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41. 发明授权

US07354903B2 Cosmetic compositions containing short bioactive peptides 有权
标题翻译：含有短生物活性肽的化妆品组合物
公开(公告)号：US07354903B2
公开(公告)日：2008-04-08
申请号：US10839525
申请日：2004-05-05
申请人： Donald R Owen
发明人： Donald R Owen
IPC分类号： A61K38/00
CPC分类号： C07K14/4723 , A61K38/00 , C07K14/001 , C07K14/43563 , Y02A50/411 , Y02A50/414
摘要： Short bioactive peptides containing phenylalanine, leucine, alanine, and lysine residues are disclosed. The peptides can be used in antibacterial, antifungal, anticancer, and other biological applications.
摘要翻译：公开了含有苯丙氨酸，亮氨酸，丙氨酸和赖氨酸残基的短生物活性肽。肽可用于抗菌，抗真菌，抗癌和其他生物应用。

42. 发明授权

US06875744B2 Short bioactive peptides 有权
标题翻译：短生物活性肽
公开(公告)号：US06875744B2
公开(公告)日：2005-04-05
申请号：US09820053
申请日：2001-03-28
申请人： Donald R. Owen
发明人： Donald R. Owen
IPC分类号： A61K38/00 , C07K14/00 , C07K14/435 , C07K14/47
CPC分类号： C07K14/4723 , A61K38/00 , C07K14/001 , C07K14/43563 , Y02A50/411 , Y02A50/414
摘要： Short bioactive peptides containing phenylalanine, leucine, alanine, and lysine residues are disclosed. The peptides can be used in antibacterial, antifungal, anticancer, and other biological applications.
摘要翻译：公开了含有苯丙氨酸，亮氨酸，丙氨酸和赖氨酸残基的短生物活性肽。肽可用于抗菌，抗真菌，抗癌和其他生物应用。

43. 发明申请

US20020025918A1 Methods of using helical peptides in plants 审中-公开
标题翻译：在植物中使用螺旋肽的方法
公开(公告)号：US20020025918A1
公开(公告)日：2002-02-28
申请号：US09898576
申请日：2001-07-03
申请人： Helix BioMedix, Inc.
发明人： Jesse M. Jaynes
IPC分类号： A01N037/18 , A61K038/00 , C12P021/06 , C12N001/00 , C07K005/00 , C07K007/00 , C07K016/00 , C07K017/00 , A61K038/17 , A01N025/00
CPC分类号： C07K7/08 , A01K2217/05 , A61K38/00 , C07K14/001 , C07K14/43563 , C12N1/06
摘要： Novel synthetic lytic and proliferative peptides were designed and constructed to encompass the structural features associated with lytic and proliferative activity. These compounds, along with the human null fibrin signal peptide share structural and functional properties of the known lytic peptides. These peptides are effective agents in the treatment of microbial infections including gram negative and gram positive bacteria, fungus, virus, yeast, and protozoa, in the lysis of cancer cells, and in the proliferation of fibroblasts and lymphocytes. Additional functions include synergy and use as general adjuvants and in the enhancement of wound healing.
摘要翻译：设计并构建了新的合成裂解和增殖肽，以包含与溶解和增殖活性相关的结构特征。这些化合物与人β纤维蛋白信号肽一起共享已知裂解肽的结构和功能特性。这些肽是治疗微生物感染（包括革兰氏阴性和革兰氏阳性细菌，真菌，病毒，酵母和原生动物）在癌细胞裂解和成纤维细胞和淋巴细胞增殖中的有效试剂。附加功能包括作为一般佐剂的协同作用和用途以及增强伤口愈合。

44. 发明专利

PL2827907T3 KRÓTKIE LIPOPEPTYDY PRZECIWDROBNOUSTROJOWE 未知
公开(公告)号：PL2827907T3
公开(公告)日：2019-08-30
申请号：PL13710751
申请日：2013-03-07
申请人： HELIX BIOMEDIX INC
发明人： ZHANG LIJUAN , CARMICHAEL ROBIN
IPC分类号： A61K38/34 , A61K38/05 , A61K47/54 , C07K5/068

45. 发明专利

CA2898717C SHORT BIO-ACTIVE PEPTIDES FOR PROMOTING WOUND HEALING 未知
公开(公告)号：CA2898717C
公开(公告)日：2019-01-08
申请号：CA2898717
申请日：2014-01-21
申请人： HELIX BIOMEDIX INC
发明人： ZHANG LIJUAN , CARMICHAEL ROBIN
IPC分类号： A61K38/16 , C07K14/435
摘要： Peptides having four to six amino acid residues are disclosed that possess biological activity. These peptides constitute short fragments of the peptide HB-107 (MPKEKVFLKIEKMGRNIRN), which itself is a fragment of the antimicrobial protein cecropin B, and exhibit cell stimulatory and migratory properties. The inventive peptides comprise four to six contiguous amino acid residues located between position 11 and 16 of HB107 (MPKEKVFLKIEKMGRNIRN), namely EKMGRN. The disclosed peptides comprise a useful agent for the medical treatment of injury to the skin, such as from diabetic ulcers. The peptides also are effective in preventing and reversing skin surface damage resulting from various environmental insults. Importantly, the therapeutic effects of the peptides manifest at concentrations equal to or greater than those of peptide HB-107, and thus represent a less expensive, more versatile means for developing effective therapies. Methods for the production and use of these peptides are also disclosed.

