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41. 发明申请

WO1995034078A1 TRANSFERRING ARTICLES BETWEEN CONTROLLED ENVIRONMENTS 审中-公开
标题翻译：在控制环境之间传送文章
公开(公告)号：WO1995034078A1
公开(公告)日：1995-12-14
申请号：PCT/EP1995002057
申请日：1995-05-30
申请人： SMITHKLINE BEECHAM BIOLOGICALS S.A. , THILLY, Jacques , LEGRAND, Jean-Pierre
发明人： SMITHKLINE BEECHAM BIOLOGICALS S.A.
IPC分类号： G21F07/005
CPC分类号： B01L1/02 , G21F7/005 , G21Y2002/205 , G21Y2002/30 , G21Y2004/30 , G21Y2004/401
摘要： A wagon (5) with a hingeless door (6) is secured to a wall (1) of a controlled atmosphere room so that the wagon door (6) is opposed to a door (3) in the wall. An expandable seal (17) in the frame (2) of the wall door (3) is inflated to form a seal between the wagon (5) and the wall (1) to isolate the opposed doors (3, 6) from the external atmosphere. The wagon door (8) is latched to the wall door (3), and an expandable seal (32) around the periphery of the wall door (3) is inflated to contact the wagon door (6) to isolate the air trapped between the doors (3, 6). By releasing an expandable seal (16) between the wall door (3) and its frame (2), the wall door (3) may be opened into the room, at the same time removing the hingeless door (6) from the container (5) and allowing articles to be transferred from the room to the container, and vice versa. The system is especially suitable for transporting sterile pharmaceutical products between sterile areas of a manufacturing plant.
摘要翻译：具有无铰接门（6）的货车（5）固定在受控气氛室的墙壁（1）上，使得货车门（6）与墙壁上的门（3）相对。在壁门（3）的框架（2）中的可膨胀密封件（17）被充气以在货车（5）和墙壁（1）之间形成密封，以将相对的门（3,6）与外部门大气层。货车门（8）被锁定到墙门（3），并且围绕壁门（3）的周边的可膨胀密封件（32）被充气以接触货车门（6），以将被捕获的空气门（3,6）。通过在壁门（3）和其框架（2）之间释放可膨胀的密封件（16），壁门（3）可以打开进入房间，同时从容器（6）上拆下无铰链门（6） 5）并允许物品从房间转移到容器，反之亦然。该系统特别适用于在制造工厂的无菌区域之间运输无菌药品。

42. 发明申请

WO1995031555A1 FUSION GLYCOPROTEIN FROM HCMV AND HSV 审中-公开
标题翻译：来自HCMV和HSV的融合糖蛋白
公开(公告)号：WO1995031555A1
公开(公告)日：1995-11-23
申请号：PCT/EP1995001800
申请日：1995-05-11
申请人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.) , GHEYSEN, Dirk, Richard
发明人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.)
IPC分类号： C12N15/62
CPC分类号： A61K39/245 , A61K38/00 , A61K39/00 , A61K39/12 , A61K2039/525 , C07K14/005 , C07K2319/00 , C12N2710/16122 , C12N2710/16134 , C12N2710/16622 , C12N2710/16634
摘要： A fusion protein comprising a portion of a glycoprotein of HCMV fused to a portion of a glycoprotein of HSV is described.
摘要翻译：描述了融合蛋白，其包含与HSV的糖蛋白部分融合的HCMV的一部分糖蛋白。

43. 发明申请

WO1995021928A1 PROCESS FOR THE PRODUCTION OF A HETEROLOGOUS PROTEIN FROM A METHYLOTROPHIC YEAST 审中-公开
标题翻译：从甲基化学生产异质蛋白的方法
公开(公告)号：WO1995021928A1
公开(公告)日：1995-08-17
申请号：PCT/EP1995000320
申请日：1995-01-30
申请人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.) , COMBERBACH, Martin
发明人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.)
IPC分类号： C12N15/81
CPC分类号： C07K14/005 , A61K39/00 , C07K14/195 , C07K14/235 , C12N15/815 , C12N2730/10122
摘要： A process for enhancing expression of a heterologous protein comprising culturing a methylotrophic yeast organism transformed with a vector containing DNA encoding the heterologous protein in a fermenter, characterised in that rate of MeOH addition is controlled during the induction phase of the cultivation, preferably using an automated feedback control loop system. Preferably, the concentration of MeOH in the fermenter broth, or the specific MeOH addition rate are maintained at substantially-constant levels during the induction phase.
摘要翻译：一种用于增强异源蛋白质表达的方法，包括培养在发酵罐中用含有编码异源蛋白质的DNA的载体转化的甲基营养酵母生物，其特征在于在培养的诱导阶段期间控制MeOH加入速率，优选使用自动化反馈控制回路系统。优选地，发酵罐肉汤中的MeOH浓度或特定的MeOH添加速率在诱导阶段保持在基本恒定的水平。

