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    • 41. 发明授权
    • Tablets immediately disintegrating in the oral cavity
    • 片剂立即在口腔内分解
    • US06743443B1
    • 2004-06-01
    • US09806823
    • 2001-04-05
    • Hisao FuritsuAkira KatoTakayuki OhwakiMasanobu Yasui
    • Hisao FuritsuAkira KatoTakayuki OhwakiMasanobu Yasui
    • A61K920
    • A61K9/0056A61K9/2095A61K31/4985A61K31/502A61K31/517A61K31/519
    • The present invention provides an intraoral quickly disintegrating tablet containing a phosphodiesterase inhibitor having an effect of improving the erectile dysfunction and a method for manufacturing the tablet. The present invention also provides an intraoral quickly disintegrating tablet containing a slightly soluble pharmaceutical agent having an improved solubility and a method for manufacturing the tablet. That is, it is an intraoral quickly disintegrating tablet containing a cyclic GMP phosphodiesterase inhibitor and a saccharide, and a method for manufacturing the tablet. Further, it is a method for manufacturing an intraoral quickly disintegrating tablet, which comprises dissolving a slightly soluble pharmaceutical agent in an organic solvent or an aqueous organic solvent together with a surfactant and/or a water-soluble polymer, coating the solution on a filler or granulating it with a filler to obtain molded products, mixing a saccharide with them, adding an organic solvent, water or an aqueous organic solvent thereto, followed by kneading, and subjecting it to a compression-molding.
    • 本发明提供含有具有改善勃起功能障碍的作用的磷酸二酯酶抑制剂的口腔内快速崩解片剂及其制造方法。 本发明还提供了含有具有改善的溶解性的微溶性药剂和制造片剂的方法的口腔内快速崩解片剂。 也就是说,它是含有环状GMP磷酸二酯酶抑制剂和糖类的口内快速崩解片及其制造方法。 此外,它是一种制造口内快速崩解片的方法,其包括将微溶性药剂与表面活性剂和/或水溶性聚合物一起溶解在有机溶剂或含水有机溶剂中,将该溶液涂覆在填料上 或者用填充剂造粒,得到成型品,与其混合,向其中加入有机溶剂,水或有机溶剂,然后捏合,并进行压缩成形。