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41. 发明申请

WO0220748A8 HOST CELLS FOR PACKING A RECOMBINANT ADENO-ASSOCIATED VIRUS (RAAV), METHOD FOR THE PRODUCTION AND USE THEREOF 审中-公开
标题翻译：宿主细胞的重组腺相关病毒（腺相关病毒）方法的包装用于生产和它们的用途
公开(公告)号：WO0220748A8
公开(公告)日：2004-03-04
申请号：PCT/EP0110370
申请日：2001-09-07
申请人： MEDIGENE AG , BERTRAN JOAN , MOEBIUS ULRICH , HOERER MARKUS , REHBERGER BERND
发明人： BERTRAN JOAN , MOEBIUS ULRICH , HOERER MARKUS , REHBERGER BERND
IPC分类号： C12N15/09 , A61K48/00 , C07K14/015 , C12N5/10 , C12N15/864 , C12N15/86
CPC分类号： C12N7/00 , A61K48/00 , C07K14/005 , C12N15/86 , C12N2750/14122 , C12N2750/14143 , C12N2750/14152
摘要： The invention relates to host cells for packing a recombinant adeno-associated virus (rAAV). Said cells contain at least one copy of a first auxiliary construct for expressing at least one AAV Rep protein, and at least one copy of another auxiliary construct for expressing at least one AAV Cap protein. The invention also relates to auxiliary constructs for expressing at least one AAV Rep protein and one AAV Cap protein in a host cell; vector constructs comprising at least one nucleic acid which is heterologous in relation to the AAV; a method for producing a host cell for packing a recombinant adeno-associated virus (rAAV); and the use of the host cell for producing an rAAV.
摘要翻译：本发明涉及一种宿主细胞用于包装含有至少一个第一辅助的副本构建表达至少一种AAV Rep蛋白和另一种辅助的至少一个拷贝的构建用于表达至少一种AAV Cap蛋白的重组腺相关病毒（腺相关病毒）。此外，本发明辅助构建用于至少一个AAV Rep蛋白的表达和AAV Cap蛋白涉及在宿主细胞中，载体构建体，其包含一种或多种异源的AAV核酸和使宿主细胞用于包装重组腺相关病毒的方法（腺相关病毒）并利用宿主细胞生产腺相关病毒的。

42. 发明申请

WO03039444B1 TOPICAL USE OF CYTOKINES AND/OR CHEMOKINES FOR THE TREATMENT OF VIRAL OR MYKOTIC SKIN DISEASES OR TUMORAL DISEASES 审中-公开
标题翻译：细胞因子和/或趋化因子用于治疗病毒或肌病皮肤病或肿瘤疾病的用途
公开(公告)号：WO03039444B1
公开(公告)日：2003-12-18
申请号：PCT/EP0212438
申请日：2002-11-07
申请人： MEDIGENE AG , NIELAND JOHN , REHFUESS CHRISTOPH
发明人： NIELAND JOHN , REHFUESS CHRISTOPH
IPC分类号： A61K9/06 , A61K9/00 , A61K9/12 , A61K38/00 , A61K38/19 , A61K38/21 , A61K47/00 , A61K47/06 , A61K47/10 , A61K47/20 , A61K47/28 , A61K47/44 , A61P17/00 , A61P31/10 , A61P31/12 , A61P35/00
CPC分类号： A61K9/0014 , A61K38/063 , A61K38/193 , A61K38/385 , A61K47/06 , A61K47/10 , A61K47/20 , A61K47/28 , A61K2300/00
摘要： The invention relates to the use of at least one cytokine and/or chemokine in the production of a topically acting medicament for treating viral and/or mykotic skin diseases and/or tumoral diseases.
摘要翻译：本发明的一个目的是至少一种细胞因子和/或趋化因子在制备用于治疗病毒和/或真菌性皮肤病和/或肿瘤疾病的局部作用药物中的用途。