44. 发明申请

WO1995017210A1 VACCINES 审中-公开
标题翻译：疫苗
公开(公告)号：WO1995017210A1
公开(公告)日：1995-06-29
申请号：PCT/EP1994004246
申请日：1994-12-20
申请人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.) , MOMIN, Patricia, Marie , GARCON, Nathalie, Marie-Josephe
发明人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.)
IPC分类号： A61K39/39
CPC分类号： A61K39/39 , A61K2039/55505 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , Y02A50/412
摘要： The present invention provides vaccine compositions comprising an oil-in-water emulsion optionally with 3 De-O-acylated monophosphoryl lipid A and QS21. The vaccines compositions are potent inducers of a range of immune responses.
摘要翻译：本发明提供疫苗组合物，其包含任选含有3个De-O-酰化单磷酰脂质A和QS21的水包油乳剂。疫苗组合物是一系列免疫应答的有效诱导剂。

45. 发明申请

WO1995016704A1 HEPATITIS B VIRUS PEPTIDES 审中-公开
标题翻译：乙型肝炎病毒肽
公开(公告)号：WO1995016704A1
公开(公告)日：1995-06-22
申请号：PCT/EP1994004137
申请日：1994-12-13
申请人： SMITHKLINE BEECHAM BIOLOGICALS S.A. , LEROUX-ROELS, Geert , SLAOUI, Mohamed, Moncef , HAUSER, Pierre
发明人： SMITHKLINE BEECHAM BIOLOGICALS S.A.
IPC分类号： C07K14/02
CPC分类号： C07K14/005 , A61K38/00 , C12N2730/10122
摘要： A synthetic peptide (or close analogue thereof) which is part of the natural sequence of hepatitis B surface antigen is chosen from the following (AA indicates amino acid number): AA 211-222, AA 316-333, AA 361-378. Also provided are derivatives of the above in which the peptide is conjugated to a hepatitis B virus T-cell epitope of forms part of a fusion protein or is conjugated to an non-immunogenic oligo- or polysaccharide or lipid. Vaccines comprising the above peptides or conjugates are also provided, together with a method of immunising or treating individuals suffering from viral disease.
摘要翻译：作为乙型肝炎表面抗原的天然序列的一部分的合成肽（或其近似类似物）选自以下（AA表示氨基酸数）：AA 211-222，AA 316-333，AA 361-378。还提供了上述的衍生物，其中肽与形成融合蛋白的一部分的乙型肝炎病毒T细胞表位缀合，或与非免疫原性寡糖或多糖或脂质缀合。还提供了包含上述肽或缀合物的疫苗，以及免疫或治疗患有病毒性疾病的个体的方法。

46. 发明申请

WO1994025594A2 CLONING, EXPRESSION AND VACCINE COMPOSITION CORRESPONDING TO A PEPTIDE ANTIGEN OF TOXOPLASMA GONDII 审中-公开
标题翻译：克隆，表达和疫苗组合物对应于牙龈卟啉的肽抗原
公开(公告)号：WO1994025594A2
公开(公告)日：1994-11-10
申请号：PCT/EP1994001298
申请日：1994-04-26
申请人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.) , BIEMANS, Ralph , BOLLEN, Alex , JACOBS, Paul
发明人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.)
IPC分类号： C12N15/30
CPC分类号： C07K14/005 , A61K39/00 , C07K14/45 , C07K2319/02 , C07K2319/40 , C12N2730/10122
摘要： The invention provides a polypeptide corresponding to residues 197 - 216 of the 54 KDa antigen of T. gondii, having the amino acid sequence TDPGDVVIEELFNRIPETSV. Also within the scope of the invention is a method of producing the 54 KD antigen of T. gondii or the polypeptide corresponding to residues 197 - 216 thereof by expression from a host cell, for example from a host cell comprising a vaccinia virus or from a CHO cell.
摘要翻译：本发明提供了对应于弓形虫的54KDa抗原的残基197-216的多肽，其具有氨基酸序列TDPGDVVIEELFNRIPETSV。也在本发明的范围内的是通过从宿主细胞，例如来自包含痘苗病毒的宿主细胞或从痘苗病毒的宿主细胞表达来产生弓形虫的54 KD抗原或对应于其残基197-216的多肽的方法 CHO细胞。