46. 发明专利

BRPI0720874B1 composições compreendendo peptídeos bioativos curtos para modulação celular e imunológica 未知
公开(公告)号：BRPI0720874B1
公开(公告)日：2018-11-21
申请号：BRPI0720874
申请日：2007-12-27
申请人： HELIX BIOMEDIX INC
发明人： LIJUAN ZHANG , SCOTT M HARRIS , TIMOTHY J FALLA
IPC分类号： A61K38/00 , C07K14/435
摘要： .

47. 发明专利

PL3002294T3 Fragmenty peptydowe do indukowania syntezy białek macierzy zewnątrzkomórkowej 未知
公开(公告)号：PL3002294T3
公开(公告)日：2018-08-31
申请号：PL15188894
申请日：2007-06-12
申请人： HELIX BIOMEDIX INC
发明人： HARRIS SCOTT , FALLA TIMOTHY , ZHANG LIJUAN
IPC分类号： C07K14/78 , A61K38/00 , A61Q19/00 , C07K5/10

48. 发明专利

CA2800301C N-ACYL AMINO ACID DERIVATIVES FOR TREATING SKIN CONDITIONS SUCH AS CELLULITE 未知
公开(公告)号：CA2800301C
公开(公告)日：2018-03-27
申请号：CA2800301
申请日：2011-06-28
申请人： HELIX BIOMEDIX INC
发明人： FALLA TIMOTHY J , ZHANG LIJUAN
IPC分类号： C07C233/05 , A61K8/42 , A61K8/44 , A61K31/16 , A61K31/198 , A61P17/00 , A61Q19/06
摘要： The invention relates to small molecules having biological and therapeutic activity. Particularly, the invention relates to small molecules having lipolytic and anti-adipogenic activity. Two examples of such molecules are 4-methyl-2-(octanoylamino) pentanoic acid and N-isopentyloctanamide. The invention further relates to methods of preventing or treating skin conditions such as cellulite using small molecules having lipolytic and anti-adipogenic activity.

49. 发明专利

CY1119087T1 ΚΟΝΤΑ ΒΙΟΔΡΑΣΤΙΚΑ ΠΕΠΤΙΔΙΑ ΓΙΑ ΤΗΝ ΠΡΟΑΓΩΓΗ ΤΗΣ ΕΠΟΥΛΩΣΗΣ ΠΛΗΓΗΣ 未知
公开(公告)号：CY1119087T1
公开(公告)日：2018-01-10
申请号：CY171100747
申请日：2017-07-14
申请人： HELIX BIOMEDIX INC
发明人： ZHANG LIJUAN , CARMICHAEL ROBIN
IPC分类号： A61K38/16 , C07K14/435
摘要： Αποκαλύπτονταιπεπτίδιαταοποίαέχουντέσσεραέωςέξιυπόλοιπααμινοξέοςταοποίαδιαθέτουνβιολογικήδραστικότητα. ΤαπεπτίδιααυτάσυνιστούνκοντάθραύσματατουπεπτιδίουΗΒ-107 (MPKEKVFLKIEKMGRNIRN) τοοποίοτοίδιοείναιέναθραύσματηςαντιμικροβιακήςπρωτεΐνηςκεκροπίνηΒ καιεπιδεικνύεικυτταροδιεγερτικέςκαιμεταναστευτικέςιδιότητες. Ταεφευρετικάπεπτίδιαπεριέχουντέσσεραέωςέξιγειτονικάυπόλοιπααμινοξέοςπουβρίσκονταιμεταξύτηςθέσης 11 και 16 τουΗΒ-107 (MPKEKVFLKIEKMGRNIRN), δηλαδή EKMGRN. Τααποκαλυπτόμεναπεπτίδιαπεριέχουνένανχρήσιμοπαράγονταγιατηνιατρικήαγωγήενόςτραυματισμούτουδέρματοςόπωςαπόδιαβητικάέλκη. Ταπεπτίδιαείναιεπίσηςαποτελεσματικάστηνπρόληψηκαιτηναντιστροφήτηςεπιφανειακήςβλάβηςτουδέρματοςπουπροκύπτειαπόδιάφορεςπεριβαλλοντικέςπροσβολές. Κατάσημαντικότρόπο, ταθεραπευτικάαποτελέσματατωνπεπτιδίωνεκδηλώνονταισεσυγκεντρώσειςίσεςπροςή μεγαλύτερεςαπόαυτέςτουπεπτιδίουΗΒ-107 καιτοιουτοτρόπωςπαριστούνέναλιγότεροακριβό, περισσότεροευέλικτομέσογιατηνανάπτυξηαποτελεσματικώνθεραπειών. Αποκαλύπτονταιεπίσηςμέθοδοιγιατηνπαραγωγήκαιχρήσητωνπεπτιδίωναυτών.

50. 发明专利

NZ711281A Short bio-active peptides for promoting wound healing 未知
公开(公告)号：NZ711281A
公开(公告)日：2017-12-22
申请号：NZ71128114
申请日：2014-01-21
申请人： HELIX BIOMEDIX INC
发明人： ZHANG LIJUAN , CARMICHAEL ROBIN
IPC分类号： A61K38/04
摘要： The present invention relates to an isolated peptide, wherein the sequence of the peptide consists of SEQ ID NO: 5 (MGRN) or SEQ ID NO: 2 (KMGRN), wherein the peptide is in free acid form, amidated at the carboxy terminus or lipidated at the amine terminus. The disclosed peptides comprise a useful agent for the medical treatment of injury to the skin, such as from diabetic ulcers. The peptides also are effective in preventing and reversing skin surface damage resulting from various environmental insults. Importantly, the therapeutic effects of the peptides manifest at concentrations equal to or greater than those of peptide HB-107, and thus represent a less expensive, more versatile means for developing effective therapies. Methods for the production and use of these peptides are also disclosed.

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