43. 发明申请

WO03037323A2 INHIBITORS OF THE FATTY ACID OXIDATION FOR PROPHYLAXIS AND TREATMENT OF DISEASES RELATED TO MITOCHONDRIAL DYSFUNCTION 审中-公开
标题翻译：抑制脂肪酸氧化预防和治疗与线粒体功能障碍有关的疾病
公开(公告)号：WO03037323A2
公开(公告)日：2003-05-08
申请号：PCT/EP0211913
申请日：2002-10-24
申请人： MEDIGENE AG GES FUER MOLEKULAR , HENKEL THOMAS , REHFUESS CHRISTOPH
发明人： HENKEL THOMAS , REHFUESS CHRISTOPH
IPC分类号： A61K31/336 , A61K31/4025 , A61K31/435 , A61K31/443 , A61K31/495 , A61K31/197
CPC分类号： A61K31/336 , A61K31/4025 , A61K31/435 , A61K31/443 , A61K31/495
摘要： Described are a method and a composition for preventing and/or treating a disease related to mitochondrial dysfunction by inhibiting the fatty acid oxidation of one or more cells of an organism. Particularly, the fatty acid oxidation is inhibited by inhibiting the expression and/or activity of the enzyme Carnitin-Palmitoyl-Transferase-1 (CPT-1) by means of an arylalkyl- or arlyoxyalkyl-substitued oxirane carboxylic acid or pharmaceutically acceptable salts and derivatives of the arylalkyl-substitued oxirane carboxylic acid.
摘要翻译：描述了通过抑制生物体的一种或多种细胞的脂肪酸氧化来预防和/或治疗与线粒体功能障碍有关的疾病的方法和组合物。特别地，脂肪酸氧化通过借助于芳烷基 - 或芳氧基烷基取代的环氧乙烷羧酸或其药学上可接受的盐和衍生物抑制肉毒碱 - 棕榈酰转移酶-1（CPT-1）的表达和/或活性而被抑制的芳基烷基取代的环氧乙烷羧酸。

44. 发明申请

WO2003025205A3 EXTRACELLULAR REGULATED KINASE 2 (ERK2) 审中-公开
公开(公告)号：WO2003025205A3
公开(公告)日：2003-03-27
申请号：PCT/EP2002/010489
申请日：2002-09-18
申请人： MEDIGENE AG , NAVÉ, Barbara , RÖNICKE, Volker , LECLAIR, Stéphane , FUNK, Martin , REUNER, Birgit , BRINKMANN, Kay , HENKEL, Thomas
发明人： NAVÉ, Barbara , RÖNICKE, Volker , LECLAIR, Stéphane , FUNK, Martin , REUNER, Birgit , BRINKMANN, Kay , HENKEL, Thomas
IPC分类号： G01N33/50
摘要： The present invention relates to a method of identifying and/or obtaining a compound or a plurality of compounds useful in the prevention or treatment of cardiac diseases which comprises the quantification of the activity of Raf-1, MEK1/2 and/or Erk1/2 depending on said compound. Preferably said compound is an inhibitor or antagonist of the signal cascade which is recruited into the sarcomere and leads to activation of Raf-1, MEK1/2 and/or Erk1/2, since said activation results in translocation of Erk2 into sarcomeres and induction of sarcomeric remodeling. Furthermore, the present invention relates to pharmaceutical compositions for prevention or treatment of hypertrophy, in particular congestive heart failure (CHF) comprising the identified and/or obtained compound or a plurality of compounds as an active ingredient.

45. 发明申请

WO0192567A3 NOVEL TARGET GENES FOR DISEASES OF THE HEART 审中-公开
标题翻译：心脏疾病的新目标基因
公开(公告)号：WO0192567A3
公开(公告)日：2003-02-13
申请号：PCT/EP0106165
申请日：2001-05-30
申请人： MEDIGENE AG , BUNK DANIELA , REUNER BIRGIT , BECK JOACHIM , HENKEL THOMAS
发明人： BUNK DANIELA , REUNER BIRGIT , BECK JOACHIM , HENKEL THOMAS
IPC分类号： A01K67/027 , A61K38/00 , A61K45/00 , A61K48/00 , A61P9/00 , A61P9/02 , A61P9/04 , A61P9/10 , A61P9/12 , C07K14/47 , C12N15/09 , C12N15/85 , C12Q1/50 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , A61K49/00 , C07K16/18
CPC分类号： C12N15/8509 , A01K2217/05 , A01K2217/075 , A01K2267/03 , A01K2267/0375 , C07K14/47 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates to a variety of genes abnormally expressed in heart tissue as well as to fragments of such genes. Assessment of the expression level of these genes may be used for testing the predisposition of mammals and preferably humans for a heart disease or for an acute state of such a disease. Preferred diseases in accordance with the invention are congestive heart failure, dilative cardiomyopathy, hypertrophic cardiomyopathy and ischemic cardiomyopathy. The present invention further relates to methods of identifying compounds capable of normalizing the expression level of the aforementioned genes and of further genes affected by the abnormal expression. The identified compounds may be used for formulating compositions, preferably pharmaceutical compositions for preventing or treating diseases. They may also be used as lead compounds for the development of medicaments having an improved efficiency, a longer half-life, a decreased toxicity etc. and to be employed in the treatment of heart diseases. Included in the invention are also somatic gene therapy methods comprising the introduction of at least one functional copy of any of the above-mentioned genes into a suitable cell. Finally, the invention relates to non-human transgenic animals comprising at least one of the aforementioned genes in their germ line. The transgenic animals of the invention may be used for the development of medicaments for the treatment of heart diseases.
摘要翻译：本发明涉及在心脏组织中异常表达的各种基因以及这些基因的片段。这些基因的表达水平的评估可以用于测试哺乳动物和优选人心脏病或这种疾病的急性状态的倾向。根据本发明的优选疾病是充血性心力衰竭，扩张性心肌病，肥厚性心肌病和缺血性心肌病。本发明还涉及鉴定能够使上述基因的表达水平正常化的化合物和受异常表达影响的其它基因的方法。鉴定的化合物可用于配制组合物，优选用于预防或治疗疾病的药物组合物。它们也可以用作开发具有改善的效率，更长的半衰期，降低的毒性等等并且用于治疗心脏病的药物的铅化合物。本发明还包括体细胞基因治疗方法，其包括将任何上述基因的至少一个功能拷贝引入合适的细胞中。最后，本发明涉及在其种系中包含至少一个上述基因的非人转基因动物。本发明的转基因动物可用于开发用于治疗心脏病的药物。