47. 发明申请

WO1994021292A1 VACCINE COMPOSITIONS CONTAINING 3-O DEACYLATED MONOPHOSPHORYL LIPID A 审中-公开
标题翻译：含有3-O脱乙烯单脂肪酸脂肪酸的疫苗组合物
公开(公告)号：WO1994021292A1
公开(公告)日：1994-09-29
申请号：PCT/EP1994000818
申请日：1994-03-14
申请人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.) , HAUSER, Pierre , VOET, Pierre , SLAOUI, Moncef , GARCON-JOHNSON, Nathalie, Marie-Josephe, Claude , DESMONS, Pierre
发明人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.)
IPC分类号： A61K39/39
CPC分类号： A61K31/7024 , A61K31/715 , A61K39/39 , A61K2039/55505 , A61K2039/55555 , A61K2039/55566 , A61K2039/55572 , Y02A50/401 , Y02A50/466 , A61K2300/00 , A61K31/70
摘要： Novel vaccine compositions comprising small particles of 3-O-deacylated monophosphoryl lipid A are provided. In particular the particle size is below 120 nm. Such vaccine compositions have superior immunological properties.
摘要翻译：提供了包含3-O-脱酰基单磷酰脂质A的小颗粒的新型疫苗组合物。特别地，粒度小于120nm。这样的疫苗组合物具有优异的免疫学特性。

48. 发明申请

WO1993019780A1 HEPATITIS VACCINES CONTAINING 3-O-DEACYLATED MONOPHOSHORYL LIPID A 审中-公开
标题翻译：含有3-O-脱乙基单一脂肪酸的乙型肝炎疫苗
公开(公告)号：WO1993019780A1
公开(公告)日：1993-10-14
申请号：PCT/EP1993000712
申请日：1993-03-24
申请人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.) , GARCON-JOHNSON, Nathalie, Marie-Josephe, Claude , HAUSER, Pierre , THIRIART, Clothilde , VOET, Pierre
发明人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.)
IPC分类号： A61K39/29
CPC分类号： A61K39/39 , A61K39/12 , A61K39/29 , A61K39/292 , A61K2039/5252 , A61K2039/55505 , A61K2039/55572 , A61K2039/70 , C12N2730/10134 , C12N2770/32434 , Y02A50/464 , Y02A50/466
摘要： A vaccine formulation for the treatment or prophylaxis of hepatitis, especially hepatitis B, infections is provided comprising the hepatitis antigen and a suitable carrier such as alum in combination with 3-O-deacylated monophosphoryl lipid A. Combination vaccines including the vaccine formulation are also described.
摘要翻译：提供了用于治疗或预防肝炎，特别是乙型肝炎感染的疫苗制剂，其包含肝炎抗原和合适的载体如明矾与3-O-脱酰基单磷酰脂质A的组合。还描述了包括疫苗制剂的组合疫苗。

49. 发明申请

WO1993015749A1 VACCINES PRODUCED FROM HERPES SIMPLEX VIRUS LIGHT PARTICLES 审中-公开
标题翻译：从疱疹病毒轻微颗粒生产的疫苗
公开(公告)号：WO1993015749A1
公开(公告)日：1993-08-19
申请号：PCT/EP1993000300
申请日：1993-02-09
申请人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.) , FRANCOTTE, Myriam , SLAOUI, Moncef , GARCON-JOHNSON, Nathalie, Marie-Josephe, Claude , PRIEELS, Jean-Paul
发明人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.)
IPC分类号： A61K35/76
CPC分类号： A61K39/245 , A61K39/12 , A61K2039/5252 , A61K2039/541 , A61K2039/55505 , A61K2039/55555 , A61K2039/55566 , A61K2039/55572 , C12N2710/16634
摘要： Therapeutic potential of Herpes Simplex Light particles are disclosed. In addition novel formulations of such Light particles are also disclosed which provide enhanced efficacy in both prophylactic and therapeutic experiments.
摘要翻译：公开了单纯疱疹小粒子的治疗潜力。此外，还公开了这样的轻微颗粒的新型制剂，其在预防和治疗实验中提供增强的功效。

50. 发明申请

WO1992006113A2 DERIVATIVES OF gp160 AND VACCINES BASED ON gp160 OR A DERIVATIVE THEREOF, CONTAINING AN ADJUVANT 审中-公开
标题翻译：基于gp160的gp160和疫苗的衍生物或其衍生物，含有ADJUVANT
公开(公告)号：WO1992006113A2
公开(公告)日：1992-04-16
申请号：PCT/EP1991001810
申请日：1991-09-21
申请人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.) , VAN WIJNENDALE, Frans , SLAOUI, Moncef , BRUCK, Claudine , FRANCOTTE, Myriam , KUMMERT, Suzy
发明人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.)
IPC分类号： C07K13/00
CPC分类号： C07K14/005 , A61K39/00 , C12N2740/16122
摘要： This invention provides novel, substantially uncleavable forms of gp160, and vaccine formulations containing gp160 or a derivative thereof, adjuvanted with 3-D Mpl. The compositions are useful for the immunotherapeutic and immunoprophylactic treatment of HIV infections.
摘要翻译：本发明提供新颖的基本上不可裂解的gp160形式，以及含有gp160或其衍生物的疫苗制剂，其与3-D Mpl佐剂化。该组合物可用于HIV感染的免疫治疗和免疫预防治疗。

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