose or loose connective tissue, and therapeutic uses thereof. Methods for treating, repairing or regenerating defective, diseased, or damaged adipose or loose connective tissues or organs in a subject, preferably a human, and/or for tissue engineering, filing soft tissue defects, and cosmetic and reconstructive surgery, using a decellularized and delipidized adipose or loose connective tissue extracellular matrix of the invention are provided. Methods of preparing tissue culture surfaces and culturing cells with adsorbed decellularized and delipidized adipose or loose connective tissue extracellular matrix are also provided.
摘要翻译：包含衍生自脂肪或松散结缔组织的脱细胞和去脂肪细胞外基质的组合物及其治疗用途。用于治疗，修复或再生受试者，优选人类和/或用于组织工程，软组织缺陷，化妆和重建手术中的有缺陷，患病或受损的脂肪或松散结缔组织或器官的方法，使用脱细胞和提供本发明的脱脂脂肪或松散结缔组织细胞外基质。还提供了用吸附的脱细胞和去脂肪的脂肪或松散结缔组织细胞外基质制备组织培养物表面和培养细胞的方法。

48. 发明申请

US20120020947A1 COMPOSITIONS AND METHODS FOR INCREASING LEAN MUSCLE MASS AFTER EXERCISE 审中-公开
标题翻译：运动后增加肌肉质量的组合物和方法
公开(公告)号：US20120020947A1
公开(公告)日：2012-01-26
申请号：US13099421
申请日：2011-05-03
申请人： Shawn Shirazi , Phil Apong , James Akrong
发明人： Shawn Shirazi , Phil Apong , James Akrong
IPC分类号： A61K38/48 , A61P21/06
CPC分类号： A61K38/1709 , A61K36/00 , A61K38/47 , A61K38/4826 , A61K38/4873 , A61K38/488 , C12Y304/22002 , A61K2300/00
摘要： The present invention relates to novel methods and compositions comprising casein, creatine or derivatives of creatine, branched chain amino acids and proteases useful for increasing lean muscle mass after exercise.
摘要翻译：本发明涉及包含酪蛋白，肌酸或肌酸衍生物，支链氨基酸和蛋白酶的新方法和组合物，其用于增加运动后的瘦肌肉质量。

49. 发明申请

US20090285776A1 IRREVERSIBLY-INACTIVATED PEPSINOGEN FRAGMENTS FOR MODULATING IMMUNE FUNCTION 有权
标题翻译：用于调节免疫功能的不可逆灭活的PEPSINOGEN片段
公开(公告)号：US20090285776A1
公开(公告)日：2009-11-19
申请号：US12487637
申请日：2009-06-18
申请人： Harry H. Zhabilov
发明人： Harry H. Zhabilov
IPC分类号： A61K38/20 , A61K39/00 , A61K38/10
CPC分类号： A61K38/488 , A61K38/2013 , A61K39/39 , A61K2300/00
摘要： Isolated anti-cancer peptides are disclosed which are characterized by the amino acid sequences TLTSGGGAIALPPSMAAPPLGPVAPLTGAIHAPTXG; TLSTATGGAIPPVAAMPPGLVAPTHGPAIHP; CCATSGPCGAVMILTPHLTA; MTLTTGSGAIAPAMPPGLPPHTGAIHAPM; and NXVPVSVEGYXQITLDSITX and a significant in vitro binding affinity for gp96. The peptides exhibit anti-tumor, anti-cancer activity in vivo. Also disclosed is an isolated antiviral peptide is characterized by the amino acid sequence GDEPLENYLDTEYF and a significant in vitro binding affinity for HIV-1 gp 120 and gp 41, and human CD4 cells. The peptide exhibits anti-retroviral activity in vivo, particularly anti-HIV-1 activity.
摘要翻译：公开了分离的抗癌肽，其特征在于氨基酸序列TLTSGGGAIALPPSMAAPPLGPVAPLTGAIHAPTXG; TLSTATGGAIPPVAAMPPGLVAPTHGPAIHP; CCATSGPCGAVMILTPHLTA; MTLTTGSGAIAPAMPPGLPPHTGAIHAPM; 和NXVPVSVEGYXQITLDSITX和对gp96的显着体外结合亲和力。肽在体内表现出抗肿瘤，抗癌活性。还公开了分离的抗病毒肽的特征在于氨基酸序列GDEPLENYLDTEYF和对HIV-1gp120和gp41以及人CD4细胞的显着体外结合亲和力。肽在体内表现出抗逆转录病毒活性，特别是抗HIV-1活性。

50. 发明申请

US20090010913A1 NATURAL LINIMENT FOR TREATMENT OF SKIN CANCERS 失效
标题翻译：用于治疗皮肤癌的天然植物
公开(公告)号：US20090010913A1
公开(公告)日：2009-01-08
申请号：US11773034
申请日：2007-07-03
申请人： James R. Privitera
发明人： James R. Privitera
IPC分类号： A61K38/54 , A61P35/00
CPC分类号： A61K35/413 , A61K31/07 , A61K31/205 , A61K33/30 , A61K36/48 , A61K38/465 , A61K38/47 , A61K38/4873 , A61K38/488 , A61K2300/00
摘要： A liniment composition for reversing or retarding the growth of cancerous skin tumors comprising primarily, pancreatin, pepsin, betaine HCL, emulsified vitamin A, and zinc, pancrelipase, fenugreek, papain, amylase and ox bile extract, with optional trace amounts of other ingredients.
摘要翻译：用于逆转或延缓癌性皮肤肿瘤生长的搽剂组合物，其主要包括胰酶，胃蛋白酶，甜菜碱HCL，乳化维生素A和锌，胰脂酶，葫芦巴，木瓜蛋白酶，淀粉酶和牛胆汁提取物，以及任选的微量其它成分。

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