46. 发明申请

WO1997045538A1 NOVEL SYNTHETIC PROTEIN STRUCTURAL TEMPLATES FOR THE GENERATION, SCREENING AND EVOLUTION OF FUNCTIONAL MOLECULAR SURFACES 审中-公开
标题翻译：用于生成，筛选和发展功能分子表面的新型合成蛋白质结构模板
公开(公告)号：WO1997045538A1
公开(公告)日：1997-12-04
申请号：PCT/EP1997002840
申请日：1997-05-30
申请人： MEDIGENE AG , STEIPE, Boris , BRUHN, Heike , FUNK, Martin , HENKEL, Thomas
发明人： MEDIGENE AG
IPC分类号： C12N15/10
CPC分类号： C12N15/1044 , A61K38/00 , A61K39/00 , C07K14/47 , C07K2319/00 , C07K2319/42 , C07K2319/61 , C07K2319/80 , C12N15/1037 , C12N15/62 , C40B40/02
摘要： The present invention relates generally to protein molecules with novel binding or catalytic properties. More specifically, the invention relates to the production of libraries of peptide sequences in the framework of a structural template derived from Pleckstrin-Homology (PH) domains and the identification of such sequences that possess the desired properties of binding macromolecular or small molecule ligands, including the transition states of chemical reactions. The invention also relates to the provision of small molecules, derived from the so-obtained peptide sequences that possess ligand binding properties comparable to those of the peptides in the context of the structural framework.
摘要翻译：本发明一般涉及具有新的结合或催化性质的蛋白质分子。更具体地，本发明涉及在衍生自Pleckstrin-Homology（PH）结构域的结构模板的框架中制备肽序列文库，以及鉴定具有所需的结合大分子或小分子配体的性质的序列，包括化学反应的过渡态。本发明还涉及提供源自如此获得的肽序列的小分子，其具有与结构框架背景下的肽相当的配体结合特性。

47. 发明申请

US20140120117A1 TREATMENT OF TUMORS USING SPECIFIC ANTI-L1 ANTIBODY 有权
标题翻译：使用特异抗原抗体治疗肿瘤
公开(公告)号：US20140120117A1
公开(公告)日：2014-05-01
申请号：US14045019
申请日：2013-10-03
申请人： MediGene AG , Deutsches Krebsforschungszentrum stiftung des Oeffentlichen Rechts
发明人： Daniela Kelm , Peter Altevogt , Gerhard Moldenhauer , Frank Breitling , Achim Krueger , Silke Baerreiter , Sandra Luettgau , Ulrich Moebius , Yi Li , Susanne Sebens , Heiner Schaefer
IPC分类号： C07K16/28 , A61K45/06 , A61N5/06 , A61N5/10 , A61N5/02 , A61K39/395 , G01N33/574
CPC分类号： C07K16/2803 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61N5/02 , A61N5/0613 , A61N5/10 , A61N2005/0661 , A61N2005/1087 , A61N2005/1089 , C07K2317/24 , C07K2317/41 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30 , G01N33/57492
摘要： The present invention relates to the anti-L1 monoclonal antibody 9.3 as well as to related antibodies or binding molecules and well as to the uses thereof, especially in tumor treatment.
摘要翻译：本发明涉及抗L1单克隆抗体9.3以及相关抗体或结合分子，以及其用途，特别是在肿瘤治疗中。

48. 发明授权

US08580258B2 Treatment of tumors using specific anti-L1 antibody 有权
标题翻译：使用特异性抗L1抗体治疗肿瘤
公开(公告)号：US08580258B2
公开(公告)日：2013-11-12
申请号：US13367178
申请日：2012-02-06
申请人： Daniela Kelm , Peter Altevogt , Gerhard Moldenhauer , Frank Brietling , Achim Krueger , Silke Wolterink , Sandra Luettgau , Ulrich Moebius , Yi Li , Susanne Sebens , Heiner Schaefer
发明人： Daniela Kelm , Peter Altevogt , Gerhard Moldenhauer , Frank Brietling , Achim Krueger , Silke Wolterink , Sandra Luettgau , Ulrich Moebius , Yi Li , Susanne Sebens , Heiner Schaefer
IPC分类号： A61K39/395 , A61K39/00
CPC分类号： C07K16/2803 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61N5/02 , A61N5/0613 , A61N5/10 , A61N2005/0661 , A61N2005/1087 , A61N2005/1089 , C07K2317/24 , C07K2317/41 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30 , G01N33/57492
摘要： The present invention relates to the anti-L1 monoclonal antibody 9.3 as well as to related antibodies or binding molecules and well as to the uses thereof, especially in tumor treatment.
摘要翻译：本发明涉及抗L1单克隆抗体9.3以及相关抗体或结合分子，以及其用途，特别是在肿瘤治疗中。

49. 发明授权

US08168216B2 Treatment of triple receptor negative breast cancer 有权
标题翻译：三联受体阴性乳腺癌的治疗
公开(公告)号：US08168216B2
公开(公告)日：2012-05-01
申请号：US12293039
申请日：2007-03-16
申请人： Kay-Oliver Kliche , Axel Mescheder , Martine Piccart
发明人： Kay-Oliver Kliche , Axel Mescheder , Martine Piccart
IPC分类号： A61K9/127
CPC分类号： A61K31/337 , A61K9/127 , A61K9/1272 , A61K45/06 , A61K2300/00
摘要： The present invention relates to the use of a liposomal preparation for the manufacture of a pharmaceutical composition and the use of such a composition for the treatment of ‘triple receptor negative’ breast cancer.
摘要翻译：本发明涉及脂质体制剂在制备药物组合物中的用途以及这种组合物用于治疗“三重受体阴性”乳腺癌的用途。

50. 发明申请

US20120087975A1 Method of Producing A Cationic Liposomal Preparation Comprising A Lipophilic Compound 有权
标题翻译：产生包含亲脂性化合物的阳离子脂质体制备方法
公开(公告)号：US20120087975A1
公开(公告)日：2012-04-12
申请号：US13278801
申请日：2011-10-21
申请人： Carsten Mundus , Christian Welz , Oliver Schramel , Heinrich Haas , Thomas Fichert , Brita Schulze , Toralf Peymann , Uwe Michaelis , Michael Teifel , Friedrich Gruber , Gerhard Winter
发明人： Carsten Mundus , Christian Welz , Oliver Schramel , Heinrich Haas , Thomas Fichert , Brita Schulze , Toralf Peymann , Uwe Michaelis , Michael Teifel , Friedrich Gruber , Gerhard Winter
IPC分类号： A61K9/127 , A61K31/337 , A61K31/4375 , A61K31/427 , A61K31/685 , A61K31/56
CPC分类号： A61K31/337 , A61K9/127 , A61K9/1272 , A61K31/335 , A61K31/47 , A61K31/4745 , A61K47/34 , A61K47/543 , A61K47/56 , A61K47/6911 , A61K49/1812 , B82Y5/00 , C07D471/14
摘要： A method for producing a cationic liposomal preparation comprising a lipophilic active compound with physical and chemical stability during manufacturing, storing and reconstituting, and further a cationic liposomal preparation obtainable by this method as well as specific cationic liposomal preparations as well as pharmaceutical compositions are disclosed.
摘要翻译：公开了一种阳离子脂质体制剂的制备方法，其包括在制造，储存和重构过程中具有物理和化学稳定性的亲脂性活性化合物，以及可通过该方法获得的阳离子脂质体制剂以及特定的阳离子脂质体制剂以及药物组合物。

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